| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sebastián Rodríguez, Kazuyuki Uchida, Hiroyuki Nakayam. Immunohistochemical changes of nigrostriatal tyrosine hydroxylase and dopamine transporter in the golden hamster after a single intrastriatal injection of 6-hydroxydopamine. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 4. 2013-09-26. PMID:22357095. |
immunohistochemical changes of nigrostriatal tyrosine hydroxylase and dopamine transporter in the golden hamster after a single intrastriatal injection of 6-hydroxydopamine. |
2013-09-26 |
2023-08-12 |
rat |
| Sebastián Rodríguez, Kazuyuki Uchida, Hiroyuki Nakayam. Immunohistochemical changes of nigrostriatal tyrosine hydroxylase and dopamine transporter in the golden hamster after a single intrastriatal injection of 6-hydroxydopamine. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 65. issue 4. 2013-09-26. PMID:22357095. |
significant decreases in tyrosine hydroxylase (th)-positive area and dopamine transporter (dat)-positive area were found in the ipsilateral striatum 3 days after the injection. |
2013-09-26 |
2023-08-12 |
rat |
| C Capper-Loup, C M Frey, D Rebell, A Kaelin-Lan. Adaptive gene expression changes on the healthy side of parkinsonian rats. Neuroscience. vol 233. 2013-09-23. PMID:23270858. |
in addition, we analyzed the expression of several striatal and cortical glutamatergic markers, as well as nigral tyrosine hydroxylase (th) and nigral dopamine transporter (dat). |
2013-09-23 |
2023-08-12 |
rat |
| Masaya Segawa, Yoshiko Nomura, Masaharu Hayash. Dopa-responsive dystonia is caused by particular impairment of nigrostriatal dopamine neurons different from those involved in Parkinson disease: evidence observed in studies on Segawa disease. Neuropediatrics. vol 44. issue 2. 2013-09-11. PMID:23468278. |
from the characteristics of its clinical features, segawa disease is considered to be caused by deficiency of the tyrosine hydroxylase (th) of the nigrostriatal dopamine neurons, which have high th activities in the terminal but not in the perikaryon. |
2013-09-11 |
2023-08-12 |
Not clear |
| R E Nordquist, E C Zeinstra, T B Rodenburg, F J van der Staa. Effects of maternal care and selection for low mortality on tyrosine hydroxylase concentrations and cell soma size in hippocampus and nidopallium caudolaterale in adult laying hen. Journal of animal science. vol 91. issue 1. 2013-09-04. PMID:23048145. |
we examined the effects of rearing with a foster hen, genetic selection for low mortality from cannibalism, and interactions between both, using cellular morphology and levels of the rate-limiting enzyme in dopamine production, tyrosine hydroxylase, in the hippocampus and nidopallium caudolaterale (ncl) as a potential measure for laying hen welfare. |
2013-09-04 |
2023-08-12 |
Not clear |
| Nicolas Aznavour, Christophe Cendres-Bozzi, Laetitia Lemoine, Colette Buda, Jean-Pierre Sastre, Zoïa Mincheva, Luc Zimmer, Jian-Sheng Li. MPTP animal model of Parkinsonism: dopamine cell death or only tyrosine hydroxylase impairment? A study using PET imaging, autoradiography, and immunohistochemistry in the cat. CNS neuroscience & therapeutics. vol 18. issue 11. 2013-08-27. PMID:23106974. |
mptp animal model of parkinsonism: dopamine cell death or only tyrosine hydroxylase impairment? |
2013-08-27 |
2023-08-12 |
cat |
| Nicolas Aznavour, Christophe Cendres-Bozzi, Laetitia Lemoine, Colette Buda, Jean-Pierre Sastre, Zoïa Mincheva, Luc Zimmer, Jian-Sheng Li. MPTP animal model of Parkinsonism: dopamine cell death or only tyrosine hydroxylase impairment? A study using PET imaging, autoradiography, and immunohistochemistry in the cat. CNS neuroscience & therapeutics. vol 18. issue 11. 2013-08-27. PMID:23106974. |
it is believed to cause a selective destruction of substantia nigra dopamine neurons, mainly based on a large reduction of tyrosine hydroxylase (th), the catecholamine's synthesizing enzyme. |
2013-08-27 |
2023-08-12 |
cat |
| Kazuhiro Nakaso, Naoko Tajima, Satoru Ito, Mari Teraoka, Atsushi Yamashita, Yosuke Horikoshi, Daisuke Kikuchi, Shinsuke Mochida, Kenji Nakashima, Tatsuya Matsur. Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein. PloS one. vol 8. issue 2. 2013-08-26. PMID:23457458. |
overexpression of wildtype α-syn in catecholaminergic pc12 cells decreased cell viability in long-term cultures, while a competitive inhibitor of tyrosine hydroxylase blocked this vulnerability, suggesting that α-syn-related cytotoxicity is associated with dopamine metabolism. |
2013-08-26 |
2023-08-12 |
human |
| Daigo Homma, Setsuko Katoh, Hirofumi Tokuoka, Hiroshi Ichinos. The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain. Journal of neurochemistry. vol 126. issue 1. 2013-08-23. PMID:23647001. |
tyrosine hydroxylase (th) is a rate-limiting enzyme for dopamine synthesis and requires tetrahydrobiopterin (bh4) as an essential cofactor. |
2013-08-23 |
2023-08-12 |
mouse |
| Scot McIntosh, Leonard Howell, Scott E Hemb. Dopaminergic dysregulation in prefrontal cortex of rhesus monkeys following cocaine self-administration. Frontiers in psychiatry. vol 4. 2013-08-23. PMID:23970867. |
the abundance of surrogate markers of dopamine signaling and plasticity in the dorsolateral prefrontal cortex (dlpfc), orbitofrontal cortex (ofc), and anterior cingulate cortex (acc) were examined: glycosylated and non-glycosylated forms of the dopamine transporter (efficiency of dopamine transport), tyrosine hydroxylase (th; marker of dopamine synthesis) and phosphorylated th at serine 30 and 40 (markers of enzyme activity), extracellular signal-regulated kinase 1 and 2 (erk1 and erk 2), and phosphorylated erk1 and erk2 (phosphorylates th serine 31; markers of synaptic plasticity), and markers of synaptic integrity, spinophilin and post-synaptic density protein 95 (roles in dopamine signaling and response to cocaine). |
2013-08-23 |
2023-08-12 |
monkey |
| Sangmi Chung, Chun-Hyung Kim, Kwang-Soo Ki. Lmx1a regulates dopamine transporter gene expression during ES cell differentiation and mouse embryonic development. Journal of neurochemistry. vol 122. issue 2. 2013-08-14. PMID:22564125. |
furthermore, during mouse embryonic development, dopamine transporter was more severely affected by lmx1a mutation compared to other dopamine markers such as tyrosine hydroxylase and dopa decarboxylase, again supporting the role of lmx1a in midbrain dopaminergic maturation in vivo. |
2013-08-14 |
2023-08-12 |
mouse |
| Francesca Grespi, Gerry Melin. P73 and age-related diseases: is there any link with Parkinson Disease? Aging. vol 4. issue 12. 2013-08-12. PMID:23271007. |
tyrosine hydroxylase is a crucial player in parkinson disease being the enzyme necessary for dopamine synthesis. |
2013-08-12 |
2023-08-12 |
Not clear |
| Fernando Cardozo-Pelaez, Monica Sanchez-Contreras, Andrew B C Nevi. Ogg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP. Neurochemistry international. vol 61. issue 5. 2013-07-29. PMID:22743193. |
aged ogg1 knock-out (ogg1 ko) mice show a decreased spontaneous locomotor behavior and evidence a decrease in striatal dopamine levels, a loss of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn), and an increase in ubiquitin-positive inclusions in their remaining sn neurons. |
2013-07-29 |
2023-08-12 |
mouse |
| Kang-Woo Lee, Joo-Young Im, Jong-Min Woo, Hilary Grosso, Yoon-Seong Kim, Ana Clara Cristovao, Patricia K Sonsalla, David S Schuster, Marla M Jalbut, Jose R Fernandez, Michael Voronkov, Eunsung Junn, Steven P Braithwaite, Jeffry B Stock, M Maral Mouradia. Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 10. issue 1. 2013-07-29. PMID:23296837. |
reductions in striatal dopamine and tyrosine hydroxylase content were also less pronounced with eht treatment. |
2013-07-29 |
2023-08-12 |
mouse |
| P Thakur, B Nehr. Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease. Neuroscience. vol 231. 2013-07-25. PMID:23159314. |
in the animals receiving rotenone+ss, significant improvement was observed in the various characteristic hallmarks of pd such as dopamine and tyrosine hydroxylase levels as well as the motor dysfunction symptoms. |
2013-07-25 |
2023-08-12 |
rat |
| K Barreto-Valer, R López-Bellido, R E Rodrígue. Cocaine modulates the expression of transcription factors related to the dopaminergic system in zebrafish. Neuroscience. vol 231. 2013-07-25. PMID:23219907. |
nodal-related protein, ndr2, and transcription factors such as lmx1b, otp, nurr1 and pitx3 are very important in the differentiation, function and maintenance of mesodiencephalic dopaminergic neurons, and are necessary for the activation of tyrosine hydroxylase (th) and dopamine (da) transporter expression. |
2013-07-25 |
2023-08-12 |
zebrafish |
| Joanne Clark, Jessica M Silvaggi, Tomas Kiselak, Kangni Zheng, Elizabeth L Clore, Ying Dai, Caroline E Bass, David K Simo. Pgc-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf. PloS one. vol 7. issue 11. 2013-07-24. PMID:23145024. |
overexpression of pgc-1α in the sn induced expression of target genes, but unexpectedly it also greatly reduced the expression of tyrosine hydroxylase (th) and other markers of the dopaminergic phenotype with resultant severe loss of striatal dopamine. |
2013-07-24 |
2023-08-12 |
mouse |
| Raffaele De Caro, Veronica Macchi, Martina M Sfriso, Andrea Porzionat. Structural and neurochemical changes in the maturation of the carotid body. Respiratory physiology & neurobiology. vol 185. issue 1. 2013-07-22. PMID:22728582. |
modulation of content and release of catecholamine occurs, together with decreased expression of tyrosine hydroxylase and dopamine β-hydroxylase and increased expression of choline acetyltransferase. |
2013-07-22 |
2023-08-12 |
Not clear |
| Donna Crabtree, Michaël Boyer-Guittaut, Xiaosen Ouyang, Naomi Fineberg, Jianhua Zhan. Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration. Neuroscience letters. vol 538. 2013-07-11. PMID:23391753. |
dopamine synthesizing enzyme tyrosine hydroxylase, metabolic enzyme monoamine oxidase, and catechol-o-methyltransferase (comt) levels are similar in the striatum in wildtype and heterozygous mice. |
2013-07-11 |
2023-08-12 |
mouse |
| Chiara Mangano, Gustav Colldén, Björn Meiste. Chemical phenotypes of P2X2 purinoreceptor immunoreactive cell bodies in the area postrema. Purinergic signalling. vol 8. issue 2. 2013-07-10. PMID:22038573. |
the majority of p2x2r-immunoreactive cells were shown to contain tyrosine hydroxylase (th) (63.5 ± 7.7%) and dopamine β-hydroxylase (61.5 ± 5.1%). |
2013-07-10 |
2023-08-12 |
rat |