| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeyoshi Eda, Makoto Mizuno, Kazuaki Araki, Yuriko Iwakura, Hisaaki Namba, Hidekazu Sotoyama, Akiyoshi Kakita, Hitoshi Takahashi, Hiroshi Satoh, Siu-Yuen Chan, Hiroyuki Naw. Neurobehavioral deficits of epidermal growth factor-overexpressing transgenic mice: impact on dopamine metabolism. Neuroscience letters. vol 547. 2014-01-16. PMID:23669645. |
there were neurochemical alterations in metabolic enzymes of dopamine (i.e., tyrosine hydroxylase, dopa decarboxylase, catechol-o-methyl transferase) and monoamine contents in various brain regions of the egf transgenic mice, but there were no apparent neuropathological signs in the brain. |
2014-01-16 |
2023-08-12 |
mouse |
| Keon Sung Shin, Hyun Sook Choi, Ting Ting Zhao, Kwang Hoon Suh, Ik Hyun Kwon, Soon Ok Choi, Myung Koo Le. Neurotoxic effects of berberine on long-term L-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Archives of pharmacal research. vol 36. issue 6. 2014-01-13. PMID:23539311. |
treatments with either concentration of berberine (5 and 15 mg/kg) in 6-ohda-lesioned groups decreased the numbers of tyrosine hydroxylase (th)-immunopositive neurons in the substantia nigra and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the striatum as compared to 6-ohda-lesioned groups. |
2014-01-13 |
2023-08-12 |
rat |
| Jian Yu Wang, Jing Yu Yang, Fang Wang, Shi Yuan Fu, Yue Hou, Bo Jiang, Jie Ma, Cui Song, Chun Fu W. Neuroprotective effect of pseudoginsenoside-f11 on a rat model of Parkinson's disease induced by 6-hydroxydopamine. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2014-01-03. PMID:24386001. |
the expression of tyrosine hydroxylase (th) in substantia nigra (sn) and the content of extracellular dopamine (da) in striatum were also significantly increased after pf11 treatment. |
2014-01-03 |
2023-08-12 |
rat |
| Esther Korpershoek, Nanne K Kloosterhof, Angelique Ziel-van der Made, Hanneke Korsten, Lindsey Oudijk, Jan Trapman, Winand N M Dinjens, Ronald R de Krijge. Trp53 inactivation leads to earlier phaeochromocytoma formation in pten knockout mice. Endocrine-related cancer. vol 19. issue 6. 2013-12-31. PMID:22930559. |
the adrenal weights were determined for all mice, and in a proportion of these mice, immunohistochemistry for tyrosine hydroxylase and dopamine β-hydroxylase was performed on the adrenals and corresponding lungs. |
2013-12-31 |
2023-08-12 |
mouse |
| Fany Messanvi, Ellie Eggens-Meijer, Benno Roozendaal, Johannes J van der Wan. A discrete dopaminergic projection from the incertohypothalamic A13 cell group to the dorsolateral periaqueductal gray in rat. Frontiers in neuroanatomy. vol 7. 2013-12-24. PMID:24367297. |
for this purpose, the retrograde tracer cholera toxin subunit b (ctb) was injected into the dlpag of male wistar rats and double immunofluorescence for ctb and tyrosine hydroxylase (th), the rate-limiting enzyme in the synthesis of dopamine, was performed. |
2013-12-24 |
2023-08-12 |
rat |
| Jiang-ping Wang, Guo-fu Ding, Qin-zhang Wan. Interstitial cells of Cajal mediate excitatory sympathetic neurotransmission in guinea pig prostate. Cell and tissue research. vol 352. issue 3. 2013-12-18. PMID:23411811. |
surprisingly, prostate iccs co-expressed tyrosine hydroxylase and dopamine β-hydroxylase, two markers of sympathetic neurons. |
2013-12-18 |
2023-08-12 |
human |
| Tsuguru Fujii, Hiroaki Abe, Munetaka Kawamoto, Susumu Katsuma, Yutaka Banno, Toru Shimad. Albino (al) is a tetrahydrobiopterin (BH4)-deficient mutant of the silkworm Bombyx mori. Insect biochemistry and molecular biology. vol 43. issue 7. 2013-12-13. PMID:23567588. |
the pathway for dopamine biosynthesis from phenylalanine involves phenylalanine hydroxylase (pah; ec 1.14.16.1) and tyrosine hydroxylase (th; ec 1.14.16.2). |
2013-12-13 |
2023-08-12 |
Not clear |
| J Zhang, X Liu, L Zhao, S Hu, S Li, F Pia. Subchronic exposure to arsenic disturbed the biogenic amine neurotransmitter level and the mRNA expression of synthetase in mice brains. Neuroscience. vol 241. 2013-12-12. PMID:23518225. |
the ultra-structural change of vesicles in the synapses of mice brains was observed by transmission electron microscopy; the mrna expressions of dopamine beta hydroxylase (dbh), tyrosine hydroxylase (th) and tryptophan hydroxylase (tph) as ne, da and 5-ht synthetases were quantitatively assessed by real time reverse transcription-polymerase chain reaction. |
2013-12-12 |
2023-08-12 |
mouse |
| Bin Liu, Roberta Traini, Bryan Killinger, Bernard Schneider, Anna Moszczynsk. Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity. Experimental neurology. vol 247. 2013-11-26. PMID:23313192. |
the levels of dopamine synthesizing enzyme, tyrosine hydroxylase, remained at the control levels; therefore, tyrosine hydroxylase immunoreactivity was used as an index of dopaminergic terminal integrity. |
2013-11-26 |
2023-08-12 |
rat |
| Patrik Brundin, Jeffrey H Kordowe. Neuropathology in transplants in Parkinson's disease: implications for disease pathogenesis and the future of cell therapy. Progress in brain research. vol 200. 2013-11-15. PMID:23195421. |
additionally, the grafted cells placed in the parkinson's disease brain eventually downregulate the expression of dopamine transporter and tyrosine hydroxylase in a manner similar to what is seen in the substantia nigra dopamine neurons that are degenerating due to the disease. |
2013-11-15 |
2023-08-12 |
Not clear |
| Brandon S Pruett, Michael F Salvator. Nigral GFRα1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity. Molecular neurobiology. vol 47. issue 3. 2013-11-11. PMID:23321789. |
nigral gfrα1 infusion in aged rats increases locomotor activity, nigral tyrosine hydroxylase, and dopamine content in synchronicity. |
2013-11-11 |
2023-08-12 |
rat |
| B Linard, S Bennani, P Jego, C Saligau. Tyrosine hydroxylase activity and dopamine turnover of rainbow trout (Oncorhynchus mykiss) brain: the special status of the hypothalamus. Fish physiology and biochemistry. vol 15. issue 1. 2013-11-07. PMID:24193987. |
tyrosine hydroxylase activity and dopamine turnover of rainbow trout (oncorhynchus mykiss) brain: the special status of the hypothalamus. |
2013-11-07 |
2023-08-12 |
rat |
| Jing Liang, Si-Si Ma, Yi-Jing Li, Xing-Jie Ping, Ling Hu, Cai-Lian Cu. Dynamic changes of tyrosine hydroxylase and dopamine concentrations in the ventral tegmental area-nucleus accumbens projection during the expression of morphine-induced conditioned place preference in rats. Neurochemical research. vol 37. issue 7. 2013-10-31. PMID:22396106. |
dynamic changes of tyrosine hydroxylase and dopamine concentrations in the ventral tegmental area-nucleus accumbens projection during the expression of morphine-induced conditioned place preference in rats. |
2013-10-31 |
2023-08-12 |
rat |
| Jared J Schwartzer, Lesley A Ricci, Richard H Mellon. Prior fighting experience increases aggression in Syrian hamsters: implications for a role of dopamine in the winner effect. Aggressive behavior. vol 39. issue 4. 2013-10-30. PMID:23519643. |
interestingly, changes in tyrosine hydroxylase, the rate limiting enzyme for dopamine production, were observed in brain regions within the social decision-making network. |
2013-10-30 |
2023-08-12 |
Not clear |
| Lauriaselle Afanador, Ina Mexhitaj, Carolyn Diaz, Dalila Ordonez, Lisa Baker, Jesus A Angul. The role of the neuropeptide somatostatin on methamphetamine and glutamate-induced neurotoxicity in the striatum of mice. Brain research. vol 1510. 2013-10-30. PMID:23524190. |
we then assessed 3-nitrotyrosine (3-nt), an indirect index of no production, tyrosine hydroxylase (th) protein levels (dopamine terminal marker) and fluoro-jade c positive cells (degenerating cells). |
2013-10-30 |
2023-08-12 |
mouse |
| Jeffrey H Kordower, C Warren Olanow, Hemraj B Dodiya, Yaping Chu, Thomas G Beach, Charles H Adler, Glenda M Halliday, Raymond T Bartu. Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain : a journal of neurology. vol 136. issue Pt 8. 2013-10-30. PMID:23884810. |
sections of the post-commissural putamen and substantia nigra pars compacta were processed for tyrosine hydroxylase and dopamine transporter immunohistochemistry. |
2013-10-30 |
2023-08-12 |
human |
| Ling Chen, Enping Huang, Huijun Wang, Pingming Qiu, Chao Li. RNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells. Brain research. vol 1521. 2013-10-23. PMID:23688541. |
the expression levels of tyrosine hydroxylase (th), dopamine transporter (dat) and vesicular monoamine transporter 2(vmat-2) were significantly decreased and the activity/levels of reactive oxygen species (ros), nitric oxide synthase (nos) and nitrogen (no) were notably increased after meth treatment. |
2013-10-23 |
2023-08-12 |
human |
| George F G Allen, Yasmin Ullah, Iain P Hargreaves, John M Land, Simon J R Heale. Dopamine but not l-dopa stimulates neural glutathione metabolism. Potential implications for Parkinson's and other dopamine deficiency states. Neurochemistry international. vol 62. issue 5. 2013-10-17. PMID:23261515. |
dopamine is produced first by hydroxylalation of l-tyrosine to l-dihydroxyphenylalanine (l-dopa) and subsequently by the decarboxylation of l-dopa to dopamine catalysed by the enzymes tyrosine hydroxylase and aromatic l-amino acid decarboxylase (aadc) respectively. |
2013-10-17 |
2023-08-12 |
human |
| K S Madathil, S S Karuppagounder, R Haobam, M Varghese, U Rajamma, K P Mohanakuma. Nitric oxide synthase inhibitors protect against rotenone-induced, oxidative stress mediated parkinsonism in rats. Neurochemistry international. vol 62. issue 5. 2013-10-17. PMID:23353925. |
treatment of these animals with specific neuronal nos inhibitor, 7-nitroindazole (7-ni) and non-specific nos inhibitor, n-ω-nitro-l-argenine methyl ester (l-name) caused reversal of rotenone-induced striatal dopamine depletion, and attenuation of the neurotoxin-induced decrease in the number of tyrosine hydroxylase immunoreactive neurons in snpc, as well as in apomorphine and amphetamine-induced unilateral rotations. |
2013-10-17 |
2023-08-12 |
rat |
| Zhi Yi Ong, Ayumi F Wanasuria, Mark Z P Lin, Jennifer Hiscock, Beverly S Muhlhausle. Chronic intake of a cafeteria diet and subsequent abstinence. Sex-specific effects on gene expression in the mesolimbic reward system. Appetite. vol 65. 2013-09-30. PMID:23402719. |
the nucleus accumbens (nac) was isolated and mrna expression of tyrosine hydroxylase (th), dopamine active transporter (dat), d1 and d2 dopamine receptors, and μ-opioid receptor determined by qrt-pcr. |
2013-09-30 |
2023-08-12 |
rat |