| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Satyndra Kumar Yadav, Jay Prakash, Shikha Chouhan, Susan Westfall, Mradul Verma, Tryambak Deo Singh, Surya Pratap Sing. Comparison of the neuroprotective potential of Mucuna pruriens seed extract with estrogen in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mice model. Neurochemistry international. vol 65. 2014-10-20. PMID:24333323. |
the recovery of dopamine neurons in the substantia nigra (sn) region was estimated by tyrosine hydroxylase (th), immunostaining. |
2014-10-20 |
2023-08-12 |
mouse |
| b' Vivian P Chou, Novie Ko, Theodore R Holman, Amy B Manning-Bo\\xc4\\x9. Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson\'s disease. Journal of visualized experiments : JoVE. issue 83. 2014-10-11. PMID:24430802.' |
the extent of mptp-induced lesioning is measured by hplc analysis of dopamine and its metabolites and semi-quantitative western blot analysis of striatum for tyrosine hydroxylase (th), the rate-limiting enzyme for the synthesis of dopamine. |
2014-10-11 |
2023-08-12 |
mouse |
| Barbara Bosier, Giulio G Muccioli, Didier M Lamber. The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB₁- and FAAH-independent mechanisms. British journal of pharmacology. vol 169. issue 4. 2014-10-08. PMID:22970888. |
given the reported effects of anandamide on dopamine transmission, we investigated the influence of endocannabinoids and urb597, a well-known faah inhibitor, on the expression of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis. |
2014-10-08 |
2023-08-12 |
Not clear |
| Zenon Pidsudk. Immunohistochemical characteristics and distribution of neurons in the paravertebral, prevertebral and pelvic ganglia supplying the urinary bladder in the male pig. Journal of molecular neuroscience : MN. vol 52. issue 1. 2014-09-25. PMID:24122239. |
the combined retrograde tracing and immunohistochemistry for tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), neuropeptide y (npy), somatostatin(som), galanin (gal), vasoactive intestinal polypeptide(vip), nitric oxide synthase (nos), calcitonin gene related peptide (cgrp), substance p (sp), choline acetyltransferase (chat) and vesicular acetylcholine transporter(vacht) were applied in the experiment. |
2014-09-25 |
2023-08-12 |
Not clear |
| Mark J Ferris, Rodrigo A España, Jason L Locke, Joanne K Konstantopoulos, Jamie H Rose, Rong Chen, Sara R Jone. Dopamine transporters govern diurnal variation in extracellular dopamine tone. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 26. 2014-09-23. PMID:24979798. |
we investigated dopamine metabolism, uptake, release, d2 autoreceptor sensitivity, and tyrosine hydroxylase expression and activity as mechanisms for this variation. |
2014-09-23 |
2023-08-13 |
mouse |
| Xiu-Qi Bao, Xiang-Chen Kong, Li-Bing Kong, Liang-Yu Wu, Hua Sun, Dan Zhan. Squamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models. Brain research. vol 1547. 2014-09-15. PMID:24384139. |
the beneficial effects of flz attributed to the elevation of dopaminergic neuron number, dopamine level and tyrosine hydroxylase (th) activity. |
2014-09-15 |
2023-08-12 |
rat |
| Yunchun Tai, Ling Chen, Enping Huang, Chao Liu, Xingyi Yang, Pingming Qiu, Huijun Wan. Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons. Neural regeneration research. vol 9. issue 9. 2014-09-10. PMID:25206917. |
striatal dopamine and tyrosine hydroxylase levels were significantly elevated in α-synuclein knockdown rats. |
2014-09-10 |
2023-08-13 |
rat |
| Danielle M Friend, Ashley N Fricks-Gleason, Kristen A Keef. Is there a role for nitric oxide in methamphetamine-induced dopamine terminal degeneration? Neurotoxicity research. vol 25. issue 2. 2014-09-07. PMID:23918001. |
methamphetamine (meth) abuse results in long-term damage to the dopaminergic system, manifesting as decreases in dopamine (da) tissue content, da transporter binding, as well as tyrosine hydroxylase and vesicular monoamine transporter immunostaining. |
2014-09-07 |
2023-08-12 |
Not clear |
| Eric W Fish, Michael C Krouse, Sierra J Stringfield, Jeffrey F Diberto, J Elliott Robinson, C J Malang. Changes in sensitivity of reward and motor behavior to dopaminergic, glutamatergic, and cholinergic drugs in a mouse model of fragile X syndrome. PloS one. vol 8. issue 10. 2014-09-04. PMID:24205018. |
we also measured brain expression of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine biosynthesis. |
2014-09-04 |
2023-08-12 |
mouse |
| Mario Riverol, Cristina Ordóñez, María Collantes, Carla DiCaudo, Iván Peñuelas, Javier Arbizu, Irene Marcilla, María R Luqui. Levodopa induces long-lasting modification in the functional activity of the nigrostriatal pathway. Neurobiology of disease. vol 62. 2014-09-03. PMID:24076099. |
striatal dopamine transporter (dat) content, tyrosine hydroxylase (th) content and aromatic l-amino acid decarboxylase (aadc) content were assessed. |
2014-09-03 |
2023-08-12 |
monkey |
| Ulrika Marklund, Zhanna Alekseenko, Elisabet Andersson, Scott Falci, Magnus Westgren, Thomas Perlmann, Anthony Graham, Erik Sundström, Johan Ericso. Detailed expression analysis of regulatory genes in the early developing human neural tube. Stem cells and development. vol 23. issue 1. 2014-08-28. PMID:24007338. |
in particular, we find that neither tyrosine hydroxylase nor nurr1 are specific markers for mesencephalic dopamine neurons, as these genes also are expressed in other neuronal subtypes in the human ventral midbrain and in human embryonic stem cell cultures directed to differentiate towards a ventral mesencephalic identity. |
2014-08-28 |
2023-08-12 |
mouse |
| N Daviaud, E Garbayo, N Lautram, F Franconi, L Lemaire, M Perez-Pinzon, C N Montero-Mene. Modeling nigrostriatal degeneration in organotypic cultures, a new ex vivo model of Parkinson's disease. Neuroscience. vol 256. 2014-08-27. PMID:24161279. |
a substantia nigra dopaminergic cell number decrease was observed by immunohistochemistry against rat tyrosine hydroxylase (th) reaching 80% after 2 days in culture associated with a 30% decrease of striatal th-positive fiber density, a 15% loss of striatal dopamine content quantified by mass spectrometry and a 70% reduction of nigrostriatal fiber fractional anisotropy quantified by dt-rmi. |
2014-08-27 |
2023-08-12 |
rat |
| Takashi Tanida, Ken Tasaka, Eiichi Akahoshi, Mitsuko Ishihara-Sugano, Michiko Saito, Shigehisa Kawata, Megumi Danjo, Junko Tokumoto, Youhei Mantani, Daichi Nagahara, Yoshiaki Tabuchi, Toshifumi Yokoyama, Hiroshi Kitagawa, Mitsuhiro Kawata, Nobuhiko Hosh. Fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin transactivates aryl hydrocarbon receptor-responsive element III in the tyrosine hydroxylase immunoreactive neurons of the mouse midbrain. Journal of applied toxicology : JAT. vol 34. issue 2. 2014-08-26. PMID:23296914. |
this motif is located upstream from the gene encoding tyrosine hydroxylase (th), the rate-limiting enzyme of dopamine biosynthesis. |
2014-08-26 |
2023-08-12 |
mouse |
| Ying Wu, Xiaodong Na, Ying Zang, Yu Cui, Wenjun Xin, Ruiping Pang, Lijun Zhou, Xuhong Wei, Yongyong Li, Xianguo Li. Upregulation of tumor necrosis factor-alpha in nucleus accumbens attenuates morphine-induced rewarding in a neuropathic pain model. Biochemical and biophysical research communications. vol 449. issue 4. 2014-08-26. PMID:24845379. |
furthermore, sni reduced dopamine (da) level and upregulated dopamine transporter (dat) in the nacc, but did not affect total tyrosine hydroxylase (th) or phospho-th (p-th), a rate-limiting enzyme of catecholamine biosynthesis, in ventral tegmental area (vta). |
2014-08-26 |
2023-08-13 |
mouse |
| A R Wild, E Akyol, S L C Brothwell, P Kimkool, J N Skepper, A J Gibb, S Jone. Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones. Neuropharmacology. vol 73. 2014-08-13. PMID:23727219. |
using immunohistochemistry, confocal imaging and stereological analysis, nmda was found to reduce the density of cells expressing tyrosine hydroxylase, a marker of viable dopamine neurones; memantine prevented the nmda-evoked decrease. |
2014-08-13 |
2023-08-12 |
Not clear |
| Sekar Sathiya, Vijayan Ranju, Periyathambi Kalaivani, Raju Jyothi Priya, Haridass Sumathy, Adoor Gopalan Sunil, Chidambaram Saravana Bab. Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice. Neuropharmacology. vol 73. 2014-08-13. PMID:23747572. |
in the present study, the effect of tel on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) induced motor dysfunctions and dopaminergic degeneration was ascertained through investigating the alterations in protein expression of dopamine transporter (dat), tyrosine hydroxylase (th) and syn in c57bl/6j mouse. |
2014-08-13 |
2023-08-12 |
mouse |
| Patrick Oeckl, Bastian Hengerer, Boris Ferge. G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology. vol 257. 2014-08-13. PMID:24747358. |
western blot analyses revealed no alteration in the expression and subcellular localisation of the dopamine d2 receptor in the striatum of gpr6(-/-) mice, and the number of tyrosine hydroxylase positive neurons in the substantia nigra was unchanged. |
2014-08-13 |
2023-08-13 |
mouse |
| Justine D Miller, Yosif M Ganat, Sarah Kishinevsky, Robert L Bowman, Becky Liu, Edmund Y Tu, Pankaj K Mandal, Elsa Vera, Jae-won Shim, Sonja Kriks, Tony Taldone, Noemi Fusaki, Mark J Tomishima, Dimitri Krainc, Teresa A Milner, Derrick J Rossi, Lorenz Stude. Human iPSC-based modeling of late-onset disease via progerin-induced aging. Cell stem cell. vol 13. issue 6. 2014-08-06. PMID:24315443. |
induced aging in pd ipsc-derived dopamine neurons revealed disease phenotypes that require both aging and genetic susceptibility, such as pronounced dendrite degeneration, progressive loss of tyrosine hydroxylase (th) expression, and enlarged mitochondria or lewy-body-precursor inclusions. |
2014-08-06 |
2023-08-12 |
human |
| Madhusmita Priyadarshini, Lori A Orosco, Pertti J Panul. Oxidative stress and regulation of Pink1 in zebrafish (Danio rerio). PloS one. vol 8. issue 11. 2014-07-29. PMID:24324558. |
the enzyme tyrosine hydroxylase (th) catalyzes the formation of l-dopa, the rate-limiting step in the biosynthesis of dopamine. |
2014-07-29 |
2023-08-12 |
zebrafish |
| Esperanza García, Ricardo Santana-Martínez, Carlos A Silva-Islas, Ana Laura Colín-González, Sonia Galván-Arzate, Yessica Heras, Perla D Maldonado, Julio Sotelo, Abel Santamarí. S-allyl cysteine protects against MPTP-induced striatal and nigral oxidative neurotoxicity in mice: participation of Nrf2. Free radical research. vol 48. issue 2. 2014-07-24. PMID:24147739. |
× 5 days)-induced striatal and nigral dopamine and tyrosine hydroxylase depletion, attenuated the loss of mn-sod and ho-1 activities, and preserved the protein content of these enzymes. |
2014-07-24 |
2023-08-12 |
mouse |