| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alana W Sullivan, Elsworth C Beach, Lucas A Stetzik, Amy Perry, Alyssa S D'Addezio, Bruce S Cushing, Heather B Patisau. A novel model for neuroendocrine toxicology: neurobehavioral effects of BPA exposure in a prosocial species, the prairie vole (Microtus ochrogaster). Endocrinology. vol 155. issue 10. 2015-01-05. PMID:25051448. |
brains were then collected and assessed for immunoreactive (ir) tyrosine hydroxylase (th) (a dopamine marker) neurons in the principal bed nucleus of the stria terminalis (pbnst) and th-ir, ot-ir, and avp-ir neurons in the paraventricular nucleus of the hypothalamus (pvn). |
2015-01-05 |
2023-08-13 |
mouse |
| Qingwei Zhou, Jiajun Chen, Shihong Yi, Yongwei Lou, Weimin Tang, Yongmao Liu, Pengguo Zhan. Zhichan powder regulates nigrostriatal dopamine synthesis and metabolism in Parkinson's disease rats. Neural regeneration research. vol 7. issue 27. 2015-01-05. PMID:25558223. |
our experimental findings indicate that zhichan powder has an antioxidant effect, it can regulate the expression of monoamine oxidase b and tyrosine hydroxylase in the substantia nigra of parkinson's disease rats, and it can facilitate the secretion of striatal dopamine and its metabolite homovanillic acid. |
2015-01-05 |
2023-08-13 |
rat |
| Jennifer Jager, W Timothy O'Brien, Jessica Manlove, Elizabeth N Krizman, Bin Fang, Zachary Gerhart-Hines, Michael B Robinson, Peter S Klein, Mitchell A Laza. Behavioral changes and dopaminergic dysregulation in mice lacking the nuclear receptor Rev-erbα. Molecular endocrinology (Baltimore, Md.). vol 28. issue 4. 2015-01-01. PMID:24552589. |
hippocampal dopamine turnover was increased in rev-erbα ko mice, due to up-regulation of tyrosine hydroxylase, the rate-limiting enzyme in dopamine production, and pharmacologic inhibition of tyrosine hydroxylase activity partially rescued locomotor hyperactivity. |
2015-01-01 |
2023-08-12 |
mouse |
| Yasuhiko Izumi, Masayuki Ezumi, Yuki Takada-Takatori, Akinori Akaike, Toshiaki Kum. Endogenous dopamine is involved in the herbicide paraquat-induced dopaminergic cell death. Toxicological sciences : an official journal of the Society of Toxicology. vol 139. issue 2. 2014-12-29. PMID:24743698. |
a decline in intracellular dopamine content achieved by inhibiting tyrosine hydroxylase (th), an enzyme for dopamine synthesis, conferred resistance to paraquat toxicity on dopaminergic cells. |
2014-12-29 |
2023-08-13 |
mouse |
| Josiane W Bortolotto, Giana P Cognato, Raissa R Christoff, Laura N Roesler, Carlos E Leite, Luiza W Kist, Mauricio R Bogo, Monica R Vianna, Carla D Bona. Long-term exposure to paraquat alters behavioral parameters and dopamine levels in adult zebrafish (Danio rerio). Zebrafish. vol 11. issue 2. 2014-12-18. PMID:24568596. |
this study evaluated the effect of the systemic administration of pq on locomotion, learning and memory, social interaction, tyrosine hydroxylase (th) expression, dopamine and 3,4-dihydroxyphenylacetic acid (dopac) levels, and dopamine transporter (dat) gene expression in zebrafish. |
2014-12-18 |
2023-08-12 |
zebrafish |
| Andrew E Christie, Tiana M Fontanilla, Vittoria Roncalli, Matthew C Cieslak, Petra H Len. Identification and developmental expression of the enzymes responsible for dopamine, histamine, octopamine and serotonin biosynthesis in the copepod crustacean Calanus finmarchicus. General and comparative endocrinology. vol 195. 2014-12-11. PMID:24148657. |
using known drosophila melanogaster proteins as templates, transcripts encoding putative calanus homologs of tryptophan-phenylalanine hydroxylase (dopamine, octopamine and serotonin biosynthesis), tyrosine hydroxylase (dopamine biosynthesis), dopa decarboxylase (dopamine and serotonin biosynthesis), histidine decarboxylase (histamine biosynthesis), tyrosine decarboxylase (octopamine biosynthesis), tyramine β-hydroxylase (octopamine biosynthesis) and tryptophan hydroxylase (serotonin biosynthesis) were identified. |
2014-12-11 |
2023-08-12 |
drosophila_melanogaster |
| Poonam Thakur, Bimla Nehr. Long-term heat shock proteins (HSPs) induction by carbenoxolone improves hallmark features of Parkinson's disease in a rotenone-based model. Neuropharmacology. vol 79. 2014-12-03. PMID:24296154. |
in addition, the decrease in apoptosis and oxidative stress following hsp upregulation prevented the decline in tyrosine hydroxylase (th) and dopamine levels in mid-brain region, which in turn resulted in improved motor functions. |
2014-12-03 |
2023-08-12 |
rat |
| Xiaoying Wang, Guiyun Cui, Xinxin Yang, Zunsheng Zhang, Hongjuan Shi, Jie Zu, Fang Hua, Xia She. Intracerebral administration of ultrasound-induced dissolution of lipid-coated GDNF microbubbles provides neuroprotection in a rat model of Parkinson's disease. Brain research bulletin. vol 103. 2014-12-03. PMID:24583079. |
moreover, gdnf microspheres reduced apomorphine-induced rotations, and increased striatal dopamine and nigral tyrosine hydroxylase (th) levels in pd rats. |
2014-12-03 |
2023-08-12 |
rat |
| Arjen J Boender, Nivard A Koning, José K van den Heuvel, Mieneke C M Luijendijk, Andrea J van Rozen, Susanne E la Fleur, Roger A H Ada. AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior. PloS one. vol 9. issue 4. 2014-12-03. PMID:24710089. |
as etv5 has been suggested to influence dopaminergic neurotransmission by driving the expression of genes that are responsible for the synthesis and release of dopamine, we investigated if expression levels of etv5 are dependent on nutritional state and subsequently influence the expression levels of tyrosine hydroxylase. |
2014-12-03 |
2023-08-13 |
mouse |
| Xuefeng Tan, Lei Zhang, Huixia Zhu, Jianbing Qin, Meiling Tian, Chuanming Dong, Haoming Li, Guohua Ji. Brn4 and TH synergistically promote the differentiation of neural stem cells into dopaminergic neurons. Neuroscience letters. vol 571. 2014-12-03. PMID:24769320. |
in this study, we directly transduced tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine biosynthesis, into nscs to induce da neuronal differentiation. |
2014-12-03 |
2023-08-13 |
Not clear |
| Dae-Jung Baek, Chae-Bin Lee, Seung-Soo Bae. Effect of treadmill exercise on social interaction and tyrosine hydroxylase expression in the attention-deficit/ hyperactivity disorder rats. Journal of exercise rehabilitation. vol 10. issue 5. 2014-11-26. PMID:25426460. |
tyrosine hydroxylase (th) is the rate-limiting enzyme that is involved in the synthesis of dopamine. |
2014-11-26 |
2023-08-13 |
rat |
| Carlos D Silva, Ana F Neves, Ana I Dias, Hugo J Freitas, Sheena M Mendes, Inês Pita, Sofia D Viana, Paulo A de Oliveira, Rodrigo A Cunha, Carlos A Fontes Ribeiro, Rui D Prediger, Frederico C Pereir. A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice. Neurotoxicity research. vol 25. issue 3. 2014-11-05. PMID:24072398. |
this depressive-like profile induced by meth was accompanied by a marked depletion of frontostriatal dopaminergic and serotonergic neurotransmission, indicated by a reduction in the levels of dopamine, dopac and hva, tyrosine hydroxylase and serotonin, observed at both 3 and 49 days post-administration. |
2014-11-05 |
2023-08-12 |
mouse |
| Yan Yang, Alexander A Moghadam, Zachary A Cordner, Nu-Chu Liang, Timothy H Mora. Long term exendin-4 treatment reduces food intake and body weight and alters expression of brain homeostatic and reward markers. Endocrinology. vol 155. issue 9. 2014-11-04. PMID:24949661. |
expression of the dopamine precursor tyrosine hydroxylase (th) gene in the ventral tegmental area and genes for dopamine receptors 1 (d1r) and dopamine receptor 2 in the nucleus accumbens were also determined. |
2014-11-04 |
2023-08-13 |
rat |
| Hong-Bin Zhao, Hui Ma, Xiao-Qin Ha, Ping Zheng, Xiao-Yun Li, Ming Zhang, Ju-Zi Dong, Yin-Shu Yan. Salidroside induces rat mesenchymal stem cells to differentiate into dopaminergic neurons. Cell biology international. vol 38. issue 4. 2014-10-30. PMID:24323403. |
the expression of dopamine neurons markers, such as dopamine-beta-hydroxy (dbh), dopa decarboxylase (ddc) and tyrosine hydroxylase (th), was significantly upregulated after treatment with salidroside for 1-12 days. |
2014-10-30 |
2023-08-12 |
rat |
| Shin-Ichi Muramats. The current status of gene therapy for Parkinson's disease. Annals of neurosciences. vol 17. issue 2. 2014-10-24. PMID:25205879. |
the delivery of triple genes including tyrosine hydroxylase (th), guanosine triphosphate cyclohydrolase i (gch) and aadc is also being undertaken, and is aimed at continuously supplying dopamine into the putamen. |
2014-10-24 |
2023-08-13 |
Not clear |
| Yue Huang, Cheng Chang, Jiewen Zhang, Xiaoqun Ga. Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum. Neural regeneration research. vol 7. issue 34. 2014-10-22. PMID:25337111. |
previous studies showed that tyrosine hydroxylase or neurturin gene-modified cells transplanted into rats with parkinson's disease significantly improved behavior and increased striatal dopamine content. |
2014-10-22 |
2023-08-13 |
rat |
| Yue Huang, Cheng Chang, Jiewen Zhang, Xiaoqun Ga. Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum. Neural regeneration research. vol 7. issue 34. 2014-10-22. PMID:25337111. |
several weeks after cell transplantation, in addition to an improvement of motor function, tyrosine hydroxylase and neurturin proteins were up-regulated in the injured striatum, and importantly, levels of dopamine and its metabolite 3,4-dihydroxyphenylacetic acid increased significantly. |
2014-10-22 |
2023-08-13 |
rat |
| Yue Huang, Cheng Chang, Jiewen Zhang, Xiaoqun Ga. Bone marrow-derived mesenchymal stem cells increase dopamine synthesis in the injured striatum. Neural regeneration research. vol 7. issue 34. 2014-10-22. PMID:25337111. |
these results indicate that transplantation of tyrosine hydroxylase and neurturin gene-modified bone marrow-derived mesenchymal stem cells increases dopamine synthesis and significantly improves the behavior of rats with parkinson's disease. |
2014-10-22 |
2023-08-13 |
rat |
| Zhi Dong Zhou, Fathima Shaffra Refai, Shao Ping Xie, Shin Hui Ng, Christine Hui Shan Chan, Patrick Ghim Hoe Ho, Xiao Dong Zhang, Tit Meng Lim, Eng King Ta. Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. Free radical biology & medicine. vol 68. 2014-10-21. PMID:24374372. |
mutant pink1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. |
2014-10-21 |
2023-08-12 |
Not clear |
| Zhi Dong Zhou, Fathima Shaffra Refai, Shao Ping Xie, Shin Hui Ng, Christine Hui Shan Chan, Patrick Ghim Hoe Ho, Xiao Dong Zhang, Tit Meng Lim, Eng King Ta. Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. Free radical biology & medicine. vol 68. 2014-10-21. PMID:24374372. |
in this study we demonstrate that the extramitochondrial pink1 can regulate tyrosine hydroxylase (th) expression and dopamine (da) content in dopaminergic neurons in a pink1 kinase activity-dependent manner. |
2014-10-21 |
2023-08-12 |
Not clear |