| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bingjie Xie, Fankai Lin, Lei Peng, Kaleem Ullah, Hanyan Wu, Hong Qing, Yulin Den. Methylglyoxal increases dopamine level and leads to oxidative stress in SH-SY5Y cells. Acta biochimica et biophysica Sinica. vol 46. issue 11. 2015-06-22. PMID:25274329. |
the expressions of tyrosine hydroxylase (th) and dopamine transporter (dat) were detected by reverse transcriptase polymerase chain reaction and western blot analysis. |
2015-06-22 |
2023-08-13 |
Not clear |
| Keun Hong Park, Hyun Jin Park, Keon Sung Shin, Myung Koo Le. Multiple treatments with L-3,4-dihydroxyphenylalanine modulate dopamine biosynthesis and neurotoxicity through the protein kinase A-transient extracellular signal-regulated kinase and exchange protein activation by cyclic AMP-sustained extracellular signal-regulated kinase signaling pathways. Journal of neuroscience research. vol 92. issue 12. 2015-06-19. PMID:25044243. |
in these states, mt-ld activated camp-response element binding protein (creb; ser133) and tyrosine hydroxylase (ser40) phosphorylation in pc12 cells, which led to an increase in intracellular dopamine levels. |
2015-06-19 |
2023-08-13 |
rat |
| Juhee Lim, Hueng-Sik Choi, Hyun Jin Cho. Estrogen-related receptor gamma regulates dopaminergic neuronal phenotype by activating GSK3β/NFAT signaling in SH-SY5Y cells. Journal of neurochemistry. vol 133. issue 4. 2015-06-18. PMID:25727910. |
ra induced neurite outgrowth of sh-sy5y cells with an increase in daergic neuron-like properties, including up-regulation of tyrosine hydroxylase, dopamine transporter, and vesicular monoamine transporter 2. |
2015-06-18 |
2023-08-13 |
human |
| Govindasamy Pushpavathi Selvakumar, Udaiyappan Janakiraman, Musthafa Mohamed Essa, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasaga. Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease. Brain research. vol 1585. 2015-06-02. PMID:24657313. |
administration of mptp led to the depleted striatal dopamine content, impaired patterns of behavior, enhanced oxidative stress and diminished expression of tyrosine hydroxylase (th), dopamine transporter (dat) and vesicular monoamine transporter-2 (vmat-2). |
2015-06-02 |
2023-08-12 |
mouse |
| Tertia D Purves-Tyson, Samantha J Owens, Kay L Double, Reena Desai, David J Handelsman, Cynthia Shannon Weicker. Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway. PloS one. vol 9. issue 3. 2015-05-29. PMID:24618531. |
we hypothesized that molecular indices of dopamine neurotransmission [synthesis (tyrosine hydroxylase), breakdown (catechol-o-methyl transferase; monoamine oxygenase), transport [vesicular monoamine transporter (vmat), dopamine transporter (dat)] and receptors (drd1-d5)] would be changed by testosterone or its metabolites, dihydrotestosterone and 17β-estradiol, in the nigrostriatal pathway of adolescent male rats. |
2015-05-29 |
2023-08-12 |
rat |
| Evangel Kummari, Shirley X Guo-Ross, Jeffrey B Eell. Laser capture microdissection--a demonstration of the isolation of individual dopamine neurons and the entire ventral tegmental area. Journal of visualized experiments : JoVE. issue 96. 2015-05-29. PMID:25742438. |
here, the lcm technique is described for collecting a specific population of dopamine neurons directly labeled with tyrosine hydroxylase immunohistochemistry and for isolation of the dopamine neuron containing region of the ventral tegmental area using indirect tyrosine hydroxylase immunohistochemistry on a section adjacent to those used for lcm. |
2015-05-29 |
2023-08-13 |
Not clear |
| Vladimir S Naumenko, Elena M Kondaurova, Daria V Bazovkina, Anton S Tsybko, Tatyana V Ilchibaeva, Nikita V Khotskin, Alina A Semenova, Nina K Popov. Effect of GDNF on depressive-like behavior, spatial learning and key genes of the brain dopamine system in genetically predisposed to behavioral disorders mouse strains. Behavioural brain research. vol 274. 2015-05-26. PMID:25101543. |
gdnf increased d1 and d2 receptor genes expression in the nucleus accumbens of asc mice but failed to alter expression of catechol-o-methyltransferase, dopamine transporter, mao b and tyrosine hydroxylase genes in both investigated mouse strains. |
2015-05-26 |
2023-08-13 |
mouse |
| Cary O Harding, Shelley R Winn, K Michael Gibson, Erland Arning, Teodoro Bottiglieri, Markus Gromp. Pharmacologic inhibition of L-tyrosine degradation ameliorates cerebral dopamine deficiency in murine phenylketonuria (PKU). Journal of inherited metabolic disease. vol 37. issue 5. 2015-05-15. PMID:24487571. |
in the second hypothesis, elevated phe competitively inhibits brain tyrosine hydroxylase (th) and tryptophan hydroxylase (tph) activities, the rate limiting steps in dopamine and serotonin synthesis. |
2015-05-15 |
2023-08-12 |
Not clear |
| James E McCutcheon, Jackson J Cone, Christopher G Sinon, Samantha M Fortin, Pranish A Kantak, Ilana B Witten, Karl Deisseroth, Garret D Stuber, Mitchell F Roitma. Optical suppression of drug-evoked phasic dopamine release. Frontiers in neural circuits. vol 8. 2015-05-15. PMID:25278845. |
we targeted halorhodopsin (nphr) specifically to dopamine cells by injecting cre-inducible virus into ventral tegmental area (vta) of transgenic rats that expressed cre recombinase under control of the tyrosine hydroxylase promoter (th-cre(+) rats). |
2015-05-15 |
2023-08-13 |
rat |
| Brenda Valeiras, María Victoria Rosato Siri, Martín Codagnone, Analía Reinés, Juana María Pasquin. Gender influence on schizophrenia-relevant abnormalities in a cuprizone demyelination model. Glia. vol 62. issue 10. 2015-05-11. PMID:24890315. |
in addition, only p90 males treated aw showed a hyperdopaminergic striatum, confirmed by an increase in tyrosine hydroxylase expression and in dopamine levels. |
2015-05-11 |
2023-08-13 |
rat |
| Hilary Afeseh Ngwa, Arthi Kanthasamy, Huajun Jin, Vellareddy Anantharam, Anumantha G Kanthasam. Vanadium exposure induces olfactory dysfunction in an animal model of metal neurotoxicity. Neurotoxicology. vol 43. 2015-04-17. PMID:24362016. |
our results revealed a significant decrease in olfactory bulb weights, tyrosine hydroxylase (th) levels, levels of dopamine (da) and its metabolite, 3,4-dihydroxyphenylacetic acid (dopac) and increases in astroglia of the glomerular layer of the olfactory bulb in the treatment groups relative to vehicle controls. |
2015-04-17 |
2023-08-12 |
mouse |
| Hui-Kang Tao, Qin Tang, Jin-Jin Dai, Yuan-Yuan Li, Ming-Yan He. [Impact of dopamine receptor modulation on reduced anxiety-like behavior in neonatal rats after hypoxic-ischemic brain damage]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 16. issue 10. 2015-04-17. PMID:25344189. |
to observe the long-term changes in anxiety-like behavior and tyrosine hydroxylase (th) expression in the substantia nigra (sn) after hypoxic-ischemic brain damage (hibd) in a neonatal rat model and to further explore the relationship between dopamine (da) level and long-term anxiety-like behavior using the da receptor (dar) antagonist. |
2015-04-17 |
2023-08-13 |
rat |
| Fang Zhang, Jian Lu, Ji-Guo Zhang, Jun-Xia Xi. Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson's disease model in C57BL/6J mice. Neural regeneration research. vol 10. issue 2. 2015-04-17. PMID:25883632. |
the results showed that the immunoreactive staining and mrna expression of the dopamine transporter and tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, in the substantia nigra, were significantly increased in mice pretreated with 800 mg/kg of the polysaccharide compared with those in mptp-treated mice. |
2015-04-17 |
2023-08-13 |
mouse |
| Xinjiang Kang, Huadong Xu, Sasa Teng, Xiaoyu Zhang, Zijun Deng, Li Zhou, Panli Zuo, Bing Liu, Bin Liu, Qihui Wu, Li Wang, Meiqin Hu, Haiqiang Dou, Wei Liu, Feipeng Zhu, Qing Li, Shu Guo, Jingli Gu, Qian Lei, Jing Lü, Yu Mu, Mu Jin, Shirong Wang, Wei Jiang, Kun Liu, Changhe Wang, Wenlin Li, Kang Zhang, Zhuan Zho. Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 44. 2015-04-14. PMID:25331880. |
here, we showed that after the striatal transplantation of pnsc-dan, (i) pnsc-dan retained tyrosine hydroxylase expression and reduced pd-like asymmetric rotation; (ii) depolarization-evoked dopamine release and reuptake were significantly rescued in the striatum both in vitro (brain slices) and in vivo, as determined jointly by microdialysis-based hplc and electrochemical carbon fiber electrodes; and (iii) the rescued dopamine was released directly from the grafted pnsc-dan (and not from injured original cells). |
2015-04-14 |
2023-08-13 |
human |
| Yong Ye, Fei Fang, Yue L. Isolation of the sapogenin from defatted seeds of Camellia oleifera and its neuroprotective effects on dopaminergic neurons. Journal of agricultural and food chemistry. vol 62. issue 26. 2015-04-13. PMID:24909656. |
the results showed that the sapogenin and its derivative increased dopamine content in striatum and tyrosine hydroxylase (th) positive cells in substantia nigra and relieved inflammation and behavioral disorder, but the effect on movement was reversed by dopamine receptor antagonist haloperidol and was not intervened by adenosine receptor antagonist cgs 15943. |
2015-04-13 |
2023-08-13 |
mouse |
| Sandra A Acosta, Naoki Tajiri, Ike de la Pena, Marina Bastawrous, Paul R Sanberg, Yuji Kaneko, Cesar V Borlonga. Alpha-synuclein as a pathological link between chronic traumatic brain injury and Parkinson's disease. Journal of cellular physiology. vol 230. issue 5. 2015-04-10. PMID:25251017. |
immunostaining was performed using tyrosine hydroxylase (th), an enzyme required for the synthesis of dopamine in neurons, α-synuclein, a presynaptic protein that plays a role in synaptic vesicle recycling, and major histocompatibility complex ii (mhcii), a protein found in antigen presenting cells such as inflammatory microglia cells, all key players in pd pathology. |
2015-04-10 |
2023-08-13 |
rat |
| Stephanie M Cox, Jason J Nichol. The neurobiology of the meibomian glands. The ocular surface. vol 12. issue 3. 2015-04-07. PMID:24999100. |
the localization and co-localization of dopamine beta-hydroxylase, tyrosine hydroxylase, neuropeptide y, vasoactive intestinal polypeptide, calcitonin gene-related peptide, and substance p are explored with emphasis on differences that exist between species. |
2015-04-07 |
2023-08-13 |
Not clear |
| Li Li, Junping Cao, Suming Zhang, Cunjin Wang, Jinfeng Wang, Ge Song, Hongjun Wang, Licai Zhan. NCAM signaling mediates the effects of GDNF on chronic morphine-induced neuroadaptations. Journal of molecular neuroscience : MN. vol 53. issue 4. 2015-04-06. PMID:24399412. |
moreover, pre-treatment with the antibody could antagonize the effect of gdnf on inhibiting the neuroadaptations induced by chronic morphine exposure, including the decreases of the number and length of neurites and the size of cell bodies of vta dopamine neurons, as well as the increase of tyrosine hydroxylase in the vta dopamine neurons. |
2015-04-06 |
2023-08-12 |
rat |
| Yan Sun, Yan-Shu Li, Jun-Wei Yang, Jia Yu, Yan-Ping Wu, Bai-Xiang L. Exposure to atrazine during gestation and lactation periods: toxicity effects on dopaminergic neurons in offspring by downregulation of Nurr1 and VMAT2. International journal of molecular sciences. vol 15. issue 2. 2015-03-30. PMID:24552878. |
dopamine (da) content was examined in striatum samples by hplc-fl; the mrna expressions of tyrosine hydroxylase (th), orphan nuclear hormone (nurr1), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) in the ventral midbrain samples were examined by fluorescence pcr when the offspring reached one year of age. |
2015-03-30 |
2023-08-12 |
rat |
| Marieke Velema, Erik Boot, Marc Engelen, Carla Holla. Parkinsonism in phenylketonuria: a consequence of dopamine depletion? JIMD reports. vol 20. 2015-03-27. PMID:25614310. |
it has been proposed that a reduction of brain tyr levels, as well as reduced activity of the key regulatory enzyme of dopamine (da) synthesis tyrosine hydroxylase, leads to a depletion in da activity in patients with pku. |
2015-03-27 |
2023-08-13 |
Not clear |