| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephan Lammel, Elizabeth E Steinberg, Csaba Földy, Nicholas R Wall, Kevin Beier, Liqun Luo, Robert C Malenk. Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Neuron. vol 85. issue 2. 2015-03-24. PMID:25611513. |
we find that transgenes under control of the tyrosine hydroxylase, but not the dopamine transporter, promoter exhibit dramatic non-da cell-specific expression patterns within and around vta nuclei. |
2015-03-24 |
2023-08-13 |
mouse |
| Richard L Jayaraj, Namasivayam Elangovan, Krishnan Manigandan, Sonu Singh, Shubha Shukl. CNB-001 a novel curcumin derivative, guards dopamine neurons in MPTP model of Parkinson's disease. BioMed research international. vol 2014. 2015-03-12. PMID:25025041. |
administration of mptp (30 mg/kg for four consecutive days) exacerbated oxidative stress and motor impairment and reduced tyrosine hydroxylase (th), dopamine transporter, and vesicular monoamine transporter 2 (vmat2) expressions. |
2015-03-12 |
2023-08-13 |
Not clear |
| Mattia Vicario, Adriana Zagari, Vincenzo Granata, Francesca Munari, Stefano Mammi, Luigi Bubacco, Stephen D Skaper, Alessandro Negr. A novel prion protein-tyrosine hydroxylase interaction. CNS & neurological disorders drug targets. vol 13. issue 5. 2015-03-09. PMID:25012618. |
we recently discovered a specific, high-affinity (nanomolar kd) interaction with tyrosine hydroxylase (th), a enzyme catalyzing the rate-limiting step in the synthesis of the neurotransmitter dopamine. |
2015-03-09 |
2023-08-13 |
Not clear |
| Mark J Ferris, Marija Milenkovic, Shuai Liu, Catharine A Mielnik, Pieter Beerepoot, Carrie E John, Rodrigo A España, Tatyana D Sotnikova, Raul R Gainetdinov, Stephanie L Borgland, Sara R Jones, Amy J Ramse. Sustained N-methyl-d-aspartate receptor hypofunction remodels the dopamine system and impairs phasic signaling. The European journal of neuroscience. vol 40. issue 1. 2015-03-03. PMID:24754704. |
we report that a global, genetic reduction in nmdars led to a remodeling of dopamine neurons, substantially affecting two key regulators of dopamine homeostasis, i.e., tyrosine hydroxylase and the dopamine transporter. |
2015-03-03 |
2023-08-13 |
mouse |
| Katalin Skrapits, Beáta Á Borsay, László Herczeg, Philippe Ciofi, Zsolt Liposits, Erik Hrabovszk. Neuropeptide co-expression in hypothalamic kisspeptin neurons of laboratory animals and the human. Frontiers in neuroscience. vol 9. 2015-02-25. PMID:25713511. |
human kp neurons do not contain neurotensin, cholecystokinin, proopiomelanocortin-derivatives, agouti-related protein, neuropeptide y, somatostatin or tyrosine hydroxylase (dopamine). |
2015-02-25 |
2023-08-13 |
mouse |
| H Kauser, S Sahu, S Kumar, U Panjwan. Guanfacine is an effective countermeasure for hypobaric hypoxia-induced cognitive decline. Neuroscience. vol 254. 2015-02-23. PMID:24056194. |
norepinephrine (ne), dopamine (da) and tyrosine hydroxylase (th) in medial prefrontal cortex (pfc) by biochemical and immunohistochemical assays. |
2015-02-23 |
2023-08-12 |
rat |
| J R Gugusheff, Z Y Ong, B S Muhlhausle. Naloxone treatment alters gene expression in the mesolimbic reward system in 'junk food' exposed offspring in a sex-specific manner but does not affect food preferences in adulthood. Physiology & behavior. vol 133. 2015-02-19. PMID:24727340. |
we measured mrna expression of key components of the reward pathway (mu-opioid receptor, proenkephalin, tyrosine hydroxylase, d1 and d2 receptors and the dopamine active transporter (dat)) in the nucleus accumbens (nac) and ventral tegmental area (vta) of the offspring of control and cafeteria fed (jf) dams at weaning and after a 10-day naloxone treatment post-weaning and determined food preferences in adulthood in the remaining offspring. |
2015-02-19 |
2023-08-13 |
Not clear |
| Dafna Lotan, Madeleine Cunningham, Daphna Joe. Antibiotic treatment attenuates behavioral and neurochemical changes induced by exposure of rats to group a streptococcal antigen. PloS one. vol 9. issue 6. 2015-02-12. PMID:24979049. |
we assessed levels of d1 and d2 dopamine receptors and tyrosine hydroxylase in the prefrontal cortex and striatum, and igg deposition in the prefrontal cortex, striatum and thalamus. |
2015-02-12 |
2023-08-13 |
rat |
| Yi-Hsien Tsou, Ching-Ting Shih, Cheng-Hsin Ching, Jui-Yen Huang, Chauying J Jen, Lung Yu, Yu-Min Kuo, Fong-Sen Wu, Jih-Ing Chuan. Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity. Experimental neurology. vol 263. 2015-02-09. PMID:25286336. |
we found that mpp(+) induced early decreases in total glutathione level and nrf2/γgclc (catalytic subunit of γgcl) expression, but late upregulation of ho-1 expression in association with loss of nigral dopaminergic neurons and downregulation of tyrosine hydroxylase and dopamine transporter expression in the striatum. |
2015-02-09 |
2023-08-13 |
rat |
| Maddalena Botti, Luisa Ragionieri, Ferdinando Gazza, Rino Pan. Localization and neurochemical features of the sympathetic trunk ganglia neurons projecting to the urethral muscle. An experimental study in a porcine animal model. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 196. issue 4. 2015-02-02. PMID:24495595. |
moreover we highlighted the presence of dopamine β hydroxylase (dβh), vesicular acetylcholine transporter (vacht), neuronal nitric oxyde sinthase (n-nos), calcitonine gene related peptide (cgrp), leu-enkephaline (lenk), neuropeptide y (npy), substance p (sp), vasoactive intestinal polypeptide (vip) and somatostatine (som) and their eventual co-existence with tyrosine hydroxylase(th) in both lumbar and sacral fb+ neurons. |
2015-02-02 |
2023-08-12 |
Not clear |
| LinLin Tian, Morvarid Karimi, Chris A Brown, Susan K Loftin, Joel S Perlmutte. In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment. Brain research. vol 1571. 2015-02-02. PMID:24845719. |
we determined axon integrity by measuring fiber length density with tyrosine hydroxylase (th) immunohistology and dopamine transporter (dat) density with dat immunohistology. |
2015-02-02 |
2023-08-13 |
Not clear |
| Wen-Ting Hsieh, Been-Huang Chian. A well-refined in vitro model derived from human embryonic stem cell for screening phytochemicals with midbrain dopaminergic differentiation-boosting potential for improving Parkinson's disease. Journal of agricultural and food chemistry. vol 62. issue 27. 2015-02-02. PMID:24933592. |
the derived cells expressed many mda markers including tyrosine hydroxylase (th), β-iii tubulin, and dopamine transporter (dat). |
2015-02-02 |
2023-08-13 |
human |
| Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, Jia Yu, Baixiang L. Age-dependent dopaminergic dysfunction following fetal exposure to atrazine in SD rats. Environmental toxicology and pharmacology. vol 37. issue 3. 2015-01-29. PMID:24863964. |
the mrna and protein expression of orphan nuclear hormone (nurr1), tyrosine hydroxylase(th), vesicular monoaminetransporter 2 (vmat2), dopamine transporter (dat), monoamine (mao), and catechol-o-methyl transferase (comt) in the midbrain were examined by fluorescence pcr and western blot when the offspring reached six-month old or one year old .when measured 6 months post-treatment, the level of da and expression of nurr1, vmat2, dat and th were reduced in the striatum and substantia nigra, respectively. |
2015-01-29 |
2023-08-13 |
human |
| G Cruz, R Riquelme, P Espinosa, P Jara, A Dagnino-Subiabre, G M Renard, R Sotomayor-Zárat. Neonatal exposure to estradiol valerate increases dopamine content in nigrostriatal pathway during adulthood in the rat. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 5. 2015-01-26. PMID:24323410. |
this might imply that estrogenized rats could have changes in the expression of key proteins in dopaminergic regulation, as tyrosine hydroxylase and dopamine transporter. |
2015-01-26 |
2023-08-12 |
rat |
| Zaijun Zhang, Daoxu Lai, Liang Wang, Pei Yu, Longjun Zhu, Baojian Guo, Lipeng Xu, Libing Zhou, Yewei Sun, Simon Ming Yuen Lee, Yuqiang Wan. Neuroprotective effects of the andrographolide analogue AL-1 in the MPP⁺/MPTP-induced Parkinson's disease model in vitro and in mice. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24726706. |
in a mouse model of parkinson's disease, al-1 rescued 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-induced loss of tyrosine hydroxylase (th)-positive neurons, improved the behavioral impairment, and elevated the striatal levels of dopamine and its metabolites 3,4-dihydroxyphenylacetic acid. |
2015-01-26 |
2023-08-13 |
mouse |
| Mieko Horiguchi, Kazutaka Ohi, Ryota Hashimoto, Qinyu Hao, Yuka Yasuda, Hidenaga Yamamori, Michiko Fujimoto, Satomi Umeda-Yano, Masatoshi Takeda, Hiroshi Ichinos. Functional polymorphism (C-824T) of the tyrosine hydroxylase gene affects IQ in schizophrenia. Psychiatry and clinical neurosciences. vol 68. issue 6. 2015-01-20. PMID:24417771. |
tyrosine hydroxylase (th) is the rate-limiting enzyme for the biosynthesis of catecholamine, including dopamine and noradrenaline. |
2015-01-20 |
2023-08-12 |
Not clear |
| Ryan Y Wong, Molly E Cumming. Expression patterns of neuroligin-3 and tyrosine hydroxylase across the brain in mate choice contexts in female swordtails. Brain, behavior and evolution. vol 83. issue 3. 2015-01-20. PMID:24854097. |
in this study, we characterized the expression of a gene involved in synaptogenesis and plasticity (neuroligin-3) and one that codes for the rate-limiting enzyme in dopamine biosynthesis (tyrosine hydroxylase; th1) in the female xiphophorus nigrensis (northern swordtail) brain as related to mate preference behavior. |
2015-01-20 |
2023-08-13 |
Not clear |
| JuOae Chang, Chojin Kueon, Jonghan Ki. Influence of lead on repetitive behavior and dopamine metabolism in a mouse model of iron overload. Toxicological research. vol 30. issue 4. 2015-01-13. PMID:25584146. |
the levels of tyrosine hydroxylase and dopamine transporter increased upon pb exposure in both genotypes, whereas hfe-mutant mice displayed down-regulation of the dopamine transporter and dopamine d1 receptor with d2 receptor elevated. |
2015-01-13 |
2023-08-13 |
mouse |
| Stephen H Braren, Damian Drapala, Ingrid K Tulloch, Peter A Serran. Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors. Frontiers in behavioral neuroscience. vol 8. 2015-01-08. PMID:25566006. |
the hippocampus and dorsal striatum were assessed for expression of glutamate receptors subunits, glua2 and glun2b; dopamine markers, dopamine 1 receptor (d1), dopamine transporter (dat) and tyrosine hydroxylase (th); and memory markers, protein kinase m zeta (pkmζ) and protein kinase c zeta (pkcζ). |
2015-01-08 |
2023-08-13 |
mouse |
| Marcelo M S Lima, Adriano D S Targa, Ana C D Noseda, Lais S Rodrigues, Ana Marcia Delattre, Fabiola V dos Santos, Mariana H Fortes, Maira J Maturana, Anete C Ferra. Does Parkinson's disease and type-2 diabetes mellitus present common pathophysiological mechanisms and treatments? CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059307. |
insulin and dopamine may exert reciprocal regulation hence; hypoinsulinemia induced by streptozotocin decreased the amounts of dopamine transporter and tyrosine hydroxylase transcripts in the substantia nigra pars compacta. |
2015-01-07 |
2023-08-12 |
Not clear |