| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gabrielle D Briggs, Gyorgy M Nagy, Phillip W Dickso. Mechanism of action of salsolinol on tyrosine hydroxylase. Neurochemistry international. vol 63. issue 8. 2014-07-22. PMID:24083987. |
tyrosine hydroxylase (th) is the first and rate-limiting enzyme in dopamine synthesis. |
2014-07-22 |
2023-08-12 |
rat |
| William Galbavy, Elham Safaie, Mario J Rebecchi, Michelino Puopol. Inhibition of tetrodotoxin-resistant sodium current in dorsal root ganglia neurons mediated by D1/D5 dopamine receptors. Molecular pain. vol 9. 2014-07-17. PMID:24283218. |
in addition, tyrosine hydroxylase, the rate-limiting enzyme for the synthesis of catecholamines, is expressed in 8-10% of dorsal root ganglia (drg) neurons, suggesting that dopamine may be released in the dorsal root ganglia. |
2014-07-17 |
2023-08-12 |
Not clear |
| Peng Zhong, Xiaojie Liu, Zhen Zhang, Ying Hu, Sarah J Liu, Martha Lezama-Ruiz, Milan Joksimovic, Qing-song Li. Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 18. 2014-06-23. PMID:24790206. |
cyclin-dependent kinase 5 (cdk5) is a proline-directed serine/threonine kinase that regulates a broad range of brain functions through phosphorylation of a myriad of substrates, including tyrosine hydroxylase (th), the rate-limiting enzyme for dopamine synthesis. |
2014-06-23 |
2023-08-13 |
mouse |
| Olof Zachrisson, Ming Zhao, Annica Andersson, Karin Dannaeus, Johan Häggblad, Ruben Isacson, Elisabet Nielsen, Cesare Patrone, Harriet Rönnholm, Lilian Wikstrom, Kristofer Delfani, Alison L McCormack, Theo Palmer, Donato A Di Monte, Michael P Hill, Ann Marie Janson Lang, Anders Haegerstran. Restorative effects of platelet derived growth factor-BB in rodent models of Parkinson's disease. Journal of Parkinson's disease. vol 1. issue 1. 2014-06-18. PMID:23939256. |
here we show that intracerebroventricular administration of platelet-derived growth factor-bb can offer an alternative strategy to restore function in parkinson's disease; in animal models of nigrostriatal injury, a two weeks treatment with platelet-derived growth factor-bb resulted in long-lasting restoration of striatal dopamine transporter binding sites and expression of nigral tyrosine hydroxylase. |
2014-06-18 |
2023-08-12 |
rat |
| Zuzanna Kurowska, Elisabet Englund, Håkan Widner, Olle Lindvall, Jia-Yi Li, Patrik Brundi. Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease. Journal of Parkinson's disease. vol 1. issue 1. 2014-06-18. PMID:23939259. |
in the case with the 22-year-old transplant, a high proportion (up to 38%) of the grafted dopaminergic (pigment-granule containing) neurons do not express tyrosine hydroxylase and dopamine transporter and their perikarya appear atrophic. |
2014-06-18 |
2023-08-12 |
human |
| Kristoffer Haugarvoll, Laurence A Bindof. A novel compound heterozygous tyrosine hydroxylase mutation (p.R441P) with complex phenotype. Journal of Parkinson's disease. vol 1. issue 1. 2014-06-18. PMID:23939262. |
tyrosine hydroxylase (th) is a tetrahydrobiopterin (bh4) dependent enzyme that catalyses the conversion of l-tyrosine to l-dopa, the rate-limiting step in the biosynthesis of dopamine. |
2014-06-18 |
2023-08-12 |
Not clear |
| Yu-Jen Chang, Tsung-Yen Ho, Mei-Ling Wu, Shiaw-Min Hwang, Tzyy-Wen Chiou, Ming-Song Tsa. Amniotic fluid stem cells with low γ-interferon response showed behavioral improvement in Parkinsonism rat model. PloS one. vol 8. issue 9. 2014-06-16. PMID:24098771. |
the implanted afscs were viable, and were able to migrate into the brain's circuitry and express specific proteins of dopamine neurons, such as tyrosine hydroxylase and dopamine transporter. |
2014-06-16 |
2023-08-12 |
human |
| Jesús Pérez-H, Carlos Carrillo-S, Esperanza García, Gabriela Ruiz-Mar, Ruy Pérez-Tamayo, Anahí Chavarrí. Neuroprotective effect of silymarin in a MPTP mouse model of Parkinson's disease. Toxicology. vol 319. 2014-06-10. PMID:24607817. |
in order to explore whether silymarin has a neuroprotective effects in a mouse model of pd we determined the concentration of striatal dopamine by hplc, the number of apoptotic cells by in situ tunel assay and the number of tyrosine hydroxylase positive neurons by immunohistochemistry in substantia nigra of vehicle-treated, silymarin-treated, mptp-intoxicated and mptp-silymarin treated c57bl/6j male mice. |
2014-06-10 |
2023-08-12 |
mouse |
| Michael F Salvator. ser31 Tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24410633. |
ser31 tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-ohda lesion. |
2014-06-04 |
2023-08-12 |
rat |
| Michael F Salvator. ser31 Tyrosine hydroxylase phosphorylation parallels differences in dopamine recovery in nigrostriatal pathway following 6-OHDA lesion. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24410633. |
properties of dopamine biosynthesis were evaluated in the 6-ohda model of parkinson's disease by studying the impact of tyrosine hydroxylase (th) protein loss on its own phosphorylation and dopamine (da) tissue content in rat nigrostriatal pathway. |
2014-06-04 |
2023-08-12 |
rat |
| D Parkinson, A Spira, J P Wyse, M Patte. The ontogenesis of the dopaminergic cell in the pre- and postnatal guinea pig retina. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 3. issue 2. 2014-06-02. PMID:24874597. |
fetal animals aged 42-69 days (full term), neonates, postnatal (pn) animals to 12 weeks, and mature animals were studied to determine retinal dopamine (da) storage, metabolism (dopac), in vitro tyrosine hydroxylase (th) activity, postsynaptic target activation (camp stimulation) and localization (formaldehyde-induced histofluorescence). |
2014-06-02 |
2023-08-13 |
Not clear |
| G A Foster, M Schultzberg, D Dahl, M Goldstein, A A Verhofsta. Ephemeral existence of a single catecholamine synthetic enzyme in the olfactory placode and the spinal cord of the embryonic rat. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 3. issue 6. 2014-06-02. PMID:24875105. |
the distribution of three catecholamine synthetic enzymes (tyrosine hydroxylase, l-aromatic acid decarboxylase and dopamine β-hydroxylase), of the catecholamines themselves (dopamine and noradrenaline) and of a marker for neuronal intermediate filaments (neurofilament) was investigated in the embryonic rat using immunohistochemical and histofluorescence methods. |
2014-06-02 |
2023-08-13 |
rat |
| T A Slotkin, W L Whitmore, L Lerea, R J Slepetis, S J Weigel, P A Trepanier, F J Seidle. Role of ornithine decarboxylase and the polyamines in nervous system development: Short-term postnatal administration of α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 1. issue 1. 2014-06-02. PMID:24875600. |
development of the adrenal medulla, a peripheral catecholaminergic tissue which displays approximately the same developmental profile as do sympathetic neurons but which does not develop axonal projections, was not slowed by dfmo treatment; similarly, central noradrenergic and dopaminergic neurons, which undergo the majority of axonal outgrowth and synaptogenesis during the second to third postnatal week (just after the period in which polyamines returned to control levels), developed normally as assessed by measurements of transmitter levels, tyrosine hydroxylase activity and synaptosomal uptake of [(3)h]norepinephrine or [(3)h]dopamine. |
2014-06-02 |
2023-08-13 |
rat |
| Phillip W Dickson, Gabrielle D Brigg. Tyrosine hydroxylase: regulation by feedback inhibition and phosphorylation. Advances in pharmacology (San Diego, Calif.). vol 68. 2014-05-29. PMID:24054138. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline. |
2014-05-29 |
2023-08-12 |
human |
| Hiroshi Ichinose, Daigo Homma, Chiho Sumi-Ichinose, Takahide Nomura, Kazunao Kond. GTP cyclohydrolase regulation: implications for brain development and function. Advances in pharmacology (San Diego, Calif.). vol 68. 2014-05-29. PMID:24054139. |
tetrahydrobiopterin (bh4) is essential for the biosynthesis of dopamine, noradrenaline, and serotonin, which serve as cofactors for tyrosine hydroxylase (th) and tryptophan hydroxylase. |
2014-05-29 |
2023-08-12 |
mouse |
| Michael V Ugrumo. Brain neurons partly expressing dopaminergic phenotype: location, development, functional significance, and regulation. Advances in pharmacology (San Diego, Calif.). vol 68. 2014-05-29. PMID:24054140. |
most of them express individual enzymes of dopamine (da) synthesis, tyrosine hydroxylase (th), or aromatic l-amino acid decarboxylase (aadc), lacking the da membrane transporter and the vesicular monoamine transporter, type 2. |
2014-05-29 |
2023-08-12 |
Not clear |
| Yanshu Li, Yan Sun, Junwei Yang, Yanping Wu, Jia Yu, Baixiang L. The long-term effects of the herbicide atrazine on the dopaminergic system following exposure during pubertal development. Mutation research. Genetic toxicology and environmental mutagenesis. vol 763. 2014-05-16. PMID:24561379. |
the content of dopamine (da) was examined in striatum samples by hplc-fl, and the mrna and protein expression of tyrosine hydroxylase (th), orphan nuclear hormone (nurr1), dopamine transporter (dat) and vesicular monoaminetransporter 2 (vmat2) were examined in samples of the ventral mid-brain by use of fluorescence pcr and western-blot analysis when the rats reached the age of one year. |
2014-05-16 |
2023-08-12 |
human |
| Stefanie Reyes, Veronica Cottam, Deniz Kirik, Kay L Double, Glenda M Hallida. Variability in neuronal expression of dopamine receptors and transporters in the substantia nigra. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 10. 2014-05-09. PMID:23674405. |
the localization of the dopamine receptors (d1-d5) and dopamine transporter proteins in the upper brain stems of elderly adult humans (n = 8) was assessed using single immunoperoxidase and double immunofluorescence (with tyrosine hydroxylase to identify dopamine neurons). |
2014-05-09 |
2023-08-12 |
human |
| Jia Liu, Jinlong Gao, Shaoang Tu, Shasha Xu, Ying Liu, Weihu Shang, Chenxin Gu, Yiyun Huang, Mei Ha. Neuroprotective Effects of Jitai Tablet, a Traditional Chinese Medicine, on the MPTP-Induced Acute Model of Parkinson's Disease: Involvement of the Dopamine System. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-05-06. PMID:24799940. |
tyrosine hydroxylase th-positive neurons in the substantia nigra and dat and dopamine d2 receptor (d2r) levels in the striatum were detected by immunohistochemical staining and/or autoradiography. |
2014-05-06 |
2023-08-13 |
mouse |
| Joshua X Gittelman, David J Perkel, Christine V Portfor. Dopamine modulates auditory responses in the inferior colliculus in a heterogeneous manner. Journal of the Association for Research in Otolaryngology : JARO. vol 14. issue 5. 2014-04-22. PMID:23835945. |
because the ic contains dopamine receptors and nerve terminals immunoreactive for tyrosine hydroxylase, we predicted that dopamine would modulate auditory responses in the ic. |
2014-04-22 |
2023-08-12 |
mouse |