| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M A Fahim, S Shehab, A Nemmar, A Adem, S Dhanasekaran, M Y Hasa. Daily subacute paraquat exposure decreases muscle function and substantia nigra dopamine level. Physiological research. vol 62. issue 3. 2014-04-21. PMID:23489189. |
dopamine concentrations in the ventral mesencephalon were measured by high performance liquid chromatography and the number of dopaminergic neurons in substantia nigra pars compacta was estimated by tyrosine hydroxylase immunohistochemistry. |
2014-04-21 |
2023-08-12 |
rat |
| M A Fahim, S Shehab, A Nemmar, A Adem, S Dhanasekaran, M Y Hasa. Daily subacute paraquat exposure decreases muscle function and substantia nigra dopamine level. Physiological research. vol 62. issue 3. 2014-04-21. PMID:23489189. |
the number of tyrosine hydroxylase positive neurons was significantly less in the substantia nigra pars compacta and nigral dopamine level was significantly reduced in pq treated animals (20.4+/-3.4 pg/mg) when compared with control animals (55.0+/-2.4 pg/mg wet tissue). |
2014-04-21 |
2023-08-12 |
rat |
| Z Pidsudk. Immunohistochemical characteristics and distribution of neurons in the intramural ganglia supplying the urinary bladder in the male pig. Polish journal of veterinary sciences. vol 16. issue 4. 2014-04-03. PMID:24597296. |
twelve tm-thick cryostat sections were processed for double-labelling immunofluorescence with antibodies against tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), neuropeptide y (npy), somatostatin (som), galanin (gal), vasoactive intestinal polypeptide (vip), nitric oxide synthase (nos), calcitonin gene-related peptide (cgrp), substance p (sp) and vesicular acetylcholine transporter (vacht). |
2014-04-03 |
2023-08-12 |
Not clear |
| Adam Przybyłkowski, Grażyna Gromadzka, Adriana Wawer, Ewa Bulska, Katarzyna Jabłonka-Salach, Tomasz Grygorowicz, Anna Schnejder-Pachołek, Andrzej Członkowsk. Neurochemical and behavioral characteristics of toxic milk mice: an animal model of Wilson's disease. Neurochemical research. vol 38. issue 10. 2014-03-28. PMID:23877404. |
in order to detect neuronal loss, expression of enzymes specific for dopaminergic [tyrosine hydroxylase (th)], noradrenergic (dopamine beta-hydroxylase) and serotoninergic [tryptophan hydroxylase (tph)] neurons was analyzed by western blot. |
2014-03-28 |
2023-08-12 |
mouse |
| Amanda R Decker, Matthew S McNeill, Aaron M Lambert, Jeffrey D Overton, Yu-Chia Chen, Ramón A Lorca, Nicolas A Johnson, Susan E Brockerhoff, Durga P Mohapatra, Heather MacArthur, Pertti Panula, Mark A Masino, Loren W Runnels, Robert A Cornel. Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern. Developmental biology. vol 386. issue 2. 2014-03-26. PMID:24291744. |
second, histological analysis reveals that in trpm7 mutants a significant fraction of dopaminergic neurons lack expression of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2014-03-26 |
2023-08-12 |
mouse |
| Joana Pérez-Tejada, Amaia Arregi, Eneritz Gómez-Lázaro, Oscar Vegas, Arantza Azpiroz, Larraitz Garmendi. Coping with chronic social stress in mice: hypothalamic-pituitary-adrenal/ sympathetic-adrenal-medullary axis activity, behavioral changes and effects of antalarmin treatment: implications for the study of stress-related psychopathologies. Neuroendocrinology. vol 98. issue 1. 2014-03-21. PMID:23796983. |
passive subjects had decreased levels of adrenal dopamine β-hydroxylase, tyrosine hydroxylase and plasma adrenaline compared to the active subjects, and lower plasma noradrenaline levels than manipulated controls. |
2014-03-21 |
2023-08-12 |
mouse |
| S Hether, K Misono, A Lessar. The neurokinin-3 receptor (NK3R) antagonist SB222200 prevents the apomorphine-evoked surface but not nuclear NK3R redistribution in dopaminergic neurons of the rat ventral tegmental area. Neuroscience. vol 247. 2014-03-18. PMID:23673279. |
vta sections were dual immunolabeled for the nk3r (immunogold) and the dopamine synthesizing enzyme tyrosine hydroxylase (th, immunoperoxidase). |
2014-03-18 |
2023-08-12 |
rat |
| Maria Galuppo, Renato Iori, Gina Rosalinda De Nicola, Placido Bramanti, Emanuela Mazzo. Anti-inflammatory and anti-apoptotic effects of (RS)-glucoraphanin bioactivated with myrosinase in murine sub-acute and acute MPTP-induced Parkinson's disease. Bioorganic & medicinal chemistry. vol 21. issue 17. 2014-03-18. PMID:23810671. |
behavioural test, body weight changes measures and immunohistochemical localization of the main pd markers were performed and post-hoc analysis has shown as bioactive rs-gra is able to reduce dopamine transporter degradation, tyrosine hydroxylase expression, il-1β release, as well as the triggering of neuronal apoptotic death pathway (data about bax/bcl-2 balance and dendrite spines loss) and the generation of radicalic species by oxidative stress (results focused on nitrotyrosine, nrf2 and gfap immunolocalization). |
2014-03-18 |
2023-08-12 |
mouse |
| Xueping Li, Jia Qi, Tsuyoshi Yamaguchi, Hui-Ling Wang, Marisela Morale. Heterogeneous composition of dopamine neurons of the rat A10 region: molecular evidence for diverse signaling properties. Brain structure & function. vol 218. issue 5. 2014-03-10. PMID:22926514. |
the a10 region contains different neurons: dopamine (expressing tyrosine hydroxylase; th), gaba, glutamate-only (expressing the vesicular glutamate transporter 2; vglut2), and th-vglut2 (coexpressing th and vglut2). |
2014-03-10 |
2023-08-12 |
rat |
| Katharine L Campi, Chelsea E Jameson, Brian C Traino. Sexual Dimorphism in the Brain of the Monogamous California Mouse (Peromyscus californicus). Brain, behavior and evolution. vol 81. issue 4. 2014-03-06. PMID:23881046. |
we also used tyrosine hydroxylase (th) immunohistochemistry to compare the number of dopamine neurons in the ventral tegmental area (vta) in female and male california mice. |
2014-03-06 |
2023-08-12 |
mouse |
| Kazue Kikuchi-Utsumi, Mami Ishizaka, Nobuko Matsumura, Masahiko Watabe, Koji Aoyama, Nobuyuki Sasakawa, Toshio Nakak. Involvement of the α(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23283760. |
meth neurotoxicity was evaluated by (1) measuring body temperature; (2) determining tyrosine hydroxylase (th) immunoreactivity levels; (3) examining levels of dopamine and its metabolites; and (4) assessing glial fibrillary acidic protein (gfap) and microglial immunoreactivity in the striatum. |
2014-03-03 |
2023-08-12 |
rat |
| Kasturi Banerjee, Yosuke Akiba, Harriet Baker, John W Cav. Epigenetic control of neurotransmitter expression in olfactory bulb interneurons. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 31. issue 6. 2014-02-14. PMID:23220178. |
a subset of ob interneurons also co-express dopamine, but transcriptional repression of tyrosine hydroxylase (th) suppresses the dopaminergic phenotype until these neurons terminally differentiate. |
2014-02-14 |
2023-08-12 |
Not clear |
| Il-Gyu Ko, Sung-Eun Kim, Tae-Woon Kim, Eun-Sang Ji, Mal-Soon Shin, Chang-Ju Kim, Min-Ha Hong, Geon Ho Bah. Swimming exercise alleviates the symptoms of attention-deficit hyperactivity disorder in spontaneous hypertensive rats. Molecular medicine reports. vol 8. issue 2. 2014-02-13. PMID:23779147. |
the expression levels of tyrosine hydroxylase (th), which catalyzes the rate‑limiting step of dopamine synthesis, and the dopamine d2 receptor in the prefrontal cortex, substantia nigra and striatum were evaluated. |
2014-02-13 |
2023-08-12 |
rat |
| Jin-Feng Li, Hong-Lei Yin, Adam Shuboy, Hai-Feng Duan, Ji-Yu Lou, Jing Li, Hong-wei Wang, Yun-Liang Wan. Differentiation of hUC-MSC into dopaminergic-like cells after transduction with hepatocyte growth factor. Molecular and cellular biochemistry. vol 381. issue 1-2. 2014-02-12. PMID:23737134. |
following transduction, the huc-mscs can differentiate into dopaminergic neuron-like cells secreting dopamine, tyrosine hydroxylase, and dopamine transporter. |
2014-02-12 |
2023-08-12 |
human |
| Yi Xia, Bei-Yu Chen, Xiao-Long Sun, Li Duan, Guo-Dong Gao, Jing-Jie Wang, Ken Kam-Lin Yung, Liang-Wei Che. Presence of proNGF-sortilin signaling complex in nigral dopamine neurons and its variation in relation to aging, lactacystin and 6-OHDA insults. International journal of molecular sciences. vol 14. issue 7. 2014-02-11. PMID:23880857. |
the expression of prongf and sortilin was abundantly and selectively identified in tyrosine hydroxylase (th)-containing dopamine neurons in the substantia nigra. |
2014-02-11 |
2023-08-12 |
rat |
| Rafael Gonzalo-Gobernado, Lucía Calatrava-Ferreras, Diana Reimers, Antonio Sánchez Herranz, Macarena Rodríguez-Serrano, Cristina Miranda, Adriano Jiménez-Escrig, Juan José Díaz-Gil, Eulalia Bazá. Neuroprotective activity of peripherally administered liver growth factor in a rat model of Parkinson's disease. PloS one. vol 8. issue 7. 2014-02-03. PMID:23861803. |
the results show that lgf stimulates sprouting of tyrosine hydroxylase-positive terminals and increases tyrosine hydroxylase and dopamine transporter expression, as well as dopamine levels in the denervated striatum of 6-ohda-lesioned rats. |
2014-02-03 |
2023-08-12 |
rat |
| Manoochehr Messripour, Azadeh Mesripou. Age related interaction of dopamine and serotonin synthesis in striatal synaptosomes. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. vol 37. issue 2. 2014-01-28. PMID:24392577. |
tyrosine hydroxylase and tryptophan hydroxylase are key rate limiting enzymes in the biosynthesis of dopamine and serotonin, respectively. |
2014-01-28 |
2023-08-12 |
rat |
| Arati A Inamdar, Muhammad M Hossain, Alison I Bernstein, Gary W Miller, Jason R Richardson, Joan Wennstrom Bennet. Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 48. 2014-01-27. PMID:24218591. |
overexpression of the vesicular monoamine transporter (vmat) rescued the dopamine toxicity and neurodegeneration, whereas mutations decreasing vmat and tyrosine hydroxylase exacerbated toxicity. |
2014-01-27 |
2023-08-12 |
human |
| Masato Asanuma, Ikuko Miyazaki, Francisco J Diaz-Corrales, Youichirou Higashi, Masayoshi Namba, Norio Ogaw. Transplantation of melanocytes obtained from the skin ameliorates apomorphine-induced abnormal behavior in rodent hemi-parkinsonian models. PloS one. vol 8. issue 6. 2014-01-23. PMID:23776585. |
replacement of dopamine synthesis by tyrosinase was reported in tyrosine hydroxylase null mice. |
2014-01-23 |
2023-08-12 |
mouse |
| L Ragionieri, M Botti, F Gazza, C Sorteni, R Chiocchetti, P Clavenzani, L Bo Minelli, R Pan. Localization of peripheral autonomic neurons innervating the boar urinary bladder trigone and neurochemical features of the sympathetic component. European journal of histochemistry : EJH. vol 57. issue 2. 2014-01-22. PMID:23807295. |
stg and cmg fb+ neurons were immunoreactive (ir) for tyrosine hydroxylase (th) (66±10.1% and 52.7±8.2%, respectively), dopamine beta-hydroxylase (dβh) (62±6.2% and 52±6.2%, respectively), neuropeptide y (npy) (59±8.2% and 65.8±7.3%, respectively), calcitonin-gene-related peptide (cgrp) (24.1±3.3% and 22.1±3.3%, respectively), substance p (sp) (21.6±2.4% and 37.7±7.5%, respectively), vasoactive intestinal polypeptide (vip) (18.9±2.3% and 35.4±4.4%, respectively), neuronal nitric oxide synthase (nnos) (15.3±2% and 32.9±7.7%, respectively), vesicular acetylcholine transporter (vacht) (15±2% and 34.7±4.5%, respectively), leu-enkephalin (lenk) (14.3±7.1% and 25.9±8.9%, respectively), and somatostatin (som) (12.4±3% and 31.8±7.3%, respectively). |
2014-01-22 |
2023-08-12 |
Not clear |