| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noelia Granado, Isabel Lastres-Becker, Sara Ares-Santos, Idaira Oliva, Eduardo Martin, Antonio Cuadrado, Rosario Moratall. Nrf2 deficiency potentiates methamphetamine-induced dopaminergic axonal damage and gliosis in the striatum. Glia. vol 59. issue 12. 2013-07-08. PMID:21882243. |
we found that nrf2 deficiency exacerbated meth-induced damage to dopamine neurons, shown by an increase in loss of tyrosine hydroxylase (th)- and dopamine transporter (dat)-containing fibers in striatum. |
2013-07-08 |
2023-08-12 |
Not clear |
| b' I Pilipovi\\xc4\\x87, K Radojevi\\xc4\\x87, M Peri\\xc5\\xa1i\\xc4\\x87, D Kosec, M Nacka-Aleksi\\xc4\\x87, J Djiki\\xc4\\x87, G Leposavi\\xc4\\x8. Catecholaminergic signalling through thymic nerve fibres, thymocytes and stromal cells is dependent on both circulating and locally synthesized glucocorticoids. Experimental physiology. vol 97. issue 11. 2013-07-02. PMID:22562811.' |
seven days postadrenalectomy, the thymic levels of mrnas encoding tyrosine hydroxylase, dopamine β-hydroxylase, monoamine oxidase-a and, consequently, noradrenaline were decreased. |
2013-07-02 |
2023-08-12 |
rat |
| b' I Pilipovi\\xc4\\x87, K Radojevi\\xc4\\x87, M Peri\\xc5\\xa1i\\xc4\\x87, D Kosec, M Nacka-Aleksi\\xc4\\x87, J Djiki\\xc4\\x87, G Leposavi\\xc4\\x8. Catecholaminergic signalling through thymic nerve fibres, thymocytes and stromal cells is dependent on both circulating and locally synthesized glucocorticoids. Experimental physiology. vol 97. issue 11. 2013-07-02. PMID:22562811.' |
administration of ketoconazole (an inhibitor of glucocorticoid synthesis/action; 25 mg kg(-1) day(-1), s.c.) to glucocorticoid-deprived rats increased the thymic levels of tyrosine hydroxylase, dopamine β-hydroxylase and, consequently, noradrenaline. |
2013-07-02 |
2023-08-12 |
rat |
| Katherine Barreto-Valer, Roger López-Bellido, Fátima Macho Sánchez-Simón, Raquel E Rodrígue. Modulation by cocaine of dopamine receptors through miRNA-133b in zebrafish embryos. PloS one. vol 7. issue 12. 2013-06-27. PMID:23285158. |
we also analysed the interaction of mir-133b with the pitx3 and pitx3 target genes drd2a and drd2b, tyrosine hydroxylase (th) and dopamine transporter (dat) by microinjection of the pitx3-3'utr sequence. |
2013-06-27 |
2023-08-12 |
zebrafish |
| Xiaohui Liu, Fengyuan Piao, Yachen L. Protective effect of taurine on the decreased biogenic amine neurotransmitter levels in the brain of mice exposed to arsenic. Advances in experimental medicine and biology. vol 776. 2013-06-12. PMID:23392890. |
the mrna expressions of dopamine beta hydroxylase (dbh), tyrosine hydroxylase (th), and tryptophan hydroxylase (tph) as ne, da, and 5-ht synzymes were also analyzed by real-time rt-pcr. |
2013-06-12 |
2023-08-12 |
mouse |
| Tristan Darland, Justin T Mauch, Ellen M Meier, Shannon J Hagan, John E Dowling, Diane C Darlan. Sulpiride, but not SCH23390, modifies cocaine-induced conditioned place preference and expression of tyrosine hydroxylase and elongation factor 1α in zebrafish. Pharmacology, biochemistry, and behavior. vol 103. issue 2. 2013-06-11. PMID:22910534. |
acute cocaine exposure also induced a rise in the expression of tyrosine hydroxylase (th), an important enzyme in dopamine synthesis, and a significant decrease in the expression of elongation factor 1α (ef1α), a housekeeping gene that regulates protein synthesis. |
2013-06-11 |
2023-08-12 |
zebrafish |
| Mariana Raineri, Betina Gonzalez, Belen Goitia, Edgar Garcia-Rill, Irina N Krasnova, Jean Lud Cadet, Francisco J Urbano, Veronica Bisagn. Modafinil abrogates methamphetamine-induced neuroinflammation and apoptotic effects in the mouse striatum. PloS one. vol 7. issue 10. 2013-06-11. PMID:23056363. |
modafinil also counteracted the decrease in tyrosine hydroxylase and dopamine transporter levels and prevented methamphetamine-induced increases in the pro-apoptotic bax and decreases in the anti-apoptotic bcl-2 protein expression. |
2013-06-11 |
2023-08-12 |
mouse |
| Samuel O Adeosun, Xu Hou, Yun Jiao, Baoying Zheng, Sherry Henry, Rosanne Hill, Zhi He, Amar Pani, Patrick Kyle, Xiaoming Ou, Thomas Mosley, Jerry M Farley, Craig Stockmeier, Ian Paul, Steven Bigler, Roberta Diaz Brinton, Richard Smeyne, Jun Ming Wan. Allopregnanolone reinstates tyrosine hydroxylase immunoreactive neurons and motor performance in an MPTP-lesioned mouse model of Parkinson's disease. PloS one. vol 7. issue 11. 2013-06-11. PMID:23209637. |
in this study, we tested the therapeutic potential of a neurogenic neurosteroid, allopregnanolone, in the restoration of the components of the nigrostriatal pathway in mptp-lesioned mice by measuring striatal dopamine levels, total and tyrosine hydroxylase immunoreactive neuron numbers and brdu-positive cells in the snpc. |
2013-06-11 |
2023-08-12 |
mouse |
| Julio César Tobón-Velasco, Genaro Vázquez-Victorio, Marina Macías-Silva, Elvis Cuevas, Syed F Ali, Perla D Maldonado, María Eva González-Trujano, Antonio Cuadrado, José Pedraza-Chaverrí, Abel Santamarí. RETRACTED: S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades. Free radical biology & medicine. vol 53. issue 5. 2013-06-07. PMID:22781654. |
these early protective effects correlated with the long-term preservation of the cellular redox status, the striatal dopamine (da) and tyrosine hydroxylase (th) levels, and the improvement of motor skills. |
2013-06-07 |
2023-08-12 |
human |
| Hong-Hua Yuan, Ren-Jin Chen, Yu-Hua Zhu, Chang-Ling Peng, Xiao-Rong Zh. The neuroprotective effect of overexpression of calbindin-D(28k) in an animal model of Parkinson's disease. Molecular neurobiology. vol 47. issue 1. 2013-06-04. PMID:22923348. |
tyrosine hydroxylase (th)-immunoreactive neurons were counted, and the concentration of total protein and dopamine (da) of striatum corpora was measured in four animal models. |
2013-06-04 |
2023-08-12 |
mouse |
| Mohammed Abul Kashem, Selina Ahmed, Ranjana Sarker, Eakhlas U Ahmed, Garth A Hargreaves, Iain S McGrego. Long-term daily access to alcohol alters dopamine-related synthesis and signaling proteins in the rat striatum. Neurochemistry international. vol 61. issue 8. 2013-05-24. PMID:22995788. |
strikingly, many of these were dopamine (da)-related proteins, including tyrosine hydroxylase (an enzyme of da biosynthesis), pyridoxal phosphate phosphatase (a co-enzyme in da biosynthesis), da and camp regulating phosphoprotein (a regulator of da receptors and transporters), protein phosphatase 1 (a signaling protein) and nitric oxide synthase (which modulates da uptake). |
2013-05-24 |
2023-08-12 |
rat |
| Xiaojing Di, Jingqi Yan, Yan Zhao, Yanzhong Chang, Baolu Zha. L-theanine inhibits nicotine-induced dependence via regulation of the nicotine acetylcholine receptor-dopamine reward pathway. Science China. Life sciences. vol 55. issue 12. 2013-05-17. PMID:23233221. |
further studies using high performance liquid chromatography, western blotting and immunofluorescence staining analyses showed that l-theanine significantly inhibited nicotine-induced tyrosine hydroxylase (th) expression and dopamine production in the midbrain of mice. |
2013-05-17 |
2023-08-12 |
mouse |
| Glenn A McConkey, Heather L Martin, Greg C Bristow, Joanne P Webste. Toxoplasma gondii infection and behaviour - location, location, location? The Journal of experimental biology. vol 216. issue Pt 1. 2013-05-14. PMID:23225873. |
recently, it was found that cells encysted with parasites in the brains of experimentally infected rodents have high levels of dopamine and that the parasite encodes a tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of this neurotransmitter. |
2013-05-14 |
2023-08-12 |
Not clear |
| P Rojas, E Ruiz-Sánchez, C Rojas, S O Ogre. Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neuroscience. vol 223. 2013-05-01. PMID:22885234. |
the genes for tyrosine hydroxylase (th), vesicular monoamine transporter 2 (vmat2), dopamine transporter (dat), dopamine d2 receptor (da-d2r), and transcription factors (pitx3 and nurr1) related to dopamine neurotransmission were selected for the analysis. |
2013-05-01 |
2023-08-12 |
mouse |
| Patrick Oeckl, Michael Lattke, Thomas Wirth, Bernd Baumann, Boris Ferge. Astrocyte-specific IKK2 activation in mice is sufficient to induce neuroinflammation but does not increase susceptibility to MPTP. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22750522. |
readouts included the determination of cytokines, striatal dopamine (da), nigral tyrosine hydroxylase (th) positive neurons, microglial activation and motor activity. |
2013-04-30 |
2023-08-12 |
mouse |
| Isabel Espadas, Sanja Darmopil, Eva Vergaño-Vera, Oskar Ortiz, Idaira Oliva, Carlos Vicario-Abejón, Eduardo D Martín, Rosario Moratall. L-DOPA-induced increase in TH-immunoreactive striatal neurons in parkinsonian mice: insights into regulation and function. Neurobiology of disease. vol 48. issue 3. 2013-04-30. PMID:22820144. |
tyrosine hydroxylase (th)-immunoreactive (ir) neurons have been found in the striatum after dopamine depletion; however, little is known about the mechanism underlying their appearance or their functional significance. |
2013-04-30 |
2023-08-12 |
mouse |
| Nicola Romanò, Siew H Yip, David J Hodson, Anne Guillou, Sébastien Parnaudeau, Siobhan Kirk, François Tronche, Xavier Bonnefont, Paul Le Tissier, Stephen J Bunn, Dave R Grattan, Patrice Mollard, Agnès O Marti. Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467359. |
however, prl-induced secretion of dopamine (da) at the median eminence was strongly blunted during lactation, at least in part attributable to lack of phosphorylation of tyrosine hydroxylase, the key enzyme involved in da synthesis. |
2013-04-26 |
2023-08-12 |
mouse |
| Lydia M Vermeer, Colin A Higgins, David L Roman, Jonathan A Door. Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay. Analytical biochemistry. vol 432. issue 1. 2013-04-15. PMID:23010244. |
tyrosine hydroxylase (th) is the rate-limiting step in dopamine (da) synthesis, oxidizing tyrosine to l-dopa, which is further metabolized to da. |
2013-04-15 |
2023-08-12 |
Not clear |
| Rudra P Ojha, Manisha Rastogi, B Parimala Devi, Aruna Agrawal, G P Dube. Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 3. 2013-04-10. PMID:22527634. |
our results show that oral administration of curcuminoids significantly prevented mptp-mediated depletion of dopamine and tyrosine hydroxylase (th) immunoreactivity. |
2013-04-10 |
2023-08-12 |
mouse |
| U Singh, S Kumar, P S Singr. Interaction between dopamine- and isotocin-containing neurones in the preoptic area of the catfish, Clarias batrachus: role in the regulation of luteinising hormone cells. Journal of neuroendocrinology. vol 24. issue 11. 2013-03-28. PMID:22672503. |
we studied the organisation of tyrosine hydroxylase (th; a marker for dopamine) and isotocin neurones in the preoptic area (poa) and hypothalamus of the catfish, clarias batrachus and its implication in the regulation of luteinising hormone (lh) cells in the pituitary. |
2013-03-28 |
2023-08-12 |
Not clear |