| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leandro C Souza, Marcelo G de Gomes, André T R Goes, Lucian Del Fabbro, Carlos B Filho, Silvana P Boeira, Cristiano R Jess. Evidence for the involvement of the serotonergic 5-HT(1A) receptors in the antidepressant-like effect caused by hesperidin in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 40. 2013-03-26. PMID:22996046. |
pretreatment of mice with prazosin (1 mg/kg, i.p., an α(1)-adrenoceptor antagonist), yohimbine (1 mg/kg, i.p., an α(2)-adrenoceptor antagonist), propranolol (2 mg/kg, i.p., a β-adrenoceptor antagonist), ampt (100 mg/kg, i.p., an inhibitor of tyrosine hydroxylase), sch23390 (0.05 mg/kg, s.c., a dopamine d(1) receptor antagonist), sulpiride (50 mg/kg, i.p., a dopamine d(2) receptor antagonist), ketanserin (1mg/kg, i.p., a 5-ht(2a/2c) receptor antagonist) or mdl72222 (1 mg/kg, i.p., a 5-ht(3) receptor antagonist) did not block the antidepressant-like effect of hesperidin (0.3 mg/kg, i.p.) |
2013-03-26 |
2023-08-12 |
mouse |
| Cory Pfeiffenberger, Ravi Allad. Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila. PLoS genetics. vol 8. issue 10. 2013-03-22. PMID:23055946. |
furthermore, the inc sleep duration phenotype can be rescued by pharmacological inhibition of tyrosine hydroxylase, the rate-limiting enzyme for dopamine biosynthesis. |
2013-03-22 |
2023-08-12 |
drosophila_melanogaster |
| Pinar Oner, Ozgur Oner, Fatih M Azik, Esra Cop, Kerim M Muni. Ferritin and hyperactivity ratings in attention deficit hyperactivity disorder. Pediatrics international : official journal of the Japan Pediatric Society. vol 54. issue 5. 2013-03-14. PMID:22591427. |
iron is a co-factor of tyrosine hydroxylase which is a critical enzyme in dopamine synthesis. |
2013-03-14 |
2023-08-12 |
Not clear |
| Tertia D Purves-Tyson, David J Handelsman, Kay L Double, Samantha J Owens, Sonia Bustamante, Cynthia Shannon Weicker. Testosterone regulation of sex steroid-related mRNAs and dopamine-related mRNAs in adolescent male rat substantia nigra. BMC neuroscience. vol 13. 2013-03-08. PMID:22867132. |
we investigated whether gonadectomy and sex steroid replacement could influence dopamine levels by changing tyrosine hydroxylase (th) protein and mrna and/or dopamine breakdown enzyme mrna levels [catechol-o-methyl transferase (comt) and monoamine oxygenase (mao) a and b] in the adolescent male rat substantia nigra. |
2013-03-08 |
2023-08-12 |
rat |
| Tianhong Pan, Julie Zhu, Wen-Jen Hwu, Joseph Jankovi. The role of alpha-synuclein in melanin synthesis in melanoma and dopaminergic neuronal cells. PloS one. vol 7. issue 9. 2013-02-28. PMID:23028833. |
the findings that α-syn can interact with tyrosinase (tyr) and inhibit tyrosine hydroxylase (th), both of which are enzymes involved in the biosynthesis of melanin and dopamine (da), led us to propose that α-syn may participate in the regulation of melanin synthesis. |
2013-02-28 |
2023-08-12 |
Not clear |
| Nandakumar S Narayanan, Benjamin B Land, John E Solder, Karl Deisseroth, Ralph J DiLeon. Prefrontal D1 dopamine signaling is required for temporal control. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 50. 2013-02-28. PMID:23185016. |
rodents were trained to perform a fixed-interval timing task with an interval of 20 s. we report several results: first, that decreasing dopaminergic neurotransmission using virally mediated rna interference of tyrosine hydroxylase impaired temporal control, and second that pharmacological disruption of prefrontal d1 dopamine receptors, but not d2 dopamine receptors, impaired temporal control. |
2013-02-28 |
2023-08-12 |
Not clear |
| ZeGang Ma, Yu Zhou, JunXia Xi. Nifedipine prevents iron accumulation and reverses iron-overload-induced dopamine neuron degeneration in the substantia nigra of rats. Neurotoxicity research. vol 22. issue 4. 2013-02-27. PMID:22259026. |
by high performance liquid chromatography-electrochemical detection, tyrosine hydroxylase (th) immunohistochemistry, and iron content array, we first quantified iron content and the number of dopamine neurons in sn of experimental rats treated with iron dextran. |
2013-02-27 |
2023-08-12 |
rat |
| Keun-Sung Lee, Jin-Koo Lee, Hyung-Gun Kim, Hak Rim Ki. Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 17. issue 1. 2013-02-27. PMID:23440908. |
the endogenous dopamine concentrations and expression levels of tyrosine hydroxylase were significantly decreased after the repeated injections, but tetrahydrobiopterin did not change in analyzed brain regions. |
2013-02-27 |
2023-08-12 |
mouse |
| Keun-Sung Lee, Jin-Koo Lee, Hyung-Gun Kim, Hak Rim Ki. Differential Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on Motor Behavior and Dopamine Levels at Brain Regions in Three Different Mouse Strains. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 17. issue 1. 2013-02-27. PMID:23440908. |
however, susceptibilities of the mice to mptp were differed based on the degree of behavioral change, dopamine concentration in brain regions, and expression levels of tyrosine hydroxylase, with c57bl/6 and balb-c mice being more sensitive to the dopaminergic neuronal toxicity of mptp than icr mice. |
2013-02-27 |
2023-08-12 |
mouse |
| Jeffrey B Eells, Josiah Wilcots, Scott Sisk, Shirley X Guo-Ros. NR4A gene expression is dynamically regulated in the ventral tegmental area dopamine neurons and is related to expression of dopamine neurotransmission genes. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21932041. |
in a separate group of mice, haloperidol injection significantly elevated nur77 and nor1, but not nurr1 mrna in the vta within 1 h and significantly increased tyrosine hydroxylase (th) and dopamine transporter (dat) mrna expression by 4 h. these data demonstrate that the nr4a genes are dynamically regulated in dopamine neurons with maintenance of nurr1 expression requiring dopamine neuron activity while both attenuation of dopamine autoreceptors activation and dopamine neuronal activity combining to induce nur77 expression. |
2013-02-25 |
2023-08-12 |
mouse |
| Frederico C Pereira, Teresa Cunha-Oliveira, Sofia D Viana, Ana S Travassos, Sara Nunes, Carlos Silva, Rui Daniel Prediger, A Cristina Rego, Syed F Ali, Carlos Alberto Fontes Ribeir. Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice. Neurotoxicology and teratology. vol 34. issue 5. 2013-02-25. PMID:22884891. |
this methamphetamine regimen also produced dopaminergic terminal degeneration in the striatum, as evidenced by dopamine and tyrosine hydroxylase depletion. |
2013-02-25 |
2023-08-12 |
mouse |
| Elin Rönnberg, Gabriela Calounova, Gunnar Pejle. Mast cells express tyrosine hydroxylase and store dopamine in a serglycin-dependent manner. Biological chemistry. vol 393. issue 1-2. 2013-02-14. PMID:22628305. |
mast cells express tyrosine hydroxylase and store dopamine in a serglycin-dependent manner. |
2013-02-14 |
2023-08-12 |
Not clear |
| Elin Rönnberg, Gabriela Calounova, Gunnar Pejle. Mast cells express tyrosine hydroxylase and store dopamine in a serglycin-dependent manner. Biological chemistry. vol 393. issue 1-2. 2013-02-14. PMID:22628305. |
moreover, the expression of tyrosine hydroxylase, the key enzyme in dopamine biosynthesis, was induced during mast cell maturation; histidine decarboxylase and tryptophan hydroxylase 1 were also induced. |
2013-02-14 |
2023-08-12 |
Not clear |
| Hyun Sook Yu, Se Hyun Kim, Hong Geun Park, Yong Sik Kim, Yong Min Ah. Intracerebroventricular administration of ouabain, a Na/K-ATPase inhibitor, activates tyrosine hydroxylase through extracellular signal-regulated kinase in rat striatum. Neurochemistry international. vol 59. issue 6. 2013-01-29. PMID:21871514. |
tyrosine hydroxylase (th) is the rate-limiting enzyme that is crucial for dopamine biosynthesis, and its activity is tightly regulated by phosphorylation at multiple n-terminal serine residues. |
2013-01-29 |
2023-08-12 |
rat |
| Abdeljalil Elgot, Omar El Hiba, Halima Gamran. Alteration of dopaminergic innervation and voluntary movements after long period of thirst in a semi-desert rodent, Meriones shawi: behavioral and immunohistochemical studies. Comptes rendus biologies. vol 335. issue 7. 2013-01-11. PMID:22847013. |
we used tyrosine hydroxylase immunohistochemistry (th: the key enzyme of catecholamine biosynthesis) to evaluate the effects of prolonged dehydration on the dopaminergic system in both substancia nigra pars compacta and ventral tegmental area (snpc and vta), which are the main sources of dopamine input to several brain areas; the immunolabelling was performed also in both the medial forebrain bundle and the caudate putamen (striatum). |
2013-01-11 |
2023-08-12 |
Not clear |
| Roxanne Dutia, Andrea J Kim, Eugene Mosharov, Eriika Savontaus, Streamson C Chua, Sharon L Wardla. Regulation of prolactin in mice with altered hypothalamic melanocortin activity. Peptides. vol 37. issue 1. 2013-01-07. PMID:22800691. |
hypothalamic tyrosine hydroxylase mrna was measured in both genetic models vs. wt mice and hypothalamic dopamine and 3,4-dihydroxyphenylacetic acid (dopac) content were measured in male agrp ko and wt mice but neither were significantly different. |
2013-01-07 |
2023-08-12 |
mouse |
| Thiago B Kirsten, Gabriela P Chaves-Kirsten, Lucas M Chaible, Ana C Silva, Daniel O Martins, Luiz R G Britto, Maria L Z Dagli, Andrea S Torrão, João Palermo-Neto, Maria M Bernard. Hypoactivity of the central dopaminergic system and autistic-like behavior induced by a single early prenatal exposure to lipopolysaccharide. Journal of neuroscience research. vol 90. issue 10. 2013-01-04. PMID:22714803. |
because we previously had demonstrated that prenatal lps decreases striatal dopamine (da) and metabolite levels, the striatal dopaminergic system (tyrosine hydroxylase [th] and da receptors d1a and d2) and glial cells (astrocytes and microglia) were analyzed by using immunohistochemistry, immunoblotting, and real-time pcr. |
2013-01-04 |
2023-08-12 |
rat |
| Regina Nostramo, Andrej Tillinger, Juan M Saavedra, Ashok Kumar, Varunkumar Pandey, Lidia Serova, Richard Kvetnansky, Esther L Sabba. Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. The Journal of endocrinology. vol 215. issue 2. 2013-01-03. PMID:22911895. |
these effects of stress on ang ii receptor expression may alter catecholamine biosynthesis, as tyrosine hydroxylase and dopamine β-hydroxylase mrna levels in pc12 cells are decreased with ang ii treatment in the presence of zd7155 (at(1) receptor antagonist) or with cgp42112 (at(2) receptor agonist) treatment. |
2013-01-03 |
2023-08-12 |
mouse |
| Min Zhang, Hak Ju Lee, Keun Hong Park, Hyun Jin Park, Hyun Sook Choi, Sung Cil Lim, Myung Koo Le. Modulatory effects of sesamin on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22293035. |
sesamin at concentration ranges of 20-75 μm exhibited a significant increase in intracellular dopamine levels at 24 h: 50 μm sesamin increased dopamine levels to 133% and tyrosine hydroxylase (th) activity to 128.2% of control levels. |
2012-12-20 |
2023-08-12 |
Not clear |
| Barbara Bosier, Giulio G Muccioli, Birgit Mertens, Sophie Sarre, Yvette Michotte, Didier M Lambert, Emmanuel Herman. Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22365976. |
differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo. |
2012-12-20 |
2023-08-12 |
rat |