| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jos L Venero, Mati Revuelta, Leila Atiki, Marti Santiago, Mayka C Toms-Camardiel, Josefina Cano, Alberto Machad. Evidence for dopamine-derived hydroxyl radical formation in the nigrostriatal system in response to axotomy. Free radical biology & medicine. vol 34. issue 1. 2003-07-07. PMID:12498986. |
short-term adaptive axotomy-induced changes in substantia nigra included downregulation of nigral tyrosine hydroxylase (th) and dopamine transporter (dat) mrna expression and more intense th immunoreactivity. |
2003-07-07 |
2023-08-12 |
Not clear |
| Yukio Oomori, Hiroshi Murabayashi, Katsushi Ishikawa, Kiyoshi Miyakawa, Kazuhiro Nakaya, Hiroshi Tanak. Neuropeptide Y- and catecholamine-synthesizing enzymes: immunoreactivities in the rat carotid body during postnatal development. Anatomy and embryology. vol 206. issue 1-2. 2003-06-24. PMID:12478366. |
immunocytochemical studies of the rat carotid body during postnatal development revealed neuropeptide y (npy), tyrosine hydroxylase (th), and dopamine beta-hydroxylase (dbh) immunoreactivities. |
2003-06-24 |
2023-08-12 |
rat |
| Kwang-Soo Kim, Chun-Hyung Kim, Dong-Youn Hwang, Hyemyung Seo, Sangmi Chung, Seok Jong Hong, Jin-Kyu Lim, Therese Anderson, Ole Isacso. Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner. Journal of neurochemistry. vol 85. issue 3. 2003-06-17. PMID:12694388. |
tyrosine hydroxylase (th) catalyzes the first and rate-limiting step of catecholamine synthesis and its expression is necessary for neurotransmitter specification of all catecholaminergic neurons, while dopamine beta-hydroxylase (dbh) is essential for the noradrenergic phenotype. |
2003-06-17 |
2023-08-12 |
Not clear |
| Dean E Dluzen, June-Hee Park, Kyungjin Ki. Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen. Brain research. Molecular brain research. vol 108. issue 1-2. 2003-06-16. PMID:12480184. |
at 14 days post-hormonal treatment, the olfactory bulbs were assayed for mrna levels of tyrosine hydroxylase, dopamine transporter and norepinephrine transporter using competitive-pcr. |
2003-06-16 |
2023-08-12 |
mouse |
| I A Moroz, H Rajabi, D Rodaros, J Stewar. Effects of sex and hormonal status on astrocytic basic fibroblast growth factor-2 and tyrosine hydroxylase immunoreactivity after medial forebrain bundle 6-hydroxydopamine lesions of the midbrain dopamine neurons. Neuroscience. vol 118. issue 2. 2003-06-16. PMID:12699782. |
effects of sex and hormonal status on astrocytic basic fibroblast growth factor-2 and tyrosine hydroxylase immunoreactivity after medial forebrain bundle 6-hydroxydopamine lesions of the midbrain dopamine neurons. |
2003-06-16 |
2023-08-12 |
rat |
| Susanna Althini, Henrik Bengtsson, Dmitry Usoskin, Stine Söderström, Annika Kylberg, Eva Lindqvist, Susana Chuva de Sousa Lopes, Lars Olson, Jonas Lindeberg, Ted Ebenda. Normal nigrostriatal innervation but dopamine dysfunction in mice carrying hypomorphic tyrosine hydroxylase alleles. Journal of neuroscience research. vol 72. issue 4. 2003-06-06. PMID:12704806. |
normal nigrostriatal innervation but dopamine dysfunction in mice carrying hypomorphic tyrosine hydroxylase alleles. |
2003-06-06 |
2023-08-12 |
mouse |
| Taizo Kita, Tutomu Saraya, Noboru Konishi, Yasunori Matsunari, Keiji Shimada, Mitsutoshi Nakamura, Kiichi O'Hara, George C Wagner, Toshikatsu Nakashim. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine pretreatment attenuates methamphetamine-induced dopamine toxicity. Pharmacology & toxicology. vol 92. issue 2. 2003-06-02. PMID:12747576. |
control mice received saline in place of the mptp or methamphetamine and mice were observed for acute changes in body temperature, self-injurious behaviour, and striatal dopamine metabolites, or long-term changes in striatal dopamine levels, tyrosine hydroxylase immunoreactivity and glial fibrillary acidic protein. |
2003-06-02 |
2023-08-12 |
mouse |
| Taizo Kita, Tutomu Saraya, Noboru Konishi, Yasunori Matsunari, Keiji Shimada, Mitsutoshi Nakamura, Kiichi O'Hara, George C Wagner, Toshikatsu Nakashim. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine pretreatment attenuates methamphetamine-induced dopamine toxicity. Pharmacology & toxicology. vol 92. issue 2. 2003-06-02. PMID:12747576. |
likewise, pretreatment with mptp attenuated the long-term depletion of striatal dopamine induced by the methamphetamine as well as the large increase in glial fibrillary acidic protein and the reduction in tyrosine hydroxylase immunoreactivity. |
2003-06-02 |
2023-08-12 |
mouse |
| Niklas Lindgren, Alessandro Usiello, Michel Goiny, John Haycock, Eric Erbs, Paul Greengard, Tomas Hokfelt, Emiliana Borrelli, Gilberto Fison. Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 7. 2003-05-22. PMID:12651945. |
dopamine d2 receptors are highly expressed in the dorsal striatum where they participate in the regulation of (i) tyrosine hydroxylase (th), in nigrostriatal nerve terminals, and (ii) the dopamine- and camp-regulated phosphoprotein of 32 kda (darpp-32), in medium spiny neurons. |
2003-05-22 |
2023-08-12 |
mouse |
| M J Decker, G E Hue, W M Caudle, G W Miller, G L Keating, D B Ry. Episodic neonatal hypoxia evokes executive dysfunction and regionally specific alterations in markers of dopamine signaling. Neuroscience. vol 117. issue 2. 2003-05-21. PMID:12614682. |
rats were killed on postnatal day 80 and tyrosine hydroxylase, vesicular monoamine transporter, dopamine transporter, and dopamine d1 receptors were quantified in the prefrontal cortex, primary sensorimotor cortex, and precommissural striatum by western blot analyses. |
2003-05-21 |
2023-08-12 |
rat |
| Donghou Kim, Hyun Jin Choi, Seong Who Kim, Sung-Woo Cho, Onyou Hwan. Upregulation of catecholamine biosynthetic enzymes by nitric oxide. Journal of neuroscience research. vol 72. issue 1. 2003-05-12. PMID:12645083. |
the no generators sodium nitroprusside (snp) and s-nitroso-n-acetyl-d,l-penicillamine, in a dose-dependent manner, upregulated transcript levels of tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine n-methyltransferase, accompanied by long-term increases in their enzyme activities and the intracellular ca levels. |
2003-05-12 |
2023-08-12 |
cattle |
| Purificación Tejedor-Real, Nicole Faucon Biguet, Sylvie Dumas, Jacques Malle. Tyrosine hydroxylase mRNA and protein are down-regulated by chronic clozapine in both the mesocorticolimbic and the nigrostriatal systems. Journal of neuroscience research. vol 72. issue 1. 2003-05-12. PMID:12645084. |
because tyrosine hydroxylase is the rate-limiting enzyme in the biosynthesis of dopamine, we studied the effect of chronic clozapine in both dopaminergic systems. |
2003-05-12 |
2023-08-12 |
Not clear |
| Purificación Tejedor-Real, Nicole Faucon Biguet, Sylvie Dumas, Jacques Malle. Tyrosine hydroxylase mRNA and protein are down-regulated by chronic clozapine in both the mesocorticolimbic and the nigrostriatal systems. Journal of neuroscience research. vol 72. issue 1. 2003-05-12. PMID:12645084. |
there was thus discordance between the clozapine-induced decrease of tyrosine hydroxylase mrna and protein and the absence of an effect on dopamine levels in the nigrostriatal system. |
2003-05-12 |
2023-08-12 |
Not clear |
| Martin Anlauf, Martin K-H Schäfer, Lee Eiden, Eberhard Weih. Chemical coding of the human gastrointestinal nervous system: cholinergic, VIPergic, and catecholaminergic phenotypes. The Journal of comparative neurology. vol 459. issue 1. 2003-05-06. PMID:12629668. |
for this purpose, antibodies against the vesicular monoamine transporters (vmat1/2), the vesicular acetylcholine transporter (vacht), tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), serotonin (5-ht), vasoactive intestinal peptide (vip), and protein gene product 9.5 (pgp 9.5) were used. |
2003-05-06 |
2023-08-12 |
human |
| Hisanori Ito, Hiroshi Nomoto, Yoshiko Furukawa, Shoei Furukaw. Neurotrophins facilitate synthesis of choline acetyltransferase and tyrosine hydroxylase in cultured mouse neural stem cells independently of their neuronal differentiation. Neuroscience letters. vol 339. issue 3. 2003-05-05. PMID:12633895. |
choline acetyltransferase (chat), tyrosine hydroxylase (th), dopamine beta hydroxylase (dbh), and glutamate decarboxylase 65 were investigated in cultured mouse neural stem cells. |
2003-05-05 |
2023-08-12 |
mouse |
| Jitka Ourednik, Václav Ourednik, William P Lynch, Melitta Schachner, Evan Y Snyde. Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nature biotechnology. vol 20. issue 11. 2003-05-01. PMID:12379867. |
functional assays paralleled the spatiotemporal recovery of tyrosine hydroxylase (th) and dopamine transporter (dat) activity, which, in turn, mirrored the spatiotemporal distribution of donor-derived cells. |
2003-05-01 |
2023-08-12 |
mouse |
| Yasuhide Iwata, Hideo Matsumoto, Yoshio Minabe, Naoko Osada, Kazuhiko Nakamura, Takahiro Sekizawa, Katsuaki Suzuki, Yoshimoto Sekine, Nori Takei, Norio Mor. Early-onset schizophrenia and dopamine-related gene polymorphism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 116B. issue 1. 2003-04-30. PMID:12497608. |
this study explored the relationship between the polymorphism of four dopamine-regulating-enzymes (tyrosine hydroxylase, dopamine-beta-hydroxylase, catechol-o-methyltransferase, monoamine oxidase-a) genes, four dopamine-receptors (dopamine d1, d2, d3, d4 receptors) genes and susceptibility to eos in a japanese sample. |
2003-04-30 |
2023-08-12 |
human |
| Jennifer L Tillerson, Gary W Mille. Grid performance test to measure behavioral impairment in the MPTP-treated-mouse model of parkinsonism. Journal of neuroscience methods. vol 123. issue 2. 2003-04-23. PMID:12606067. |
these measures are significantly correlated with the loss of striatal dopamine and immunoreactivity of the dopamine transporter, vesicular monoamine transporter and tyrosine hydroxylase. |
2003-04-23 |
2023-08-12 |
mouse |
| D P Figlewicz, S B Evans, J Murphy, M Hoen, D G Baski. Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain research. vol 964. issue 1. 2003-04-18. PMID:12573518. |
extensive co-expression of tyrosine hydroxylase (a marker for dopamine neurons) with both the insulin receptor and the leptin receptor was observed in the ventral tegmentum and substantia nigra. |
2003-04-18 |
2023-08-12 |
rat |
| Mayada Akil, Bhaskar S Kolachana, Debora A Rothmond, Thomas M Hyde, Daniel R Weinberger, Joel E Kleinma. Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 6. 2003-04-17. PMID:12657658. |
we measured tyrosine hydroxylase (th) mrna in mesencephalic dopamine neurons in human brain and found that the comt valine allele is also associated with increased th gene expression, especially in neuronal populations that project to the striatum. |
2003-04-17 |
2023-08-12 |
human |