| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhenyi Liu, Andrew Brown, Dan Fisher, Yumei Wu, Joe Warren, Xiaoxia Cu. Tissue Specific Expression of Cre in Rat Tyrosine Hydroxylase and Dopamine Active Transporter-Positive Neurons. PloS one. vol 11. issue 2. 2016-08-02. PMID:26886559. |
tissue specific expression of cre in rat tyrosine hydroxylase and dopamine active transporter-positive neurons. |
2016-08-02 |
2023-08-13 |
mouse |
| Zhenyi Liu, Andrew Brown, Dan Fisher, Yumei Wu, Joe Warren, Xiaoxia Cu. Tissue Specific Expression of Cre in Rat Tyrosine Hydroxylase and Dopamine Active Transporter-Positive Neurons. PloS one. vol 11. issue 2. 2016-08-02. PMID:26886559. |
here we report the characterization of two cre rats, tyrosine hydroxylase (th)-cre and dopamine active transporter (dat or slc6a3)-cre, by using a combination of immunohistochemistry (ihc) and mrna fluorescence in situ hybridization (fish) as well as a fluorescent reporter for cre activity. |
2016-08-02 |
2023-08-13 |
mouse |
| Bryce D Grier, Leonardo Belluscio, Claire E J Cheetha. Olfactory Sensory Activity Modulates Microglial-Neuronal Interactions during Dopaminergic Cell Loss in the Olfactory Bulb. Frontiers in cellular neuroscience. vol 10. 2016-07-29. PMID:27471450. |
dopaminergic (da) neurons in the glomerular layer (gl) of the ob are particularly plastic, with loss of sensory input rapidly reducing tyrosine hydroxylase (th) expression and dopamine production, followed by a substantial reduction in da neuron number. |
2016-07-29 |
2023-08-13 |
mouse |
| Magda Nowicki, Steven Tran, Diptendu Chatterjee, Robert Gerla. Inhibition of phosphorylated tyrosine hydroxylase attenuates ethanol-induced hyperactivity in adult zebrafish (Danio rerio). Pharmacology, biochemistry, and behavior. vol 138. 2016-07-28. PMID:26366782. |
acute ethanol exposure increases dopamine (da) in the zebrafish brain, and it has been suggested that tyrosine hydroxylase, the rate-limiting enzyme of da synthesis, may be activated in response to ethanol via phosphorylation. |
2016-07-28 |
2023-08-13 |
zebrafish |
| Lacey Pflibsen, Katherine A Stang, Michelle D Sconce, Vanessa B Wilson, Rebecca L Hood, Charles K Meshul, Suzanne H Mitchel. Executive function deficits and glutamatergic protein alterations in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Journal of neuroscience research. vol 93. issue 12. 2016-07-27. PMID:26332770. |
although within the dorsolateral (dl) striatum mice that had been given mptp showed a 63% and 83% loss of tyrosine hydroxylase and dopamine transporter expression, respectively, there were no changes in the nucleus accumbens or medial prefrontal cortex (mpfc). |
2016-07-27 |
2023-08-13 |
mouse |
| Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Rajamani Barathidasan, Chidambaram SaravanaBabu, Gilles J Guillemin, Mohammed A S Kha. Influences of Chronic Mild Stress Exposure on Motor, Non-Motor Impairments and Neurochemical Variables in Specific Brain Areas of MPTP/Probenecid Induced Neurotoxicity in Mice. PloS one. vol 11. issue 1. 2016-07-26. PMID:26765842. |
injections (once in 3.5 days for 5 weeks) of mptp/p or exposure to cms for 4 weeks, the behavioural (motor and non-motor) impairments, levels and expressions of dopamine (da), serotonin (5-ht), daergic markers such as tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporters-2 (vmat 2) and α-synuclein in nigrostriatal (striatum (st) and substantia nigra (sn)) and extra-nigrostriatal (hippocampus, cortex and cerebellum) tissues were analysed. |
2016-07-26 |
2023-08-13 |
mouse |
| Doris Tomas, Augustinus H Prijanto, Emma L Burrows, Anthony J Hannan, Malcolm K Horne, Tim D Auman. Environmental modulations of the number of midbrain dopamine neurons in adult mice. Journal of visualized experiments : JoVE. issue 95. 2016-07-18. PMID:25650697. |
two environmental manipulations are described which increase or decrease the number of tyrosine hydroxylase immunopositive (th+, the rate-limiting enzyme in dopamine (da) synthesis) neurons in the adult mouse midbrain. |
2016-07-18 |
2023-08-13 |
mouse |
| S Vanhatal. Comparison of the Distributions of Neuropeptide Y-, Tyrosine Hydroxylase-, and Tryptophan Hydroxylase-Expressing Neurons in the Hypothalamic Arcuate Nucleus. Nutritional neuroscience. vol 3. issue 1. 2016-07-16. PMID:27416156. |
in addition, their distribution was compared to that of tyrosine hydroxylase (th), the dopamine synthesizing enzyme. |
2016-07-16 |
2023-08-13 |
Not clear |
| Tian Tian, Zhaoming Li, Hong L. Common pathophysiology affecting diabetic retinopathy and Parkinson's disease. Medical hypotheses. vol 85. issue 4. 2016-07-12. PMID:26141638. |
it is reported that retinal dopamine and tyrosine hydroxylase protein levels are downregulated, and dopaminergic amacrine cells appear to be degenerating in the animal models of dr. further, injecting the diabetic mice with dopamine-restoring or dopamine-activating drugs already used to treat pd can restore dopamine levels and significantly improve diabetes-associated visual dysfunction in the early stage. |
2016-07-12 |
2023-08-13 |
mouse |
| H E Vuong, L Pérez de Sevilla Müller, C N Hardi, D G McMahon, N C Brech. Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines. Neuroscience. vol 307. 2016-07-06. PMID:26335381. |
this report compares transgene expression in the retina of a tyrosine hydroxylase (th)-red fluorescent protein (rfp) mouse line with three catecholamine-related cre recombinase mouse lines [th-bacterial artificial chromosome (bac)-, th-, and dopamine transporter (dat)-cre] that were crossed with a rosa26-tdtomato reporter line. |
2016-07-06 |
2023-08-13 |
mouse |
| Katarzyna Palus, Jarosław Całk. The Influence of Prolonged Acetylsalicylic Acid Supplementation-Induced Gastritis on the Neurochemistry of the Sympathetic Neurons Supplying Prepyloric Region of the Porcine Stomach. PloS one. vol 10. issue 11. 2016-06-27. PMID:26606050. |
then fourteen-micrometer-thick cryostat sections were processed for routine double-labeling immunofluorescence, using primary antisera directed towards tyrosine hydroxylase (th), dopamine β-hydroxylase (dβh), neuropeptide y (npy), galanin (gal), neuronal nitric oxide synthase (nnos), leu 5-enkephalin (lenk), cocaine- and amphetamine- regulated transcript peptide (cart), calcitonin gene-related peptide (cgrp), substance p (sp) and vasoactive intestinal peptide (vip). |
2016-06-27 |
2023-08-13 |
Not clear |
| Catherine M Davis, Kathleen L DeCicco-Skinner, Robert D Hien. Deficits in Sustained Attention and Changes in Dopaminergic Protein Levels following Exposure to Proton Radiation Are Related to Basal Dopaminergic Function. PloS one. vol 10. issue 12. 2016-06-27. PMID:26658810. |
fischer 344 rats displayed greater tyrosine hydroxylase and dopamine transporter levels in the frontal cortex compared to the lewis rats, even though radiation exposure increased both of these proteins in the lewis rats only. |
2016-06-27 |
2023-08-13 |
human |
| Andrés Ciudad-Roberts, Leticia Duart-Castells, Jorge Camarasa, David Pubill, Elena Escubed. The combination of ethanol with mephedrone increases the signs of neurotoxicity and impairs neurogenesis and learning in adolescent CD-1 mice. Toxicology and applied pharmacology. vol 293. 2016-06-22. PMID:26747301. |
the combination with ethanol impaired mephedrone-induced decreases in dopamine transporter and tyrosine hydroxylase in the frontal cortex; and in serotonin transporter and tryptophan hydroxylase in the hippocampus by approximately 2-fold, 7days post-treatment. |
2016-06-22 |
2023-08-13 |
mouse |
| Yan Liu, Jian-Dong Sun, Lian-Kun Song, Jing Li, Shi-Feng Chu, Yu-He Yuan, Nai-Hong Che. Environment-contact administration of rotenone: A new rodent model of Parkinson's disease. Behavioural brain research. vol 294. 2016-06-14. PMID:26239001. |
accordingly, rotenone caused significant dopamine depletion from the striatum (hplc analysis), nigrostriatal degeneration (quantitative tyrosine hydroxylase immunohistochemistry and western blot), and accumulation of α-synuclein in the substantia nigra and striatum (α-synuclein immunohistochemistry) in a time-dependent manner. |
2016-06-14 |
2023-08-13 |
mouse |
| Carol A Lazzara, Rebeccah R Riley, Anand Rane, Julie K Andersen, Yong-Hwan Ki. The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy. Brain research. vol 1622. 2016-06-02. PMID:26119916. |
calpain inhibition has previously been associated with increased levels of the rate-limiting enzyme in dopamine synthesis, tyrosine hydroxylase (th), which is probably mediated by the up-regulation of the transcription factors mef-2a and 2d. |
2016-06-02 |
2023-08-13 |
mouse |
| YanFang Zhang, YiMei Chen, Lin Li, Christian Hölsche. Neuroprotective effects of (Val8)GLP-1-Glu-PAL in the MPTP Parkinson's disease mouse model. Behavioural brain research. vol 293. 2016-06-02. PMID:26187689. |
(val8)glp-1-glu-pal showed good effects in preventing the mptp-induced motor impairment (rotarod, open field locomotion, swim test), reduction in tyrosine hydroxylase levels (dopamine synthesis) in the substantia nigra, a reduction of activated caspase 3 levels, of tunel positive cell numbers, of the pro-apoptotic signaling molecule bax and an increase in the growth signaling molecule bcl-2. |
2016-06-02 |
2023-08-13 |
mouse |
| Tiffany S Kung, Jason R Richardson, Keith R Cooper, Lori A Whit. Developmental Deltamethrin Exposure Causes Persistent Changes in Dopaminergic Gene Expression, Neurochemistry, and Locomotor Activity in Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. vol 146. issue 2. 2016-05-31. PMID:25912032. |
deltamethrin exposure resulted in decreased transcript levels of the d1 dopamine (da) receptor (drd1) and increased levels of tyrosine hydroxylase at 72 hpf. |
2016-05-31 |
2023-08-13 |
human |
| Guoxiang Liu, Carmelo Sgobio, Xinglong Gu, Lixin Sun, Xian Lin, Jia Yu, Loukia Parisiadou, Chengsong Xie, Namratha Sastry, Jinhui Ding, Kelly M Lohr, Gary W Miller, Yolanda Mateo, David M Lovinger, Huaibin Ca. Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression. Human molecular genetics. vol 24. issue 18. 2016-05-31. PMID:26123485. |
this reduction in dopamine content/release coincided with the degeneration of da axon terminals and decreased expression of da neuron-enriched genes tyrosine hydroxylase (th), vesicular monoamine transporter 2, dopamine transporter and aldehyde dehydrogenase 1. |
2016-05-31 |
2023-08-13 |
mouse |
| Claudia Sagheddu, Sonia Aroni, Marta De Felice, Salvatore Lecca, Antonio Luchicchi, Miriam Melis, Anna Lisa Muntoni, Rosaria Romano, Enza Palazzo, Francesca Guida, Sabatino Maione, Marco Pisti. Enhanced serotonin and mesolimbic dopamine transmissions in a rat model of neuropathic pain. Neuropharmacology. vol 97. 2016-05-24. PMID:26113399. |
extracellular dopamine levels and the expression of dopamine d1, d2 receptors and tyrosine hydroxylase (th) were measured in the nucleus accumbens. |
2016-05-24 |
2023-08-13 |
rat |
| X Cui, R Pertile, P Liu, D W Eyle. Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator. Neuroscience. vol 304. 2016-05-24. PMID:26210580. |
here we show that in vdr-expressing sh-sy5y cells, 1,25(oh)2d3 significantly increased production of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis. |
2016-05-24 |
2023-08-13 |
human |