| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Liu, J Jalewa, M Sharma, G Li, L Li, C Hölsche. Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Neuroscience. vol 303. 2016-05-06. PMID:26141845. |
both liraglutide and lixisenatide showed effects in preventing the mptp-induced motor impairment (rotarod, open-field locomotion, catalepsy test), reduction in tyrosine hydroxylase (th) levels (dopamine synthesis) in the substantia nigra and basal ganglia, a reduction of the pro-apoptotic signaling molecule bax and an increase in the anti-apoptotic signaling molecule b-cell lymphoma-2. |
2016-05-06 |
2023-08-13 |
mouse |
| Jingjing Song, Xintong Hou, Xinyu Hu, Chengyu Lu, Chungang Liu, Juan Wang, Wei Liu, Lirong Teng, Di Wan. Not only serotonergic system, but also dopaminergic system involved in albiflorin against chronic unpredictable mild stress-induced depression-like behavior in rats. Chemico-biological interactions. vol 242. 2016-05-03. PMID:26475043. |
altered levels of tyrosine hydroxylase, dopamine d2 receptor and dopamine transporter in hypothalamus reverted to the normal level after treatment with both af and fluoxetine. |
2016-05-03 |
2023-08-13 |
rat |
| Eric Grouzmann, Oliver Tschopp, Frédéric Triponez, Maurice Matter, Stefan Bilz, Michael Brändle, Tilman Drechser, Sarah Sigrist, Henryk Zulewski, Christoph Henzen, Stefan Fischli, Karim Abi. Catecholamine metabolism in paraganglioma and pheochromocytoma: similar tumors in different sites? PloS one. vol 10. issue 5. 2016-04-25. PMID:25946206. |
tyrosine hydroxylase (th), dopamine β-hydroxylase (dbh) and phenylethanolamine n-methyltransferase (pnmt). |
2016-04-25 |
2023-08-13 |
cat |
| A M Willard, R S Bouchard, A H Gitti. Differential degradation of motor deficits during gradual dopamine depletion with 6-hydroxydopamine in mice. Neuroscience. vol 301. 2016-04-18. PMID:26067595. |
levels of dopamine within the striatum declined linearly with successive injections, quantified using tyrosine hydroxylase immunostaining and high-performance liquid chromatography. |
2016-04-18 |
2023-08-13 |
mouse |
| Thamara E Osinga, Esther Korpershoek, Ronald R de Krijger, Michiel N Kerstens, Robin P F Dullaart, Ido P Kema, Bernard F A M van der Laan, Anouk N A van der Horst-Schrivers, Thera P Link. Catecholamine-Synthesizing Enzymes Are Expressed in Parasympathetic Head and Neck Paraganglioma Tissue. Neuroendocrinology. vol 101. issue 4. 2016-04-06. PMID:25677368. |
tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (aadc) and dopamine β-hydroxylase (dbh) in hnpgl tissue. |
2016-04-06 |
2023-08-13 |
Not clear |
| Chunhai Chen, Qinglong Ma, Xiaowei Chen, Min Zhong, Ping Deng, Gang Zhu, Yanwen Zhang, Lei Zhang, Zhiqi Yang, Kuan Zhang, Lu Guo, Liting Wang, Zhengping Yu, Zhou Zho. Thyroid Hormone-Otx2 Signaling Is Required for Embryonic Ventral Midbrain Neural Stem Cells Differentiated into Dopamine Neurons. Stem cells and development. vol 24. issue 15. 2016-04-06. PMID:25867707. |
we find that thyroid hormone deficiency during development reduces the midbrain da neuron number, downregulates the expression of tyrosine hydroxylase (th) and the dopamine transporter (dat), and impairs the da neuron-dependent motor behavior. |
2016-04-06 |
2023-08-13 |
Not clear |
| Lorena B Areal, Livia C M Rodrigues, Filipe Andrich, Livia S Moraes, Maria A Cicilini, Josideia B Mendonça, Fabricio S Pelição, Ester M Nakamura-Palacios, Cristina Martins-Silva, Rita G W Pire. Behavioural, biochemical and molecular changes induced by chronic crack-cocaine inhalation in mice: The role of dopaminergic and endocannabinoid systems in the prefrontal cortex. Behavioural brain research. vol 290. 2016-04-04. PMID:25940765. |
these changes may have decreased dopamine and its metabolites levels, which in turn may be related with the extreme upregulation of dopamine receptors and tyrosine hydroxylase observed in the prefrontal cortex of these animals. |
2016-04-04 |
2023-08-13 |
mouse |
| Laura M Grant, David G Barnett, Emerald J Doll, Glen Leverson, Michelle Ciucc. Relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion. Behavioural brain research. vol 291. 2016-03-28. PMID:26026785. |
relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion. |
2016-03-28 |
2023-08-13 |
rat |
| Laura M Grant, David G Barnett, Emerald J Doll, Glen Leverson, Michelle Ciucc. Relationships among rat ultrasonic vocalizations, behavioral measures of striatal dopamine loss, and striatal tyrosine hydroxylase immunoreactivity at acute and chronic time points following unilateral 6-hydroxydopamine-induced dopamine depletion. Behavioural brain research. vol 291. 2016-03-28. PMID:26026785. |
however, it is unclear if mild/acute dopamine depletion, paralleling earlier stages of pd, results in vocalization deficits, or to what degree vocalization parameters are correlated with other dopamine-dependent indicators of lesion severity or percent of tyrosine hydroxylase (%th) loss. |
2016-03-28 |
2023-08-13 |
rat |
| Karin Nordenankar, Casey J A Smith-Anttila, Nadine Schweizer, Thomas Viereckel, Carolina Birgner, Jana Mejia-Toiber, Marisela Morales, Richardson N Leao, Åsa Wallén-Mackenzi. Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity. Brain structure & function. vol 220. issue 4. 2016-03-18. PMID:24802380. |
three populations of neurons expressing the vesicular glutamate transporter 2 (vglut2) were recently described in the a10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (th).one of these populations ("th-vglut2 class1") also expressed the dopamine transporter (dat) gene while one did not ("th-vglut2 class2"), and the remaining population did not express th at all ("vglut2-only"). |
2016-03-18 |
2023-08-13 |
mouse |
| Jian-Qing Liang, Li Wang, Jian-Cheng He, Xian-Dong Hu. Verbascoside promotes the regeneration of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra. Neural regeneration research. vol 11. issue 1. 2016-03-16. PMID:26981096. |
tyrosine hydroxylase is a key enzyme in dopamine biosynthesis. |
2016-03-16 |
2023-08-13 |
rat |
| Subhashie Wijemanne, Joseph Jankovi. Dopa-responsive dystonia--clinical and genetic heterogeneity. Nature reviews. Neurology. vol 11. issue 7. 2016-03-15. PMID:26100751. |
autosomal dominant gtp cyclohydrolase 1 deficiency, also known as segawa disease, is the most common and best-characterized condition that manifests as drd, but a similar presentation can be seen with genetic abnormalities that lead to deficiencies in tyrosine hydroxylase, sepiapterin reductase or other enzymes that are involved in the biosynthesis of dopamine. |
2016-03-15 |
2023-08-13 |
Not clear |
| Michael J Bannon, Candace L Savonen, Zachary J Hartley, Magen M Johnson, Carl J Schmid. Investigating the potential influence of cause of death and cocaine levels on the differential expression of genes associated with cocaine abuse. PloS one. vol 10. issue 2. 2016-03-14. PMID:25658879. |
most of the genes studied (i.e., tyrosine hydroxylase, dopamine transporter, forkhead box a2, histone variant h3 family 3b, nuclear factor kappa b inhibitor alpha, growth arrest and dna damage-inducible beta) were found to be differentially expressed in chronic cocaine abusers irrespective of immediate cause of death or perimortem levels of cocaine, suggesting that these may represent core pathophysiological changes arising with chronic drug abuse. |
2016-03-14 |
2023-08-13 |
human |
| Kelly M Lohr, Kristen A Stout, Amy R Dunn, Minzheng Wang, Ali Salahpour, Thomas S Guillot, Gary W Mille. Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25746685. |
while wildtype mice show significant losses in striatal levels of the dopamine transporter (65% loss) and tyrosine hydroxylase (46% loss) following a 4 × 10 mg/kg meth dosing regimen, vmat2-hi mice were protected from this damage. |
2016-03-07 |
2023-08-13 |
mouse |
| S Sarkar, B Gough, J Raymick, M A Beaudoin, S F Ali, A Virmani, Z K Biniend. Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. Neuroscience letters. vol 606. 2016-03-01. PMID:26321151. |
rats were perfused immediately after testing with 4% paraformaldehyde and immunohistochemical analysis of dopamine transporter (dat), tyrosine hydroxylase (th), glial fibrillary acidic protein (gfap), and microglial cd11b marker was performed in the caudate-putamen (cpu) and the substantia nigra pars compacta (snc) in order to estimate dopaminergic neuronal and transporter damage. |
2016-03-01 |
2023-08-13 |
rat |
| Kevin S Edgar, Nuria Matesanz, Tom A Gardiner, Zvonimir S Katusic, Denise M McDonal. Hyperoxia depletes (6R)-5,6,7,8-tetrahydrobiopterin levels in the neonatal retina: implications for nitric oxide synthase function in retinopathy. The American journal of pathology. vol 185. issue 6. 2016-02-25. PMID:25913075. |
retinal dopamine levels were similarly diminished, consistent with the dependence of tyrosine hydroxylase on bh4. |
2016-02-25 |
2023-08-13 |
mouse |
| Minjeong Kim, Sangwook Seo, Kyunghwa Sung, Kisok Ki. Arsenic exposure in drinking water alters the dopamine system in the brains of C57BL/6 mice. Biological trace element research. vol 162. issue 1-3. 2016-02-23. PMID:25319007. |
in this study, the dopamine content and expression of tyrosine hydroxylase (th) and dopamine receptors (drs) were examined in the striatum and cerebral cortex of the mouse brain following the administration of as (1-100 mg/l naaso2 in drinking water). |
2016-02-23 |
2023-08-13 |
mouse |
| Fernanda M Tahamtani, Janicke Nordgreen, Margrethe Brantsæter, Gunn C Østby, Rebecca E Nordquist, Andrew M Jancza. Does Early Environmental Complexity Influence Tyrosine Hydroxylase in the Chicken Hippocampus and "Prefrontal" Caudolateral Nidopallium? Frontiers in veterinary science. vol 3. 2016-02-23. PMID:26904550. |
these brains were prepared for immunohistochemical detection of tyrosine hydroxylase (th), the rate-limiting enzyme in the biosynthesis of dopamine, in the hippocampus and the caudolateral nidopallium (ncl). |
2016-02-23 |
2023-08-13 |
chicken |
| Edinson Lucumi Moreno, Siham Hachi, Kathrin Hemmer, Sebastiaan J Trietsch, Aidos S Baumuratov, Thomas Hankemeier, Paul Vulto, Jens C Schwamborn, Ronan M T Flemin. Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture. Lab on a chip. vol 15. issue 11. 2016-02-05. PMID:25902196. |
differentiation was as efficient as in macroscopic culture, with up to 19% of differentiated neurons immunoreactive for tyrosine hydroxylase, the penultimate enzyme in the synthesis of dopamine. |
2016-02-05 |
2023-08-13 |
human |
| Xin He, Stetson Thacker, Todd Romigh, Qi Yu, Thomas W Frazier, Charis En. Erratum to: Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits. Molecular autism. vol 7. 2016-02-05. PMID:26843920. |
erratum to: cytoplasm-predominant pten associates with increased region-specific brain tyrosine hydroxylase and dopamine d2 receptors in mouse model with autistic traits. |
2016-02-05 |
2023-08-13 |
mouse |