| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ila Mishra, Devraj Singh, Vinod Kuma. Daily expression of genes coding for neurotransmitters in central and peripheral tissues of redheaded bunting: Implication for circadian regulation of physiology in songbirds. Chronobiology international. vol 33. issue 3. 2016-12-15. PMID:26930260. |
the present study investigated this, by monitoring daily oscillation of genes coding for peptides (neuropeptide y, npy; vasoactive intestinal peptide, vip; somatostatis, sst) and intermediary enzymes of amine and amino acid neurotransmitters (dopamine [tyrosine hydroxylase, th]; glutamate [glutaminase, gls; glutamate oxaloacetate transaminase 2, got2]; gamma amino butyric actid, gaba [glutamic acid decarboxylase 65, gad65]) biosynthetic pathway, along with c-fos as an activation marker, in different tissues of migratory redheaded buntings, emberiza bruniceps. |
2016-12-15 |
2023-08-13 |
Not clear |
| Kazuyoshi Sakai, Ryuji Nomura, Yoshimi Hasegawa, Masanori Sinzato, Kazuhiro Nishii, Yoshimitsu Katoh, Kouji Yamad. Phenotypic changes of AADC-only-immunoreactive cells in the alimentary canal of the laboratory shrew, Suncus murinus, induced by systemic administration of monoamine precursors. Okajimas folia anatomica Japonica. vol 92. issue 2. 2016-12-14. PMID:26639565. |
in order to elucidate the function of anti-aromatic acid decarboxylase (aadc)-only-positive cells in the alimentary canal, 5-hydroxy-l-tryptophan (5-htp) or l-3,4-dihydroxyphenylalanine (l-dopa) was intraperitoneally injected into the laboratory shrew, suncus murinus, and immunohistochemical studies were conducted on continuous sections of the alimentary canal using specific antisera against tyrosine hydroxylase (th), aadc, dopamine (da), and serotonin (5-ht). |
2016-12-14 |
2023-08-13 |
Not clear |
| Pedro Barroso-Chinea, Ignacio Cruz-Muros, Domingo Afonso-Oramas, Javier Castro-Hernández, Josmar Salas-Hernández, Abdelwahed Chtarto, Diego Luis-Ravelo, Marie Humbert-Claude, Liliane Tenenbaum, Tomás González-Hernánde. Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system. Neurobiology of disease. vol 88. 2016-12-13. PMID:26777664. |
long-term controlled gdnf over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system. |
2016-12-13 |
2023-08-13 |
human |
| Guoliang Zhang, Shuangcheng Li, Yunxiao Kang, Jing Che, Rui Cui, Shuang Song, Huixian Cui, Geming Sh. Enhancement of dopaminergic activity and region-specific activation of Nrf2-ARE pathway by intranasal supplements of testosterone propionate in aged male rats. Hormones and behavior. vol 80. 2016-12-13. PMID:26893122. |
the exploratory and motor behavioral deficits, as well as the reduced expression of dopamine, tyrosine hydroxylase, and dopamine transporter, which indicated the declined activity of mesodopaminergic system, were ameliorated in rats administered with 12-week intp. |
2016-12-13 |
2023-08-13 |
rat |
| Pedro Espinosa, Roxana A Silva, Nicole K Sanguinetti, Francisca C Venegas, Raul Riquelme, Luis F González, Gonzalo Cruz, Georgina M Renard, Pablo R Moya, Ramón Sotomayor-Zárat. Programming of Dopaminergic Neurons by Neonatal Sex Hormone Exposure: Effects on Dopamine Content and Tyrosine Hydroxylase Expression in Adult Male Rats. Neural plasticity. vol 2016. 2016-12-13. PMID:26904299. |
programming of dopaminergic neurons by neonatal sex hormone exposure: effects on dopamine content and tyrosine hydroxylase expression in adult male rats. |
2016-12-13 |
2023-08-13 |
rat |
| Motokazu Uchigashima, Toshihisa Ohtsuka, Kazuto Kobayashi, Masahiko Watanab. Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 15. 2016-12-13. PMID:27035941. |
the presynaptic structure expressed tyrosine hydroxylase, vesicular monoamine transporter-2, and plasmalemmal dopamine transporter, which are essential for dopamine synthesis, vesicular filling, and recycling, but was below the detection threshold for molecules involving gaba synthesis and vesicular filling or for gaba itself. |
2016-12-13 |
2023-08-13 |
Not clear |
| Arathy S Kumar, Sankar Jagadeeshan, Anirudh Subramanian, Saravana Babu Chidambaram, Rohan Prasad Surabhi, Mahak Singhal, Hemadev Bhoopalan, Sathiya Sekar, Ravi Shankar Pitani, Prathiba Duvuru, Ganesh Venkatraman, Suresh K Rayal. Molecular Mechanism of Regulation of MTA1 Expression by Granulocyte Colony-stimulating Factor. The Journal of biological chemistry. vol 291. issue 23. 2016-12-13. PMID:27044752. |
metastasis-associated protein 1 (mta1) is an upstream modulator of tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine synthesis, and hence mta1 plays a significant role in pd pathogenesis. |
2016-12-13 |
2023-08-13 |
mouse |
| Jing Xiong, Xiaowei Zhang, Jinsha Huang, Chunnuan Chen, Zhenzhen Chen, Ling Liu, Guoxin Zhang, Jiaolong Yang, Zhentao Zhang, Zhaohui Zhang, Zhicheng Lin, Nian Xiong, Tao Wan. Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration. Molecular neurobiology. vol 53. issue 2. 2016-11-14. PMID:25575680. |
decreased tyrosine hydroxylase (th) and vesicular monoamine transporter 2 (vmat2) immunoreactivity, while increased dopamine transporter (dat) immunoreactivity were observed in rats of either i.p or st group 60 days after the last exposure to fenpropathrin. |
2016-11-14 |
2023-08-13 |
rat |
| Elena H Chartoff, Shayla R Ebner, Angela Sparrow, David Potter, Phillip M Baker, Michael E Ragozzino, Mitchell F Roitma. Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 4. 2016-11-08. PMID:26239494. |
quantitative real-time pcr was used to show that kor and prodynorphin mrna levels were decreased in the nac, whereas tyrosine hydroxylase and dopamine transporter mrna levels and tissue dopamine content were increased in the ventral tegmental area 24 h post-salva. |
2016-11-08 |
2023-08-13 |
rat |
| Izel Tekin, Nurgul Carkaci-Salli, Mechelle M Lewis, Richard B Mailman, Xuemei Huang, Kent E Vran. The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease. Parkinsonism & related disorders. vol 23. 2016-11-01. PMID:26732803. |
many of the symptoms and signs of parkinson's disease (pd) arise from the death of midbrain dopamine neurons that utilize tyrosine hydroxylase (th) as the rate-limiting enzyme in catecholamine biosynthesis. |
2016-11-01 |
2023-08-13 |
Not clear |
| Anna-Maija Penttinen, Ilida Suleymanova, Katrina Albert, Jenni Anttila, Merja H Voutilainen, Mikko Airavaar. Characterization of a new low-dose 6-hydroxydopamine model of Parkinson's disease in rat. Journal of neuroscience research. vol 94. issue 4. 2016-10-25. PMID:26762168. |
this study compares seven experimental settings in a single study on d-amphetamine-induced rotations, tyrosine hydroxylase (th)-positive neurites in the striatum, dopamine transporter (dat)-positive neurites in the striatum, and th-positive cells in the substantia nigra pars compacta (snpc) in rats. |
2016-10-25 |
2023-08-13 |
rat |
| Shelley R Winn, Tanja Scherer, Beat Thöny, Cary O Hardin. High dose sapropterin dihydrochloride therapy improves monoamine neurotransmitter turnover in murine phenylketonuria (PKU). Molecular genetics and metabolism. vol 117. issue 1. 2016-10-24. PMID:26653793. |
increased brain phenylalanine concentration likely competitively inhibits the activities of tyrosine hydroxylase (th) and tryptophan hydroxylase (tph), the rate limiting steps in dopamine and serotonin synthesis respectively. |
2016-10-24 |
2023-08-13 |
mouse |
| Stefan Hallgren, Henrik Viber. Postnatal exposure to PFOS, but not PBDE 99, disturb dopaminergic gene transcription in the mouse CNS. Environmental toxicology and pharmacology. vol 41. 2016-10-18. PMID:26686188. |
here, 10 days old mice were exposed to single oral doses of either pfos, pbde99 or vehicle control and were examined for changes in dopaminergic gene transcription in cns tissue collected at 24h or 2 months post exposure.qpcr analyses of brain tissue from mice euthanized 24h post exposure revealed that pfos affected transcription of dopamine receptor-d5 (drd5) in cerebral cortex and tyrosine hydroxylase (th) in the hippocampus. |
2016-10-18 |
2023-08-13 |
mouse |
| Subhashree Sridharan, Kumaravel Mohankumar, Syam Praveen Kumar Jeepipalli, Divya Sankaramourthy, Larance Ronsard, Kavimani Subramanian, Manivasagam Thamilarasan, Kumar Raja, Varshney Khub Chandra, Sudha Rani Sadra. Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice. Neurotoxicology. vol 51. 2016-10-12. PMID:26522450. |
the levels of striatal dopamine, mid brain tyrosine hydroxylase positive (th(+)) cell count, th protein expression, reactive oxygen species (ros), lipid peroxidation (lpo), antioxidants and inflammatory cytokines were analysed. |
2016-10-12 |
2023-08-13 |
mouse |
| Ying Huang, Qiong Zhang, Ning-Ning Song, Lei Zhang, Yu-Ling Sun, Ling Hu, Jia-Ying Chen, Weidong Zhu, Jue Li, Yu-Qiang Din. Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin. Molecular brain. vol 9. 2016-10-10. PMID:26772978. |
tyrosine hydroxylase (th) is the key enzyme for the synthesis of catecholamines, including dopamine and noradrenaline, and it is normally not expressed in cerebellar neurons. |
2016-10-10 |
2023-08-13 |
Not clear |
| Tsui-Ling Ko, Yu-Yi Fu, Yang-Hsin Shih, Yi-Hui Lin, Miau-Hwa Ko, Tz-Win Fu, Tzu-Yung Lin, Hsiao-Sheng Hsiao, Pei-Ming Chu, Yu-Show F. A high-efficiency induction of dopaminergic cells from human umbilical mesenchymal stem cells for the treatment of hemiparkinsonian rats. Cell transplantation. vol 24. issue 11. 2016-10-06. PMID:25289862. |
the success rate was about 71%, as determined by immunostaining for tyrosine hydroxylase and around 94 nm dopamine synthesis (intracellular and released into the culture medium), as measured by hplc. |
2016-10-06 |
2023-08-13 |
human |
| Kelly R Genskow, Joshua M Bradner, Muhammad M Hossain, Jason R Richardson, W Michael Caudl. Selective damage to dopaminergic transporters following exposure to the brominated flame retardant, HBCDD. Neurotoxicology and teratology. vol 52. issue Pt B. 2016-10-06. PMID:26073293. |
however, no changes were seen in the expression of tyrosine hydroxylase in the dopamine terminal, or striatal levels of dopamine. |
2016-10-06 |
2023-08-13 |
human |
| Jia Song, Gaoyang Xing, Jiaming Cao, Lirong Teng, Chenliang Li, Qingfan Meng, Jiahui Lu, Yulin Zhou, Yang Liu, Di Wang, Lesheng Ten. Investigation of the antidepressant effects of exopolysaccharides obtained from Marasmius androsaceus fermentation in a mouse model. Molecular medicine reports. vol 13. issue 1. 2016-10-05. PMID:26648283. |
additionally, an increase in the expression of tyrosine hydroxylase and a reduction in the level of dopamine transporter in the hypothalamus were noted following 7 days of meps administration. |
2016-10-05 |
2023-08-13 |
mouse |
| Miriam Kannebley Frank, Marco Tulio de Mello, Kil Sun Lee, Paulo Daubian-Nosé, Sergio Tufik, Andrea Maculano Esteve. Sleep-related movement disorder symptoms in SHR are attenuated by physical exercise and an angiotensin-converting enzyme inhibitor. Physiology & behavior. vol 154. 2016-09-30. PMID:26650246. |
dopaminergic receptors, dopamine transporter and tyrosine hydroxylase levels at the striatum were evaluated by western blotting. |
2016-09-30 |
2023-08-13 |
rat |
| S K Franke, R E van Kesteren, J A M Wubben, S Hofman, I Paliukhovich, R C van der Schors, P van Nierop, A B Smit, I H C H M Philippen. Progression and recovery of Parkinsonism in a chronic progressive MPTP-induction model in the marmoset without persistent molecular and cellular damage. Neuroscience. vol 312. 2016-09-29. PMID:26431624. |
postmortem analyses, after the recovery period, revealed no alteration of the number and sizes of tyrosine hydroxylase (th)-positive dopamine (da) neurons in the substantia nigra. |
2016-09-29 |
2023-08-13 |
monkey |