| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosemary S E Brown, Ilona C Kokay, Hollian R Phillipps, Siew Hoong Yip, Papillon Gustafson, Amanda Wyatt, Caroline M Larsen, Penelope Knowles, Sharon R Ladyman, Paul LeTissier, David R Gratta. Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 35. 2017-08-17. PMID:27581458. |
the absence of coexpression of tyrosine hydroxylase, a marker for dopamine production, in gabaergic nerve terminals in the median eminence suggested that rather than a functional redundancy within the tida population, the dopamine/gaba neurons in the arcuate nucleus represent a subpopulation with a functional role distinct from the regulation of prolactin secretion. |
2017-08-17 |
2023-08-13 |
mouse |
| Yoshitaka Hamanaka, Run Minoura, Hiroshi Nishino, Toru Miura, Makoto Mizunam. Dopamine- and Tyrosine Hydroxylase-Immunoreactive Neurons in the Brain of the American Cockroach, Periplaneta americana. PloS one. vol 11. issue 8. 2017-08-16. PMID:27494326. |
in the present study, we investigated the distribution of dopaminergic neurons in the brain of the american cockroach, periplaneta americana, using two antisera: 1) an antiserum against dopamine, and 2) an antiserum against tyrosine hydroxylase (th, an enzyme required for dopamine synthesis), and identified about 250 putatively dopaminergic neurons. |
2017-08-16 |
2023-08-13 |
Not clear |
| Qingkun Liu, Ariela Hazan, Eddie Grinman, Jesus A Angul. Pharmacological activation of the neurotensin receptor 1 abrogates the methamphetamine-induced striatal apoptosis in the mouse brain. Brain research. vol 1659. 2017-08-07. PMID:28130052. |
there was no effect of ntr1 agonist on meth-induced dopamine terminal degeneration, as evidenced by tyrosine hydroxylase levels determined by western blot. |
2017-08-07 |
2023-08-13 |
mouse |
| Cristian Arredondo, Marcela González, María Estela Andrés, Katia Gyslin. Opposite effects of acute and chronic amphetamine on Nurr1 and NF-κB p65 in the rat ventral tegmental area. Brain research. vol 1652. 2017-07-28. PMID:27687740. |
nurr1 is a transcription factor crucial for dopamine neurons survival and dopamine production, activating the transcription of key genes like tyrosine hydroxylase (th). |
2017-07-28 |
2023-08-13 |
rat |
| Na Hyea Kang, Candace H Carriere, Sarra G Bahna, Lennard P Nile. Altered melatonin MT Brain research. vol 1652. 2017-07-28. PMID:27693415. |
melatonin induces the expression of tyrosine hydroxylase, the rate-limiting enzyme for dopamine synthesis, in the ventral midbrain, where g protein-coupled melatonin receptors are present. |
2017-07-28 |
2023-08-13 |
rat |
| Na Hyea Kang, Candace H Carriere, Sarra G Bahna, Lennard P Nile. Altered melatonin MT Brain research. vol 1652. 2017-07-28. PMID:27693415. |
a loss of tyrosine hydroxylase immunoreactivity and/or immunofluorescence in the striatum and substantia nigra was seen in animals lesioned in either the striatum or medial forebrain bundle, indicating degeneration of dopamine neurons. |
2017-07-28 |
2023-08-13 |
rat |
| N S Bondarenko, A R Murtazina, Yu O Nikishina, A Ya Sapronova, M V Ugrumo. Molecular mechanisms of synthesis of noradrenaline as an inducer of development in the adrenal glands of rats in ontogenesis. Doklady. Biochemistry and biophysics. vol 472. issue 1. 2017-07-27. PMID:28421436. |
the level of gene expression and the protein content of tyrosine hydroxylase and dopamine β-hydroxylase were determined. |
2017-07-27 |
2023-08-13 |
rat |
| Brajesh Kumar Singh, Vinod Kumar, Amit Kumar Chauhan, Ashish Dwivedi, Shweta Singh, Ashutosh Kumar, Deepali Singh, Devendra Kumar Patel, Ratan Singh Ray, Swatantra Kumar Jain, Chetna Sing. Neuronal Nitric Oxide Synthase Negatively Regulates Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration. Molecular neurobiology. vol 54. issue 4. 2017-07-11. PMID:26995406. |
snp/snap discernibly alleviated zn-induced neurobehavioral impairments, dopaminergic neurodegeneration, tyrosine hydroxylase (th) expression, and striatal dopamine depletion. |
2017-07-11 |
2023-08-13 |
human |
| Martin Klietz, Ursula Keber, Thomas Carlsson, Wei-Hua Chiu, Günter U Höglinger, Eberhard Weihe, Martin K-H Schäfer, Candan Depboyl. l-DOPA-induced dyskinesia is associated with a deficient numerical downregulation of striatal tyrosine hydroxylase mRNA-expressing neurons. Neuroscience. vol 331. 2017-07-11. PMID:27320210. |
recent evidence suggests an involvement of striatal tyrosine hydroxylase (th) protein-expressing neurons, as they are capable of endogenously producing l-dopa and possibly dopamine. |
2017-07-11 |
2023-08-13 |
mouse |
| Daniela Elgueta, María S Aymerich, Francisco Contreras, Andro Montoya, Marta Celorrio, Estefanía Rojo-Bustamante, Eduardo Riquelme, Hugo González, Mónica Vásquez, Rafael Franco, Rodrigo Pachec. Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease. Neuropharmacology. vol 113. issue Pt A. 2017-06-30. PMID:27693549. |
treatment of mptpp-intoxicated mice with pg01037 (30 mg/kg, administrated twice a week for five weeks) attenuated the loss of dopaminergic neurons in the substantia nigra pars compacta, as evaluated by stereological analysis, and the loss of striatal dopaminergic terminals, as determined by densitometric analyses of tyrosine hydroxylase and dopamine transporter immunoreactivities. |
2017-06-30 |
2023-08-13 |
mouse |
| Roberto De Luca, Tatsiana Suvorava, Danqing Yang, Wilhelm Baumgärtel, Georg Kojda, Helmut L Haas, Olga A Sergeev. Identification of histaminergic neurons through histamine 3 receptor-mediated autoinhibition. Neuropharmacology. vol 106. 2017-06-27. PMID:26297536. |
using a reporter mouse model with expression of the tomato fluorescent protein under the dopamine transporter promoter (tmt-dat) we discovered a new group of neurons in the histaminergic tuberomamillary nucleus (tmn), which, in contrast to tuberoinfundibular dopaminergic neurons of the dorsomedial arcuate nucleus, do not express tyrosine hydroxylase but can synthesize and store dopamine. |
2017-06-27 |
2023-08-13 |
mouse |
| Pier Francesca Porceddu, Ismail Ogunbayode Ishola, Liliana Contu, Micaela Morell. Metformin Prevented Dopaminergic Neurotoxicity Induced by 3,4-Methylenedioxymethamphetamine Administration. Neurotoxicity research. vol 30. issue 1. 2017-06-26. PMID:27251371. |
the neuroprotective effect of metformin on mdma-induced dopaminergic damage was evaluated by dopamine transporter (dat) and tyrosine hydroxylase (th) immunohistochemistry in snc and cpu. |
2017-06-26 |
2023-08-13 |
mouse |
| Matan Soll, Orit Bar Am, Atif Mahammed, Irena Saltsman, Silvia Mandel, Moussa B H Youdim, Zeev Gros. Neurorescue by a ROS Decomposition Catalyst. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27442690. |
important findings that accompanied the ability to rescue dopaminergic neurons were increased expression of phenotypic dopaminergic proteins, such as tyrosine hydroxylase (th) and dopamine transporter (dat), which were significantly depleted upon 6-ohda-mediated damage. |
2017-06-21 |
2023-08-13 |
Not clear |
| Asmaa M Teema, Sawsan A Zaitone, Yasser M Moustaf. Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis. Neuropharmacology. vol 107. 2017-06-19. PMID:27016022. |
rotenone-treated rats showed motor dysfunction, lower striatal dopamine, lower staining for nigral tyrosine hydroxylase but higher level of striatal cyclooxygenase-2 (cox-2) and vascular endothelial growth factor (vegf) compared to vehicle-treated rats (p < 0.05). |
2017-06-19 |
2023-08-13 |
rat |
| Xiao-Feng Zhang, Mark Thompson, Yi-Hua X. Multifactorial theory applied to the neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 5. 2017-06-12. PMID:26829122. |
oxidative stress and the metabolic processes of pq-inducing excitotoxicity, α-synuclein aggregate formation, autophagy, alteration of dopamine catabolism, and inactivation of tyrosine hydroxylase are positioned as causes for the loss of dopaminergic cells. |
2017-06-12 |
2023-08-13 |
human |
| Richard Jay Smeyne, Charles B Breckenridge, Melissa Beck, Yun Jiao, Mark T Butt, Jeffrey C Wolf, Dan Zadory, Daniel J Minnema, Nicholas C Sturgess, Kim Z Travis, Andrew R Cook, Lewis L Smith, Philip A Botha. Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice. PloS one. vol 11. issue 10. 2017-06-12. PMID:27788145. |
dopamine neurons in the substantia nigra pars compacta (snpc) were identified by antibodies to tyrosine hydroxylase (th+) and microglia were identified using iba-1 immunoreactivity. |
2017-06-12 |
2023-08-13 |
mouse |
| Sheraz Khoja, Vivek Shah, Damaris Garcia, Liana Asatryan, Michael W Jakowec, Daryl L Davie. Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors. Journal of neurochemistry. vol 139. issue 1. 2017-06-09. PMID:27402173. |
p2x4r ko mice exhibited altered density of pre-synaptic markers including tyrosine hydroxylase, dopamine transporter; post-synaptic markers including dopamine receptors and phosphorylation of downstream targets including dopamine and cyclic-amp regulated phosphoprotein of 32 kda and cyclic-amp-response element binding protein in different parts of the striatum. |
2017-06-09 |
2023-08-13 |
mouse |
| Bettina Wurzinger, Peter Köni. [Iron deficiency, Fatigue and Restless-Legs-Syndrome]. Wiener medizinische Wochenschrift (1946). vol 166. issue 13-14. 2017-05-30. PMID:27577248. |
in particular when it comes to fatigue and rls, it's assumed that reduced activity of tyrosine hydroxylase - a central iron-dependent element of dopamine synthesis - can lead to deficiencies.as part of the therapy, oral iron supplementation is considered to be treatment of choice since it's most cost-effective and well tolerated. |
2017-05-30 |
2023-08-13 |
human |
| Yu-Chia Chen, Svetlana Semenova, Stanislav Rozov, Maria Sundvik, Joshua L Bonkowsky, Pertti Panul. A Novel Developmental Role for Dopaminergic Signaling to Specify Hypothalamic Neurotransmitter Identity. The Journal of biological chemistry. vol 291. issue 42. 2017-05-22. PMID:27539857. |
to characterize the role of dopamine in the development of histamine neurons, we inhibited the translation of the two non-allelic forms of tyrosine hydroxylase (th1 and th2) in zebrafish larvae. |
2017-05-22 |
2023-08-13 |
zebrafish |
| Kai-Cheng Hsu, Feng-Sheng Wan. Fuzzy Decision Making Approach to Identify Optimum Enzyme Targets and Drug Dosage for Remedying Presynaptic Dopamine Deficiency. PloS one. vol 11. issue 10. 2017-05-22. PMID:27736960. |
a fuzzy optimization method was applied to formulate a multiobjective drug design problem for detecting enzyme targets in the presynaptic dopamine metabolic network to remedy two types of enzymopathies caused by deficiencies of vesicular monoamine transporter 2 (vmat2) and tyrosine hydroxylase (th). |
2017-05-22 |
2023-08-13 |
human |