| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Chiavaroli, L Recinella, C Ferrante, S Martinotti, M Vacca, L Brunetti, G Orlando, S Leon. Effects of central fibroblast growth factor 21 and irisin in anxiety-like behavior. Journal of biological regulators and homeostatic agents. vol 31. issue 3. 2017-12-14. PMID:28890831. |
prefrontal cortex levels of norepinephrine (ne), dopamine (da) and serotonin (5-hydroxytryptamine, 5-ht) and the gene expression of catechol-o-methyltransferase (comt), dopamine transport (dat) and tyrosine hydroxylase (th), were measured by high performance liquid chromatography (hplc) analysis and real-time reverse transcription polymerase chain reaction (rt-pcr). |
2017-12-14 |
2023-08-13 |
rat |
| Takayo Sasagawa, Noriko Horii-Hayashi, Akinori Okuda, Takashi Hashimoto, Cho Azuma, Mayumi Nish. Long-term effects of maternal separation coupled with social isolation on reward seeking and changes in dopamine D1 receptor expression in the nucleus accumbens via DNA methylation in mice. Neuroscience letters. vol 641. 2017-12-12. PMID:28111354. |
we then focused on the mesolimbic dopamine pathway associated with reward-seeking behavior and measured both mrna and protein levels of tyrosine hydroxylase (th) in the ventral tegmental area (vta) and dopamine d1 and d2 receptors in the nucleus accumbens (nac). |
2017-12-12 |
2023-08-13 |
mouse |
| Wei Chen, Hai Jun Wang, Ning Ning Shang, Jun Liu, Juan Li, Dong Hui Tang, Qiong L. Moderate intensity treadmill exercise alters food preference via dopaminergic plasticity of ventral tegmental area-nucleus accumbens in obese mice. Neuroscience letters. vol 641. 2017-12-12. PMID:28130186. |
levels of tyrosine hydroxylase (th) in the ventral tegmental area-nucleus accumbens system were also analysed, as well as levels of dopamine, dopamine transporter, and d2 receptors in the nucleus accumbens. |
2017-12-12 |
2023-08-13 |
mouse |
| Kouki Kato, Seigo Fushuku, Yoshio Yamamot. Age-related changes in immunoreactivity for dopamine β-hydroxylase in carotid body glomus cells in spontaneously hypertensive rats. Autonomic neuroscience : basic & clinical. vol 205. 2017-12-12. PMID:28473232. |
the purpose of this study was to investigate immunoreactivity for dopamine β-hydroxylase (dbh) and tyrosine hydroxylase (th) in carotid body (cb) glomus cells in spontaneously hypertensive rats (shr/izm) at 4 (prehypertensive stage), 8 (early stage of developmental hypertension), 12 (later stage of developmental hypertension), and 16weeks of age (established hypertensive stage). |
2017-12-12 |
2023-08-13 |
rat |
| Egle Janenaite, Valentina Vengeliene, Anton Bespalov, Berthold Beh. Potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity. Behavioural brain research. vol 334. 2017-12-11. PMID:28750831. |
potential role of tyrosine hydroxylase in the loss of psychostimulant effect of amphetamine under conditions of impaired dopamine transporter activity. |
2017-12-11 |
2023-08-13 |
human |
| David R Bonsall, Michelle Kokkinou, Mattia Veronese, Christopher Coello, Lisa A Wells, Oliver D Howe. Single cocaine exposure does not alter striatal pre-synaptic dopamine function in mice: an [ Journal of neurochemistry. vol 143. issue 5. 2017-12-07. PMID:28921596. |
furthermore, expression levels of two key enzymes related to dopamine synthesis, tyrosine hydroxylase and aromatic l-amino acid decarboxylase, within the striatum of scanned mice were not significantly affected by acute cocaine pre-treatment (p > 0.05). |
2017-12-07 |
2023-08-13 |
mouse |
| Steven Tran, Amanda Facciol, Magda Nowicki, Diptendu Chatterjee, Robert Gerla. Acute alcohol exposure increases tyrosine hydroxylase protein expression and dopamine synthesis in zebrafish. Behavioural brain research. vol 317. 2017-11-29. PMID:27666381. |
acute alcohol exposure increases tyrosine hydroxylase protein expression and dopamine synthesis in zebrafish. |
2017-11-29 |
2023-08-13 |
zebrafish |
| Steven Tran, Amanda Facciol, Magda Nowicki, Diptendu Chatterjee, Robert Gerla. Acute alcohol exposure increases tyrosine hydroxylase protein expression and dopamine synthesis in zebrafish. Behavioural brain research. vol 317. 2017-11-29. PMID:27666381. |
in the current study, we characterize the effects of alcohol on the zebrafish dopaminergic system by focusing on tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2017-11-29 |
2023-08-13 |
zebrafish |
| Steven Tran, Amanda Facciol, Magda Nowicki, Diptendu Chatterjee, Robert Gerla. Acute alcohol exposure increases tyrosine hydroxylase protein expression and dopamine synthesis in zebrafish. Behavioural brain research. vol 317. 2017-11-29. PMID:27666381. |
enzymatic activity assays confirmed that alcohol also increases tyrosine hydroxylase enzymatic activity, whereas hplc analysis demonstrated increased levels of whole-brain dopamine and its metabolite dopac. |
2017-11-29 |
2023-08-13 |
zebrafish |
| Steven Tran, Amanda Facciol, Magda Nowicki, Diptendu Chatterjee, Robert Gerla. Acute alcohol exposure increases tyrosine hydroxylase protein expression and dopamine synthesis in zebrafish. Behavioural brain research. vol 317. 2017-11-29. PMID:27666381. |
these findings suggest that acute alcohol exposure elevates dopamine synthesis via increased tyrosine hydroxylase protein expression. |
2017-11-29 |
2023-08-13 |
zebrafish |
| Amita R Somalwar, Gajanan P Shelkar, Nishikant K Subhedar, Dadasaheb M Kokar. The role of neuropeptide CART in the lateral hypothalamic-ventral tegmental area (LH-VTA) circuit in motivation. Behavioural brain research. vol 317. 2017-11-29. PMID:27686026. |
while the icss experience seems to activate cart cells in the lh, the pvta showed significant increment in the cart fiber terminals on the dopamine cells, increase in tyrosine hydroxylase (th)-immunoreactivity, and cart and synaptophysin colabeled elements. |
2017-11-29 |
2023-08-13 |
rat |
| Young C Chung, Won-Ho Shin, Jeong Y Baek, Eun J Cho, Hyung H Baik, Sang R Kim, So-Yoon Won, Byung K Ji. CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease. Experimental & molecular medicine. vol 48. issue 1. 2017-11-20. PMID:27534533. |
the mechanisms underlying cb2 receptor-mediated neuroprotection of dopamine neurons in the substantia nigra (sn) were evaluated in the mptp mouse model of parkinson's disease (pd) by immunohistochemical staining (tyrosine hydroxylase, macrophage ag complex-1, glial fibrillary acidic protein, myeloperoxidase (mpo), and cd3 and cd68), real-time pcr and a fluorescein isothiocyanate-labeled albumin assay. |
2017-11-20 |
2023-08-13 |
mouse |
| T D Purves-Tyson, S J Owens, D A Rothmond, G M Halliday, K L Double, J Stevens, T McCrossin, C Shannon Weicker. Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28094812. |
in vivo imaging studies indicate an increased presynaptic dopamine synthesis capacity in striatal terminals and cell bodies in the midbrain in schizophrenia; however, measures of the dopamine-synthesising enzyme, tyrosine hydroxylase (th), have not identified consistent changes. |
2017-11-16 |
2023-08-13 |
human |
| T Dahoun, S V Trossbach, N J Brandon, C Korth, O D Howe. The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28140405. |
here we summarise the impact of disc1 disruption on the dopamine system in animal models, considering its effects on presynaptic dopaminergic function (tyrosine hydroxylase levels, dopamine transporter levels, dopamine levels at baseline and after amphetamine administration) and postsynaptic dopaminergic function (dopamine d1 and d2 receptor levels, dopamine receptor-binding potential and locomotor activity after amphetamine administration). |
2017-11-16 |
2023-08-13 |
Not clear |
| T Dahoun, S V Trossbach, N J Brandon, C Korth, O D Howe. The impact of Disrupted-in-Schizophrenia 1 (DISC1) on the dopaminergic system: a systematic review. Translational psychiatry. vol 7. issue 1. 2017-11-16. PMID:28140405. |
there is also limited evidence for decreased tyrosine hydroxylase levels in the frontal cortex and increased dopamine transporter levels in the striatum but not nucleus accumbens, but these conclusions warrant further replication. |
2017-11-16 |
2023-08-13 |
Not clear |
| Anne-Sophie Rolland, Tatyana Kareva, Nikolai Kholodilov, Robert E Burk. A quantitative evaluation of a 2.5-kb rat tyrosine hydroxylase promoter to target expression in ventral mesencephalic dopamine neurons in vivo. Neuroscience. vol 346. 2017-11-09. PMID:28108256. |
a quantitative evaluation of a 2.5-kb rat tyrosine hydroxylase promoter to target expression in ventral mesencephalic dopamine neurons in vivo. |
2017-11-09 |
2023-08-13 |
human |
| Melike Sever, Mesut Turkyilmaz, Cansu Sevinc, Aysen Cakir, Busra Ocalan, Mehmet Cansev, Mustafa O Guler, Ayse B Tekina. Regenerative effects of peptide nanofibers in an experimental model of Parkinson's disease. Acta biomaterialia. vol 46. 2017-11-06. PMID:27619838. |
the behavioral improvement with pa nanofiber administration was associated with enhanced striatal dopamine and tyrosine hydroxylase content as well as reduced cleaved-caspase-3 levels. |
2017-11-06 |
2023-08-13 |
rat |
| Yeomoon Sim, Gunhyuk Park, Hyeyoon Eo, Eugene Huh, Pil Sung Gu, Seon-Pyo Hong, Youngmi Kim Pak, Myung Sook O. Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein. Neuroscience. vol 340. 2017-11-06. PMID:27771535. |
further, nurr1 engages in synthesizing and storing dopamine through regulating levels of tyrosine hydroxylase (th), dopamine transporter (dat) and vesicular monoamine transporter 2 (vmat2). |
2017-11-06 |
2023-08-13 |
mouse |
| T T Zhao, K S Shin, K S Kim, H J Park, H J Kim, K E Lee, M K Le. Effects of (-)-sesamin on motor and memory deficits in an MPTP-lesioned mouse model of Parkinson's disease treated with l-DOPA. Neuroscience. vol 339. 2017-11-06. PMID:27789382. |
both (-)-sesamin doses reduced decreases in the retention latency time in the passive avoidance test, latency to fall of rotarod test and distance traveled in the open field test, and attenuated decreases in tyrosine hydroxylase (th)-immunopositive cells, dopamine, and its metabolites in the substantia nigra-striatum. |
2017-11-06 |
2023-08-13 |
mouse |
| Francesca Zoratto, Emilia Romano, Esterina Pascale, Mariangela Pucci, Anastasia Falconi, Bernardo Dell'Osso, Mauro Maccarrone, Giovanni Laviola, Claudio D'Addario, Walter Adrian. Down-regulation of serotonin and dopamine transporter genes in individual rats expressing a gambling-prone profile: A possible role for epigenetic mechanisms. Neuroscience. vol 340. 2017-11-06. PMID:27789384. |
a selective down-regulation of i) serotonin transporter in prefrontal cortex, ii) tyrosine hydroxylase in ventral striatum, iii) dopamine transporter in lymphocytes was evidenced in "gambler" vs "non-gambler" rats. |
2017-11-06 |
2023-08-13 |
rat |