| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hidekazu Sotoyama, Yuriko Iwakura, Kanako Oda, Toshikuni Sasaoka, Nobuyuki Takei, Akiyoshi Kakita, Hideki Enomoto, Hiroyuki Naw. Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor. Neuroscience letters. vol 654. 2018-04-17. PMID:28645787. |
however, there were reductions in the levels of tyrosine hydroxylase (th), dopamine, and its metabolite homovanillic acid in the striatum of transgenic mice. |
2018-04-17 |
2023-08-13 |
mouse |
| Rajib Paul, Amarendranath Choudhury, Dulal Chandra Boruah, Rajlakshmi Devi, Pallab Bhattacharya, Manabendra Dutta Choudhury, Anupom Bora. Hypercholesterolemia causes psychomotor abnormalities in mice and alterations in cortico-striatal biogenic amine neurotransmitters: Relevance to Parkinson's disease. Neurochemistry international. vol 108. 2018-04-13. PMID:28167224. |
the significant decrease in tyrosine hydroxylase immunoreactivity in striatum supports the observed depleted level dopamine in striatum, which is relevant to the pathophysiology of pd. |
2018-04-13 |
2023-08-13 |
mouse |
| Jung-Hoon Koo, Yong-Chul Jang, Dong-Ju Hwang, Hyun-Seob Um, Nam-Hee Lee, Jae-Hoon Jung, Joon-Yong Ch. Treadmill exercise produces neuroprotective effects in a murine model of Parkinson's disease by regulating the TLR2/MyD88/NF-κB signaling pathway. Neuroscience. vol 356. 2018-04-12. PMID:28527958. |
additionally, it promoted the expression of tyrosine hydroxylase and the dopamine transporter, as well as plasma dopamine levels, in mptp mice; these effects were associated with decreased caspase-3 expression and cleavage, as well as increased bcl-2 expression in the snpc. |
2018-04-12 |
2023-08-13 |
mouse |
| Andrea Herrera-Soto, Gabriela Díaz-Veliz, Sergio Mora, Patricia Muñoz, Pablo Henny, Harry W M Steinbusch, Juan Segura-Aguila. On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo. Neurotoxicity research. vol 32. issue 1. 2018-03-27. PMID:28285345. |
because of a recent report that substantia nigra pars compacta (snpc) tyrosine hydroxylase (t-oh) levels were unaltered by aminochrome when there was cell shrinkage of dopaminergic neurons along with a reduction in striatal dopamine release, the following study was conducted to more accurately determine the role of dt-diaphorase in aminochrome neurotoxicity. |
2018-03-27 |
2023-08-13 |
rat |
| YongXin Hao, Aref Shabanpoor, Gerlinde A Met. Stress and corticosterone alter synaptic plasticity in a rat model of Parkinson's disease. Neuroscience letters. vol 651. 2018-03-26. PMID:28473257. |
midbrain mrna expression assessments included markers of dopamine function and neuroplasticity, such as tyrosine hydroxylase (th), synaptophysin (syn), calcyon, and glucocorticoid receptor (gr). |
2018-03-26 |
2023-08-13 |
rat |
| Lin Wu, Zhong-Rui Du, Ai-Li Xu, Zhen Yan, Hui-Hui Xiao, Man-Sau Wong, Xin-Sheng Yao, Wen-Fang Che. Neuroprotective effects of total flavonoid fraction of the Epimedium koreanum Nakai extract on dopaminergic neurons: In vivo and in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-26. PMID:28494419. |
tf pretreatment could ameliorate the decrease of striatal dopamine (da) content and the loss of tyrosine hydroxylase (th)-immunoreactive neurons in the substantia nigra pars compacta (snpc) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2018-03-26 |
2023-08-13 |
mouse |
| Nicholas B Miner, James P O'Callaghan, Tamara J Phillips, Aaron Janowsk. The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity. Neurotoxicology and teratology. vol 61. 2018-03-21. PMID:28212938. |
drug effects on thermoregulation were characterized and striatal tissue analyzed after 2 or 7days for dopamine (da) and tyrosine hydroxylase (th) levels, as well as glial fibrillary acidic protein (gfap) expression. |
2018-03-21 |
2023-08-13 |
mouse |
| Gelareh Alam, Melissa Edler, Shelbie Burchfield, Jason R Richardso. Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss. Neurotoxicology. vol 60. 2018-03-21. PMID:28377118. |
here, we determined the effect of a single intraperitoneal injection of one of three doses of mptp (0.1, 2 and 20mg/kg) on dopamine neurons, labeled by tyrosine hydroxylase (th |
2018-03-21 |
2023-08-13 |
mouse |
| Ciara C Tate, Vivian P Chou, Carla Campos, Alimohammed S Moalem, Donato A Di Monte, Michael McGrogan, Casey C Case, Amy B Manning-Bo. Mesenchymal stromal SB623 cell implantation mitigates nigrostriatal dopaminergic damage in a mouse model of Parkinson's disease. Journal of tissue engineering and regenerative medicine. vol 11. issue 6. 2018-03-09. PMID:26440859. |
specifically, mice with the sb623 cell transplants revealed significantly higher levels of striatal dopamine, tyrosine hydroxylase immunoreactivity and stereological nigral cell counts in the ipsilateral hemisphere vs vehicle-treated mice following mptp administration. |
2018-03-09 |
2023-08-13 |
mouse |
| Boxian Huang, Song Ning, Qinjing Zhang, Aiqin Chen, Chunyan Jiang, Yugui Cui, Jian Hu, Hong Li, Guoping Fan, Lianju Qin, Jiayin Li. Bisphenol A Represses Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells through Downregulating the Expression of Insulin-like Growth Factor 1. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27271280. |
furthermore, yield of da neuron-secreted tyrosine hydroxylase (th) and dopamine were also reduced. |
2018-03-09 |
2023-08-13 |
human |
| Ghada A Badawi, Mai A Abd El Fattah, Hala F Zaki, Moushira I El Saye. Sitagliptin and liraglutide reversed nigrostriatal degeneration of rodent brain in rotenone-induced Parkinson's disease. Inflammopharmacology. vol 25. issue 3. 2018-03-08. PMID:28258522. |
furthermore, they reversed rotenone-induced nigral neuronal loss, associated with marked decrease of pro-inflammatory cytokines: interleukin (il)-1β, il-6, transforming growth factor (tgf)-β1, together with a significant increase of striatal dopamine, nigral glial cell line-derived neurotrophic factor (gdnf), and tyrosine hydroxylase positive (th+) cells. |
2018-03-08 |
2023-08-13 |
rat |
| Neha Sharma, Sheetal Sharma, Bimla Nehr. Curcumin protects dopaminergic neurons against inflammation-mediated damage and improves motor dysfunction induced by single intranigral lipopolysaccharide injection. Inflammopharmacology. vol 25. issue 3. 2018-03-08. PMID:28409389. |
the behavioral observations, biochemical markers, quantification of dopamine and its metabolites (dopac and hva) using hplc followed by ihc of tyrosine hydroxylase (th) were evaluated after 21 days of lps injection. |
2018-03-08 |
2023-08-13 |
rat |
| Hale Zerrin Toklu, Yasemin Sakarya, Nihal Tüme. A Proteomic Evaluation of Sympathetic Activity Biomarkers of the Hypothalamus-Pituitary-Adrenal Axis by Western Blotting Technique Following Experimental Traumatic Brain Injury. Methods in molecular biology (Clifton, N.J.). vol 1598. 2018-03-05. PMID:28508370. |
tyrosine hydroxylase, dopamine beta hydroxylase are the key enzymes for the synthesis of norepinephrine; and neuropeptide y (npy) is the peptide that is co-stored and co-released with norepinephrine. |
2018-03-05 |
2023-08-13 |
Not clear |
| Angie M Ameen, Amany Y Elkazaz, Hala M F Mohammad, Bassant M Baraka. Anti-inflammatory and neuroprotective activity of boswellic acids in rotenone parkinsonian rats. Canadian journal of physiology and pharmacology. vol 95. issue 7. 2018-03-01. PMID:28249117. |
bas taken by rats with rotenone-induced parkinsonism showed enhanced general motor performance, reduced inflammatory markers, and increased striatal dopamine level and nigral tyrosine hydroxylase immunostaining. |
2018-03-01 |
2023-08-13 |
rat |
| Elena A Kozina, Aleksandr R Kim, Anna Y Kurina, Michael V Ugrumo. Cooperative synthesis of dopamine by non-dopaminergic neurons as a compensatory mechanism in the striatum of mice with MPTP-induced Parkinsonism. Neurobiology of disease. vol 98. 2018-02-27. PMID:27940203. |
since the late 80s it has been repeatedly shown that besides dopaminergic neurons, the brain contains so-called monoenzymatic neurons possessing one of the enzymes of dopamine (da) synthesis, tyrosine hydroxylase (th) or aromatic l-amino acid decarboxylase (aadc). |
2018-02-27 |
2023-08-13 |
mouse |
| Alexander A Nevue, Richard A Felix, Christine V Portfor. Dopaminergic projections of the subparafascicular thalamic nucleus to the auditory brainstem. Hearing research. vol 341. 2018-02-13. PMID:27620513. |
the superior olivary complex (soc) is also a likely target of dopaminergic projections from the spf because it receives projections from the spf and contains fibers and terminals immunoreactive for tyrosine hydroxylase, the rate limiting enzyme in dopamine synthesis. |
2018-02-13 |
2023-08-13 |
Not clear |
| Werner J Geldenhuys, Stanley A Benkovic, Li Lin, Heather M Yonutas, Samuel D Crish, Patrick G Sullivan, Altaf S Darvesh, Candice M Brown, Jason R Richardso. MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype. ACS chemical neuroscience. vol 8. issue 12. 2018-01-30. PMID:28880525. |
here, we demonstrate that loss of mitoneet (cisd1), an iron-sulfur containing protein that regulates mitochondrial bioenergetics, results in mitochondrial dysfunction and loss of striatal dopamine and tyrosine hydroxylase. |
2018-01-30 |
2023-08-13 |
mouse |
| Maowen Ba, Min Kong, Lina Guan, Maoli Yi, Hongli Zhan. Repetitive transcranial magnetic stimulation (rTMS) improves behavioral and biochemical deficits in levodopa-induced dyskinetic rats model. Oncotarget. vol 7. issue 37. 2018-01-29. PMID:27613848. |
after ending the experiments, we further determined tyrosine hydroxylase (th)-positive dopaminergic neurons number by immunohistochemistry, dopamine levels by hplc, glial cell line-derived neurotrophic factor (gdnf) levels by elisa, nr2b tyrosine phosphorylation and interactions of nr2b with fyn by immunoblotting and immunoprecipitation. |
2018-01-29 |
2023-08-13 |
rat |
| Silvia Fuentes, Javier Carrasco, Abigail Hatto, Juan Navarro, Antonio Armario, Manel Monsonet, Jordi Ortiz, Roser Nada. Sex-dependent impact of early-life stress and adult immobilization in the attribution of incentive salience in rats. PloS one. vol 13. issue 1. 2018-01-29. PMID:29324797. |
els in imo-treated females was able to reduce sign-tracking and decrease tyrosine hydroxylase expression in the ventral tegmental area and dopamine d1 receptor expression in the accumbens shell. |
2018-01-29 |
2023-08-13 |
human |
| D M Buffalari, L Rinama. Cocaine self-administration and extinction alter medullary noradrenergic and limbic forebrain cFos responses to acute, noncontingent cocaine injections in adult rats. Neuroscience. vol 281. 2018-01-26. PMID:25050821. |
tissue sections were processed for immunoperoxidase labeling of nuclear cfos with either immunoperoxidase or immunofluorescent cytoplasmic labeling of dopamine beta hydroxylase or tyrosine hydroxylase. |
2018-01-26 |
2023-08-13 |
rat |