| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jia Li, Yajuan Sun, Jiajun Che. Identification of Critical Genes and miRNAs Associated with the Development of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 65. issue 4. 2018-11-08. PMID:30083784. |
tyrosine hydroxylase (th) and solute carrier family 6 member 3 (slc6a3) were significantly related to the functional terms of catecholamine biosynthetic process and dopamine biosynthetic process. |
2018-11-08 |
2023-08-13 |
rat |
| Peng Feng, Xiangjian Zhang, Dongfang Li, Chenhui Ji, Ziyue Yuan, Ruifang Wang, Guofang Xue, Guanglai Li, Christian Hölsche. Two novel dual GLP-1/GIP receptor agonists are neuroprotective in the MPTP mouse model of Parkinson's disease. Neuropharmacology. vol 133. 2018-11-05. PMID:29462693. |
dopamine synthesis as indicated by levels of tyrosine hydroxylase was much reduced by mptp in the substantia nigra and striatum, and da-ch5 was the best drug to reverse this. |
2018-11-05 |
2023-08-13 |
mouse |
| Katelyn H Struntz, Jessica A Siege. Effects of methamphetamine exposure on anxiety-like behavior in the open field test, corticosterone, and hippocampal tyrosine hydroxylase in adolescent and adult mice. Behavioural brain research. vol 348. 2018-11-05. PMID:29680785. |
tyrosine hydroxylase is the rate limiting enzyme in the synthesis of dopamine and was used as a marker of the hippocampal dopaminergic system. |
2018-11-05 |
2023-08-13 |
mouse |
| Maiko Ohta, Naoyuki Chosa, Seiko Kyakumoto, Seiji Yokota, Naoto Okubo, Akira Nemoto, Masaharu Kamo, Shigeharu Joh, Kenichi Satoh, Akira Ishisak. IL‑1β and TNF‑α suppress TGF‑β‑promoted NGF expression in periodontal ligament‑derived fibroblasts through inactivation of TGF‑β‑induced Smad2/3‑ and p38 MAPK‑mediated signals. International journal of molecular medicine. vol 42. issue 3. 2018-10-29. PMID:29901090. |
ngf secreted by tgf‑β1‑treated scdc2 cells promoted neurite extension and the expression of tyrosine hydroxylase, a rate‑limiting enzyme in dopamine synthesis in rat pheochromocytoma pc12 cells. |
2018-10-29 |
2023-08-13 |
rat |
| Luísa Becker Bertotto, Jaben Richards, Jay Gan, David Christopher Volz, Daniel Schlen. Effects of bifenthrin exposure on the estrogenic and dopaminergic pathways in zebrafish embryos and juveniles. Environmental toxicology and chemistry. vol 37. issue 1. 2018-10-22. PMID:28815728. |
quantitative reverse transcriptase polymerase chain reaction was used to investigate transcripts of tyrosine hydroxylase (th), dopamine receptor 1 (dr1) and 2a (dr2a), dopamine active transporter (dat), estrogen receptor α (erα), erβ1, erβ2, luteinizing hormone β (lhβ), follicle-stimulating hormone β (fshβ), vitellogenin (vtg), cytochrome p450 cyp19a1a, and cyp19a1b. |
2018-10-22 |
2023-08-13 |
zebrafish |
| Sabah H Enayah, Brigitte C Vanle, Laurence J Fuortes, Jonathan A Doorn, Gabriele Ludewi. PCB95 and PCB153 change dopamine levels and turn-over in PC12 cells. Toxicology. vol 394. 2018-10-19. PMID:29233657. |
levels of da and of 3,4-dihydroxyphenylacetaldehyde (dopal), 3, 4-dihyroxylphenylethanol (dopet), and 3,4-dihyroxylphenylacetic acid (dopac) metabolite, gene expression of the dopamine synthesis enzyme tyrosine hydroxylase (th) and the vesicular monoamine transporter (vmat2), and gene expression of the anti-oxidant enzymes cu/zn and mn superoxide oxidase (cu/znsod, mnsod), glutathione peroxidase (gpx) and catalase were determined. |
2018-10-19 |
2023-08-13 |
Not clear |
| Mohammad Reza Sarukhani, Hashem Haghdoost-Yazdi, Gilda Khandan-Chelarc. Changes in the Serum Urate Level Can Predict the Development of Parkinsonism in the 6-Hydroxydopamine Animal Model. Neurochemical research. vol 43. issue 5. 2018-09-27. PMID:29616443. |
the immunohistofluorescence and biochemical analyses showed that the serum ua level was also correlated with the death of tyrosine hydroxylase (th)-positive neurons in the substantia nigra pars compacta (snc), reduced level of striatal dopamine, and severity of oxidative stress in the midbrain. |
2018-09-27 |
2023-08-13 |
rat |
| Thomas Müller, Willi Kohlhep. Nigral depigmentation reflects monoamine exhaustion as initial step to Parkinson's disease. Medical hypotheses. vol 110. 2018-08-27. PMID:29317067. |
to compensate monoamine exhaustion, conversion of endogenous levodopa to dopamine by tyrosine hydroxylase is up regulated. |
2018-08-27 |
2023-08-13 |
Not clear |
| Giulia Costa, Micaela Morelli, Nicola Simol. Progression and Persistence of Neurotoxicity Induced by MDMA in Dopaminergic Regions of the Mouse Brain and Association with Noradrenergic, GABAergic, and Serotonergic Damage. Neurotoxicity research. vol 32. issue 4. 2018-08-07. PMID:28597409. |
in order to characterize how the number of administrations influenced the severity of mdma-induced dopaminergic damage and to describe the localization and persistence of this damage, we evaluated the changes in tyrosine hydroxylase (th) and dopamine transporter (dat) in different regions of the mouse brain. |
2018-08-07 |
2023-08-13 |
mouse |
| Mayuko Y Kumasaka, Ichiro Yajima, Nobutaka Ohgami, Hiromasa Ninomiya, Machiko Iida, Xiang Li, Reina Oshino, Hiroko Tanihata, Masafumi Yoshinaga, Masashi Kat. Manganese-Mediated Decrease in Levels of c-RET and Tyrosine Hydroxylase Expression In Vitro. Neurotoxicity research. vol 32. issue 4. 2018-08-07. PMID:28730349. |
previous studies also showed that activity of c-ret kinase controls dopamine production through regulation of tyrosine hydroxylase (th) expression, suggesting the involvement of c-ret in the development of parkinsonism. |
2018-08-07 |
2023-08-13 |
human |
| Andrea Pirone, Vincenzo Miragliotta, Federica Ciregia, Elisabetta Giannessi, Bruno Cozz. The catecholaminergic innervation of the claustrum of the pig. Journal of anatomy. vol 232. issue 1. 2018-08-06. PMID:28967096. |
to study a possible role of the cl in catecholaminergic pathways, we analyzed the presence and the distribution of afferents immunostained with antibodies against tyrosine hydroxylase (th) and dopamine betahydroxylase (dbh) in the pig cl. |
2018-08-06 |
2023-08-13 |
human |
| Esfandiar Azadmarzabadi, Arvin Haghighatfard, Alireza Mohammad. Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. vol 18. issue 3. 2018-08-01. PMID:29423959. |
here, we aimed to describe the association between comprehensive psychological characteristics and messenger rna levels of dopamine receptor d1 (drd1), dopamine receptor d2 (drd2), dopamine receptor d3 (drd3), dopamine receptor d4 (drd4), dopamine receptor d5 (drd5), comt, dopamine beta-hydroxylase (dbh), tyrosine hydroxylase (th), monoamine oxidase a (maom), dopa decarboxylase (ddc), dopamine transporter (dat), serotonin transporter (5-htt), brain-derived neurotrophic factor (bdnf) and glial cell line-derived neurotrophic factor (gdnf) genes based on peripheral blood samples from 400 subjects who react differently to major life event stressors. |
2018-08-01 |
2023-08-13 |
human |
| Yi Yu, Huiyong Sun, Keith Gilmore, Tingjun Hou, Suidong Wang, Youyong L. Aggregated Single-Walled Carbon Nanotubes Absorb and Deform Dopamine-Related Proteins Based on Molecular Dynamics Simulations. ACS applied materials & interfaces. vol 9. issue 38. 2018-07-30. PMID:28859474. |
by using all-atom molecular dynamics simulations, we investigate the effects of single and aggregated swcnts (single-(10,10)cnt, aggregated-7-(10,10)cnts, and single-(35,35)cnt with the same diameter as that of the aggregated one) on the activity of dopamine-related proteins [tyrosine hydroxylase (tyroh) and dopamine transporter (dat), which are related to the synthesis and transport of dopamine, respectively]. |
2018-07-30 |
2023-08-13 |
Not clear |
| Panagiotis Perdikaris, Martha Tsarouchi, Eleni Fanarioti, Evangelos Natsaridis, Ada Mitsacos, Panagiotis Giompre. Long lasting effects of chronic WIN55,212-2 treatment on mesostriatal dopaminergic and cannabinoid systems in the rat brain. Neuropharmacology. vol 129. 2018-07-27. PMID:29113897. |
acute and chronic administration of win55,212-2 decreased dopamine transporter (dat) binding and mrna levels, as well as tyrosine hydroxylase (th) mrna expression in the substantia nigra (sn) and ventral tegmental area (vta). |
2018-07-27 |
2023-08-13 |
rat |
| Vinod Kumar, Deepali Singh, Brajesh Kumar Singh, Shweta Singh, Namrata Mittra, Rakesh Roshan Jha, Devendra Kumar Patel, Chetna Sing. Alpha-synuclein aggregation, Ubiquitin proteasome system impairment, and L-Dopa response in zinc-induced Parkinsonism: resemblance to sporadic Parkinson's disease. Molecular and cellular biochemistry. vol 444. issue 1-2. 2018-07-25. PMID:29198021. |
l-dopa treatment rescued from zn-induced neurobehavioral deficits and restored dopamine levels towards normalcy; however, zn-induced dopaminergic neuronal loss, reduction in tyrosine hydroxylase expression, and increase in oxidative stress were unaffected. |
2018-07-25 |
2023-08-13 |
rat |
| Jing Ma, Cui Huang, Kun Ma, Yan-Ping Wu, Bai-Xiang Li, Yan Su. Effect of Wnt1 and Wnt5a on the development of dopaminergic neurons, and toxicity induced by combined exposure to paraquat and maneb during gestation and lactation. Molecular medicine reports. vol 16. issue 6. 2018-07-20. PMID:29152652. |
dopamine content in the striatum was examined by high performance liquid chromatography with a fluorescence detector and mrna and protein expression of wnt1, wnt5a, nuclear receptor related factor 1 (nurr1) and tyrosine hydroxylase (th) in the midbrain was examined by reverse transcription‑quantitative polymerase chain reaction and western blotting. |
2018-07-20 |
2023-08-13 |
rat |
| Yajie Zhang, Hongyan Long, Fuqiong Zhou, Weina Zhu, Jie Ruan, Yang Zhao, Yan L. Echinacoside's nigrostriatal dopaminergic protection against 6-OHDA-Induced endoplasmic reticulum stress through reducing the accumulation of Seipin. Journal of cellular and molecular medicine. vol 21. issue 12. 2018-07-18. PMID:28767194. |
it also rescued tyrosine hydroxylase and dopamine transporter expression in the striatum, and decreased α-synuclein aggregation following 6-ohda treatment in vivo. |
2018-07-18 |
2023-08-13 |
Not clear |
| Edward Lu, Sumit Sarkar, James Raymick, Merle G Paule, Qiang G. Decreased Mcl-1 protein level in the striatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Brain research. vol 1678. 2018-07-16. PMID:29158176. |
dramatic decreases in the immunoreactivities of tyrosine hydroxylase and dopamine transporters were observed. |
2018-07-16 |
2023-08-13 |
mouse |
| Jaakko Kopra, Marian Villarta-Aguilera, Mari Savolainen, Samo Weingerl, Timo T Myöhänen, Saara Rannanpää, Michael F Salvatore, Jaan-Olle Andressoo, T Petteri Pieppone. Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine. Neuropharmacology. vol 128. 2018-07-13. PMID:29031851. |
the enhanced duration of cpp was correlated with increased tyrosine hydroxylase (th) expression and dopamine content in the ventral striatum. |
2018-07-13 |
2023-08-13 |
mouse |
| Hailong Li, Jessica M Illenberger, Kristen A McLaurin, Charles F Mactutus, Rosemarie M Booz. Identification of Dopamine D1-Alpha Receptor Within Rodent Nucleus Accumbens by an Innovative RNA In Situ Detection Technology. Journal of visualized experiments : JoVE. issue 133. 2018-07-13. PMID:29658920. |
using a novel rna in situ hybridization assay, the current study identified dopamine drd1α receptor and tyrosine hydroxylase (th) rna expression from da-related circuitry in the nucleus accumbens (nac) area and substantia nigra region (snr), respectively. |
2018-07-13 |
2023-08-13 |
rat |