| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xueting Li, Jia Yu, Yanping Wu, Baixiang L. Effect on the dopaminergic metabolism induced by oral exposure to simazine during the prepubertal period in rats. International journal of molecular medicine. vol 41. issue 1. 2018-07-09. PMID:29115391. |
quantitative polymerase chain reaction and western blotting were used to analyze the mrna and protein expression of aromatic amino acid decarboxylase (aadc), tyrosine hydroxylase, orphan nuclear hormone (nurr1), dopamine transporter (dat), vesicular monoamine transporter 2 (vmat2), monoamine oxidase (mao) and catechol-o-methyltransferase (comt). |
2018-07-09 |
2023-08-13 |
rat |
| A C Kramer, A J Mirto, K J Austin, C E Roselli, B M Alexande. Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-A role for dopamine. Animal reproduction science. vol 187. 2018-07-06. PMID:29100664. |
tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-a role for dopamine. |
2018-07-06 |
2023-08-13 |
Not clear |
| A C Kramer, A J Mirto, K J Austin, C E Roselli, B M Alexande. Tyrosine hydroxylase in the ventral tegmental area of rams with high or low libido-A role for dopamine. Animal reproduction science. vol 187. 2018-07-06. PMID:29100664. |
alternating sections of the vta were stained for fos related antigens (fra), tyrosine hydroxylase, and dopamine beta-hydroxylase activity. |
2018-07-06 |
2023-08-13 |
Not clear |
| Jordan T Schmidt, Anna Rushin, Jonna Boyda, Christopher Laurence Souders, Christopher J Martyniu. Dieldrin-induced neurotoxicity involves impaired mitochondrial bioenergetics and an endoplasmic reticulum stress response in rat dopaminergic cells. Neurotoxicology. vol 63. 2018-06-25. PMID:28844784. |
dopamine cells were also assessed for changes in tyrosine hydroxylase (th) protein, which did not differ among treatments. |
2018-06-25 |
2023-08-13 |
human |
| Shilpa K Bhat, C B Ganes. Distribution of tyrosine hydroxylase-immunoreactive neurons in the brain of the viviparous fish Gambusia affinis. Journal of chemical neuroanatomy. vol 85. 2018-06-22. PMID:28546123. |
tyrosine hydroxylase (th) is the common precursor enzyme involved in the biosynthetic pathway of the catecholaminergic neurotransmitters, dopamine and norepinephrine. |
2018-06-22 |
2023-08-13 |
Not clear |
| Satyndra Kumar Yadav, Shivani Pandey, Babita Sing. Role of estrogen and levodopa in 1-methyl-4-pheny-l-1, 2, 3, 6-tetrahydropyridine (mptp)-induced cognitive deficit in Parkinsonian ovariectomized mice model: A comparative study. Journal of chemical neuroanatomy. vol 85. 2018-06-22. PMID:28711564. |
the recovery of dopamine neurons in the substantia nigra (sn) region was estimated by immunostaining of tyrosine hydroxylase (th). |
2018-06-22 |
2023-08-13 |
mouse |
| Mohammad Naderi, Arash Salahinejad, Ankur Jamwal, Douglas P Chivers, Som Niyog. Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio). Environmental science & technology. vol 51. issue 21. 2018-06-11. PMID:28981273. |
the impaired learning was associated with the induction of oxidative stress and altered mrna expression of dopamine receptors, tyrosine hydroxylase, and dopamine transporter genes in the zebrafish brain. |
2018-06-11 |
2023-08-13 |
zebrafish |
| Giuseppe Perruolo, Davide Viggiano, Francesca Fiory, Angela Cassese, Cecilia Nigro, Antonietta Liotti, Claudia Miele, Francesco Beguinot, Pietro Formisan. Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice. Scientific reports. vol 6. 2018-06-04. PMID:27426254. |
in the same region, we have observed 26% decrease of dopamine fibers, confirmed by immunohistochemistry and western blot for tyrosine hydroxylase. |
2018-06-04 |
2023-08-13 |
mouse |
| Jiang He, Tao Liao, Guo-Xin Zhong, Ji-Da Zhang, Yan-Ping Chen, Qi Wang, Qing-Ping Zen. Alzheimer's Disease-like Early-phase Brain Pathogenesis: Self-curing Amelioration of Neurodegeneration from Pro-inflammatory 'Wounding' to Anti-inflammatory 'Healing'. Current Alzheimer research. vol 14. issue 10. 2018-05-29. PMID:28413987. |
cc not only upregulates the cerebral pro-inflammatory cytokines including tumor necrosis factor α (tnf-α) and interleukin 8 (il-8), but also downregulates the cerebral interleukin 10 (il-10), an anti-inflammatory cytokine, and tyrosine hydroxylase (th), a ratelimiting enzyme for biosynthesis of the anti-inflammatory neurotransmitter dopamine. |
2018-05-29 |
2023-08-13 |
mouse |
| Carine Lampert, Danusa Mar Arcego, Natividade de Sá Couto-Pereira, Aline Dos Santos Vieira, Ana Paula Toniazzo, Rachel Krolow, Emily Garcia, Deusa Aparecida Vendite, Maria Elisa Calcagnotto, Carla Dalma. Short post-weaning social isolation induces long-term changes in the dopaminergic system and increases susceptibility to psychostimulants in female rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 61. 2018-05-18. PMID:28559209. |
social isolation also increased dopamine transporter, tyrosine hydroxylase, and decreased dopamine d2 receptor immunocontent. |
2018-05-18 |
2023-08-13 |
rat |
| Ziyue Yuan, Dongfang Li, Peng Feng, Guofang Xue, Chenhui Ji, Guanglai Li, Christian Hölsche. A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease. European journal of pharmacology. vol 812. 2018-05-15. PMID:28666800. |
dopamine synthesis as indicated by levels of tyrosine hydroxylase was much reduced by mptp in the substantia nigra and striatum, and da3-ch reversed this while liragutide only partially reversed this. |
2018-05-15 |
2023-08-13 |
mouse |
| Liping Huang, Minzhen Deng, Sheng Zhang, Shiyao Lu, Xuehong Gui, Yongqi Fan. β-asarone and levodopa coadministration increases striatal levels of dopamine and levodopa and improves behavioral competence in Parkinson's rat by enhancing dopa decarboxylase activity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-15. PMID:28787702. |
neurotransmitters, dopa decarboxylase (ddc), tyrosine hydroxylase (th), catechol-o-methyltransferase (comt), monoamine oxidase b (mao-b) and dopamine transporter (dat) levels were detected. |
2018-05-15 |
2023-08-13 |
rat |
| Juan Wang, Yange Liu, Lanzhou Li, Yidi Qi, Yuanzhu Zhang, Longtu Li, Lirong Teng, Di Wan. Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats. Molecular medicine reports. vol 16. issue 4. 2018-05-11. PMID:28849191. |
moreover, phc enhanced the expression of tyrosine hydroxylase and reduced the levels of dopamine d2 receptor and 5‑ht2a receptor in hypothalamus. |
2018-05-11 |
2023-08-13 |
rat |
| Anatoly Uzdensky, Svetlana Demyanenko, Grigory Fedorenko, Tayana Lapteva, Alexej Fedorenk. Protein Profile and Morphological Alterations in Penumbra after Focal Photothrombotic Infarction in the Rat Cerebral Cortex. Molecular neurobiology. vol 54. issue 6. 2018-05-10. PMID:27324898. |
diverse cellular subsystems were involved in the penumbra tissue response: signal transduction pathways such as protein kinase bα/gsk-3, protein kinase c and its β1 and β2 isoforms, wnt/β-catenin (axin1, gsk-3, frat1), notch/numb, dyrk1a, tdp43; mitochondria quality control (pink1, parkin, htra2); ubiquitin-mediated proteolysis (ubiquilin-1, uchl1); axon outgrowth and guidance (nav-3, crmp2, pkcβ2); vesicular trafficking (syntaxin-8, tmp21, munc-18-3, synip, als2, vilip1, syntaxin, synaptophysin, synaptotagmin); biosynthesis of neuromediators (tryptophan hydroxylase, monoamine oxidase b, glutamate decarboxylase, tyrosine hydroxylase, dopa decarboxylase, dopamine transporter); intercellular interactions (n-cadherin, pmp22); cytoskeleton (neurofilament 68, neurofilament-m, doublecortin); and other proteins (lrp1, prion protein, β-amyloid). |
2018-05-10 |
2023-08-13 |
rat |
| Haidy E Michel, Mariane G Tadros, Ahmed Esmat, Amani E Khalifa, Ahmed M Abdel-Tawa. Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson's Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions. Molecular neurobiology. vol 54. issue 7. 2018-05-10. PMID:27514753. |
catalepsy, locomotor activity, striatal dopamine content, and tyrosine hydroxylase "th" and α-synuclein immunoreactivity were evaluated. |
2018-05-10 |
2023-08-13 |
rat |
| Ivan Carrera, Lucia Fernandez-Novoa, Carolina Sampedro, Ramon Cacabelo. Neuroprotective Effect of Atremorine in an Experimental Model of Parkinson's Disease. Current pharmaceutical design. vol 23. issue 18. 2018-05-09. PMID:28190394. |
data demonstrated that atremorine promotes neuroprotection and behavior recovery in the injured mtpt-mouse brain by modulating the expression levels of tyrosine hydroxylase, glial proteins, apoptosis and endogenous dopamine and neuromelanin concentrations, probably the key to recover the basal ganglia function. |
2018-05-09 |
2023-08-13 |
mouse |
| Wen Zhang, Zhizi Zhou, Xiuzhen Li, Yonglan Huang, Taolin Li, Yunting Lin, Yongxian Shao, Hao Hu, Hongsheng Liu, Li Li. Dopa-responsive dystonia in Chinese patients: Including a novel heterozygous mutation in the GCH1 gene with an intermediate phenotype and one case of prenatal diagnosis. Neuroscience letters. vol 644. 2018-04-26. PMID:28087438. |
drd is caused by the mutations in the genes encoding the enzymes involved in the dopamine and tetrahydrobiopterin (bh4) biosynthesis, including the gtp cyclohydrolase 1 (gch1) gene and the tyrosine hydroxylase (th) gene. |
2018-04-26 |
2023-08-13 |
Not clear |
| David H Root, Hui-Ling Wang, Bing Liu, David J Barker, László Mód, Péter Szocsics, Afonso C Silva, Zsófia Maglóczky, Marisela Morale. Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans. Scientific reports. vol 6. 2018-04-19. PMID:27477243. |
here, we revealed vglut2 neurons within the vta and snc of nonhuman primates and humans by simultaneous detection of vglut2 mrna and tyrosine hydroxylase (th; for identification of dopamine neurons). |
2018-04-19 |
2023-08-13 |
human |
| Yoon-Mi Oh, Fuyuki Karube, Susumu Takahashi, Kenta Kobayashi, Masahiko Takada, Motokazu Uchigashima, Masahiko Watanabe, Kayo Nishizawa, Kazuto Kobayashi, Fumino Fujiyam. Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations. Brain structure & function. vol 222. issue 5. 2018-04-17. PMID:27995326. |
we initially found that (1) 57% of pv neurons co-expressed lim-homeobox 6, (2) the pv-gp terminals were preferentially distributed in the ventral part of dorsal tier of snc, (3) pv-gp neurons formed basket-like appositions with the somata of tyrosine hydroxylase, pv, calretinin and cholecystokinin immunoreactive neurons in the sn, and (4) in vitro whole-cell recording during optogenetic photo-stimulation of pv-gp terminals in snc demonstrated that pv-gp neurons strongly inhibited dopamine neurons via gaba |
2018-04-17 |
2023-08-13 |
rat |
| Hong Li, Chenyue Ding, Zhi-Liang Ding, Mingfa Ling, Ting Wang, Wei Wang, Boxian Huan. 17β-Oestradiol promotes differentiation of human embryonic stem cells into dopamine neurons via cross-talk between insulin-like growth factors-1 and oestrogen receptor β. Journal of cellular and molecular medicine. vol 21. issue 8. 2018-04-17. PMID:28244646. |
furthermore, yield of da neuron-secreted tyrosine hydroxylase (th) and dopamine was also increased. |
2018-04-17 |
2023-08-13 |
human |