| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rajib Paul, Ankumoni Dutta, Banashree Chetia Phukan, Muhammed Khairujjaman Mazumder, Arokiasamy Justin-Thenmozhi, Thamilarasan Manivasagam, Pallab Bhattacharya, Anupom Bora. Accumulation of Cholesterol and Homocysteine in the Nigrostriatal Pathway of Brain Contributes to the Dopaminergic Neurodegeneration in Mice. Neuroscience. vol 388. 2019-03-29. PMID:30075243. |
injection of homocysteine in hypercholesterolemic mice exacerbated the motor abnormalities as well as caused depletion of striatal dopamine level significantly, which was supported by a significant decrease in tyrosine hydroxylase (th) immunoreactivity in striatum. |
2019-03-29 |
2023-08-13 |
mouse |
| Andreia Moreira da Silva Santos, John P Kelly, Peter Dockery, Karen M Doyl. Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 89. 2019-03-25. PMID:30296469. |
effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain. |
2019-03-25 |
2023-08-13 |
rat |
| Andreia Moreira da Silva Santos, John P Kelly, Peter Dockery, Karen M Doyl. Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 89. 2019-03-25. PMID:30296469. |
tyrosine hydroxylase expression is induced downstream of dopamine activity, and it is the rate limiting enzyme in dopamine synthesis. |
2019-03-25 |
2023-08-13 |
rat |
| I V Ekimova, A R Gazizova, M N Karpenko, D V Plaksin. [Signs of anhedonia and destructive changes in the ventral tegmental area of the midbrain in the model of the preclinical Parkinson's disease stage in experiment]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 9. 2019-03-25. PMID:30335074. |
anhedonia was combined with the death of about one third of dopamine (da)-ergic neurons in the ventral tegmental area of the midbrain and their axons in the ventral striatum; and a decrease of dopamine concentration in the ventral striatum (by 40%) and the tyrosine hydroxylase level in surviving da-ergic neurons. |
2019-03-25 |
2023-08-13 |
rat |
| M C Sanchez Vega, S Chong, T H J Burn. Prenatal vitamin D deficiency does not exacerbate behavioural impairments associated with prenatal ethanol exposure in juvenile male mice. Behavioural brain research. vol 356. 2019-03-22. PMID:30142394. |
gene expression analysis of transcripts involved in dopamine regulation revealed a main effect of ethanol exposure on dopamine- and cyclic adenosine monophosphate- regulated neuronal phosphoprotein (darpp-32), a main effect of vitamin d diet on dopamine 2 receptors (d2r) and a main effect of sex on tyrosine hydroxylase (th) expression. |
2019-03-22 |
2023-08-13 |
mouse |
| Josiel M Mack, Tainara M Moura, Débora Lanznaster, Franciane Bobinski, Caio M Massari, Tuane B Sampaio, Ariana E Schmitz, Luiz F Souza, Roger Walz, Carla I Tasca, Anicleto Poli, Richard L Doty, Alcir L Dafre, Rui D Predige. Intranasal administration of sodium dimethyldithiocarbamate induces motor deficits and dopaminergic dysfunction in mice. Neurotoxicology. vol 66. 2019-03-21. PMID:29605442. |
nadmdc infusions on olfactory bulb (ob) and striatal measures of cell death, reactive oxygen species (ros), tyrosine hydroxylase, and the levels of dopamine, noradrenaline, serotonin, and their metabolites. |
2019-03-21 |
2023-08-13 |
mouse |
| Raly James Perez Custodio, Chrislean Jun Botanas, June Bryan de la Peña, Irene Joy Dela Peña, Mikyung Kim, Leandro Val Sayson, Arvie Abiero, Zae Young Ryoo, Bung-Nyun Kim, Hee Jin Kim, Jae Hoon Cheon. Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice. Neuroscience. vol 390. 2019-03-21. PMID:30138648. |
we have also found that expression of dopamine-related genes (dopamine transporter, tyrosine hydroxylase, and dopamine d1 and d2 receptors) in the str increased. |
2019-03-21 |
2023-08-13 |
mouse |
| Yongchul Jang, Insu Kwon, Wankeun Song, Ludmila M Cosio-Lima, Youngil Le. Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson's Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy. Neuroscience. vol 379. 2019-03-18. PMID:29559387. |
our biochemical data showed that ee-induced neuroprotection occurs in combination with multiple synergic neuroprotective pathways: (1) increased neurogenesis shown by an increase in brdu-positive neurons; (2) diminished loss of dopaminergic neurons evidenced by upregulated tyrosine hydroxylase (th) and dopamine transporter (dat) levels; (3) increased antioxidant capacity (e.g., cuznsod, catalase, gpx1/2, ho-1, dj1 and prxiii); and (4) enhanced autophagy (lc3 ii, p62, beclin1, bnip3, lamp2, cathepsin l and tfeb). |
2019-03-18 |
2023-08-13 |
mouse |
| Amit Kumar Chauhan, Namrata Mittra, Brajesh Kumar Singh, Chetna Sing. Inhibition of glutathione S-transferase-pi triggers c-jun N-terminal kinase-dependent neuronal death in Zn-induced Parkinsonism. Molecular and cellular biochemistry. vol 452. issue 1-2. 2019-03-18. PMID:30076580. |
catalytic activity and expression of gst-π protein, total gst activity, neurobehavioral indexes, striatal dopamine and its metabolites, nigral tyrosine hydroxylase (th)-positive neurons and expression of th and b-cell lymphoma-2 (bcl-2) proteins were reduced in zn-treated rats. |
2019-03-18 |
2023-08-13 |
rat |
| Stephanie Mandic, Hélène Volkof. The effects of fasting and appetite regulators on catecholamine and serotonin synthesis pathways in goldfish (Carassius auratus). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 223. 2019-03-15. PMID:29730451. |
in order to better understand the role of monoamine neurotransmitters in the regulation of feeding in fish, we examined the effects of fasting on the brain and intestine gene expression of enzymes involved in their synthesis pathways (spr: sepiapterin reductase; dhpr: dihydropteridine reductase; th: tyrosine hydroxylase; tph: tryptophan hydroxylase; aadc: aromatic l-amino acid decarboxylase; dbh: dopamine β-hydroxylase) in goldfish. |
2019-03-15 |
2023-08-13 |
Not clear |
| Sathiya Sekar, Sugumar Mani, Barathidasan Rajamani, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Abid Bhat, Bipul Ray, Musthafa Mohamed Essa, Gilles J Guillemin, Saravana Babu Chidambara. Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism. Neurotoxicity research. vol 34. issue 3. 2019-03-14. PMID:30006683. |
on the other hand, tel upregulated tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) expressions. |
2019-03-14 |
2023-08-13 |
mouse |
| Hwei-Hsien Chen, Pei-Chi Chang, Shiaw-Pyng Wey, Pei-Mei Chen, Chinpiao Chen, Ming-Huan Cha. Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 108. 2019-03-14. PMID:30223096. |
recovery of motor function was correlated with reversal of nigrostriatal dopaminergic neuronal loss, accompanied by higher tyrosine hydroxylase (th) density, dopamine transporter (dat) expression and vesicular monoamine transporter-2 (vmat2) levels. |
2019-03-14 |
2023-08-13 |
mouse |
| Asya Ozkizilcik, Aruna Sharma, Dafin F Muresanu, José V Lafuente, Z Ryan Tian, Ranjana Patnaik, Herbert Mössler, Hari S Sharm. Timed Release of Cerebrolysin Using Drug-Loaded Titanate Nanospheres Reduces Brain Pathology and Improves Behavioral Functions in Parkinson's Disease. Molecular neurobiology. vol 55. issue 1. 2019-03-12. PMID:28875428. |
a significant decrease in dopamine (da) and its metabolites 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) along with a marked decrease in the number of tyrosine hydroxylase (th)-positive cells in the substantia nigra pars compacta (snpc) and striatum (str) confirms the validity of this model for studying pd. |
2019-03-12 |
2023-08-13 |
mouse |
| Hector Rosas-Hernandez, Srinivasulu Chigurupati, James Raymick, Bonnie Robinson, Elvis Cuevas, Joseph Hanig, Sumit Sarka. Identification of altered microRNAs in serum of a mouse model of Parkinson's disease. Neuroscience letters. vol 687. 2019-03-11. PMID:30025832. |
chronic mptp treatment induced loss of dopaminergic terminals in the snpc and caudate putamen, confirmed by a decrease in the number of tyrosine hydroxylase and dopamine transporter positive cells. |
2019-03-11 |
2023-08-13 |
mouse |
| Giulia Costa, Marcello Serra, Nicholas Pintori, Maria Antonietta Casu, Mary Tresa Zanda, Daniela Murtas, Maria Antonietta De Luca, Nicola Simola, Liana Fattor. The novel psychoactive substance methoxetamine induces persistent behavioral abnormalities and neurotoxicity in rats. Neuropharmacology. vol 144. 2019-03-04. PMID:30366005. |
after completion of behavioral analysis, neurotoxic effects of mxe were evaluated by measuring densities of dopamine transporter, tyrosine hydroxylase, and serotonin transporter in various brain regions. |
2019-03-04 |
2023-08-13 |
human |
| Peijian Yue, Lin Gao, Xuejing Wang, Xuebing Ding, Junfang Ten. Ultrasound-triggered effects of the microbubbles coupled to GDNF- and Nurr1-loaded PEGylated liposomes in a rat model of Parkinson's disease. Journal of cellular biochemistry. vol 119. issue 6. 2019-02-27. PMID:29240240. |
the immunohistochemical staining of tyrosine hydroxylase (th) and dopamine transporter (dat) was used to assess the neuron loss. |
2019-02-27 |
2023-08-13 |
rat |
| Mariama S Azmy, Esther T Menze, Reem N El-Naga, Mariane G Tadro. Neuroprotective Effects of Filgrastim in Rotenone-Induced Parkinson's Disease in Rats: Insights into its Anti-Inflammatory, Neurotrophic, and Antiapoptotic Effects. Molecular neurobiology. vol 55. issue 8. 2019-02-26. PMID:29327204. |
the effects of two doses of filgrastim (20 and 40 μg/kg) on spontaneous locomotion, catalepsy, body weight, histology, and striatal dopamine (da) content, as well as tyrosine hydroxylase (th) and α-synuclein expression, were evaluated. |
2019-02-26 |
2023-08-13 |
rat |
| Juho-Matti Renko, Susanne Bäck, Merja H Voutilainen, T Petteri Piepponen, Ilkka Reenilä, Mart Saarma, Raimo K Tuomine. Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats. Molecular neurobiology. vol 55. issue 8. 2019-02-26. PMID:29349573. |
although gdnf did not affect the extracellular level of dopamine, we found significantly elevated tyrosine hydroxylase (th) and catechol-o-methyltransferase (comt) activity and decreased monoamine oxidase a (mao-a) activity in striatal tissue samples 1 week after gdnf injection. |
2019-02-26 |
2023-08-13 |
rat |
| Catalina Meléndez, Patricia Muñoz, Juan Segura-Aguila. DT-Diaphorase Prevents Aminochrome-Induced Lysosome Dysfunction in SH-SY5Y Cells. Neurotoxicity research. vol 35. issue 1. 2019-02-20. PMID:30203271. |
the cells differentiated with retinoic acid and 12-o-tetradecanoylphorbol-13-acetate show a significant increase in the expression of tyrosine hydroxylase, vesicular monoamine transporter-2, and dopamine transporter. |
2019-02-20 |
2023-08-13 |
Not clear |
| Ying-Li Zhu, Meng-Fei Sun, Xue-Bing Jia, Pei-Hao Zhang, Yi-Da Xu, Zhi-Lan Zhou, Zhou-Heng Xu, Chun Cui, Xue Chen, Xu-Sheng Yang, Yan-Qin She. Aucubin alleviates glial cell activation and preserves dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian mice. Neuroreport. vol 29. issue 13. 2019-02-18. PMID:29985188. |
measurement of dopamine levels was performed by high-performance liquid chromatography and tyrosine hydroxylase expression was assessed by western blot. |
2019-02-18 |
2023-08-13 |
mouse |