| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyung In Kim, Young Cheul Chung, Byung Kwan Ji. Norfluoxetine Prevents Degeneration of Dopamine Neurons by Inhibiting Microglia-Derived Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease. Mediators of inflammation. vol 2018. 2019-06-05. PMID:30692871. |
analysis by tyrosine hydroxylase (th) immunohistochemistry demonstrated that norfluoxetine prevents degeneration of nigrostriatal dopamine neurons |
2019-06-05 |
2023-08-13 |
mouse |
| Andrew E Christie, Meredith E Stanhope, Helen I Gandler, Tess J Lameyer, Micah G Pascual, Devlin N Shea, Andy Yu, Patsy S Dickinson, J Joe Hul. Molecular characterization of putative neuropeptide, amine, diffusible gas and small molecule transmitter biosynthetic enzymes in the eyestalk ganglia of the American lobster, Homarus americanus. Invertebrate neuroscience : IN. vol 18. issue 4. 2019-05-28. PMID:30276482. |
similarly, transcripts encoding full complements of the enzymes responsible for dopamine [tryptophan-phenylalanine hydroxylase (tph), tyrosine hydroxylase and dopa decarboxylase (ddc)], octopamine (tph, tyrosine decarboxylase and tyramine β-hydroxylase), serotonin (tph or tryptophan hydroxylase and ddc) and histamine (histidine decarboxylase) biosynthesis were identified from the eyestalk ganglia, as were those responsible for the generation of the gases nitric oxide (nitric oxide synthase) and carbon monoxide (heme oxygenase), and the small molecule transmitters acetylcholine (choline acetyltransferase), glutamate (glutaminase) and gaba (glutamic acid decarboxylase). |
2019-05-28 |
2023-08-13 |
lobster |
| E S Dorey, C L Cullen, D Lucia, K M Mah, M-L Roy Manchadi, B S Muhlhausler, K M Morit. The impact of periconceptional alcohol exposure on fat preference and gene expression in the mesolimbic reward pathway in adult rat offspring. Journal of developmental origins of health and disease. vol 9. issue 2. 2019-05-24. PMID:29039297. |
there was no effect of pc:etoh on mrna expression of the µ-opioid receptor, tyrosine hydroxylase (th), dopamine receptor type 2 (drd2) or dopamine active transporter (slc6a3). |
2019-05-24 |
2023-08-13 |
rat |
| Rosalba Siracusa, Irene Paterniti, Marika Cordaro, Rosalia Crupi, Giuseppe Bruschetta, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposit. Neuroprotective Effects of Temsirolimus in Animal Models of Parkinson's Disease. Molecular neurobiology. vol 55. issue 3. 2019-05-23. PMID:28357809. |
treatment with temsirolimus significantly ameliorated behavioral deficits, increased the expression of specific markers of pd such as tyrosine hydroxylase, dopamine transporter, as well as decreased the upregulation of α-synuclein in the substantia nigra after mptp induction. |
2019-05-23 |
2023-08-13 |
Not clear |
| Tarik Dahoun, Antonio F Pardiñas, Mattia Veronese, Michael A P Bloomfield, Sameer Jauhar, Ilaria Bonoldi, Sean Froudist-Walsh, Chiara Nosarti, Carsten Korth, William Hennah, James Walters, Diana Prata, Oliver D Howe. The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study. Human molecular genetics. vol 27. issue 20. 2019-05-20. PMID:29945223. |
the common allele (a) of the disc1 single-nucleotide polymorphism (snp) rs821616 encodes a serine (ser) at the ser704cys polymorphism, and has been shown to increase the phosphorylation of extracellular signal-regulated protein kinases 1 and 2 (erk1/2) that stimulate the phosphorylation of tyrosine hydroxylase, the rate-limiting enzyme for dopamine biosynthesis. |
2019-05-20 |
2023-08-13 |
human |
| Tarik Dahoun, Antonio F Pardiñas, Mattia Veronese, Michael A P Bloomfield, Sameer Jauhar, Ilaria Bonoldi, Sean Froudist-Walsh, Chiara Nosarti, Carsten Korth, William Hennah, James Walters, Diana Prata, Oliver D Howe. The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study. Human molecular genetics. vol 27. issue 20. 2019-05-20. PMID:29945223. |
our finding is consistent with its previous association with heightened activation of erk1/2, which stimulates tyrosine hydroxylase activity for dopamine synthesis. |
2019-05-20 |
2023-08-13 |
human |
| Stefano Di Santo, Morten Meyer, Angélique D Ducray, Lukas Andereggen, Hans R Widme. A Combination of NT-4/5 and GDNF Is Favorable for Cultured Human Nigral Neural Progenitor Cells. Cell transplantation. vol 27. issue 4. 2019-05-17. PMID:29701077. |
both neurotrophic factors increased dopamine content in the culture medium and in the number of tyrosine hydroxylase immunoreactive neurons, most prominently after combined gdnf + nt-4/5 treatment. |
2019-05-17 |
2023-08-13 |
human |
| Ghada A Badawi, Mai A Abd El Fattah, Hala F Zaki, Moushira I El Saye. Sitagliptin and Liraglutide Modulate L-dopa Effect and Attenuate Dyskinetic Movements in Rotenone-Lesioned Rats. Neurotoxicity research. vol 35. issue 3. 2019-05-15. PMID:30673988. |
moreover, they preserved substantia nigra pars compacta (snpc) tyrosine hydroxylase (th) and vesicular monoamine transporter 2-positive (vmat2) cells with prominent increase of the striatal dopamine (da) content. |
2019-05-15 |
2023-08-13 |
rat |
| Phuong-Tram Nguyen, Duy-Khanh Dang, Hai-Quyen Tran, Eun-Joo Shin, Ji Hoon Jeong, Seung-Yeol Nah, Min Chang Cho, Yong Sup Lee, Choon-Gon Jang, Hyoung-Chun Ki. Methiopropamine, a methamphetamine analogue, produces neurotoxicity via dopamine receptors. Chemico-biological interactions. vol 305. 2019-05-10. PMID:30922767. |
moreover, treatment with mpa resulted in significant impairments in dopaminergic parameters [i.e., changes in dopamine level, dopamine turnover rate, tyrosine hydroxylase (th) levels, dopamine transporter (dat) expression, and vesicular monoamine transporter-2 (vmat-2) expression], and in behavioral deficits. |
2019-05-10 |
2023-08-13 |
mouse |
| Hui-Ju Huang, Yi-Ting Wang, Hui-Ching Lin, Yi-Hsuan Lee, Anya Maan-Yuh Li. Soluble Epoxide Hydrolase Inhibition Attenuates MPTP-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System: Involvement of α-Synuclein Aggregation and ER Stress. Molecular neurobiology. vol 55. issue 1. 2019-05-08. PMID:28822080. |
compared with the mptp-treated wt mice, mptp-induced reductions in striatal dopamine content and nigral tyrosine hydroxylase level (th, a biomarker of dopaminergic neurons) were less significant in the treated seh mice. |
2019-05-08 |
2023-08-13 |
mouse |
| Ana Canseco-Alba, Norman Schanz, Branden Sanabria, Juan Zhao, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaiv. Behavioral effects of psychostimulants in mutant mice with cell-type specific deletion of CB2 cannabinoid receptors in dopamine neurons. Behavioural brain research. vol 360. 2019-05-02. PMID:30508607. |
the deletion of cb2rs in dopamine neurons modified the levels of tyrosine hydroxylase, and reduced the expression of dopamine transporter gene expression in dat-cnr2 cko midbrain region. |
2019-05-02 |
2023-08-13 |
mouse |
| Guotao Chen, Jianhuai Chen, Baibing Yang, Wen Yu, Yun Chen, Yutian Da. Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction. Andrologia. vol 51. issue 1. 2019-04-23. PMID:30276840. |
the expression levels of dopamine d1/d2 receptors and tyrosine hydroxylase in the basolateral amygdala were also measured. |
2019-04-23 |
2023-08-13 |
human |
| Guotao Chen, Jianhuai Chen, Baibing Yang, Wen Yu, Yun Chen, Yutian Da. Dopamine D2 receptors in the basolateral amygdala modulate erectile function in a rat model of nonorganic erectile dysfunction. Andrologia. vol 51. issue 1. 2019-04-23. PMID:30276840. |
lower expression levels of tyrosine hydroxylase and the dopamine d2 receptor in the basolateral amygdala were observed in rats with nonorganic erectile dysfunction. |
2019-04-23 |
2023-08-13 |
human |
| Ciarán M Fitzpatrick, Annika H Runegaard, Søren H Christiansen, Nikolaj W Hansen, Søren H Jørgensen, Julia C McGirr, Amaia de Diego Ajenjo, Andreas T Sørensen, Jean-François Perrier, Anders Petersen, Ulrik Gether, David P D Woldbye, Jesper T Andrease. Differential effects of chemogenetic inhibition of dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task. Progress in neuro-psychopharmacology & biological psychiatry. vol 90. 2019-04-22. PMID:30529002. |
by selective inhibition of tyrosine hydroxylase (th)-positive vta dopamine neurons expressing the gi-coupled dreadd (hm4di), we observed a marked impairment of effort-based motivation and subsequently speed and overall vigor of responding. |
2019-04-22 |
2023-08-13 |
mouse |
| Rosilane Taveira-da-Silva, Luzia da Silva Sampaio, Adalberto Vieyra, Marcelo Einicker-Lama. L-Tyr-Induced Phosphorylation of Tyrosine Hydroxylase at Ser40: An Alternative Route for Dopamine Synthesis and Modulation of Na+/K+-ATPase in Kidney Cells. Kidney & blood pressure research. vol 44. issue 1. 2019-04-22. PMID:30808844. |
l-tyr-induced phosphorylation of tyrosine hydroxylase at ser40: an alternative route for dopamine synthesis and modulation of na+/k+-atpase in kidney cells. |
2019-04-22 |
2023-08-13 |
Not clear |
| Darya A Meshalkina, Elana V Kysil, Kristina A Antonova, Konstantin A Demin, Tatiana O Kolesnikova, Sergey L Khatsko, Raul R Gainetdinov, Polina A Alekseeva, Allan V Kaluef. The Effects of Chronic Amitriptyline on Zebrafish Behavior and Monoamine Neurochemistry. Neurochemical research. vol 43. issue 6. 2019-04-19. PMID:29740748. |
the latter effect was not reported in this model previously, and accompanied higher brain expression of tyrosine hydroxylase (a rate-limiting enzyme of catecholamine biosynthesis), but unaltered expression of dopamine-β-hydroxylase and monoamine oxidase (the enzymes of dopamine metabolism). |
2019-04-19 |
2023-08-13 |
zebrafish |
| b' Nata\\xc5\\xa1a Popovi\\xc4\\x87, Vesna Stojiljkovi\\xc4\\x87, Sne\\xc5\\xbeana Peji\\xc4\\x87, Ana Todorovi\\xc4\\x87, Ivan Pavlovi\\xc4\\x87, Ljubica Gavrilovi\\xc4\\x87, Sne\\xc5\\xbeana B Pajovi\\xc4\\x8. Modulation of Hippocampal Antioxidant Defense System in Chronically Stressed Rats by Lithium. Oxidative medicine and cellular longevity. vol 2019. 2019-04-15. PMID:30911352.' |
in addition, we examined the effects of lithium on anxiety behaviors, hippocampal concentrations of dopamine (da) and malondialdehyde (mda), protein levels of brain-derived neurotrophic factor (bdnf), tyrosine hydroxylase (th), dopamine transporter (dat), and catechol-o-methyltransferase (comt), as well as activity of monoamine oxidase (mao) in chronically stressed rats. |
2019-04-15 |
2023-08-13 |
rat |
| Phuong-Tram Nguyen, Eun-Joo Shin, Duy-Khanh Dang, Hai-Quyen Tran, Choon-Gon Jang, Ji Hoon Jeong, Yu Jeung Lee, Hyo Jong Lee, Yong Sup Lee, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Ki. Role of dopamine D1 receptor in 3-fluoromethamphetamine-induced neurotoxicity in mice. Neurochemistry international. vol 113. 2019-04-10. PMID:29197543. |
moreover, 3-fma significantly produced dopaminergic impairments [i.e., increase in dopamine (da) turnover rate and decreases in da level, and in the expression of tyrosine hydroxylase (th), dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat-2)] with behavioral impairments. |
2019-04-10 |
2023-08-13 |
mouse |
| Han Gao, Lianrong Dou, Liang Shan, Yan Sun, Wentao L. Proliferation and committed differentiation into dopamine neurons of neural stem cells induced by the active ingredients of radix astragali. Neuroreport. vol 29. issue 7. 2019-04-09. PMID:29481521. |
moreover, results from quantitative rt-pcr showed asi, aps, and asf could promote the expressions of tyrosine hydroxylase and dopamine transporter mrna, which are specifically expressed in da neurons. |
2019-04-09 |
2023-08-13 |
Not clear |
| Sachiko Konosu-Fukaya, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Yayoi Aoyama, Fumitoshi Satoh, Fumiyoshi Fujishima, Hironobu Sasano, Yasuhiro Nakamur. Catecholamine-Synthesizing Enzymes in Pheochromocytoma and Extraadrenal Paraganglioma. Endocrine pathology. vol 29. issue 4. 2019-04-05. PMID:30155766. |
in chromaffin cells, tyrosine hydroxylase (th), aromatic l-amino acid decarboxylase (aadc), dopamine β-hydroxylase (dbh), and phenylethanolamine n-methyltransferase (pnmt) are mainly involved in catecholamine synthesis. |
2019-04-05 |
2023-08-13 |
Not clear |