| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei Hou, Chengqing Yang, Jingfei Hu, Ya Guo, Peipei Liu, Yedan Liu, Jie Song, Wei Wei, Zongbo Che. Levodopa is effective in the treatment of three Chinese Tyrosine hydroxylase (TH) deficiency children. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 78. 2020-04-03. PMID:31419477. |
tyrosine hydroxylase (th) deficiency is a rare autosomal recessive inborn error of dopamine transmission, which the deficient gene is at the chromosome 11, also called'segawa syndrome'. |
2020-04-03 |
2023-08-13 |
Not clear |
| Samantha L Regan, Jillian R Hufgard, Emily M Pitzer, Chiho Sugimoto, Yueh-Chiang Hu, Michael T Williams, Charles V Vorhee. Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers. Neurobiology of disease. vol 130. 2020-03-24. PMID:31176715. |
striatal tyrosine hydroxylase, aromatic l-amino acid decarboxylase (aadc), and the dopamine transporter were increased and dopamine d1 receptor (drd1) and dopamine- and camp-regulated neuronal phosphoprotein (darpp-32) decreased with no changes in drd2, drd4, vesicular monoamine transporter-2, n-methyl-d-aspartate (nmda)-nr1, -nr2a, or -nr2b. |
2020-03-24 |
2023-08-13 |
mouse |
| Jacqueline Shehadeh, Kay L Double, Karen E Murphy, Larisa Bobrovskaya, Stefanie Reyes, Peter R Dunkley, Glenda M Halliday, Phillip W Dickso. Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease. Neurobiology of disease. vol 130. 2020-03-24. PMID:31276794. |
tyrosine hydroxylase is the key enzyme controlling the synthesis of the catecholamines including dopamine. |
2020-03-24 |
2023-08-13 |
human |
| Jacqueline Shehadeh, Kay L Double, Karen E Murphy, Larisa Bobrovskaya, Stefanie Reyes, Peter R Dunkley, Glenda M Halliday, Phillip W Dickso. Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease. Neurobiology of disease. vol 130. 2020-03-24. PMID:31276794. |
surviving neurons in parkinson's disease brain exhibit a substantial increase in tyrosine hydroxylase phosphorylation consistent with a compensatory mechanism of increased dopamine synthesis in the terminal field regions. |
2020-03-24 |
2023-08-13 |
human |
| Armaz Aschrafi, Adama Berndt, Jeffrey A Kowalak, Jenna R Gale, Anthony E Gioio, Barry B Kapla. Angiotensin II mediates the axonal trafficking of tyrosine hydroxylase and dopamine β-hydroxylase mRNAs and enhances norepinephrine synthesis in primary sympathetic neurons. Journal of neurochemistry. vol 150. issue 6. 2020-03-23. PMID:31306490. |
angiotensin ii mediates the axonal trafficking of tyrosine hydroxylase and dopamine β-hydroxylase mrnas and enhances norepinephrine synthesis in primary sympathetic neurons. |
2020-03-23 |
2023-08-13 |
rat |
| Peter R Dunkley, Phillip W Dickso. Tyrosine hydroxylase phosphorylation in vivo. Journal of neurochemistry. vol 149. issue 6. 2020-03-13. PMID:30714137. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, noradrenaline and adrenaline. |
2020-03-13 |
2023-08-13 |
Not clear |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
this study aims to investigate the effects of different light intensity and dual light intensity choice (dlic) lighting program on plasma corticosterone (cort), and tryptophan hydroxylase 2 (tph2, the rate-limiting enzyme of serotonin biosynthesis) and tyrosine hydroxylase (th, the rate-limiting enzyme of dopamine biosynthesis) gene expression in the brainstem of male chickens. |
2020-03-13 |
2023-08-13 |
Not clear |
| Swati Shah, Dragan Maric, Frank Denaro, Wael Ibrahim, Ronald Mason, Ashutosh Kumar, Dima A Hammoud, William Rei. Nitrosative Stress Is Associated with Dopaminergic Dysfunction in the HIV-1 Transgenic Rat. The American journal of pathology. vol 189. issue 7. 2020-03-11. PMID:31230667. |
colocalization of 3-nt staining with neurofilament proteins and evidence of decreased tyrosine hydroxylase and dopamine transporter expression in the old rats support dopaminergic involvement. |
2020-03-11 |
2023-08-13 |
rat |
| Jicheng Li, Shaojun Yang, Xiaofeng Liu, Yuliang Han, Yanhui Li, Jingjing Feng, Hua Zha. Hypoactivity of the lateral habenula contributes to negative symptoms and cognitive dysfunction of schizophrenia in rats. Experimental neurology. vol 318. 2020-03-02. PMID:31082390. |
finally, we examined levels of the dopamine d1 receptor (d1r) and tyrosine hydroxylase (th) in the mpfc, and tryptophan hydroxylase 2 (tph2) in the drn of rats with lhb lesions to determine the possible mechanism underlying the schizophrenia-like behavior associated with lesioned lhb. |
2020-03-02 |
2023-08-13 |
rat |
| Michela Campolo, Irene Paterniti, Rosalba Siracusa, Alessia Filippone, Emanuela Esposito, Salvatore Cuzzocre. TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model. Brain, behavior, and immunity. vol 76. 2020-02-28. PMID:30550933. |
our experiments have demonstrated that the absence of tlr4 prevented dopamine depletion, increased tyrosine hydroxylase and dopamine transporter activities and reduced the number of α-synuclein-positive neurons. |
2020-02-28 |
2023-08-13 |
mouse |
| Juliet Richetto, Marcello Polesel, Ulrike Weber-Stadlbaue. Effects of light and dark phase testing on the investigation of behavioural paradigms in mice: Relevance for behavioural neuroscience. Pharmacology, biochemistry, and behavior. vol 178. 2020-02-25. PMID:29782942. |
in addition, animals tested in the light phase also exhibit increased locomotor response to systemic amphetamine treatment, which is paralleled by alterations in the expression patterns of tyrosine hydroxylase (th) and dopamine transporter (dat) in the nucleus accumbens (nac) and/or midbrain (mid). |
2020-02-25 |
2023-08-13 |
mouse |
| Zhenyi Liu, Andrew Brown, Dan Fisher, Yumei Wu, Joe Warren, Xiaoxia Cu. Correction: Tissue Specific Expression of Cre in Rat Tyrosine Hydroxylase and Dopamine Active Transporter-Positive Neurons. PloS one. vol 14. issue 6. 2020-02-25. PMID:31220192. |
correction: tissue specific expression of cre in rat tyrosine hydroxylase and dopamine active transporter-positive neurons. |
2020-02-25 |
2023-08-13 |
rat |
| Zhijuan Wang, Yedan Gai, Jinlian Zhou, Jiali Liu, Sheng Cu. miR-375 mediates the CRF signaling pathway to regulate catecholamine biosynthesis by targeting Sp1 in porcine adrenal gland. Stress (Amsterdam, Netherlands). vol 22. issue 3. 2020-02-18. PMID:30714474. |
functional studies showed that mir-375 negatively regulated cats synthesis in primary cells by affecting the expression of the cats synthetases tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), and phenylethanolamine-n-methyltransferase (pnmt). |
2020-02-18 |
2023-08-13 |
mouse |
| Yizhi Zhang, Weiwei Xu, Shanji Nan, Meiji Chang, Jia Fa. MicroRNA-326 Inhibits Apoptosis and Promotes Proliferation of Dopaminergic Neurons in Parkinson's Disease Through Suppression of KLK7-Mediated MAPK Signaling Pathway. Journal of molecular neuroscience : MN. vol 69. issue 2. 2020-02-10. PMID:31270675. |
the content of striatal dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), homovanillic acid (hva), 3-methoxytyrosine (3-mt), superoxide dismutase (sod), glutathione peroxidase (gsh-px), and malondialdehyde (mda); positive expression of tyrosine hydroxylase (th) and inducible nitric oxide synthase (inos); and the levels of il-1, il-6, tnf-α, inf-γ, and mapk signaling pathway-related genes were determined accordingly. |
2020-02-10 |
2023-08-13 |
mouse |
| Andrew E Christi. Identification of putative amine biosynthetic enzymes in the nervous system of the crab, Cancer borealis. Invertebrate neuroscience : IN. vol 19. issue 2. 2020-01-27. PMID:31263964. |
transcripts encoding full complements of the enzymes involved in the production of dopamine, octopamine, serotonin, and histamine were deduced from the c. borealis assembly, i.e., tryptophan-phenylalanine hydroxylase, tyrosine hydroxylase, dopa decarboxylase, tyrosine decarboxylase, tyramine β-hydroxylase, tryptophan hydroxylase, and histidine decarboxylase. |
2020-01-27 |
2023-08-13 |
Not clear |
| Berhanu Geresu, Ana Canseco-Alba, Branden Sanabria, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaivi, Ephrem Engidawor. Involvement of CB2 Receptors in the Neurobehavioral Effects of Molecules (Basel, Switzerland). vol 24. issue 17. 2020-01-22. PMID:31480324. |
locomotor activity test, immunohistochemistry, and reverse transcriptase polymerase chain reaction technique were utilized to assess locomotor activity, tyrosine hydroxylase immunoreactivity, and expression of dopamine transporter mrna gene. |
2020-01-22 |
2023-08-13 |
mouse |
| Berhanu Geresu, Ana Canseco-Alba, Branden Sanabria, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaivi, Ephrem Engidawor. Involvement of CB2 Receptors in the Neurobehavioral Effects of Molecules (Basel, Switzerland). vol 24. issue 17. 2020-01-22. PMID:31480324. |
khat extract also increased expression of tyrosine hydroxylase positive cells and expression of dopamine transporter mrna gene in wild type mice. |
2020-01-22 |
2023-08-13 |
mouse |
| Berhanu Geresu, Ana Canseco-Alba, Branden Sanabria, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaivi, Ephrem Engidawor. Involvement of CB2 Receptors in the Neurobehavioral Effects of Molecules (Basel, Switzerland). vol 24. issue 17. 2020-01-22. PMID:31480324. |
nevertheless, jwh133 did not alter the effect of khat extract on tyrosine hydroxylase immunoreactivity and dopamine transporter mrna expression when given together with khat extract. |
2020-01-22 |
2023-08-13 |
mouse |
| Hiroki Kurosaki, Kentaro Yamaguchi, Kohei Man-Yoshi, Shin-Ichi Muramatsu, Satoshi Hara, Hiroshi Ichinos. Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP. Neurochemistry international. vol 125. 2020-01-03. PMID:30739038. |
6r-5,6,7,8-tetrahydrobiopterin (bh4) is a cofactor for tyrosine hydroxylase (th), the rate-limiting enzyme for production of dopamine, and easily oxidized to its dihydro-form. |
2020-01-03 |
2023-08-13 |
mouse |
| Emmanuel Quansah, Tyra S C Zetterströ. Chronic methylphenidate preferentially alters catecholamine protein targets in the parietal cortex and ventral striatum. Neurochemistry international. vol 124. 2019-12-24. PMID:30660754. |
for this purpose, the density of dat, net, the vesicular monoamine transporter 2 (vmat2), the rate limiting enzyme for catecholamine synthesis tyrosine hydroxylase (th) and the dopamine d |
2019-12-24 |
2023-08-13 |
rat |