| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jesús M López, Daniel Lozano, Ruth Morona, Agustín Gonzále. Organization of the catecholaminergic systems in two basal actinopterygian fishes, Polypterus senegalus and Erpetoichthys calabaricus (Actinopterygii: Cladistia). The Journal of comparative neurology. vol 527. issue 2. 2020-06-17. PMID:30281776. |
we have investigated the catecholaminergic (ca) systems in the brain of two representative cladistian species, the bichir polypterus senegalus and the reedfish erpetoichthys calabaricus, by means of antibodies against tyrosine hydroxylase (th; the first enzyme in the synthesis of catecholamines) and dopamine (da). |
2020-06-17 |
2023-08-13 |
Not clear |
| Rafieh Alizadeh, Zohreh Bagher, Seyed Kamran Kamrava, Masoumeh Falah, Hatef Ghasemi Hamidabadi, Mahdi Eskandarian Boroujeni, Fatemeh Mohammadi, Sepideh Khodaverdi, Arash Zare-Sadeghi, Arta Olya, Ali Komeil. Differentiation of human mesenchymal stem cells (MSC) to dopaminergic neurons: A comparison between Wharton's Jelly and olfactory mucosa as sources of MSCs. Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30639339. |
however, it was demonstrated that having the same neuroectodermal origin as the nervous system, the olfactory ectomesenchymal stem cells (oe-mscs) expressed the neural marker map2 as well as dopaminergic markers such as tyrosine hydroxylase (th), dopamine transporter (dat) and pitx3 to a greater extent than the wj-mscs both at the level of mrna and protein. |
2020-06-15 |
2023-08-13 |
human |
| Sara Simorgh, Rafieh Alizadeh, Mina Eftekharzadeh, Seyed Mohammad Amin Haramshahi, Peiman Brouki Milan, Maryam Doshmanziari, Farnaz Ramezanpour, Mazaher Gholipourmalekabadi, Morteza Seifi, Fatemeh Morad. Olfactory mucosa stem cells: An available candidate for the treatment of the Parkinson's disease. Journal of cellular physiology. vol 234. issue 12. 2020-06-15. PMID:31173364. |
the results demonstrate that the expression of pax2, pax5, pitx3, dopamine transporter, and tyrosine hydroxylase was increased by oe-mscs compared to the control group which is analyzed with real-time polymerase chain reaction technique and immunohistochemical staining. |
2020-06-15 |
2023-08-13 |
rat |
| Eunna Chung, Youngsil Choi, Jiae Park, Wonheum Nah, Jaehyung Park, Yukdong Jung, Joonno Lee, Hyunji Lee, Soyoung Park, Sunyoung Hwang, Seongcheol Kim, Jongseok Lee, Dongjae Min, Junghwan Jo, Shinyoung Kang, Minyong Jung, Phil Hyu Lee, H Earl Ruley, Daewoong J. Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein. Science advances. vol 6. issue 18. 2020-06-06. PMID:32494688. |
last, icp-parkin prevented and reversed declines in tyrosine hydroxylase and dopamine expression concomitant with improved motor function induced by mitochondrial poisons or enforced α-synuclein expression. |
2020-06-06 |
2023-08-13 |
Not clear |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Swati Chaturvedi, M Wahajuddin, Shubha Shukl. Dopamine receptor activation mitigates mitochondrial dysfunction and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA lesioned rats: A role of Wnt signalling. Neurochemistry international. vol 129. 2020-06-01. PMID:31078578. |
unilateral administration of 6-ohda into medial forebrain bundle potentially reduced tyrosine hydroxylase immunoreactivity, dopamine content in substantia nigra pars compacta (snpc) and striatum region and impaired motor functions in adult rats. |
2020-06-01 |
2023-08-13 |
rat |
| Mostofa Jamal, Ikuko Tsukamoto, Maki Takata, Asuka Ito, Naoko Tanaka, Takanori Miki, Ayaka Takakura, Kiyoshi Ameno, Yasuo Kubota, Ryoji Konishi, Hiroshi Kinoshit. COA-Cl induces dopamine release and tyrosine hydroxylase phosphorylation: In vivo reverse microdialysis and in vitro analysis. Brain research. vol 1706. 2020-05-29. PMID:30366020. |
coa-cl induces dopamine release and tyrosine hydroxylase phosphorylation: in vivo reverse microdialysis and in vitro analysis. |
2020-05-29 |
2023-08-13 |
mouse |
| Yaping Chu, Scott Muller, Adriana Tavares, Olivier Barret, David Alagille, John Seibyl, Gilles Tamagnan, Ken Marek, Kelvin C Luk, John Q Trojanowski, Virginia M Y Lee, Jeffrey H Kordowe. Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes. Brain : a journal of neurology. vol 142. issue 11. 2020-05-26. PMID:31580415. |
nigral neurons with α-synuclein inclusions exhibited a phenotypic downregulation of the dopamine markers tyrosine hydroxylase and nurr1. |
2020-05-26 |
2023-08-13 |
monkey |
| Pedro Barbosa, Bimali Hapuarachchi, Atbin Djamshidian, Kate Strand, Andrew J Lees, Rohan de Silva, Janice L Holton, Thomas T Warne. Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours. Brain : a journal of neurology. vol 142. issue 11. 2020-05-26. PMID:31603207. |
no differences were seen between groups in the other brain areas and in the analysis of tyrosine hydroxylase and dopamine d2 receptor levels. |
2020-05-26 |
2023-08-13 |
Not clear |
| Akinyinka O Alabi, Abayomi M Ajayi, Benneth Ben-Azu, Osarume Omorobge, Solomon Umukor. Methyl jasmonate ameliorates rotenone-induced motor deficits in rats through its neuroprotective activity and increased expression of tyrosine hydroxylase immunopositive cells. Metabolic brain disease. vol 34. issue 6. 2020-05-14. PMID:31463866. |
decreased tyrosine hydroxylase (th) activity, due to degeneration of dopaminergic neurons contributes to the low dopamine content and the motor deficits that characterized parkinson's disease (pd). |
2020-05-14 |
2023-08-13 |
rat |
| Steven P Trau, William B Gallentine, Mohamad A Mikat. Child Neurology: A young child with an undiagnosed case of dystonia responsive to l-dopa. Neurology. vol 94. issue 7. 2020-05-14. PMID:32015175. |
classical drd is caused by deficiency of gtp cyclohydrolase 1 or tyrosine hydroxylase, but other conditions can cause dystonias that are partially responsive to dopamine. |
2020-05-14 |
2023-08-13 |
Not clear |
| Francesca Fiory, Paola Mirra, Cecilia Nigro, Francesca Chiara Pignalosa, Federica Zatterale, Luca Ulianich, Nella Prevete, Pietro Formisano, Francesco Beguinot, Claudia Miel. Role of the HIF-1α/Nur77 axis in the regulation of the tyrosine hydroxylase expression by insulin in PC12 cells. Journal of cellular physiology. vol 234. issue 7. 2020-05-11. PMID:30536670. |
tyrosine hydroxylase (th), catalyzing the conversion of tyrosine into l-dopa, is the rate-limiting enzyme in dopamine synthesis. |
2020-05-11 |
2023-08-13 |
Not clear |
| Matheus C Bianchini, Claudia Ortiz Alves Gularte, Pablo A Nogara, Bárbara N Krum, Mateus C Gayer, Jessika C Bridi, Daniel H Roos, Rafael Roehrs, Roselei Fachinetto, Simone Pinton, Daiana S Ávila, Frank Hirth, João B T Rocha, Robson L Punte. Thimerosal inhibits Drosophila melanogaster tyrosine hydroxylase (DmTyrH) leading to changes in dopamine levels and impaired motor behavior: implications for neurotoxicity. Metallomics : integrated biometal science. vol 11. issue 2. 2020-05-04. PMID:30516209. |
thimerosal inhibits drosophila melanogaster tyrosine hydroxylase (dmtyrh) leading to changes in dopamine levels and impaired motor behavior: implications for neurotoxicity. |
2020-05-04 |
2023-08-13 |
drosophila_melanogaster |
| Matheus C Bianchini, Claudia Ortiz Alves Gularte, Pablo A Nogara, Bárbara N Krum, Mateus C Gayer, Jessika C Bridi, Daniel H Roos, Rafael Roehrs, Roselei Fachinetto, Simone Pinton, Daiana S Ávila, Frank Hirth, João B T Rocha, Robson L Punte. Thimerosal inhibits Drosophila melanogaster tyrosine hydroxylase (DmTyrH) leading to changes in dopamine levels and impaired motor behavior: implications for neurotoxicity. Metallomics : integrated biometal science. vol 11. issue 2. 2020-05-04. PMID:30516209. |
we focused on the dopaminergic system, and the rate-limiting enzyme tyrosine hydroxylase (dmtyrh), to test the hypothesis that thim can impair dopamine (da) homeostasis and subsequently cause dysfunction. |
2020-05-04 |
2023-08-13 |
drosophila_melanogaster |
| Steven Vetel, Sophie Sérrière, Johnny Vercouillie, Jackie Vergote, Gabrielle Chicheri, Jean-Bernard Deloye, Frédéric Dollé, Sylvie Bodard, Claire Tronel, Lydie Nadal-Desbarats, Antoine Lefèvre, Patrick Emond, Sylvie Chalo. Extensive exploration of a novel rat model of Parkinson's disease using partial 6-hydroxydopamine lesion of dopaminergic neurons suggests new therapeutic approaches. Synapse (New York, N.Y.). vol 73. issue 3. 2020-04-22. PMID:30368914. |
the degenerative process was assessed through in vivo positron emission tomography (pet) imaging and in vitro autoradiographic quantitation of the striatal dopamine transporter (dat) and immunostaining of tyrosine hydroxylase (th). |
2020-04-22 |
2023-08-13 |
rat |
| Daniel Lozano, Ruth Morona, Agustín González, Jesús M Lópe. Comparative Analysis of the Organization of the Catecholaminergic Systems in the Brain of Holostean Fishes (Actinopterygii/Neopterygii). Brain, behavior and evolution. vol 93. issue 4. 2020-04-20. PMID:31711060. |
we have studied the catecholaminergic (caergic) systems by means of antibodies against tyrosine hydroxylase (th) and dopamine (da) in the brain of representative species of the 3 genera included in the 2 orders of holostean fishes: amia calva (amiiformes) and lepisosteus platyrhincus, lepisosteus oculatus, and atractosteus spatula (lepisosteiformes). |
2020-04-20 |
2023-08-13 |
Not clear |
| Elizabeth N Johnson, Teleza Westbrook, Rod Shayesteh, Emily L Chen, Joseph W Schumacher, David Fitzpatrick, Greg D Fiel. Distribution and diversity of intrinsically photosensitive retinal ganglion cells in tree shrew. The Journal of comparative neurology. vol 527. issue 1. 2020-04-16. PMID:29238991. |
surprisingly, these cells immunolabeled for tyrosine hydroxylase, a key component in dopamine synthesis. |
2020-04-16 |
2023-08-13 |
Not clear |
| Yasuhide Mitsumoto, Saika Takamori, Karin Kishid. Psychosocial stress enhances susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in C57BL/6N mice. Biomedical research (Tokyo, Japan). vol 40. issue 6. 2020-04-15. PMID:31839669. |
administration of mptp after ch for 24 h caused severe damage of striatal dopaminergic neurons as indicated by decreases in dopamine transporter and tyrosine hydroxylase proteins and an increase of glial fibrillary acidic protein levels compared to ch alone. |
2020-04-15 |
2023-08-13 |
mouse |
| Fenfen Ji, Zhou Zhu, Mengtao Zhang, Huan Zhang, Lin Zhu, Xiaodong Cai, Wenlan Liu, Juxian Song, Min Li, Zongwei Ca. 6-OH-BDE-47 exposure-induced Parkinson's disease pathology in Sprague Dawley rat. The Science of the total environment. vol 711. 2020-04-07. PMID:32000351. |
the resulting deteriorated motor function and decreased levels of striatal dopamine and nigrostriatal tyrosine hydroxylase indicate the dopaminergic neuron loss after the injection. |
2020-04-07 |
2023-08-13 |
rat |
| Wiebke Bensmann, Nicolas Zink, Larissa Arning, Christian Beste, Ann-Kathrin Stoc. The Presynaptic Regulation of Dopamine and Norepinephrine Synthesis Has Dissociable Effects on Different Kinds of Cognitive Conflicts. Molecular neurobiology. vol 56. issue 12. 2020-04-06. PMID:31183808. |
we investigated the effects of presynaptic differences in dopamine and norepinephrine synthesis with the help of the tyrosine hydroxylase (th) rs10770141 and the dopamine-β-hydroxylase (dbh) rs1611115, rs6271, and rs1611122 polymorphisms. |
2020-04-06 |
2023-08-13 |
human |
| N A Sinyakova, E Yu Bazhenova, E A Kulikova, D V Fursenko, A V Kuliko. [Effect of the C1473G Polymorphic Variant of the Tryptophan Hydroxylase 2 Gene and Photoperiod Length on the Dopamine System of the Mouse Brain]. Molekuliarnaia biologiia. vol 54. issue 1. 2020-04-06. PMID:32163389. |
the presence of the c1473g variant in the tryptophan hydroxylase 2 gene did not affect the expression of key genes of da system: drd1, drd2, scl6a3, th, and comt, that encode the d1 and d2 receptors, dopamine transporter, tyrosine hydroxylase, and catechol-o-methyltransferase, respectively. |
2020-04-06 |
2023-08-13 |
mouse |