| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Catherine F Moore, Michael Z Leonard, Nicholas M Micovic, Klaus A Miczek, Valentina Sabino, Pietro Cotton. Reward sensitivity deficits in a rat model of compulsive eating behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 4. 2020-12-28. PMID:31622973. |
we then quantified da release in the nucleus accumbens (nac) shell after treatment with d-amphetamine using in vivo microdialysis, quantified levels of tyrosine hydroxylase (th) and dopamine transporter (dat) mrna using quantitative polymerase chain reaction (qpcr), and lastly, quantified baseline extracellular da and function of dat in vivo using quantitative "no-net-flux" microdialysis. |
2020-12-28 |
2023-08-13 |
rat |
| Dirleise Colle, Danúbia Bonfanti Santos, Aline Aita Naime, Cinara Ludvig Gonçalves, Heloisa Ghizoni, Mariana Appel Hort, Marcelo Farin. Early Postnatal Exposure to Paraquat and Maneb in Mice Increases Nigrostriatal Dopaminergic Susceptibility to a Re-challenge with the Same Pesticides at Adulthood: Implications for Parkinson's Disease. Neurotoxicity research. vol 37. issue 1. 2020-12-21. PMID:31422567. |
however, pn pesticides exposure decreased the number of tyrosine hydroxylase (th)- and dopamine transporter (dat)-positive neurons in the substantia nigra pars compacta (snpc), as well as reduced th and dat immunoreactivity in the striatum. |
2020-12-21 |
2023-08-13 |
mouse |
| Xuran Li, Weiwei Yang, Xin Li, Min Chen, Chengwei Liu, Jie Li, Shun Y. Alpha-synuclein oligomerization and dopaminergic degeneration occur synchronously in the brain and colon of MPTP-intoxicated parkinsonian monkeys. Neuroscience letters. vol 716. 2020-12-14. PMID:31759083. |
here, in mptp-intoxicated cynomolgus monkeys, we showed a parallel daergic degeneration in the colon as well as in the substantia nigra and striatum (sn/str), as indicated by reduced expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2020-12-14 |
2023-08-13 |
human |
| Zhong-Wen Chang, Chin-Chyuan Chan. Novel protein kinase C participates catecholamine biosynthesis and immunocompetence modulation in haemocytes of Litopenaeus vannamei. Developmental and comparative immunology. vol 103. 2020-12-01. PMID:31563459. |
tyrosine hydroxylase and dopamine β-hydroxylase activities are significantly reduced in haemocytes of lvnpkc-silenced shrimp. |
2020-12-01 |
2023-08-13 |
Not clear |
| Z Syambani Ulha. Dopamine D2 receptor influences eye development and function in Zebrafish. Archivos de la Sociedad Espanola de Oftalmologia. vol 95. issue 2. 2020-11-23. PMID:31955999. |
dopamine is synthesized by tyrosine hydroxylase and is considered as a major catecholamine in the vertebrate retina, including zebrafish. |
2020-11-23 |
2023-08-13 |
zebrafish |
| Robin Ji, Morgan Smith, Yusuke Niimi, Maria E Karakatsani, Maria F Murillo, Vernice Jackson-Lewis, Serge Przedborski, Elisa E Konofago. Focused ultrasound enhanced intranasal delivery of brain derived neurotrophic factor produces neurorestorative effects in a Parkinson's disease mouse model. Scientific reports. vol 9. issue 1. 2020-11-06. PMID:31852909. |
herein, we evaluated whether the expression of tyrosine hydroxylase (th), the rate limiting enzyme in dopamine catalysis, could be enhanced by in + fus delivery of brain-derived neurotrophic factor (bdnf) in a toxin-based pd mouse model. |
2020-11-06 |
2023-08-13 |
mouse |
| Rafieh Alizadeh, Farnaz Ramezanpour, Amirhossein Mohammadi, Mina Eftekharzadeh, Sara Simorgh, Milad Kazemiha, Fatemeh Morad. Differentiation of human olfactory system-derived stem cells into dopaminergic neuron-like cells: A comparison between olfactory bulb and mucosa as two sources of stem cells. Journal of cellular biochemistry. vol 120. issue 12. 2020-11-05. PMID:31297865. |
quantitative real-time polymerase chain reaction analysis 3 weeks after induction demonstrated that the mrna expression of the dopaminergic activity markers tyrosine hydroxylase (th), dopamine transporter (dat), paired box gene 2 (pax2), and pax5 in the neuron-like cells derived from ob-nscs was significantly higher than those derived from oe-mscs. |
2020-11-05 |
2023-08-13 |
human |
| Mohammad D Memon, Sadaf Faiz, Mitul P Zaveri, Jamal C Perry, Tayná M Schuetz, Ivan Cancarevi. Unraveling the Mysteries of Restless Leg Syndrome. Cureus. vol 12. issue 10. 2020-10-22. PMID:33083159. |
they also highlight the role of iron in the pathogenesis of rls as it is required for the synthesis of tyrosine hydroxylase, which is the rate-limiting step for dopamine synthesis. |
2020-10-22 |
2023-08-13 |
Not clear |
| Dasiel O Borroto-Escuela, Kjell Fux. On the G Protein-Coupled Receptor Neuromodulation of the Claustrum. Neurochemical research. vol 45. issue 1. 2020-10-19. PMID:31172348. |
double immunolabeling studies on dopamine (da) d1 receptor (d1r) and tyrosine hydroxylase (th) immunoreactivities (ir) demonstrated that d1r ir existed in almost all claustral and dorsal endopiriform nucleus (den) nerve cell bodies, known as glutamate projection neurons, and d4r ir in large numbers of nerve cell bodies of the claustrum and den. |
2020-10-19 |
2023-08-13 |
rat |
| Namrata Mittra, Amit Kumar Chauhan, Garima Singh, Devendra Kumar Patel, Chetna Sing. Postnatal zinc or paraquat administration increases paraquat or zinc-induced loss of dopaminergic neurons: insight into augmented neurodegeneration. Molecular and cellular biochemistry. vol 467. issue 1-2. 2020-10-19. PMID:32060784. |
while the expression of vesicular monoamine transporter-2 and tyrosine hydroxylase were attenuated, dopamine transporter and microglial marker iba-1 expression, activated microglia, nuclear factor-kappa b activation, mitochondrial cytochrome c release and caspase-3/9 activation were augmented following zn or pq exposure. |
2020-10-19 |
2023-08-13 |
rat |
| Daniela Impellizzeri, Michela Campolo, Giuseppe Bruschetta, Rosalia Crupi, Marika Cordaro, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposit. Traumatic Brain Injury Leads to Development of Parkinson's Disease Related Pathology in Mice. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:27790086. |
following tbi there was a significant decrease in expression of tyrosine hydroxylase and dopamine transporter in the substantia nigra as well as significant behavioral alterations. |
2020-10-01 |
2023-08-13 |
mouse |
| Yunseon Jang, Min Joung Lee, Jeongsu Han, Soo Jeong Kim, Ilhwan Ryu, Xianshu Ju, Min Jeong Ryu, Woosuk Chung, Eungseok Oh, Gi Ryang Kweon, Jun Young He. A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities. Experimental neurobiology. vol 26. issue 2. 2020-10-01. PMID:28442947. |
a dopaminergic neuronal pathway from the substantia nigra (sn) to the striatum is responsible for regulating grip strength and motor initiation through tyrosine hydroxylase (th) activity-dependent dopamine release. |
2020-10-01 |
2023-08-13 |
mouse |
| Liliane Tenenbaum, Marie Humbert-Claud. Glial Cell Line-Derived Neurotrophic Factor Gene Delivery in Parkinson's Disease: A Delicate Balance between Neuroprotection, Trophic Effects, and Unwanted Compensatory Mechanisms. Frontiers in neuroanatomy. vol 11. 2020-10-01. PMID:28442998. |
in addition to its anti-apoptotic and neurotrophic properties, gdnf also interferes with dopamine homeostasis via time and dose-dependent effects such as: stimulation of dopamine neuron excitability, inhibition of dopamine transporter activity, tyrosine hydroxylase phosphorylation, and inhibition of tyrosine hydroxylase transcription. |
2020-10-01 |
2023-08-13 |
human |
| Katrine Fabricius, Pernille Barkholt, Jacob Jelsing, Henrik H Hanse. Application of the Physical Disector Principle for Quantification of Dopaminergic Neuronal Loss in a Rat 6-Hydroxydopamine Nigral Lesion Model of Parkinson's Disease. Frontiers in neuroanatomy. vol 11. 2020-10-01. PMID:29276478. |
therefore, we applied an established automated physical disector principle in a fractionator design for efficient stereological quantitative analysis of tyrosine hydroxylase (th)-positive dopamine neurons in the substantia nigra pars compacta of hemiparkinsonian rats with unilateral 6-hydroxydopamine (6-ohda) lesions. |
2020-10-01 |
2023-08-13 |
rat |
| Bence Paul, Dominic J Hare, David P Bishop, Chad Paton, Van Tran Nguyen, Nerida Cole, Megan M Niedwiecki, Erica Andreozzi, Angela Vais, Jessica L Billings, Lisa Bray, Ashley I Bush, Gawain McColl, Blaine R Roberts, Paul A Adlard, David I Finkelstein, John Hellstrom, Janet M Hergt, Jon D Woodhead, Philip A Dobl. Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging. Chemical science. vol 6. issue 10. 2020-10-01. PMID:29449912. |
we used gold (au) nanoparticle and ytterbium (yb)-tagged tyrosine hydroxylase antibodies to assess the co-localisation of fe and dopamine throughout the entire mouse brain. |
2020-10-01 |
2023-08-13 |
mouse |
| Jorge A Avila, Roseanna M Zanca, Denis Shor, Nicholas Paleologos, Amber A Alliger, Maria E Figueiredo-Pereira, Peter A Serran. Chronic voluntary oral methamphetamine induces deficits in spatial learning and hippocampal protein kinase Mzeta with enhanced astrogliosis and cyclooxygenase-2 levels. Heliyon. vol 4. issue 2. 2020-10-01. PMID:29560440. |
compared to controls, the voma paradigm also induced decreases in hippocampal levels of dopamine transporter (dat) and tyrosine hydroxylase (th), as well as increases in dopamine 1 receptor (d1r), glial fibrillary acidic protein (gfap) and cyclooxygenase-2 (cox-2), with a decrease in prostaglandins e2 (pge2) and d2 (pgd2). |
2020-10-01 |
2023-08-13 |
mouse |
| Rebecca Playne, Kathryn Jones, Bronwen Conno. Generation of dopamine neuronal-like cells from induced neural precursors derived from adult human cells by non-viral expression of lineage factors. Journal of stem cells & regenerative medicine. vol 14. issue 1. 2020-10-01. PMID:30018471. |
previous reports have indicated that induced neural precursors (inps) derived from adult human fibroblasts by lineage factor-mediated direct reprogramming can give rise to dopamine neurons expressing tyrosine hydroxylase (th+). |
2020-10-01 |
2023-08-13 |
human |
| Stefano Di Santo, Hans R Widme. Neurotrophic factor-based strategies to enhance survival and differentiation of neural progenitor cells toward the dopaminergic phenotype. Brain circulation. vol 4. issue 3. 2020-10-01. PMID:30450422. |
using organotypic explant cultures of fetal human ventral mesencephalon, we observed that nt-4/5 and gdnf as single factors, or in combination on daergic neurons, increased survival and number of tyrosine hydroxylase immunoreactive neurons as well as the dopamine content in the culture medium. |
2020-10-01 |
2023-08-13 |
human |
| Xuan He, Shuangshuang Yang, Rui Zhang, Lina Hou, Jianrong Xu, Yaer Hu, Rang Xu, Hao Wang, Yongfang Zhan. Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid-Lesioned Parkinson's Disease Models. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30804756. |
smi increased the tyrosine hydroxylase (th) positive and nissl positive neuron number in the substantia nigra pars compacta (snpc), augmented striatal da and its metabolites concentration and elevated striatal dopamine transporter density (dat). |
2020-10-01 |
2023-08-13 |
mouse |
| Ling-Ling Fan, Bo Deng, Jun-Bao Yan, Zhi-Hong Hu, Ai-Hong Ren, Dong-Wei Yan. Lesions of mediodorsal thalamic nucleus reverse abnormal firing of the medial prefrontal cortex neurons in parkinsonian rats. Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089064. |
results demonstrated that after injury, the immunoreactivity of dopamine neurons and tyrosine hydroxylase decreased in the substantia nigra compacta and ventral tegmental areas of rats. |
2020-10-01 |
2023-08-13 |
rat |