| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rahul Patel, Joshua M Bradner, Kristen A Stout, William Michael Caudl. Alteration to Dopaminergic Synapses Following Exposure to Perfluorooctane Sulfonate (PFOS), in Vitro and in Vivo. Medical sciences (Basel, Switzerland). vol 4. issue 3. 2020-09-30. PMID:29083377. |
however, subsequent exposure to the selective dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) significantly reduced the expression of dopamine transporter (dat) and tyrosine hydroxylase (th), and resulted in an even greater reduction in dat expression in animals previously exposed to pfos. |
2020-09-30 |
2023-08-13 |
mouse |
| Mei-Fang Liu, Yan Xue, Cui Liu, Yun-Hai Liu, Hui-Ling Diao, Ying Wang, Yi-Peng Pan, Lei Che. Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson's Disease. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30524223. |
the results from animal experiments demonstrated that orexin-a attenuated the loss of dopaminergic neurons and the decrease of tyrosine hydroxylase (th) expression in the substantia nigra, normalized the striatal dopaminergic fibers, and prevented the depletion of dopamine and its metabolites in the striatum. |
2020-09-30 |
2023-08-13 |
mouse |
| Sergio D Iñiguez, Antonio Aubry, Lace M Riggs, Jason B Alipio, Roseanna M Zanca, Francisco J Flores-Ramirez, Mirella A Hernandez, Steven J Nieto, David Musheyev, Peter A Serran. Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice. Neurobiology of stress. vol 5. 2020-09-29. PMID:27981196. |
hippocampi were then dissected and western blots were conducted to quantify protein levels for various markers important for synaptic plasticity including protein kinase m zeta (pkmζ), protein kinase c zeta (pkcζ), the dopamine-1 (d1) receptor, tyrosine hydroxylase (th), and the dopamine transporter (dat). |
2020-09-29 |
2023-08-13 |
mouse |
| Minghui Shan, Sen Lin, Shurong Li, Yuchen Du, Haixia Zhao, Huarong Hong, Ming Yang, Xi Yang, Yongmei Wu, Liyi Ren, Jiali Peng, Jing Sun, Hongli Zhou, Bingyin S. TIR-Domain-Containing Adapter-Inducing Interferon-β (TRIF) Is Essential for MPTP-Induced Dopaminergic Neuroprotection via Microglial Cell M1/M2 Modulation. Frontiers in cellular neuroscience. vol 11. 2020-09-29. PMID:28275337. |
in the mptp induced neurodegeneration model, we examined the concentration of dopamine (da) related metabolites and the survival of tyrosine hydroxylase (th) positive cells in wt and |
2020-09-29 |
2023-08-13 |
Not clear |
| Domenico Bucci, Carla L Busceti, Maria T Calierno, Paola Di Pietro, Michele Madonna, Francesca Biagioni, Larisa Ryskalin, Fiona Limanaqi, Ferdinando Nicoletti, Francesco Forna. Systematic Morphometry of Catecholamine Nuclei in the Brainstem. Frontiers in neuroanatomy. vol 11. 2020-09-29. PMID:29163071. |
tyrosine hydroxylase (th) immune-positive cells of the brainstem correspond to dopamine (da)-, norepinephrine (ne)-, and epinephrine (e)-containing cells. |
2020-09-29 |
2023-08-13 |
mouse |
| Lisette Blanco-Lezcano, Esteban Alberti-Amador, Mei-Li Díaz-Hung, María Elena González-Fraguela, Bárbara Estupiñán-Díaz, Teresa Serrano-Sánchez, Liliana Francis-Turner, Javier Jiménez-Martín, Yamilé Vega-Hurtado, Isabel Fernández-Jiméne. Tyrosine Hydroxylase, Vesicular Monoamine Transporter and Dopamine Transporter mRNA Expression in Nigrostriatal Tissue of Rats with Pedunculopontine Neurotoxic Lesion. Behavioral sciences (Basel, Switzerland). vol 8. issue 2. 2020-09-29. PMID:29389881. |
tyrosine hydroxylase, vesicular monoamine transporter and dopamine transporter mrna expression in nigrostriatal tissue of rats with pedunculopontine neurotoxic lesion. |
2020-09-29 |
2023-08-13 |
rat |
| Gizem Turac, Gokhan Duruksu, Erdal Karao. The Effect of Recombinant Tyrosine Hydroxylase Expression on the Neurogenic Differentiation Potency of Mesenchymal Stem Cells. Neurospine. vol 15. issue 1. 2020-09-29. PMID:29656620. |
tyrosine hydroxylase (th) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. |
2020-09-29 |
2023-08-13 |
rat |
| Diptaman Chatterjee, Mansi Bhatt, David Butler, Erwin De Genst, Christopher M Dobson, Anne Messer, Jeffrey H Kordowe. Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson's disease model. NPJ Parkinson's disease. vol 4. 2020-09-29. PMID:30155513. |
vh14*pest showed considerable maintenance of striatal dopaminergic tone in comparison to saline-treated and nbsyn87*pest-treated animals as measured by tyrosine hydroxylase immunoreactivity (optical density), dat immunoreactivity (optical density), and dopamine concentration (high-performance liquid chromatography). |
2020-09-29 |
2023-08-13 |
rat |
| Cong Zheng, Guiqin Chen, Yang Tan, Weiqi Zeng, Qiwei Peng, Ji Wang, Chi Cheng, Xiaoman Yang, Shuke Nie, Yan Xu, Zhentao Zhang, Stella M Papa, Keqiang Ye, Xuebing Ca. TRH Analog, Taltirelin Improves Motor Function of Hemi-PD Rats Without Inducing Dyskinesia via Sustained Dopamine Stimulating Effect. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30555300. |
the da-releasing effect of taltirelin was alleviated by reserpine, vanoxerine (gbr12909) or ampt, indicating a mechanism involving vesicular monoamine transporter-2 (vmat-2), dopamine transporter (dat) and tyrosine hydroxylase (th). |
2020-09-29 |
2023-08-13 |
rat |
| Qi Chen, Shurong Li, Yuping Han, Xiaohong Wei, Juan Du, Xiaolin Wang, Bingyin Su, Jun L. Toxicological effects of propofol abuse on the dopaminergic neurons in ventral tegmental area and corpus striatum and its potential mechanisms. The Journal of toxicological sciences. vol 45. issue 7. 2020-09-29. PMID:32612007. |
collectively, our present work suggested long-term abuse of propofol induces neuropsychiatric function impairments, and the possible mechanisms are related to dopamine dyssynthesis via down-regulating tyrosine hydroxylase and dopamine transporter. |
2020-09-29 |
2023-08-13 |
mouse |
| Ruchi Sharma, Imke P M Smits, Laura De La Vega, Christopher Lee, Stephanie M Willert. 3D Bioprinting Pluripotent Stem Cell Derived Neural Tissues Using a Novel Fibrin Bioink Containing Drug Releasing Microspheres. Frontiers in bioengineering and biotechnology. vol 8. 2020-09-28. PMID:32117936. |
these bioprinted neural tissues expressed tuj1 (15 ± 1.3%), the dopamine marker, tyrosine hydroxylase (th) (8 ± 1%) and other glial markers such as glial fibrillary acidic protein (gfap) (15 ± 4%) and oligodendrocyte progenitor marker (o4) (4 ± 1%) after 30 days. |
2020-09-28 |
2023-08-13 |
human |
| Dong-Joo Hwang, Ki-Chun Kwon, Hyun-Keun Song, Kil-Soo Kim, Young-Suk Jung, Dae-Youn Hwang, Joon-Yong Ch. Comparative analysis of dose-dependent neurotoxic response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 N mice derived from three different sources. Laboratory animal research. vol 35. 2020-09-28. PMID:32257898. |
we measured biological features (body weight, temperature, and composition), nigrostriatal neurotoxic responses (dopamine levels, tyrosine hydroxylase enzymes, and protein carbonylation) and motor function. |
2020-09-28 |
2023-08-13 |
mouse |
| Giorgio Turconi, Jaakko Kopra, Vootele Võikar, Natalia Kulesskaya, Carolina Vilenius, T Petteri Piepponen, Jaan-Olle Andresso. Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice. Molecular therapy. Methods & clinical development. vol 17. 2020-09-28. PMID:32368564. |
in pre-clinical models, ectopic gdnf is effective but causes adverse effects, including downregulation of tyrosine hydroxylase, only a transient boost in dopamine metabolism, aberrant neuronal sprouting, and hyperactivity. |
2020-09-28 |
2023-08-13 |
mouse |
| Geiza Fernanda Antunes, Flavia Venetucci Gouveia, Fabiana Strambio Rezende, Midiã Dias de Jesus Seno, Milene Cristina de Carvalho, Caroline Cruz de Oliveira, Lennon Cardoso Tosati Dos Santos, Marina Correia de Castro, Mayra Akemi Kuroki, Manoel Jacobsen Teixeira, José Pinhata Otoch, Marcus Lira Brandao, Erich Talamoni Fonoff, Raquel Chacon Ruiz Martine. Dopamine modulates individual differences in avoidance behavior: A pharmacological, immunohistochemical, neurochemical and volumetric investigation. Neurobiology of stress. vol 12. 2020-09-28. PMID:32435668. |
furthermore, we quantified the contents of dopamine and metabolites (3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva)) in the amygdala, evaluated the basal levels of tyrosine hydroxylase expression (catecholamine synthesis enzyme) and measured the volume of the substantia nigra, ventral tegmental area and locus coeruleus. |
2020-09-28 |
2023-08-13 |
Not clear |
| Thomson Patrick Joseph, Nataraj Jagadeesan, Liu Yang Sai, Stanley Li Lin, Sudhanshu Sahu, Melitta Schachne. Adhesion Molecule L1 Agonist Mimetics Protect Against the Pesticide Paraquat-Induced Locomotor Deficits and Biochemical Alterations in Zebrafish. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32547358. |
both l1 mimetic compounds prevented reduction in tyrosine hydroxylase and dopamine levels, reduced reactive oxygen species (ros) generation, protected against impairment of mitochondrial viability, improved the antioxidant enzyme system, and prevented a decrease in atp levels. |
2020-09-28 |
2023-08-13 |
zebrafish |
| Govindhasamy Pushpavathi Selvakumar, Mohammad Ejaz Ahmed, Shankar S Iyer, Ramasamy Thangavel, Duraisamy Kempuraj, Sudhanshu P Raikwar, Kieran Bazley, Kristopher Wu, Asher Khan, Klaudia Kukulka, Bret Bussinger, Smita Zaheer, Casey Burton, Donald James, Asgar Zahee. Absence of Glia Maturation Factor Protects from Axonal Injury and Motor Behavioral Impairments after Traumatic Brain Injury. Experimental neurobiology. vol 29. issue 3. 2020-09-28. PMID:32565489. |
results reveal a significant improvement in substantia nigral tyrosine hydroxylase and dopamine transporter expression with motor behavioral performance in gmf-ko mice following tbi. |
2020-09-28 |
2023-08-13 |
mouse |
| Shankhamala Sen, Pooja Parishar, Arvind Singh Pundir, Anton Reiner, Soumya Iyenga. The expression of tyrosine hydroxylase and DARPP-32 in the house crow (Corvus splendens) brain. The Journal of comparative neurology. vol 527. issue 11. 2020-09-14. PMID:30697741. |
since the catecholaminergic system, especially the neurotransmitter dopamine, plays a role in cognition, we decided to study the distribution of tyrosine hydroxylase (th), the rate-limiting enzyme in the synthesis of catecholamines in the brain of house crows (corvus splendens). |
2020-09-14 |
2023-08-13 |
crow |
| Radouane El Fari, Abdellatif Abbaoui, Anas Bourziq, Mohamed Zroudi, Ahmed Draoui, Abdelaati El Khiat, Mounir Belkouch, Abdeljalil Elgot, Halima Gamran. Neuroprotective effects of docosahexaenoic acid against sub-acute manganese intoxication induced dopaminergic and motor disorders in mice. Journal of chemical neuroanatomy. vol 102. 2020-09-14. PMID:31562917. |
data also showed the ability of mn to disrupt dopamine neurotransmission by altering tyrosine hydroxylase activity in the nigrostriatal pathway while in pretreated animals, dha prevented this disruption. |
2020-09-14 |
2023-08-13 |
mouse |
| Suresh B Rangasamy, Sridevi Dasarathi, Priyanka Pahan, Malabendu Jana, Kalipada Paha. Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 2. 2020-09-11. PMID:30187283. |
low-dose aspirin upregulates tyrosine hydroxylase and increases dopamine production in dopaminergic neurons: implications for parkinson's disease. |
2020-09-11 |
2023-08-13 |
mouse |
| Suresh B Rangasamy, Sridevi Dasarathi, Priyanka Pahan, Malabendu Jana, Kalipada Paha. Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 2. 2020-09-11. PMID:30187283. |
although tyrosine hydroxylase (th) is the rate-limiting enzyme in the dopamine (da) biosynthesis pathway, there are no effective drugs/molecules to upregulate th and increase the production of da in nigral dopaminergic neurons. |
2020-09-11 |
2023-08-13 |
mouse |