| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suresh B Rangasamy, Sridevi Dasarathi, Priyanka Pahan, Malabendu Jana, Kalipada Paha. Low-Dose Aspirin Upregulates Tyrosine Hydroxylase and Increases Dopamine Production in Dopaminergic Neurons: Implications for Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 2. 2020-09-11. PMID:30187283. |
although tyrosine hydroxylase (th) is the rate-limiting enzyme in the dopamine (da) biosynthesis pathway, there are no effective drugs/molecules to upregulate th and increase the production of da in nigral dopaminergic neurons. |
2020-09-11 |
2023-08-13 |
mouse |
| Falk W Lohoff, Gregory V Carr, Bethany Brookshire, Thomas N Ferraro, Irwin Luck. Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling. Brain research. vol 1712. 2020-09-11. PMID:30685272. |
protein expression of tyrosine hydroxylase and d2 dopamine receptors was measured using western blot analysis. |
2020-09-11 |
2023-08-13 |
mouse |
| Falk W Lohoff, Gregory V Carr, Bethany Brookshire, Thomas N Ferraro, Irwin Luck. Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling. Brain research. vol 1712. 2020-09-11. PMID:30685272. |
results show that vmat1 ko mice have decreased dopamine levels in the frontal cortex, increased postsynaptic d2 expression, and lower frontal cortex tyrosine hydroxylase expression compared to wt mice. |
2020-09-11 |
2023-08-13 |
mouse |
| Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Kai Zhang, Kenji Hashimot. Antibiotic-induced microbiome depletion protects against MPTP-induced dopaminergic neurotoxicity in the brain. Aging. vol 11. issue 17. 2020-09-02. PMID:31479418. |
mptp significantly decreased dopamine transporter (dat) immunoreactivity in the striatum and tyrosine hydroxylase (th) immunoreactivity in the substantia nigra of water-treated mice. |
2020-09-02 |
2023-08-13 |
mouse |
| Thomas Gerald Mast, Kelsey Zuk, Andrew Rinke, Khaleel Quasem, Bradley Savard, Charles Brobbey, Jacob Reiss, Michael Dryde. Temporary Anosmia in Mice Following Nasal Lavage With Dilute Detergent Solution. Chemical senses. vol 44. issue 8. 2020-08-28. PMID:31363734. |
olfactory sensory deprivation induces anosmia and reduces tyrosine hydroxylase and dopamine levels in the olfactory bulb. |
2020-08-28 |
2023-08-13 |
mouse |
| Thomas Gerald Mast, Kelsey Zuk, Andrew Rinke, Khaleel Quasem, Bradley Savard, Charles Brobbey, Jacob Reiss, Michael Dryde. Temporary Anosmia in Mice Following Nasal Lavage With Dilute Detergent Solution. Chemical senses. vol 44. issue 8. 2020-08-28. PMID:31363734. |
one treatment-induced anosmia that lasted 24 to 48 h. three treatments over 5 days reduced olfactory bulb tyrosine hydroxylase and dopamine levels indicating that anosmia persists between treatments. |
2020-08-28 |
2023-08-13 |
mouse |
| Ju Hwan Kim, Choong-Hyun Lee, Hyung-Gun Kim, Hak Rim Ki. Decreased dopamine in striatum and difficult locomotor recovery from MPTP insult after exposure to radiofrequency electromagnetic fields. Scientific reports. vol 9. issue 1. 2020-08-19. PMID:30718744. |
rf-emf exposure led to a reduction in dopamine concentration in the striatum and also to a decrease in the expression of tyrosine hydroxylase in striatal neurons. |
2020-08-19 |
2023-08-13 |
mouse |
| Qiaohui Lu, Akihiro Mouri, Yang Yang, Kazuo Kunisawa, Tomoaki Teshigawara, Mami Hirakawa, Yuko Mori, Yasuko Yamamoto, Zou Libo, Toshitaka Nabeshima, Kuniaki Sait. Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression. Behavioural brain research. vol 372. 2020-08-19. PMID:31288060. |
the levels of dopamine, its metabolites and turnover, and protein level of tyrosine hydroxylase (th) were increased by cums in the nucleus accumbens (nac). |
2020-08-19 |
2023-08-13 |
mouse |
| Adithya Gopinath, Andria Doty, Phillip M Mackie, Basil Hashimi, Madison Francis, Leila Saadatpour, Kaustuv Saha, Gerry Shaw, Adolfo Ramirez-Zamora, Michael S Okun, Wolfgang J Streit, Habibeh Khoshboue. A novel approach to study markers of dopamine signaling in peripheral immune cells. Journal of immunological methods. vol 476. 2020-08-17. PMID:31634479. |
human monocytes express known markers of dopamine synthesis, storage and clearance, including dopamine transporter (dat), tyrosine hydroxylase (th), all subtypes of dopamine receptors and vesicular monoamine transporter 2 (vmat2). |
2020-08-17 |
2023-08-13 |
human |
| Amanda L Blaker, Eric A Rodriguez, Bryan K Yamamot. Neurotoxicity to dopamine neurons after the serial exposure to alcohol and methamphetamine: Protection by COX-2 antagonism. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31228610. |
these effects preceded the activation of cleaved caspase-3 in dopamine cell bodies, as well as decreases in tyrosine hydroxylase (th) immunoreactivity in the substantia nigra and dopamine transporter (dat) immunoreactivity in the striatum measured at 7 days after meth. |
2020-08-14 |
2023-08-13 |
rat |
| Anthony Klambatsen, Stephanie K Nygard, Anna J Chang, Vanya Quinones, Shirzad Jena. Sex differences in memory and intracellular signaling after methamphetamine binge treatment. Brain research. vol 1711. 2020-08-04. PMID:30629943. |
we did not find a significant effect of methamphetamine on the dopamine neuron markers tyrosine hydroxylase (th) or dopamine transporter (dat) 7 days after methamphetamine administrations. |
2020-08-04 |
2023-08-13 |
rat |
| Mikyung Kim, Raly James Custodio, Chrislean Jun Botanas, June Bryan de la Peña, Leandro Val Sayson, Arvie Abiero, Zae Young Ryoo, Jae Hoon Cheong, Hee Jin Ki. The circadian gene, Per2, influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice. Addiction biology. vol 24. issue 5. 2020-08-03. PMID:30091820. |
in addition, we measured expression levels of dopamine and dopamine-related genes (monoamine oxidase a, da receptor 1, da receptor 2, da active transporter, tyrosine hydroxylase and camp response element-binding protein 1) in the striatum of the mice after repeated meth treatments, using qrt-pcr. |
2020-08-03 |
2023-08-13 |
mouse |
| Mostafa A Rabie, Mai A Abd El Fattah, Noha N Nassar, Dalaal M Abdallah, Hanan S El-Abha. Correlation between angiotensin 1-7-mediated Mas receptor expression with motor improvement, activated STAT3/SOCS3 cascade, and suppressed HMGB-1/RAGE/NF-κB signaling in 6-hydroxydopamine hemiparkinsonian rats. Biochemical pharmacology. vol 171. 2020-07-27. PMID:31669235. |
this correlation extends to involve other effects of ang 1-7, such as the increased striatal dopamine content (r = 0.98, p = 0.0005), substantia nigra pars compacta tyrosine hydroxylase immune-reactivity (r = 0.97, p = 0.001), active py705-stat3 (r = 0.99, p < 0.0001) and socs3 (r = 0.99, p < 0.0001). |
2020-07-27 |
2023-08-13 |
rat |
| Li Ma, Jiaxin Song, Xueying Sun, Wenyong Ding, Kaiyang Fan, Minghua Qi, Yuefei Xu, Wenli Zhan. Role of microtubule-associated protein 6 glycosylated with Gal-(β-1,3)-GalNAc in Parkinson's disease. Aging. vol 11. issue 13. 2020-07-22. PMID:31289257. |
induction of pd-like features was verified by assessing motor impairment and confirming reductions in biological markers, including dopamine, 5-hydroxytryptamine and tyrosine hydroxylase, as well as the aggregation of α-synuclein. |
2020-07-22 |
2023-08-13 |
mouse |
| Marianna A Pagida, Anastasia E Konstantinidou, Margarita A Chrysanthou-Piterou, Efstratios S Patsouris, Maria T Panayotacopoulo. Apoptotic Markers in the Midbrain of the Human Neonate After Perinatal Hypoxic/Ischemic Injury. Journal of neuropathology and experimental neurology. vol 79. issue 1. 2020-07-20. PMID:31803912. |
our previous postmortem studies on neonates with neuropathological injury of perinatal hypoxia/ischemia (phi) showed a dramatic reduction of tyrosine hydroxylase expression (dopamine synthesis enzyme) in substantia nigra (sn) neurons, with reduction of their cellular size. |
2020-07-20 |
2023-08-13 |
human |
| Bai Xue, Wen Xiao, Hong Tia. Nei-like 1 inhibition results in motor dysfunction and promotes inflammation in Parkinson's disease mice model. Biochemical and biophysical research communications. vol 521. issue 1. 2020-07-06. PMID:31653343. |
furthermore, da neuronal loss was further accelerated by neil1 deletion in 6-ohda-injected mice, as evidenced by the significantly reduced expression of tyrosine hydroxylase (th) and dopamine transporter (dat). |
2020-07-06 |
2023-08-13 |
mouse |
| Zaher Arraf, Moussa B H Youdi. Prevention of MPTP (N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) dopaminergic neurotoxicity in mice by chronic lithium: involvements of Bcl-2 and Bax. Neuropharmacology. vol 46. issue 8. 2020-06-29. PMID:32585786. |
with the diet containing the highest lithium concentration there was an almost complete prevention of striatal dopamine depletion and the reduction in tyrosine hydroxylase activity and protein and it prevented the increase in dopamine turnover (dopac+hva/da) normally observed in mptp treatment. |
2020-06-29 |
2023-08-13 |
mouse |
| Airi Otsuka, Kenta Shimomura, Haruka Niwa, Nao Kagaw. The presence of a conspecific induces risk-taking behaviour and enlargement of somata size of dopaminergic neurons in the brain of male medaka fish. Journal of fish biology. vol 96. issue 4. 2020-06-25. PMID:32060927. |
large somata expressing tyrosine hydroxylase, which is the rate-limiting enzyme in dopamine synthesis, were detected in the telencephalic and diencephalic brain regions in risk-taking medaka, whereas large somata were detected in the diencephalic region in medaka confined to the dark condition. |
2020-06-25 |
2023-08-13 |
Not clear |
| Shuang Liu, Miao Yu, Xincen Xie, Yiran Ru, Shaoguo R. Carbofuran induces increased anxiety-like behaviors in female zebrafish (Danio rerio) through disturbing dopaminergic/norepinephrinergic system. Chemosphere. vol 253. 2020-06-24. PMID:32278909. |
the results demonstrated that acute carbofuran exposure stimulated the mrna expression and enzyme activity of tyrosine hydroxylase, which sequentially induced the increased levels of dopamine and norepinephrine. |
2020-06-24 |
2023-08-13 |
zebrafish |
| Shuang Liu, Miao Yu, Xincen Xie, Yiran Ru, Shaoguo R. Carbofuran induces increased anxiety-like behaviors in female zebrafish (Danio rerio) through disturbing dopaminergic/norepinephrinergic system. Chemosphere. vol 253. 2020-06-24. PMID:32278909. |
tyrosine hydroxylase inhibitor relieved the anxiety-related changes induced by carbofuran, confirming the overactive tyrosine hydroxylase-mediated accumulation of dopamine and norepinephrine in the brain was one of the main reasons for carbofuran-induced anxiety-like behaviors in the female zebrafish. |
2020-06-24 |
2023-08-13 |
zebrafish |