| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suguru Uemura, Kyaw San Lin, Khin Kyae Mon Thwin, Naoko Nakatani, Toshiaki Ishida, Nobuyuki Yamamoto, Akihiro Tamura, Atsuro Saito, Takeshi Mori, Daiichiro Hasegawa, Yoshiyuki Kosaka, Nanako Nino, China Nagano, Satoru Takafuji, Kazumoto Iijima, Noriyuki Nishimur. Limited correlation between tumor markers and minimal residual disease detected by seven neuroblastoma-associated mRNAs in high-risk neuroblastoma patients. Molecular and clinical oncology. vol 15. issue 1. 2021-06-01. PMID:34055352. |
the level of bm-mrd and pb-mrd was determined by quantifying 7 nb-mrnas (collapsin response mediator protein 1, dopamine beta-hydroxylase, dopa decarboxylase, growth-associated protein 43, isl lim homeobox 1, pairedlike homeobox 2b and tyrosine hydroxylase) using droplet digital pcr. |
2021-06-01 |
2023-08-13 |
Not clear |
| Rahul Bharatiya, Jessica Bratzu, Carla Lobina, Giulia Corda, Cristina Cocco, Philippe De Deurwaerdere, Antonio Argiolas, Maria Rosaria Melis, Fabrizio Sann. The pesticide fipronil injected into the substantia nigra of male rats decreases striatal dopamine content: A neurochemical, immunohistochemical and behavioral study. Behavioural brain research. vol 384. 2021-05-20. PMID:32070689. |
sixteen days after fipronil or dmso injection into the substantia nigra, rats were sacrificed, and either striatal dopamine content or substantia nigra tyrosine hydroxylase (th) immunoreactivity were measured. |
2021-05-20 |
2023-08-13 |
rat |
| Leandro Val Sayson, Raly James Perez Custodio, Darlene Mae Ortiz, Hyun Jun Lee, Mikyung Kim, Youngdo Jeong, Yong Sup Lee, Hee Jin Kim, Jae Hoon Cheon. The potential rewarding and reinforcing effects of the substituted benzofurans 2-EAPB and 5-EAPB in rodents. European journal of pharmacology. vol 885. 2021-05-18. PMID:32871174. |
2-eapb and 5-eapb did not alter the expressions of dopamine d1 and d2 receptors in the nucleus accumbens, nor changed tyrosine hydroxylase and dopamine transporter expressions in the ventral tegmental area. |
2021-05-18 |
2023-08-13 |
mouse |
| Yaoyu Pu, Lijia Chang, Youge Qu, Siming Wang, Yunfei Tan, Xingming Wang, Jiancheng Zhang, Kenji Hashimot. Glyphosate exposure exacerbates the dopaminergic neurotoxicity in the mouse brain after repeated administration of MPTP. Neuroscience letters. vol 730. 2021-05-14. PMID:32387710. |
in this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (dat) in the striatum and tyrosine hydroxylase (th) in the substantial nigra (snr) of mouse brain after repeated administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2021-05-14 |
2023-08-13 |
mouse |
| R Gomez-Flores, I Gutierrez-Leal, D Caballero-Hernández, A Orozco-Flores, P Tamez-Guerra, R Tamez-Guerra, C Rodríguez-Padill. Association of tyrosine hydroxylase expression in brain and tumor with increased tumor growth in sympathectomized mice. BMC research notes. vol 14. issue 1. 2021-05-14. PMID:33691777. |
lymphocytes express tyrosine hydroxylase (th), the rate-limiting enzyme for the synthesis of dopamine, norepinephrine and epinephrine. |
2021-05-14 |
2023-08-13 |
mouse |
| Enshan Fan, Zhiru Xu, Jie Yan, Fanglin Wang, Shaoyang Sun, Yurong Zhang, Shuiqing Zheng, Xu Wang, Yulan Ra. Acute exposure to N-Ethylpentylone induces developmental toxicity and dopaminergic receptor-regulated aberrances in zebrafish larvae. Toxicology and applied pharmacology. vol 417. 2021-05-10. PMID:33667508. |
besides, the expression of th (tyrosine hydroxylase) and th2 (tyrosine hydroxylase 2), identifying dopamine (da) release, were significantly increased during one-hour free swimming after effective low-dosed nep administration, along with the upregulation of gene fosab and fosb related to stress and anxiety response. |
2021-05-10 |
2023-08-13 |
zebrafish |
| Fatma Nihan Cankara, Caner Günaydın, Süleyman Sırrı Bilge, Özlem Özmen, Arjan Korthol. The neuroprotective action of lenalidomide on rotenone model of Parkinson's Disease: Neurotrophic and supportive actions in the substantia nigra pars compacta. Neuroscience letters. vol 738. 2021-04-30. PMID:32932183. |
in addition, chronic treatment mitigated tyrosine hydroxylase expression prevented the rotenone-induced decrease in dopamine levels, and consequently a decrease in caspase-3/9 immunoreactivity. |
2021-04-30 |
2023-08-13 |
rat |
| Michael T Williams, Chiho Sugimoto, Samantha L Regan, Emily M Pitzer, Adam L Fritz, Anthony E Mascia, Mathieu Sertorio, Ralph E Vatner, John P Perentesis, Charles V Vorhee. Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects. Scientific reports. vol 10. issue 1. 2021-04-30. PMID:33299021. |
proton groups also had reduced striatal levels of the dopamine transporter, tyrosine hydroxylase, and the dopamine receptor d1, effects consistent with egocentric learning deficits. |
2021-04-30 |
2023-08-13 |
rat |
| Xin Liu, Zhong-Rui Du, Xiong Wang, Kar-Him Luk, Cheuk-Hin Chan, Xu Cao, Qing Zhao, Fang Zhao, Wing-Tak Wong, Ka-Hing Wong, Xiao-Li Don. Colonic Dopaminergic Neurons Changed Reversely With Those in the Midbrain via Gut Microbiota-Mediated Autophagy in a Chronic Parkinson's Disease Mice Model. Frontiers in aging neuroscience. vol 13. 2021-04-30. PMID:33912026. |
tyrosine hydroxylase expressions and dopamine content reduced greatly in the substantia nigra pars compacta (snpc) or striatum, but increased in the colon of pd mice. |
2021-04-30 |
2023-08-13 |
mouse |
| Govindhasamy Pushpavathi Selvakumar, Mohammad Ejaz Ahmed, Ramasamy Thangavel, Duraisamy Kempuraj, Iuliia Dubova, Sudhanshu P Raikwar, Smita Zaheer, Shankar S Iyer, Asgar Zahee. A role for glia maturation factor dependent activation of mast cells and microglia in MPTP induced dopamine loss and behavioural deficits in mice. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:31982500. |
similarly, tyrosine hydroxylase, dopamine transporters and vesicular monoamine transporters 2 proteins expression were significantly reduced in the sn of mptp treated wt mice. |
2021-04-27 |
2023-08-13 |
mouse |
| Jingjing Sherry Wu, Eunyoung Yi, Marco Manca, Hamad Javaid, Amanda M Lauer, Elisabeth Glowatzk. Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers. eLife. vol 9. 2021-04-23. PMID:31975688. |
sound exposure upregulates tyrosine hydroxylase, an enzyme responsible for dopamine synthesis, in cholinergic loc intrinsic neurons, suggesting that individual loc neurons might at times co-release ach and da. |
2021-04-23 |
2023-08-13 |
Not clear |
| Neha Milind Chitre, Bo Jarrett Wood, Azizi Ray, Nader H Moniri, Kevin Sean Murnan. Docosahexaenoic acid protects motor function and increases dopamine synthesis in a rat model of Parkinson's disease via mechanisms associated with increased protein kinase activity in the striatum. Neuropharmacology. vol 167. 2021-04-23. PMID:32001239. |
our results also demonstrate that dha increases striatal dopamine synthesis via phosphorylation of the rate-limiting catecholamine synthesizing enzyme tyrosine hydroxylase, in a manner dependent on the second messenger-linked protein kinases pka and pkc. |
2021-04-23 |
2023-08-13 |
rat |
| Jessica S Fortin, Matthew J Benskey, Keith J Lookingland, Jon S Patterson, Erin B Howey, John L Goudreau, Harold C Schot. Restoring pars intermedia dopamine concentrations and tyrosine hydroxylase expression levels with pergolide: evidence from horses with pituitary pars intermedia dysfunction. BMC veterinary research. vol 16. issue 1. 2021-04-23. PMID:32977825. |
restoring pars intermedia dopamine concentrations and tyrosine hydroxylase expression levels with pergolide: evidence from horses with pituitary pars intermedia dysfunction. |
2021-04-23 |
2023-08-13 |
Not clear |
| Jessica S Fortin, Matthew J Benskey, Keith J Lookingland, Jon S Patterson, Erin B Howey, John L Goudreau, Harold C Schot. Restoring pars intermedia dopamine concentrations and tyrosine hydroxylase expression levels with pergolide: evidence from horses with pituitary pars intermedia dysfunction. BMC veterinary research. vol 16. issue 1. 2021-04-23. PMID:32977825. |
dopamine (da) concentrations and tyrosine hydroxylase (th) immunoreactivity are markedly reduced in pi tissue of ppid-affected equids and treatment with the da receptor agonist pergolide results in notable clinical improvement. |
2021-04-23 |
2023-08-13 |
Not clear |
| Eliana Jardim Fernandes, Marcia Rósula Poetini, Magna Sotelo Barrientos, Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Elize Aparecida Santos Musachio, Amarilis Santos De Carvalho, Fernanda Vitória Leimann, Odinei Hess Gonçalves, Bruna Piaia Ramborger, Rafael Roehrs, Marina Prigol, Gustavo Petri Guerr. Exposure to lutein-loaded nanoparticles attenuates Parkinson's model-induced damage in Drosophila melanogaster: Restoration of dopaminergic and cholinergic system and oxidative stress indicators. Chemico-biological interactions. vol 340. 2021-04-22. PMID:33716020. |
the survival percentage was assessed, the flies were submitted to negative geotaxis, open field tasks and the determination of dopamine levels, tyrosine hydroxylase (th) and acetylcholinesterase activities and oxidative stress indicators (superoxide dismutase, catalase, thiobarbituric acid reactive substances and glutathione s-transferase) were carried out. |
2021-04-22 |
2023-08-13 |
drosophila_melanogaster |
| Won Kil Lee, Yeongyeong Kim, Heejin Jang, Joo Hye Sim, Hye Jin Choi, Younmin Shin, Jeong June Cho. Exogenous Transforming Growth Factor-β in Brain-Induced Symptoms of Central Fatigue and Suppressed Dopamine Production in Mice. International journal of molecular sciences. vol 22. issue 5. 2021-04-22. PMID:33806649. |
intracranial injection of tgf-β1 significantly reduced the production of tyrosine hydroxylase (th) in the ventral tegmental area, accompanied by a decreased level of dopamine in the striatum. |
2021-04-22 |
2023-08-13 |
mouse |
| Zhong-Wen Chang, Yi-Chun Yeh, Chin-Chyuan Chan. Role of novel protein kinase C in neuroendocrine-immune regulatory network in haemocytes of Litopenaeus vannamei: An in vitro approach. Fish & shellfish immunology. vol 105. 2021-04-16. PMID:32645515. |
the same deviated pattern was observed in tyrosine, dopamine, and norepinephrine levels, and in dopamine β-hydroxylase (dbh) activity and gene expressions of tyrosine hydroxylase, dopa decarboxylase, and dbh involving in ba biosynthesis. |
2021-04-16 |
2023-08-13 |
Not clear |
| Yi-Bo He, Yong-Lin Liu, Zheng-Dong Yang, Jia-Hong Lu, Yao Song, Yan-Ming Guan, Yi-Min Che. Effect of ginsenoside-Rg1 on experimental Parkinson's disease: A systematic review and meta-analysis of animal studies. Experimental and therapeutic medicine. vol 21. issue 6. 2021-04-16. PMID:33850524. |
primary outcomes were tyrosine hydroxylase (th)-positive cells in the nigra, nissl staining-positive cells in the nigra, pole test time and dopamine (da) levels in the striatum. |
2021-04-16 |
2023-08-13 |
human |
| Neicí Cáceres Silva, Márcia Rósula Poetini, Matheus Chimelo Bianchini, Francielli Polet Almeida, Mustafá Munir Mustafa Dahle, Stífani Machado Araujo, Vandreza Cardoso Bortolotto, Elize Aparecida Santos Musachio, Bruna Piaia Ramborger, Diogo La Rosa Novo, Rafael Roehrs, Marcia Foster Mesko, Marina Prigol, Robson Luiz Punte. Protective effect of gamma-oryzanol against manganese-induced toxicity in Drosophila melanogaster. Environmental science and pollution research international. vol 28. issue 14. 2021-03-31. PMID:33403631. |
moreover, flies treated with mn exhibited a significant decrease in dopamine levels and in tyrosine hydroxylase activity, as well as in mitochondrial and cellular viability. |
2021-03-31 |
2023-08-13 |
drosophila_melanogaster |
| Laia Cros-Brunsó, Laura Camacho-Rodríguez, Ángel Martínez-González, Pablo Llévenes, Mercedes Salaices, Ana Belen García-Redondo, Javier Blanco-River. A Blunted Sympathetic Function and an Enhanced Nitrergic Activity Contribute to Reduce Mesenteric Resistance in Hyperthyroidism. International journal of molecular sciences. vol 22. issue 2. 2021-03-30. PMID:33430047. |
in line with this, noradrenaline release, tyrosine hydroxylase expression and activation and dopamine β hydroxylase expression were diminished in ht. |
2021-03-30 |
2023-08-13 |
rat |