| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicole E Chambers, Michael Coyle, Jordan Sergio, Kathryn Lanza, Carolyn Saito, Brent Topping, Stewart D Clark, Christopher Bisho. Effects of pedunculopontine nucleus cholinergic lesion on gait and dyskinesia in hemiparkinsonian rats. The European journal of neuroscience. vol 53. issue 8. 2021-06-30. PMID:33426708. |
lesions, verified via tyrosine hydroxylase and choline acetyltransferase immunohistochemistry reduced an average of 95% of nigral dopamine neurons and 80% of ppn cholinergic neurons, respectively. |
2021-06-30 |
2023-08-13 |
rat |
| Shigekazu Sugino, Daisuke Konno, Junko Abe, Yuka Imamura-Kawasawa, Kanta Kido, Jun Suzuki, Yasuhiro Endo, Masanori Yamauch. Crucial involvement of catecholamine neurotransmission in postoperative nausea and vomiting: Whole-transcriptome profiling in the rat nucleus of the solitary tract. Genes, brain, and behavior. 2021-06-29. PMID:34114352. |
the gene expression levels of tyrosine hydroxylase and dopamine beta-hydroxylase in the catecholamine biosynthesis pathway decreased significantly in the ponv model. |
2021-06-29 |
2023-08-13 |
rat |
| Rory Pritchard, Helene Chen, Ben Romoli, Nicholas C Spitzer, Davide Dulci. Photoperiod-induced neurotransmitter plasticity declines with aging: An epigenetic regulation? The Journal of comparative neurology. vol 528. issue 2. 2021-06-25. PMID:31343079. |
chronic exposure to different photoperiods alters the number of dopamine (tyrosine hydroxylase, th+) and somatostatin (sst+) neurons in the paraventricular nucleus (pavn) of the hypothalamus of adult rats and results in discrete behavioral changes. |
2021-06-25 |
2023-08-13 |
rat |
| T C Peixoto, E G Moura, P N Soares, V S T Rodrigues, S Claudio-Neto, E Oliveira, A C Manhães, P C Lisbo. Nicotine exposure during lactation causes disruption of hedonic eating behavior and alters dopaminergic system in adult female rats. Appetite. vol 160. 2021-06-24. PMID:33453337. |
nic females showed hyperphagia, preference for a high-sucrose diet, increased anxiety-like behavior, lower tyrosine hydroxylase (th), lower dopamine transporter and higher dopamine receptor (drd2) in nac; lower drd1 in prefrontal cortex and lower th in dorsal striatum (ds). |
2021-06-24 |
2023-08-13 |
rat |
| Maria Teresa Rivera-Garcia, Aqilah M McCane, Tara G Chowdhury, Kathryn G Wallin-Miller, Bita Moghadda. Sex and strain differences in dynamic and static properties of the mesolimbic dopamine system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 12. 2021-06-23. PMID:32663840. |
static measures included assessing ventral tegmental area (vta) dopamine cell number and volume and expression of tyrosine hydroxylase and dopamine transporter. |
2021-06-23 |
2023-08-13 |
rat |
| F Y Wong, A Gogos, N Hale, S A Ingelse, N Brew, K L Shepherd, M van den Buuse, D W Walke. Impact of hypoxia-ischemia and dopamine treatment on dopamine receptor binding density in the preterm fetal sheep brain. Journal of applied physiology (Bethesda, Md. : 1985). vol 129. issue 6. 2021-06-23. PMID:33054660. |
we determined the effect of hi and dopamine on d1 and d2 receptor binding and expressions of dopamine transporter (dat) and tyrosine hydroxylase (th) in the striatum of the preterm fetal sheep. |
2021-06-23 |
2023-08-13 |
Not clear |
| Aya Yassin Labib, Ramy M Ammar, Reem N El-Naga, Alshaymaa Amin Zaki El-Bahy, Mariane G Tadros, Haidy E Miche. Mechanistic insights into the protective effect of paracetamol against rotenone-induced Parkinson's disease in rats: Possible role of endocannabinoid system modulation. International immunopharmacology. vol 94. 2021-06-22. PMID:33578261. |
and their effects on body weight changes, spontaneous locomotor activity, rotarod test, tyrosine hydroxylase (th) and α-synuclein expression, and striatal dopamine (da) content were evaluated. |
2021-06-22 |
2023-08-13 |
rat |
| David Godefroy, Loubna Boukhzar, Christophe Dubessy, Maité Montero-Hadjadje, Laurent Yon, Lee E Eiden, Youssef Anoua. Three-dimensional mapping of tyrosine hydroxylase in the transparent brain and adrenal of prenatal and pre-weaning mice: Comprehensive methodological flowchart and quantitative aspects of 3D mapping. Journal of neuroscience methods. vol 335. 2021-06-21. PMID:32035089. |
tyrosine hydroxylase (th) catalyzes the rate-limiting step for the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline. |
2021-06-21 |
2023-08-13 |
mouse |
| Piotr Podlasz, Krzysztof Wasowic. Effect of partial hysterectomy on the neurons of the paracervical ganglion (PCG) of the pig. PloS one. vol 16. issue 1. 2021-06-21. PMID:33497400. |
the study was performed using a neuronal retrograde tracing and double immunofluorescent staining for tyrosine hydroxylase (th), dopamine beta-hydroxylase (dβh), choline acetyltransferase (chat), vesicular acetylcholine transporter (vacht), neuronal nictric oxide synthase (nnos), galanin, neuropeptide y (npy), vasoactive intestinal peptide (vip), pituitary adenylate cyclase-activating peptide (pacap), somatostatin and substance p (sp). |
2021-06-21 |
2023-08-13 |
Not clear |
| Hany H Arab, Marwa M Safar, Nancy N Shahi. Targeting ROS-Dependent AKT/GSK-3β/NF-κB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson's Disease Rat Model. ACS chemical neuroscience. vol 12. issue 4. 2021-06-18. PMID:33543924. |
it also diminished the histopathologic alterations and α-synuclein expression and augmented tyrosine hydroxylase and dopamine levels. |
2021-06-18 |
2023-08-13 |
rat |
| M E Chávez-Pichardo, D Y Reyes-Bravo, M S Mendoza-Trejo, A G Marín-López, M Giordano, N Hernández-Chan, K Domínguez-Marchan, L C Ortega-Rosales, V M Rodrígue. Brain alterations in GABA, glutamate and glutamine markers after chronic atrazine exposure in the male albino rat. Archives of toxicology. vol 94. issue 9. 2021-06-16. PMID:32561961. |
studies in rodents have shown that chronic atr exposure is associated with alterations in the nigrostriatal dopaminergic pathway such as hyperactivity, decreased striatal dopamine levels, and diminished numbers of tyrosine hydroxylase positive cells in substantia nigra pars compacta. |
2021-06-16 |
2023-08-13 |
rat |
| Elvi Gil-Lievana, Israela Balderas, Perla Moreno-Castilla, Jorge Luis-Islas, Ross A McDevitt, Fatuel Tecuapetla, Ranier Gutierrez, Antonello Bonci, Federico Bermúdez-Ratton. Glutamatergic basolateral amygdala to anterior insular cortex circuitry maintains rewarding contextual memory. Communications biology. vol 3. issue 1. 2021-06-15. PMID:32198461. |
using a cre-recombinase under the tyrosine hydroxylase (th+) promoter mouse model to induce a real-time conditioned place preference (rtcpp), we show that photoactivation of th+ neurons induced electrophysiological responses in vta neurons, dopamine release and neuronal modulation in the aic. |
2021-06-15 |
2023-08-13 |
mouse |
| Frederick Wasinski, Fernanda M Chaves, João A B Pedroso, Naira S Mansano, João Paulo Camporez, Daniela O Gusmão, Edward O List, John J Kopchick, Renata Frazão, Raphael E Szawka, Jose Donat. Growth hormone receptor in dopaminergic neurones regulates stress-induced prolactin release in male mice. Journal of neuroendocrinology. vol 33. issue 3. 2021-06-15. PMID:33769619. |
mice carrying specific deletion of gh receptor (ghr) in tyrosine hydroxylase (th)- or dopamine transporter (dat)-expressing cells were produced. |
2021-06-15 |
2023-08-13 |
mouse |
| Li Zhang, Xiufen Chen, Mingxiu Chang, Boning Jia. MiR-30c-5p/ATG5 Axis Regulates the Progression of Parkinson's Disease. Frontiers in cellular neuroscience. vol 15. 2021-06-12. PMID:34113238. |
tyrosine hydroxylase (th) and dopamine metabolic markers were detected using immunofluorescence and diode array detector (dad), respectively. |
2021-06-12 |
2023-08-13 |
mouse |
| Suresh B Rangasamy, Sridevi Dasarathi, Aparna Nutakki, Shreya Mukherjee, Rohith Nellivalasa, Kalipada Paha. Stimulation of Dopamine Production by Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive. Journal of Alzheimer's disease reports. vol 5. issue 1. 2021-06-12. PMID:34113786. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in the dopamine (da) biosynthesis pathway. |
2021-06-12 |
2023-08-13 |
human |
| Marte I Flydal, Trond-André Kråkenes, Mary Dayne S Tai, Maria P A Tran, Knut Teigen, Aurora Martine. Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. Biochimie. vol 183. 2021-06-09. PMID:33309753. |
levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. |
2021-06-09 |
2023-08-13 |
human |
| Marte I Flydal, Trond-André Kråkenes, Mary Dayne S Tai, Maria P A Tran, Knut Teigen, Aurora Martine. Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. Biochimie. vol 183. 2021-06-09. PMID:33309753. |
tyrosine hydroxylase (th) catalyses the (6r)-l-erythro-5,6,7,8-tetrahydrobiopterin (bh4)-dependent conversion of l-tyrosine to l-3,4-dihydroxyphenylalanine (l-dopa), which is the rate-limiting step in the synthesis of dopamine and other catecholamine neurotransmitters and hormones. |
2021-06-09 |
2023-08-13 |
human |
| Yao Fan, Rongrong Zha, Tomohiko Sano, Xinyu Zhao, Shengzhi Liu, Mark D Woollam, Di Wu, Xun Sun, Kexin Li, Motoki Egi, Fangjia Li, Kazumasa Minami, Amanda P Siegel, Takashi Horiuchi, Jing Liu, Mangilal Agarwal, Akihiro Sudo, Harikrishna Nakshatri, Bai-Yan Li, Hiroki Yokot. Mechanical tibial loading remotely suppresses brain tumors by dopamine-mediated downregulation of CCN4. Bone research. vol 9. issue 1. 2021-06-09. PMID:34031366. |
the results revealed that loading the tibia with elevated levels of tyrosine hydroxylase, a rate-limiting enzyme in dopamine synthesis, markedly reduced the progression of the brain tumors. |
2021-06-09 |
2023-08-13 |
mouse |
| Chen-Meng Qiao, Meng-Fei Sun, Xue-Bing Jia, Yang Li, Bo-Ping Zhang, Li-Ping Zhao, Yun Shi, Zhi-Lan Zhou, Ying-Li Zhu, Chun Cui, Yan-Qin She. Sodium Butyrate Exacerbates Parkinson's Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model. Neurochemical research. vol 45. issue 9. 2021-06-08. PMID:32556930. |
interestingly, nab significantly aggravated mptp-induced motor dysfunction (p < 0.01), decreased dopamine (p < 0.05) and 5-ht (p < 0.05) levels, exacerbated declines of dopaminergic neurons (34%, p < 0.05) and downregulated expression of tyrosine hydroxylase (th, 47%, p < 0.05), potentiated glia-mediated neuroinflammation by increasing the number of microglia (17%, p < 0.05) and activating astrocytes (28%, p < 0.01). |
2021-06-08 |
2023-08-13 |
mouse |
| Juhee Lim, Hyo In Kim, Hyun Jin Cho. Regulation of dopaminergic neuronal phenotypes by the estrogen-related receptor gamma ligand GSK4716 via the activation of CREB signaling. Neurochemistry international. vol 136. 2021-06-07. PMID:32173553. |
our previous study showed the relevance of errγ in the regulation of the daergic neuronal phenotype with the upregulation of dopamine synthesizing tyrosine hydroxylase (th) and dopamine transporter (dat) and the possibility that errγ could be a novel target for regulating daergic neuronal differentiation. |
2021-06-07 |
2023-08-13 |
Not clear |