| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Angel Carvajal-Oliveros, Carmen Domínguez-Baleón, Rafaella V Zárate, Jorge M Campusano, Verónica Narváez-Padilla, Enrique Reynau. Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels. Scientific reports. vol 11. issue 1. 2021-10-22. PMID:33953275. |
nicotine is beneficial on fly survival and motility increasing tyrosine hydroxylase and dopamine levels, suggesting that cholinergic agonists may promote survival and metabolic function of the dopaminergic neurons that express sph-1. |
2021-10-22 |
2023-08-13 |
drosophila_melanogaster |
| Cong Liu, Wenjuan Wang, Hao Li, Jiangang Liu, Peng Zhang, Yong Cheng, Xiaoyan Qin, Yang Hu, Yun We. The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease. Food & function. vol 12. issue 13. 2021-10-22. PMID:34047315. |
it was found that isoquercitrin ameliorated the animal behaviors against mptp-induced neurotoxicity, mitigated the loss of dopamine neurons induced by mptp, increased tyrosine hydroxylase and dopamine transporter expression, reduced the pro-apoptotic signaling molecule bax expression and inhibited mptp-triggered oxidative stress. |
2021-10-22 |
2023-08-13 |
mouse |
| Mario F Wullimann, Kosisochukwu E Umeasalug. Sonic hedgehog expression in zebrafish forebrain identifies the teleostean pallidal signaling center and shows preglomerular complex and posterior tubercular dopamine cells to arise from shh cells. The Journal of comparative neurology. vol 528. issue 8. 2021-10-20. PMID:31760659. |
(d) immunostains for tyrosine hydroxylase demonstrate that there is selective colocalization in adult dopamine cells with shh-gfp in the posterior tuberculum, including in projection cells to striatum, which represents a striking parallel to amniote mesodiencephalic dopamine cell origin from shh expressing floor plate cells. |
2021-10-20 |
2023-08-13 |
zebrafish |
| Michiko Yamane, Nanako Takaoka, Koya Obara, Kyoumi Shirai, Ryoichi Aki, Yuko Hamada, Nobuko Arakawa, Robert M Hoffman, Yasuyuki Amo. Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons. Cells. vol 10. issue 4. 2021-10-20. PMID:33920157. |
in the present study, we demonstrated that mouse hap stem cells cultured in neural-induction medium can extensively differentiate to dopaminergic neurons, which express tyrosine hydroxylase and secrete dopamine. |
2021-10-20 |
2023-08-13 |
mouse |
| David S Goldstei. The "Sick-but-not-Dead" Phenomenon Applied to Catecholamine Deficiency in Neurodegenerative Diseases. Seminars in neurology. vol 40. issue 5. 2021-10-19. PMID:32906170. |
the malfunctions include diminished dopamine biosynthesis via tyrosine hydroxylase (th) and l-aromatic-amino-acid decarboxylase (laaad), inefficient vesicular sequestration of cytoplasmic catecholamines, and attenuated neuronal reuptake via cell membrane catecholamine transporters. |
2021-10-19 |
2023-08-13 |
Not clear |
| Xiaokang Zeng, Kai Xu, Ji Wang, Yunqi Xu, Shaogang Q. Pretreatment of Ascorbic Acid Inhibits MPTP-Induced Astrocytic Oxidative Stress through Suppressing NF- Neural plasticity. vol 2020. 2021-10-14. PMID:33281897. |
study has illuminated that ascorbic acid (aa) stimulates dopamine synthesis and expression of tyrosine hydroxylase in human neuroblastoma cells. |
2021-10-14 |
2023-08-13 |
human |
| Jun-Lin Liu, Shao-Qing Li, Feng Zhu, Yu-Xiang Zhang, Ya-Nan Wu, Jing-Si Yang, Bao Zhang, Chun-Xia Ya. Tyrosine Hydroxylase Gene Polymorphisms Contribute to Opioid Dependence and Addiction by Affecting Promoter Region Function. Neuromolecular medicine. vol 22. issue 3. 2021-10-07. PMID:32232669. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in dopamine (da) synthesis, which plays an essential role in the development of drug addiction. |
2021-10-07 |
2023-08-13 |
human |
| Kousuke Okimura, Yusuke Nakane, Taeko Nishiwaki-Ohkawa, Takashi Yoshimur. Photoperiodic regulation of dopamine signaling regulates seasonal changes in retinal photosensitivity in mice. Scientific reports. vol 11. issue 1. 2021-10-06. PMID:33469071. |
transcriptome analysis identified short day-mediated suppression of the th gene, which encodes tyrosine hydroxylase, a rate-limiting enzyme for dopamine biosynthesis. |
2021-10-06 |
2023-08-13 |
mouse |
| Mohammad Farhadi, Mahdi Eskandarian Boroujeni, Seyed Kamran Kamrava, Zohreh Bagher, Ava Modirzadeh Tehrani, Fakhroddin Aghajanpour, Samira Ezi, Reza Soltani, Aysan Khatmi, Rafieh Alizade. Implantation of human olfactory ecto-mesenchymal stem cells restores locomotion in a rat model of Parkinson's disease. Journal of chemical neuroanatomy. vol 114. 2021-10-05. PMID:33933574. |
our results displayed that the grafting of oe-mscs increased the expression of daergic markers namely dopamine transporter (dat), tyrosine hydroxylase (th), nuclear receptor related-1 (nurr1) in a 6-ohda model compared with that of control, detected by immunohistochemical staining and western blot. |
2021-10-05 |
2023-08-13 |
human |
| Tomohiro Watanabe, Ken Sasak. Regulation of dopamine production in the brains during sexual maturation in male honey bees. Journal of insect physiology. vol 132. 2021-10-04. PMID:34175313. |
to explore the physiological mechanisms that underlie age-related dopamine increases during sexual maturation in the brains of male honey bees, we focused on the expression of genes encoding the enzymes tyrosine hydroxylase (amth) and dopa decarboxylase (amddc), which are involved in dopamine biosynthesis in the brain. |
2021-10-04 |
2023-08-13 |
bee |
| Anna Brancato, Valentina Castelli, Gianluca Lavanco, Giuseppe Tringali, Vincenzo Micale, Martin Kuchar, Cesare D'Amico, Giuseppe Pizzolanti, Salvatore Feo, Carla Cannizzar. Binge-like Alcohol Exposure in Adolescence: Behavioural, Neuroendocrine and Molecular Evidence of Abnormal Neuroplasticity… and Return. Biomedicines. vol 9. issue 9. 2021-10-01. PMID:34572345. |
besides, nac tyrosine hydroxylase levels increase at late withdrawal, while the expression of dopamine transporter, d1 and d2 receptors is dynamically altered during binge and withdrawal. |
2021-10-01 |
2023-08-13 |
rat |
| Yongjing Li, Liting Ren, Huiru Fu, Ben Yang, Jing Tian, Qi Li, Zhanjiang Liu, Shikai Li. Crosstalk between dopamine and insulin signaling in growth control of the oyster. General and comparative endocrinology. vol 313. 2021-09-29. PMID:34480943. |
in the present study, we showed that tyrosine hydroxylase (th), the rate-limiting enzyme of dopamine synthesis, was highly expressed in all tissues of the fast-growing oysters, and gradually increased with the development, which indicated the potential role of dopamine in growth regulation. |
2021-09-29 |
2023-08-13 |
Not clear |
| Jing Jiang, Xiujuan Hu, Lihua Liu, Zhicheng He, Qingjie Wu, Qunchao Li, Xianwei Hu, Nan Jiang, Chao Li. Age-related changes in expression of lysine48 and lysine63 ubiquitin linkages in dopamine neurons of midbrain in mice. Neuroreport. vol 32. issue 7. 2021-09-17. PMID:33657079. |
aging promoted the formation of protein aggregates that are positive for both k48 and k63 ubiquitin linkages, together with tyrosine hydroxylase, a dopamine neuron marker. |
2021-09-17 |
2023-08-13 |
mouse |
| Hayden Torres, Clara Huesing, David H Burk, Adrien J R Molinas, Winfried L Neuhuber, Hans-Rudolf Berthoud, Heike Münzberg, Andrei V Derbenev, Andrea Zsombo. Sympathetic innervation of the mouse kidney and liver arising from prevertebral ganglia. American journal of physiology. Regulatory, integrative and comparative physiology. vol 321. issue 3. 2021-09-16. PMID:34231420. |
we used tyrosine hydroxylase (th) and dopamine β-hydroxylase (dbh) reporter mice to visualize abdominal prevertebral ganglia. |
2021-09-16 |
2023-08-13 |
mouse |
| b' Macarena L Herrera, Romina Deza-Ponzio, Marisa S Ghersi, Emilce A de la Villarmois, Miriam B Virgolini, Mariela F P\\xc3\\xa9rez, Victor A Molina, Mar\\xc3\\xada J Bellini, Claudia B Here\\xc3\\xb1\\xc3\\xb. Early Cognitive Impairment Behind Nigrostriatal Circuit Neurotoxicity: Are Astrocytes Involved? ASN neuro. vol 12. 2021-09-15. PMID:32466659.' |
we evaluated tyrosine hydroxylase (th) as a dopamine marker, aldehyde dehydrogenase 2 (aldh2), a mitochondria detoxification enzyme and astrocyte glial fibrillar acid protein (gfap) an immunoreactivity marker involved in different areas: cpu, substantia nigra, prefrontal cortex, and hippocampus. |
2021-09-15 |
2023-08-13 |
Not clear |
| Tadasu Sato, Takehiro Yajima, Souichi Kokubun, Daisuke Tachiya, Hiroyuki Ichikaw. Distribution of neuronal cells which contain dopamine β-hydroxylase, tyrosine hydroxylase, neuropeptide Y and vasoactive intestinal polypeptide in the human internal carotid nerve. Anatomical record (Hoboken, N.J. : 2007). 2021-09-15. PMID:34486238. |
distribution of neuronal cells which contain dopamine β-hydroxylase, tyrosine hydroxylase, neuropeptide y and vasoactive intestinal polypeptide in the human internal carotid nerve. |
2021-09-15 |
2023-08-13 |
human |
| Yan Feng, Jianjun Ma, Lipin Yua. β-Methylphenylalanine exerts neuroprotective effects in a Parkinson's disease model by protecting against tyrosine hydroxylase depletion. Journal of cellular and molecular medicine. vol 24. issue 17. 2021-09-13. PMID:32697044. |
in a rat model of pd, dopamine (da) and 3,4-dihydroxyphenylacetic acid (dopac) levels, bradykinesia and tyrosine hydroxylase expression were determined. |
2021-09-13 |
2023-08-13 |
rat |
| Hsin-Yun Lin, Hsin-Wei Kuo, Yen-Ling Song, Winton Chen. Cloning and characterization of DOPA decarboxylase in Litopenaeus vannamei and its roles in catecholamine biosynthesis, immunocompetence, and antibacterial defense by dsRNA-mediated gene silencing. Developmental and comparative immunology. vol 108. 2021-09-06. PMID:32145295. |
in shrimp, two genes encoding ca-related enzymes, tyrosine hydroxylase and dopamine beta-hydroxylase, were further identified and characterized as neuroendocrine-immune regulators. |
2021-09-06 |
2023-08-13 |
Not clear |
| Erin M Rhinehart, Madison Waldron, Hannah Kelly-Quigley, McKenzie Zellers, Abby Turco, Judith E Grise. β-Endorphin and sex differentially modulate the response to EtOH in a site-specific manner. Brain research. vol 1741. 2021-09-01. PMID:32315606. |
brain sections (35 μm) were immunohistochemically processed for tyrosine hydroxylase (th), dopamine's rate-limiting enzyme, and c-fos, a neuronal activation marker. |
2021-09-01 |
2023-08-13 |
mouse |
| Victor A D Holanda, Julia J Didonet, Manara B B Costa, Adriano H do Nascimento Rangel, Edilson D da Silva, Elaine C Gaviol. Neuropeptide S Receptor as an Innovative Therapeutic Target for Parkinson Disease. Pharmaceuticals (Basel, Switzerland). vol 14. issue 8. 2021-08-31. PMID:34451872. |
a growing body of evidence suggests a close relationship between neuropeptide s (nps) and its receptor (npsr) system in pd: (i) double immunofluorescence labeling studies showed that npsr is expressed in the nigral tyrosine hydroxylase (th)-positive neurons; (ii) central administration of nps increases spontaneous locomotion in naïve rodents; (iii) central administration of nps ameliorates motor and nonmotor dysfunctions in animal models of pd; (iv) microdialysis studies showed that nps stimulates dopamine release in naïve and parkinsonian rodents; (v) central injection of nps decreases oxidative damage to proteins and lipids in the rodent brain; and, (vi) 7 days of central administration of nps protects from the progressive loss of nigral th-positive cells in parkinsonian rats. |
2021-08-31 |
2023-08-13 |
rat |