| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victor A D Holanda, Julia J Didonet, Manara B B Costa, Adriano H do Nascimento Rangel, Edilson D da Silva, Elaine C Gaviol. Neuropeptide S Receptor as an Innovative Therapeutic Target for Parkinson Disease. Pharmaceuticals (Basel, Switzerland). vol 14. issue 8. 2021-08-31. PMID:34451872. |
a growing body of evidence suggests a close relationship between neuropeptide s (nps) and its receptor (npsr) system in pd: (i) double immunofluorescence labeling studies showed that npsr is expressed in the nigral tyrosine hydroxylase (th)-positive neurons; (ii) central administration of nps increases spontaneous locomotion in naïve rodents; (iii) central administration of nps ameliorates motor and nonmotor dysfunctions in animal models of pd; (iv) microdialysis studies showed that nps stimulates dopamine release in naïve and parkinsonian rodents; (v) central injection of nps decreases oxidative damage to proteins and lipids in the rodent brain; and, (vi) 7 days of central administration of nps protects from the progressive loss of nigral th-positive cells in parkinsonian rats. |
2021-08-31 |
2023-08-13 |
rat |
| Yolanda Gómez-Gálvez, Heidi R Fuller, Silvia Synowsky, Sally L Shirran, Monte A Gate. Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease. Journal of neuroscience research. vol 98. issue 7. 2021-08-26. PMID:32270889. |
however, the expression levels of the rate-limiting enzyme for dopamine production, tyrosine hydroxylase (th), were maintained even in the oldest animals, despite a reduction in the number of dopamine neurons in the sn pars compact(snc) as aging progressed. |
2021-08-26 |
2023-08-13 |
rat |
| Tingting Yu, Guangdi Zhou, Zhenzhen Cai, Wei Liang, Yatao Du, Weiye Wan. Behavioral effects of early-life exposure to perfluorooctanoic acid might synthetically link to multiple aspects of dopaminergic neuron development and dopamine functions in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). vol 238. 2021-08-24. PMID:34340000. |
after exposure to pfoa for 7 days, the locomotor activity of zebrafish was decreased; the mrna levels of nuclear receptor subfamily 4 group a member 2b (nr4a2b), paired box 2 and 5 (pax2, pax5), tyrosine hydroxylase 1/2 (th1/th2) and dopamine transporter (dat) were increased; mrna and protein level of mesencephalic astrocyte-derived neurotrophic factor (manf) were decreased. |
2021-08-24 |
2023-08-13 |
human |
| Débora da Luz Scheffer, Fernando Cini Freitas, Aderbal Silva Aguiar, Catherine Ward, Luiz Guilherme Antonacci Guglielmo, Rui Daniel Prediger, Shane J F Cronin, Roger Walz, Nick A Andrews, Alexandra Latin. Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson's disease patients. Brain communications. vol 3. issue 3. 2021-08-24. PMID:34423297. |
the dopamine synthesis is mediated by the rate-limiting enzyme tyrosine hydroxylase, which requires tetrahydrobiopterin as a mandatory cofactor. |
2021-08-24 |
2023-08-13 |
mouse |
| Katsuya Miyajima, Chiaki Kawamoto, Satoshi Hara, Masayo Mori-Kojima, Tamae Ohye, Chiho Sumi-Ichinose, Nae Saito, Toshikuni Sasaoka, Daniel Metzger, Hiroshi Ichinos. Tyrosine hydroxylase conditional KO mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways. The Journal of biological chemistry. vol 296. 2021-08-23. PMID:33737022. |
tyrosine hydroxylase conditional ko mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways. |
2021-08-23 |
2023-08-13 |
mouse |
| Wagner Antonio Barbosa da Silva, Karla Ferreira Oliveira, Louise Caroline Vitorino, Luciana Ferreira Romão, Silvana Allodi, Clynton Lourenço Corre. Physical exercise increases the production of tyrosine hydroxylase and CDNF in the spinal cord of a Parkinson's disease mouse model. Neuroscience letters. vol 760. 2021-08-17. PMID:34182056. |
this study investigated the effects of exercise on tyrosine hydroxylase (th)- and cerebral dopamine neurotrophic factor (cdnf)-containing spinal-cord neurons. |
2021-08-17 |
2023-08-13 |
mouse |
| Maxime Fougère, Cornelis Immanuel van der Zouwen, Joël Boutin, Dimitri Ryczk. Heterogeneous expression of dopaminergic markers and Vglut2 in mouse mesodiencephalic dopaminergic nuclei A8-A13. The Journal of comparative neurology. vol 529. issue 7. 2021-08-16. PMID:32869307. |
here, we used in mice a cell fate mapping strategy based on reporter protein expression (zsgreen) consecutive to previous expression of the vesicular glutamate transporter 2 (vglut2) gene, coupled with immunofluorescence experiments against tyrosine hydroxylase (th) or dopamine transporter (dat). |
2021-08-16 |
2023-08-13 |
mouse |
| Kristen M Lee, Ananya Talikoti, Keith Shelton, Mike Grotewie. Tyramine synthesis, vesicular packaging, and the SNARE complex function coordinately in astrocytes to regulate Drosophila alcohol sedation. Addiction biology. vol 26. issue 4. 2021-08-16. PMID:33538092. |
manipulation of the genes tyramine β-hydroxylase and tyrosine hydroxylase, which respectively synthesize octopamine and dopamine from tyramine and tyrosine, had no discernable effect on alcohol sedation, suggesting that tdc2 affects alcohol sedation by regulating tyramine production. |
2021-08-16 |
2023-08-13 |
drosophila_melanogaster |
| So-Yoon Won, Soon-Tae You, Seung-Won Choi, Catriona McLean, Eun-Young Shin, Eung-Gook Ki. cAMP Response Element Binding-Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy. Molecules and cells. vol 44. issue 7. 2021-08-12. PMID:34238765. |
camp response element binding-protein- and phosphorylation-dependent regulation of tyrosine hydroxylase by pak4: implications for dopamine replacement therapy. |
2021-08-12 |
2023-08-13 |
Not clear |
| Ashish Singh, Arun Kumar Yadawa, Swati Chaturvedi, M Wahajuddin, Amit Mishra, Sarika Sing. Mechanism for antiParkinsonian effect of resveratrol: Involvement of transporters, synaptic proteins, dendrite arborization, biochemical alterations, ER stress and apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 155. 2021-08-09. PMID:34302886. |
resveratrol treatment significantly protects the pd related pathological markers like level of tyrosine hydroxylase, dopamine and apoptotic proteins (bax and cleaved caspase-3). |
2021-08-09 |
2023-08-13 |
Not clear |
| Yung-Chih Kuo, He-Cheng Tsai, Rajendiran Rajes. Glutathione Liposomes Carrying Ceftriaxone, FK506, and Nilotinib to Control Overexpressed Dopamine Markers and Apoptotic Factors in Neurons. ACS biomaterials science & engineering. vol 7. issue 7. 2021-08-02. PMID:34189904. |
treatment with cef-fk506-nilotinib-gsh-cl-liposomes reduced the expression of bax and α-syn and promoted the expression of bcl-2, tyrosine hydroxylase, and the dopamine transporter. |
2021-08-02 |
2023-08-13 |
Not clear |
| Ani Gasparyan, Francisco Navarrete, Marta Rodríguez-Arias, José Miñarro, Jorge Manzanare. Cannabidiol Modulates Behavioural and Gene Expression Alterations Induced by Spontaneous Cocaine Withdrawal. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 1. 2021-07-30. PMID:33230690. |
furthermore, gene expression changes in dopamine transporter (dat) and tyrosine hydroxylase (th) in the ventral tegmental area, and in cannabinoid receptors 1 (cnr1) and 2 (cnr2) in the nucleus accumbens, were analysed by real-time pcr. |
2021-07-30 |
2023-08-13 |
mouse |
| Hexin Yan, Hui Zhao, Yunxiao Kang, Xiaoming Ji, Tianyun Zhang, Yu Wang, Rui Cui, Guoliang Zhang, Geming Sh. Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition. Neuropharmacology. vol 194. 2021-07-28. PMID:34089729. |
we found that parecoxib administration to aged rats for 10 weeks decreased cox-2/pge2 expression, increased tyrosine hydroxylase and dopamine transporter expression in nigrostriatal dopaminergic neurons, and alleviated motor behavioral decline. |
2021-07-28 |
2023-08-13 |
rat |
| Haesoo Kim, Daeun Lee, Kisok Ki. Combined Exposure to Metals in Drinking Water Alters the Dopamine System in Mouse Striatum. International journal of environmental research and public health. vol 18. issue 12. 2021-07-21. PMID:34207128. |
in this study, motor coordination and dopamine content, along with the expression of tyrosine hydroxylase (th), dopamine transporter (dat), vesicular monoamine transporter 2 (vmat2), and dopamine receptors (drs), were examined in the striatum of adult male mice following exposure to drinking water containing as, pb, and/or cd. |
2021-07-21 |
2023-08-13 |
mouse |
| Hyeon Joo Ham, In Jun Yeo, Seong Hee Jeon, Jun Hyung Lim, Sung Sik Yoo, Dong Ju Son, Sung-Su Jang, Haksup Lee, Seung-Jin Shin, Sang Bae Han, Jae Suk Yun, Jin Tae Hon. Botulinum Toxin A Ameliorates Neuroinflammation in the MPTP and 6-OHDA-Induced Parkinson's Disease Models. Biomolecules & therapeutics. 2021-07-19. PMID:34078752. |
we found that bont-a ameliorated mptp and 6-ohda-induced pd progression, reduced acetylcholine release, levels of il-1β, il-6 and tnf-α as well as gfap expression, but enhanced dopamine release and tyrosine hydroxylase expression. |
2021-07-19 |
2023-08-13 |
Not clear |
| Sharonda Harris, Renee Afram, Takashi Shimano, Bozena Fyk-Kolodziej, Paul D Walker, Rod D Braun, Avril Genene Hol. Dopamine in Auditory Nuclei and Lemniscal Projections is Poised to Influence Acoustic Integration in the Inferior Colliculus. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:33746717. |
previous studies have identified neurons and fibers in the inferior colliculus (ic) which are positively labeled for tyrosine hydroxylase (th), a key enzyme in the synthesis of dopamine. |
2021-07-16 |
2023-08-13 |
rat |
| Rayul Wi, Young Cheul Chung, Byung Kwan Ji. Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson's Disease. Journal of immunology research. vol 2020. 2021-07-12. PMID:33062722. |
mptp induced a significant loss of nigrostriatal dopamine neurons and glial activation in the substantia nigra (sn) and striatum (str) as visualized by tyrosine hydroxylase (th) or macrophage antigen complex-1 (mac-1) or glial fibrillary acidic protein (gfap) immunocytochemistry, respectively. |
2021-07-12 |
2023-08-13 |
mouse |
| Shawn Zheng Kai Tan, Yasin Temel, Ariel Yovela Chan, Andrea Tsz Ching Mok, Jose Angelo Udal Perucho, Arjan Blokland, Luca Aquili, Wei Ling Lim, Lee Wei Li. Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation. Brain structure & function. vol 225. issue 7. 2021-07-06. PMID:32594260. |
we then attempted to unravel some of the interactions with dopamine signalling using tyrosine hydroxylase (th) immunohistochemistry to probe the effects on dopaminergic neurons. |
2021-07-06 |
2023-08-13 |
rat |
| Bertalan Dudas, Istvan Merchenthale. Thyrotropin-releasing hormone axonal varicosities appear to innervate dopaminergic neurons in the human hypothalamus. Brain structure & function. vol 225. issue 7. 2021-07-06. PMID:32737582. |
in rodents and teleosts, trh axons densely innervate tida neurons to inhibit tyrosine hydroxylase (th) biosynthesis, neuronal firing, and dopamine turnover which may contribute to increasing prl secretion. |
2021-07-06 |
2023-08-13 |
human |
| Steven Vetel, Laura Foucault-Fruchard, Claire Tronel, Frédéric Buron, Jackie Vergote, Sylvie Bodard, Sylvain Routier, Sophie Sérrière, Sylvie Chalo. Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson's disease. Neural regeneration research. vol 16. issue 6. 2021-07-03. PMID:33269756. |
although no effect was noticed in the amphetamine-induced rotation test, our data has shown that the pha/pre treatment induced partial protection of the dopaminergic neurons (15-20%), assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra. |
2021-07-03 |
2023-08-13 |
rat |