| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kathrine Stokholm, Majken Borup Thomsen, Jenny-Ann Phan, Line K Møller, Cecilie Bay-Richter, Søren H Christiansen, David P D Woldbye, Marina Romero-Ramos, Anne M Landa. α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson's Disease. Biomedicines. vol 9. issue 12. 2021-12-24. PMID:34944691. |
we performed: (1) in situ hybridization of nigral tyrosine hydroxylase mrna, (2) hplc of striatal dopamine content, and (3) autoradiography with [ |
2021-12-24 |
2023-08-13 |
human |
| Ningning Guo, Le Zhang, Wei Fan, Liping Bai, Xianwen Zhang, Zhizhou Shi, Jie Ba. Inhibition of Geranylgeranylacetone on cholecystokinin-B receptor, BDNF and dopamine D1 receptor induced by morphine. Biochemical and biophysical research communications. vol 588. 2021-12-23. PMID:34942530. |
then, our results showed that morphine increased the expressions of dopamine d1 receptor, tyrosine hydroxylase (th), cckb receptor and bdnf in the vta and nac in mice, which was inhibited by gga. |
2021-12-23 |
2023-08-13 |
mouse |
| Shunya Inukai, Satoshi Hara, Hiroshi Ichinos. Tyrosine hydroxylase activity is regulated through the modification of the 176th cysteine residue. Biochemical and biophysical research communications. vol 589. 2021-12-18. PMID:34922205. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in the biosynthesis of dopamine (da), and the regulation of its activity is important for da homeostasis. |
2021-12-18 |
2023-08-13 |
human |
| Guang-Wen Li, Ji Li, Xiao-Yan Feng, Hui Chen, Ye Chen, Jing-Hua Liu, Yue Zhang, Feng Hong, Jin-Xia Zh. Pancreatic acinar cells utilize tyrosine to synthesize L-dihydroxyphenylalanine. Experimental biology and medicine (Maywood, N.J.). vol 246. issue 23. 2021-12-11. PMID:34313482. |
however, only l-dihydroxyphenylalanine, but not dopamine, was detected when ar42j cells (rat pancreatic acinar cell line) were treated with tyrosine, which was blocked by tyrosine hydroxylase inhibitor ampt. |
2021-12-11 |
2023-08-13 |
rat |
| Iwona Przybylska, Damian Kania, Piotr Tymosiewicz, Józef Langfort, Małgorzata Chalimoniu. Post-translational and post-transcriptional mechanisms of activity regulation of tyrosine hydroxylase in the central nervous system – the effect of physical exercise Postepy biochemii. vol 67. issue 3. 2021-12-11. PMID:34894394. |
post-translational and post-transcriptional mechanisms of activity regulation of tyrosine hydroxylase in the central nervous system – the effect of physical exercise numerous studies indicate that dopamine (da) is an important regulator of motor, psychological and cognitive functions. |
2021-12-11 |
2023-08-13 |
Not clear |
| Iwona Przybylska, Damian Kania, Piotr Tymosiewicz, Józef Langfort, Małgorzata Chalimoniu. Post-translational and post-transcriptional mechanisms of activity regulation of tyrosine hydroxylase in the central nervous system – the effect of physical exercise Postepy biochemii. vol 67. issue 3. 2021-12-11. PMID:34894394. |
on the other hand, increased physical activity, in particular prolonged repetitive physical exercises by increasing the level of testosterone and bdnf in the blood, may activate signaling pathways dependent on them, increasing the activity of tyrosine hydroxylase, and thus increase the level of dopamine in the extrapyramidal system. |
2021-12-11 |
2023-08-13 |
Not clear |
| Alex M Maya-Romero, Gina E Dodd, Justine D Landin, Helen K Zaremba, Omar F Allen, Mackenzie A Bilbow, Rhyce D Hammaker, Jessica L Santerre-Anderso. Adolescent high-fructose corn syrup consumption leads to dysfunction in adult affective behaviors and mesolimbic proteins in male Sprague-Dawley rats. Behavioural brain research. vol 419. 2021-12-10. PMID:34838930. |
molecularly, protracted decreases in accumbal dopamine d1 and d2 receptors and protein kinase g (pkg), as well as increases in tyrosine hydroxylase and glua2 receptor subunits, were observed following hfcs-exposure. |
2021-12-10 |
2023-08-13 |
rat |
| Amanda L Sharpe, Marta Trzeciak, Nicole L Eliason, Harris E Blankenship, Bre' Ana M Byrd, Phillip D Douglas, Willard M Freeman, Michael J Beckstea. Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Addiction biology. 2021-12-03. PMID:34825430. |
in addition, we observed increased labelling of crf2 in drug treated groups, a decrease in the number of s100β positive cells, and an increase of co-staining of crf2 with both s100β and tyrosine hydroxylase (dopamine neurons). |
2021-12-03 |
2023-08-13 |
mouse |
| Sendegul Yildirim, Ayse Ozkan, Gunes Aytac, Aysel Agar, Gamze Tanriove. Role of melatonin in TLR4-mediated inflammatory pathway in the MTPT-induced mouse model. Neurotoxicology. vol 88. 2021-12-02. PMID:34808223. |
the effects on dopamine neurons in the snpc was determined by tyrosine hydroxylase (th) immunohistochemistry. |
2021-12-02 |
2023-08-13 |
mouse |
| Joseph J Lebowitz, Mason Trinkle, James R Bunzow, Judith Joyce Balcita-Pedicino, Savas Hetelekides, Brooks Robinson, Santiago De La Torre, Sue A Aicher, Susan R Sesack, John T William. Subcellular localization of D2 receptors in the murine substantia nigra. Brain structure & function. 2021-12-02. PMID:34854963. |
sep-d2rs appeared as puncta-like structures along the surface of dendrites and soma of dopamine neurons visualized by antibodies to tyrosine hydroxylase (th). |
2021-12-02 |
2023-08-13 |
mouse |
| Kui Cui, Fan Yang, Turan Tufan, Muhammad U Raza, Yanqiang Zhan, Yan Fan, Fei Zeng, Russell W Brown, Jennifer B Price, Thomas C Jones, Gary W Miller, Meng-Yang Zh. Restoration of Noradrenergic Function in Parkinson's Disease Model Mice. ASN neuro. vol 13. 2021-11-30. PMID:33940943. |
biochemical analysis showed that microinjection of lentiviral expression cassettes into the lc significantly increased mrna levels of phox2a, and phox2b, which were accompanied by parallel increases of mrna and proteins of dopamine β-hydroxylase (dbh) and tyrosine hydroxylase (th) in the lc. |
2021-11-30 |
2023-08-13 |
mouse |
| D Halperin, A Stavsky, R Kadir, M Drabkin, O Wormser, Y Yogev, V Dolgin, R Proskorovski-Ohayon, Y Perez, H Nudelman, O Stoler, B Rotblat, T Lifschytz, A Lotan, G Meiri, D Gitler, O S Bir. CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice. Nature communications. vol 12. issue 1. 2021-11-30. PMID:34702855. |
specific downstream molecular pathways were affected in both the ventral midbrain and prefrontal cortex, with reduced tyrosine hydroxylase expression and dopamine levels. |
2021-11-30 |
2023-08-13 |
mouse |
| Anna Maria Lavezz. Altered Development of Mesencephalic Dopaminergic Neurons in SIDS: New Insights into Understanding Sudden Infant Death Pathogenesis. Biomedicines. vol 9. issue 11. 2021-11-30. PMID:34829763. |
dopaminergic structures in midbrain sections of a large series of sudden infant deaths (36 sids and 26 controls) were identified using polyclonal rabbit antibodies against tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, and the dopamine transporter, a membrane protein specifically expressed in dopaminergic cells. |
2021-11-30 |
2023-08-13 |
human |
| George Mpekoulis, Vassilina Tsopela, Georgios Panos, Vasileiοs Siozos, Katerina I Kalliampakou, Efseveia Frakolaki, Constantinos D Sideris, Alice G Vassiliou, Diamantis C Sideris, Dido Vassilacopoulou, Niki Vassilak. Association of Hepatitis C Virus Replication with the Catecholamine Biosynthetic Pathway. Viruses. vol 13. issue 11. 2021-11-30. PMID:34834946. |
to counteract the effect of catecholamines, hcv, apart from the already reported effects on ddc, causes the down-regulation of tyrosine hydroxylase that encodes the rate-limiting enzyme of catecholamine biosynthesis and suppresses dopamine beta-hydroxylase mrna and protein amounts, while increasing the catecholamine degradation enzyme monoamine oxidase. |
2021-11-30 |
2023-08-13 |
Not clear |
| Sara Simorgh, Rafieh Alizadeh, Ronk Shabani, Fariba Karimzadeh, Elham Seidkhani, Jamal Majidpoor, Fatemeh Moradi, Hamidreza Kasbiya. Olfactory mucosa stem cells delivery via nasal route: a simple way for the treatment of Parkinson disease. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33433781. |
the results of real-time pcr and immunohistochemistry (ihc) analysis showed the expression of dopaminergic neuron markers such as pitx3, pax2, pax5 (as dopaminergic neurons markers), tyrosine hydroxylase (th), and dopamine transporter (dat) 2 months after ina of 1 × 10 |
2021-11-29 |
2023-08-13 |
rat |
| Mutsuko Kawashima, Takehiro Yajima, Daisuke Tachiya, Souichi Kokubun, Hiroyuki Ichikawa, Tadasu Sat. Parasympathetic neurons in the human submandibular ganglion. Tissue & cell. vol 70. 2021-11-29. PMID:33517097. |
in this study, immunohistochemistry for vasoactive intestinal polypeptide (vip), neuropeptide y (npy), choline acetyltransferase (chat), dopamine β-hydroxylase (dbh), tyrosine hydroxylase (th), and the transient receptor potential cation channel subfamily v members 1 (trpv1) and 2 (trpv2) was performed on the human smg. |
2021-11-29 |
2023-08-13 |
human |
| Guiran Xiao, Mengran Zhao, Zhihua Liu, Fan Du, Bing Zho. Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster. BMC biology. vol 19. issue 1. 2021-11-29. PMID:34732185. |
zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in drosophila melanogaster. |
2021-11-29 |
2023-08-13 |
drosophila_melanogaster |
| Fei Zeng, Yan Fan, Russell W Brown, Wesley Drew Gill, Jennifer B Price, Thomas C Jones, Meng-Yang Zh. Effects of Manipulation of Noradrenergic Activities on the Expression of Dopaminergic Phenotypes in Aged Rat Brains. ASN neuro. vol 13. 2021-11-27. PMID:34812056. |
results showed that the administration of l-threo-3,4-dihydroxyphenylserine (l-dops) for 21 days significantly increased the expression of tyrosine hydroxylase (th) and dopamine transporter (dat) in the striatum and substantia nigra (sn) of 23-month-old rats. |
2021-11-27 |
2023-08-13 |
rat |
| Noriko Kimura, Kiyoto Shiga, Ken-Ichi Kaneko, Yutaka Oki, Chiho Sugisawa, Jun Saito, Seiich Tawara, Hiroshi Akahori, Susumu Sogabe, Takafumi Yamashita, Kazuhiro Takekoshi, Mitsuhide Naruse, Takayuki Katabam. Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas. Endocrine pathology. vol 32. issue 4. 2021-11-23. PMID:34743284. |
to determine the phenotypic features of these pgls, we performed an immunohistochemical study using specific antibodies against choline acetyltransferase (chat), an enzyme involved in acetylcholine synthesis, and enzymes for the catecholamine-synthesis, tyrosine hydroxylase (th), and dopamine beta-hydroxylase (dbh), in 34 hnpgls from 31 patients, 12 thoracoabdominal pgls from 12 patients, and 26 pheochromocytomas from 22 patients. |
2021-11-23 |
2023-08-13 |
Not clear |
| Mijung Yeom, Sora Ahn, Ju-Young Oh, Song-Yi Kim, Hyangsook Lee, Dae-Hyun Hahm, Hi-Joon Par. Atopic dermatitis induces anxiety- and depressive-like behaviors with concomitant neuronal adaptations in brain reward circuits in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31743694. |
under these conditions, enhanced camp response element binding protein (creb) and dopamine and camp-regulated phosphoprotein, 32 kda (darpp32) phosphorylation, significantly higher brain-derived neurotrophic factor (bdnf) and Δfosb, but reduced tyrosine hydroxylase (th) and dopamine d1 receptor (d1r) protein expression were found in the nac, ds and vta. |
2021-11-22 |
2023-08-13 |
mouse |