| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta González-Sepúlveda, Muhammad Yusof Omar, Sally Hamdon, Guofen Ma, Santi Rosell-Vilar, Noora Raivio, Doaa Abass, Anna Martínez-Rivas, Miquel Vila, Jesús Giraldo, Montserrat Carrascal, Joaquín Abián, Carles Gil, Josefa Sabriá, Jordi Ortiz, David Moreno-Delgad. Spontaneous changes in brain striatal dopamine synthesis and storage dynamics ex vivo reveal end-product feedback-inhibition of tyrosine hydroxylase. Neuropharmacology. 2022-04-16. PMID:35429504. |
we analyzed whether these changes in brain dopamine biosynthesis and storage were linked to dopamine feedback inhibition of its synthesis-limiting enzyme tyrosine hydroxylase. |
2022-04-16 |
2023-08-13 |
rat |
| Yu Sun, Congyu Wang, Min Sun, Zhen Fa. Bioinspired polymeric pigments to mimic natural hair coloring. RSC advances. vol 11. issue 3. 2022-04-15. PMID:35424122. |
first, in the presence of tyrosine hydroxylase and metal ions, dopamine could be oxidized into polydopamine, a mimic of human eumelanin, and then self-assembled into nanometer-scale pigments. |
2022-04-15 |
2023-08-13 |
human |
| Kasthuri Bai Magalingam, Sushela Devi Somanath, Nagaraja Haleagrahara, Kanga Rani Selvaduray, Ammu Kutty Radhakrishna. Unravelling the neuroprotective mechanisms of carotenes in differentiated human neural cells: Biochemical and proteomic approaches. Food chemistry. Molecular sciences. vol 4. 2022-04-13. PMID:35415676. |
furthermore, tmc elevated the levels of intra-neuronal dopamine and tyrosine hydroxylase (th) in differentiated neural cells. |
2022-04-13 |
2023-08-13 |
human |
| Joanna Oi-Yue Yau, Gavan P McNall. The activity of ventral tegmental area dopamine neurons during shock omission predicts safety learning. Behavioral neuroscience. 2022-03-31. PMID:35357862. |
we studied the role of dopamine [tyrosine hydroxylase (th)] neurons in the rat ventral tegmental area (vta) in safety learning. |
2022-03-31 |
2023-08-13 |
rat |
| George Mpekoulis, Vassilina Tsopela, Anna Chalari, Katerina I Kalliampakou, Georgios Panos, Efseveia Frakolaki, Raphaela S Milona, Diamantis C Sideris, Dido Vassilacopoulou, Niki Vassilak. Dengue Virus Replication Is Associated with Catecholamine Biosynthesis and Metabolism in Hepatocytes. Viruses. vol 14. issue 3. 2022-03-26. PMID:35336971. |
in turn, dv apart from its negative impact on ddc, inhibits tyrosine hydroxylase, dopamine beta-hydroxylase, monoamine oxidase, and vmat2 expression. |
2022-03-26 |
2023-08-13 |
Not clear |
| Wesley Zhi Chung See, Rakesh Naidu, Kim San Tan. Cellular and Molecular Events Leading to Paraquat-Induced Apoptosis: Mechanistic Insights into Parkinson's Disease Pathophysiology. Molecular neurobiology. 2022-03-20. PMID:35306641. |
these include oxidative stress, mitochondria dysfunction, endoplasmic reticulum stress, alteration in dopamine catabolism, inactivation of tyrosine hydroxylase, and decreased levels of neurotrophic factors. |
2022-03-20 |
2023-08-13 |
human |
| Ozgur Mete, Sylvia L Asa, Anthony J Gill, Noriko Kimura, Ronald R de Krijger, Arthur Tischle. Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas. Endocrine pathology. 2022-03-14. PMID:35285002. |
in addition to the general neuroendocrine cell biomarkers insm1, synaptophysin, and chromogranins, these tumors are typically negative for keratins and instead have highly specific biomarkers, including the gata3 transcription factor and enzymes involved in catecholamine biosynthesis: tyrosine hydroxylase that converts l-tyrosine to l-dopa as the rate-limiting step in catecholamine biosynthesis, dopamine beta-hydroxylase that is present in cells expressing norepinephrine, and phenylethanolamine n-methyltransferase, which converts norepinephrine to epinephrine and therefore can be used to distinguish tumors that make epinephrine. |
2022-03-14 |
2023-08-13 |
Not clear |
| Kena Wang, Hongbo Zhang, Jinshan Ji, Rui Zhang, Wei Dang, Qiaoli Xie, Yongsheng Zhu, Jianbo Zhan. Expression Quantitative Trait Locus rs6356 Is Associated with Susceptibility to Heroin Addiction by Potentially Influencing TH Gene Expression in the Hippocampus and Nucleus Accumbens. Journal of molecular neuroscience : MN. 2022-03-08. PMID:35258801. |
encoding a dopamine synthetase, the tyrosine hydroxylase (th) gene has long been an interesting candidate in genetic association studies for opioid addiction. |
2022-03-08 |
2023-08-13 |
Not clear |
| Luyin Wu, Yao Dang, Li-Xia Liang, Yan-Chen Gong, Mohammed Zeeshan, Zhengmin Qian, Sarah Dee Geiger, Michael G Vaughn, Yang Zhou, Qing-Qing Li, Chu Chu, Ya-Wen Tan, Li-Zi Lin, Ru-Qing Liu, Li-Wen Hu, Bo-Yi Yang, Xiao-Wen Zeng, Yunjiang Yu, Guang-Hui Don. Perfluorooctane sulfonates induces neurobehavioral changes and increases dopamine neurotransmitter levels in zebrafish larvae. Chemosphere. 2022-03-08. PMID:35259355. |
upregulation of dopamine-related genes tyrosine hydroxylase (th) and dopamine transporter (dat) associated with increased dopamine contents in the 3.2 mg/l of pfos. |
2022-03-08 |
2023-08-13 |
zebrafish |
| Leigh Dairaghi, Stephanie Constantin, Andy Oh, David Shostak, Susan Wra. The Dopamine D4 Receptor Regulates Gonadotropin-Releasing Hormone Neuron Excitability in Male Mice. eNeuro. 2022-02-15. PMID:35165199. |
previous studies in adult rodents have reported juxtaposition of fibers containing tyrosine hydroxylase (th), a marker of catecholaminergic cells, onto gnrh neurons and that exogenous dopamine inhibits gnrh neurons postsynaptically through dopamine d1-like and/or d2-like receptors. |
2022-02-15 |
2023-08-13 |
mouse |
| Yongjie Xu, Tao Peng, Yang Xiang, Gengze Liao, Fei Zou, Xiaojing Men. Neurotoxicity and gene expression alterations in zebrafish larvae in response to manganese exposure. The Science of the total environment. 2022-02-12. PMID:35150691. |
the terminal deoxynucleotidyl transferase dutp nick end labeling assay and acridine orange staining were performed to monitor cell apoptosis, while dopamine transporter (dat) and tyrosine hydroxylase (th) expression were detected by immunohistochemical staining. |
2022-02-12 |
2023-08-13 |
zebrafish |
| G E Pennacchio, F E Santonja, F J Neira, C Bregonzio, M Soaj. Prenatal Amphetamine-Induced Dopaminergic Alteration in a Gender- and Estrogen-Dependent Manner. Neurochemical research. 2022-02-11. PMID:35147850. |
we evaluated the effects of prenatal amphetamine exposure on locomotor activity, dopamine receptors and tyrosine hydroxylase mrna expression in nucleus accumbens and caudate-putamen in response to amphetamine challenge in adult female and male rats. |
2022-02-11 |
2023-08-13 |
rat |
| Andrew Gao, Hannah M McCoy, Vandana Zaman, Donald C Shields, Naren L Banik, Azizul Haqu. Calpain activation and progression of inflammatory cycles in Parkinson's disease. Frontiers in bioscience (Landmark edition). vol 27. issue 1. 2022-01-29. PMID:35090325. |
α-syn aggregation also results in the disruption of dopamine synthesis through phosphorylation of tyrosine hydroxylase (th), a key enzyme involved in the conversion of tyrosine to levodopa (l-dopa), the amino acid precursor to dopamine. |
2022-01-29 |
2023-08-13 |
Not clear |
| Fernando Caravaggio, Alexander J Barnett, Shinichiro Nakajima, Yusuke Iwata, Julia Kim, Carol Borlido, Wanna Mar, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrer. The effects of acute dopamine depletion on resting-state functional connectivity in healthy humans. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 57. 2022-01-29. PMID:35091322. |
alpha-methyl-para-tyrosine (ampt), a competitive inhibitor of tyrosine hydroxylase, can be used to deplete endogenous dopamine in humans. |
2022-01-29 |
2023-08-13 |
human |
| Qi Hu, Mei Hong, Mengyang Huang, Quan Gong, Xiaofan Zhang, Vladimir N Uversky, Francisco Pan-Montojo, Teng Huang, Honglian Zhou, Suiqiang Zh. Age-dependent aggregation of α-synuclein in the nervous system of gut-brain axis is associated with caspase-1 activation. Metabolic brain disease. 2022-01-28. PMID:35089485. |
whereas, the expression of tyrosine hydroxylase (th), the rate-limiting enzyme for dopamine synthesis, was decreased with aging in the midbrain. |
2022-01-28 |
2023-08-13 |
mouse |
| Kasthuri Bai Magalingam, Sushela Devi Somanath, Shadab Md, Nagaraja Haleagrahara, Ju-Yen Fu, Kanga Rani Selvaduray, Ammu Kutty Radhakrishna. Tocotrienols protect differentiated SH-SY5Y human neuroblastoma cells against 6-hydroxydopamine-induced cytotoxicity by ameliorating dopamine biosynthesis and dopamine receptor D2 gene expression. Nutrition research (New York, N.Y.). vol 98. 2022-01-22. PMID:35065349. |
notably, trf was highly efficient in scavenging reactive oxygen species and upregulating dopamine and tyrosine hydroxylase levels in the differentiated sh-sy5y cells. |
2022-01-22 |
2023-08-13 |
human |
| Lulu Tian, Murad Al-Nusaif, Xi Chen, Song Li, Weidong L. Roles of Transcription Factors in the Development and Reprogramming of the Dopaminergic Neurons. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35055043. |
in vitro and in vivo, tfs regulate the expression of tyrosine hydroxylase, a dopamine transporter, vesicular monoamine transporter 2, and l-aromatic amino acid decarboxylase, all of which are critical for dopamine synthesis and transport in dopaminergic neurons (da neurons). |
2022-01-21 |
2023-08-13 |
human |
| María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M Valpuest. Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nature communications. vol 13. issue 1. 2022-01-11. PMID:35013193. |
structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by ser40 phosphorylation. |
2022-01-11 |
2023-08-13 |
human |
| María Teresa Bueno-Carrasco, Jorge Cuéllar, Marte I Flydal, César Santiago, Trond-André Kråkenes, Rune Kleppe, José R López-Blanco, Miguel Marcilla, Knut Teigen, Sara Alvira, Pablo Chacón, Aurora Martinez, José M Valpuest. Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nature communications. vol 13. issue 1. 2022-01-11. PMID:35013193. |
tyrosine hydroxylase (th) catalyzes the rate-limiting step in the biosynthesis of dopamine (da) and other catecholamines, and its dysfunction leads to da deficiency and parkinsonisms. |
2022-01-11 |
2023-08-13 |
human |
| Khalid A Mohamad, Reem N El-Naga, Sara A Wahda. Neuroprotective effects of indole-3-carbinol on the rotenone rat model of Parkinson's disease: Impact of the SIRT1-AMPK signaling pathway. Toxicology and applied pharmacology. 2022-01-01. PMID:34973289. |
the effects of i3c (25, 50, and 100 mg/kg/day) were assessed by catalepsy test (bar test), spontaneous locomotor activity, rotarod test, weight change, tyrosine hydroxylase (th) expression, α-synuclein (α-syn) expression, striatal dopamine (da) content, and histological examination. |
2022-01-01 |
2023-08-13 |
rat |