| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiajing Shan, Youge Qu, Siming Wang, Yan Wei, Lijia Chang, Li Ma, Kenji Hashimot. Regulation of neurotoxicity in the striatum and colon of MPTP-induced Parkinson's disease mice by gut microbiome. Brain research bulletin. vol 177. 2021-11-18. PMID:34560239. |
mptp caused the reduction of dopamine transporter (dat) and tyrosine hydroxylase (th) in the striatum, and increases in phosphorylated α-synuclein (p-α-syn) in the striatum and colon. |
2021-11-18 |
2023-08-13 |
mouse |
| Bárbara Mendes-Pinheiro, Carina Soares-Cunha, Ana Marote, Eduardo Loureiro-Campos, Jonas Campos, Sandra Barata-Antunes, Daniela Monteiro-Fernandes, Diogo Santos, Sara Duarte-Silva, Luísa Pinto, António José Salgad. Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34768962. |
these results were accompanied by a decrease in tyrosine hydroxylase (th)-labelling and dopamine levels within the nigrostriatal pathway. |
2021-11-18 |
2023-08-13 |
mouse |
| Kathryn Gallman, Eric Fortune, Daihana Rivera, Daphne Soare. Differences in behavior between surface and cave Astyanax mexicanus may be mediated by changes in catecholamine signaling. The Journal of comparative neurology. vol 528. issue 16. 2021-11-16. PMID:32291742. |
we examined the distribution of tyrosine hydroxylase, a conserved precursor for the synthesis of the catecholamines dopamine and noradrenaline, in the brains of surface and cave astyanax using immunohistochemistry. |
2021-11-16 |
2023-08-13 |
Not clear |
| Rehab El-Shehawy, Sandra Luecke-Johansson, Anton Ribbenstedt, Elena Gorokhov. Microbiota-Dependent and -Independent Production of l-Dopa in the Gut of Daphnia magna. mSystems. 2021-11-13. PMID:34751589. |
we demonstrate the following: (i) tyrosine hydroxylase and dopa (3,4-dihydroxyphenylalanine) decarboxylase enzymes are present in the gut wall; (ii) dopa decarboxylase gene is expressed in the gut by the host, and its expression follows the molt cycle peaking after ecdysis; (iii) biologically active l-dopa, but not dopamine, is present in the gut lumen; (iv) gut bacteria produce l-dopa in a concentration-dependent manner when provided l-tyrosine as a substrate. |
2021-11-13 |
2023-08-13 |
Not clear |
| b' Mustafa \\xc3\\x87a\\xc4\\x9flar Beker, Merve Beker, Ahmet Burak \\xc3\\x87a\\xc4\\x9flayan, Busenur Bolat, \\xc3\\x9clkan Kili\\xc3\\xa7, Gamze K\\xc3\\xb6se, Ertu\\xc4\\x9frul Kili\\xc3\\xa. Striatal dopaminergic neurons as a potential target for GDNF based ischemic stroke therapy. Turkish journal of medical sciences. 2021-11-13. PMID:34773698.' |
this study aimed to investigate the potential protective role of lentiviral gndf delivery on the small population of tyrosine hydroxylase (th) positive dopamine producing striatal neurons after ischemic stroke. |
2021-11-13 |
2023-08-13 |
Not clear |
| Arvie Abiero, Raly James Perez Custodio, Chrislean Jun Botanas, Darlene Mae Ortiz, Leandro Val Sayson, Mikyung Kim, Hyun Jun Lee, Seolmin Yoon, Yong Sup Lee, Jae Hoon Cheong, Hee Jin Ki. 1-Phenylcyclohexan-1-amine hydrochloride (PCA HCl) alters mesolimbic dopamine system accompanied by neuroplastic changes: A neuropsychopharmacological evaluation in rodents. Neurochemistry international. vol 144. 2021-11-12. PMID:33460722. |
pca altered the da, tyrosine hydroxylase, dopamine d1 and d2 receptors as well as p-creb and deltafosb. |
2021-11-12 |
2023-08-13 |
mouse |
| Piniel Alphayo Kambey, Ma Chengcheng, Guo Xiaoxiao, Ayanlaja Abiola Abdulrahman, Kouminin Kanwore, Iqra Nadeem, Wu Jiao, Dianshuai Ga. The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33507465. |
we first demonstrated that amodiaquine treatment ameliorated behavioural deficits in 6-ohda parkinson's disease mouse model, and it promoted dopaminergic neurons protection signified by tyrosine hydroxylase (th) and dopamine transporter (dat) mrna; tyrosine hydroxylase (th) protein expression level and the immunoreactivity in the substantia nigra compacta. |
2021-11-12 |
2023-08-13 |
mouse |
| Anna Masato, Luigi Bubacco, Elisa Greggi. Too much for your own good: Excessive dopamine damages neurons and contributes to Parkinson's disease: An Editorial Highlight for "Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo". Journal of neurochemistry. vol 158. issue 4. 2021-11-12. PMID:34184261. |
too much for your own good: excessive dopamine damages neurons and contributes to parkinson's disease: an editorial highlight for "enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo". |
2021-11-12 |
2023-08-13 |
mouse |
| Anna Masato, Luigi Bubacco, Elisa Greggi. Too much for your own good: Excessive dopamine damages neurons and contributes to Parkinson's disease: An Editorial Highlight for "Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo". Journal of neurochemistry. vol 158. issue 4. 2021-11-12. PMID:34184261. |
generated and characterized a new in vivo model of chronic dopamine accumulation through the overexpression of a hyperactive form of tyrosine hydroxylase (th-hi), the rate-limiting step enzyme in dopamine biosynthesis. |
2021-11-12 |
2023-08-13 |
mouse |
| Laura M Vecchio, Patricia Sullivan, Amy R Dunn, Marie Kristel Bermejo, Rong Fu, Shababa T Masoud, Emil Gregersen, Nikhil M Urs, Reza Nazari, Poul Henning Jensen, Amy Ramsey, David S Goldstein, Gary W Miller, Ali Salahpou. Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo. Journal of neurochemistry. vol 158. issue 4. 2021-11-11. PMID:33991113. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in dopamine biosynthesis. |
2021-11-11 |
2023-08-13 |
mouse |
| Tristan J Hynes, Kelly M Hrelja, Brett A Hathaway, Celine D Hounjet, Chloe S Chernoff, Sophie A Ebsary, Graeme D Betts, Brittney Russell, Lawrence Ma, Sukhbir Kaur, Catharine A Winstanle. Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity. Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33559379. |
to test this hypothesis, we first gained specific inhibitory control over vta dopamine neurons by transducing a floxed inhibitory dreadd (aav5-hsyn-dio-hm4d(gi)-mcherry) in rats expressing cre recombinase in tyrosine hydroxylase neurons. |
2021-11-10 |
2023-08-13 |
rat |
| Nathan Beals, Mohamed M Farhath, Prakash Kharel, Brintha Croos, Thulasi Mahendran, John Johnson, Soumitra Bas. Rationally designed DNA therapeutics can modulate human TH expression by controlling specific GQ formation in its promoter. Molecular therapy : the journal of the American Society of Gene Therapy. 2021-11-09. PMID:33992806. |
tyrosine hydroxylase (th) catalyzes the rate-limiting step in the catecholamine (ca) biosynthesis pathway, making th a molecular target for controlling ca production, specifically dopamine. |
2021-11-09 |
2023-08-13 |
human |
| Alcmène Chalazonitis, ZhiShan Li, Tuan D Pham, Jason Chen, Meenakshi Rao, Päivi Lindholm, Mart Saarma, Maria Lindahl, Michael D Gersho. Cerebral dopamine neurotrophic factor is essential for enteric neuronal development, maintenance, and regulation of gastrointestinal transit. The Journal of comparative neurology. vol 528. issue 14. 2021-11-05. PMID:32154930. |
expression of cdnf, moreover, is essential for the normal development and survival of enteric dopaminergic neurons; thus, expression of the dopaminergic neuronal markers, dopamine, tyrosine hydroxylase, and dopamine transporter are deficient in the ileum of cdnf |
2021-11-05 |
2023-08-13 |
Not clear |
| Yan Teng, Zhihao Liu, Xingmin Chen, Yanzhuo Liu, Fan Geng, Weidong Le, Haisong Jiang, Lu Yan. Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function. Journal of cellular and molecular medicine. vol 25. issue 17. 2021-11-04. PMID:34288397. |
tyrosine hydroxylase (th), an essential enzyme for dopamine synthesis, was also down-regulated upon mettl14 deletion, while the activation of microglia and astrocyte was enhanced. |
2021-11-04 |
2023-08-13 |
mouse |
| Maria T Bezem, Fredrik G Johannessen, Trond-André Kråkenes, Michael J Sailor, Aurora Martine. Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles. Molecular pharmaceutics. vol 18. issue 3. 2021-11-02. PMID:33417459. |
tyrosine hydroxylase (th) is the enzyme catalyzing the rate-limiting step in the synthesis of dopamine in the brain. |
2021-11-02 |
2023-08-13 |
Not clear |
| Takuya Yokoyama, Yoshio Yamamoto, Masato Hirakawa, Kouki Kato, Tomoyuki Sain. Vesicular nucleotide transporter-immunoreactive type I cells associated with P2X3-immunoreactive nerve endings in the rat carotid body. The Journal of comparative neurology. vol 528. issue 9. 2021-11-01. PMID:31808543. |
among syn-immunoreactive type i cells, vnut immunoreactivity was selectively localized in the sub-population of tyrosine hydroxylase (th)-immunorective type i cells associated with nerve endings immunoreactive for the p2x3 purinoceptor; however, it was not detected in the sub-population of type i cells immunoreactive for dopamine beta-hydroxylase. |
2021-11-01 |
2023-08-13 |
rat |
| Josephine Timm, Mara Scherner, Jannik Matschke, Martina Kern, Uwe Homber. Tyrosine hydroxylase immunostaining in the central complex of dicondylian insects. The Journal of comparative neurology. vol 529. issue 12. 2021-11-01. PMID:33825188. |
to infer a possible influence of evolutionary history and lifestyle on the neurochemical architecture of the cx, we have studied the distribution of neurons immunoreactive to tyrosine hydroxylase (th), the rate-limiting enzyme in dopamine biosynthesis. |
2021-11-01 |
2023-08-13 |
Not clear |
| Elize Aparecida Santos Musachio, Shanda de Freitas Couto, Marcia Rósula Poetini, Vandreza Cardoso Bortolotto, Mustafa Munir Mustafa Dahleh, Dieniffer Espinosa Janner, Stífani Machado Araujo, Bruna Piaia Ramborger, Rafael Rohers, Gustavo Petri Guerra, Marina Prigo. Bisphenol A exposure during the embryonic period: Insights into dopamine relationship and behavioral disorders in Drosophila melanogaster. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 157. 2021-11-01. PMID:34461193. |
furthermore, decreases in dopamine levels and tyrosine hydroxylase activity have also been observed in flies' heads, possibly related to oxidative damage. |
2021-11-01 |
2023-08-13 |
drosophila_melanogaster |
| Shunyi Zhao, Jaclyn H DeFinis, Shaoping Ho. Alterations of Dopamine-Related Transcripts in A11 Diencephalospinal Pathways after Spinal Cord Injury. Neural plasticity. vol 2021. 2021-10-27. PMID:33510781. |
the results showed that, compared to naïve rats, mrna levels of tyrosine hydroxylase (th), dopamine decarboxylase (ddc), and d |
2021-10-27 |
2023-08-13 |
rat |
| Sayantan Sur, Aakansha Sharma, Indu Malik, Sanjay Kumar Bhardwaj, Vinod Kuma. Daytime light spectrum affects photoperiodic induction of vernal response in obligate spring migrants. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. vol 259. 2021-10-25. PMID:34126231. |
similarly, we found in birds under blue daylight an increased hypothalamic expression of genes involved in the photoperiodic induction (thyroid stimulating hormone subunit beta, tshb; eye absent 3, eya3; deiodinase type 2, dio2) and associated neural responses such as the calcium signaling (atpase sarcoplasmic/endoplasmic reticulum ca2+ transporting 2, atp2a2), dopamine biosynthesis (tyrosine hydroxylase, th) and neurogenesis (brain-derived neurotrophic factor, bdnf). |
2021-10-25 |
2023-08-13 |
Not clear |