| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew R Holahan, Catherine A Smith, Bryan E Luu, Kenneth B Store. Preadolescent Phthalate (DEHP) Exposure Is Associated With Elevated Locomotor Activity and Reward-Related Behavior and a Reduced Number of Tyrosine Hydroxylase Positive Neurons in Post-Adolescent Male and Female Rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 165. issue 2. 2019-09-25. PMID:29982774. |
because a number of exogenous agents have been shown to interfere with dopamine function, we evaluated post-adolescent behavioral (operant conditioning for food reward and locomotor activity), histological (tyrosine hydroxylase; th), and genetic (mrna levels) outcomes of preadolescent (postnatal days [pnd] 16-22) phthalate exposure. |
2019-09-25 |
2023-08-13 |
rat |
| Gejuan Zhang, Geqiang Yang, Jian Li. Phloretin attenuates behavior deficits and neuroinflammatory response in MPTP induced Parkinson's disease in mice. Life sciences. vol 232. 2019-09-24. PMID:31251998. |
mptp intoxication in mice cause motor abnormalities, decreased dopamine (da) levels, reduced tyrosine hydroxylase (th) enzyme protein expression and inflammation which were effectively restored by phl. |
2019-09-24 |
2023-08-13 |
mouse |
| S K Tahajjul Taufique, Abhilash Prabhat, Vinod Kuma. Constant light environment suppresses maturation and reduces complexity of new born neuron processes in the hippocampus and caudal nidopallium of a diurnal corvid: Implication for impairment of the learning and cognitive performance. Neurobiology of learning and memory. vol 147. 2019-09-09. PMID:29229413. |
we performed immunohistochemistry of doublecortin (dcx; a neurogenesis marker) and tyrosine hydroxylase (th, a key enzyme of the dopamine biosynthesis) in the brain section containing hippocampus or caudal nidopallium of indian house crows exposed for 2 weeks to ll, with controls maintained under 12l:12d. |
2019-09-09 |
2023-08-13 |
Not clear |
| Xianwen Zhang, Liping Bai, Se Zhang, Xiaoshuang Zhou, Ye Li, Jie Ba. Trx-1 ameliorates learning and memory deficits in MPTP-induced Parkinson's disease model in mice. Free radical biology & medicine. vol 124. 2019-09-06. PMID:29960099. |
the expressions of tyrosine hydroxylase (th) and dopamine d1 receptor (d1r) were decreased by mptp, which were restored in trx-1 tg mice. |
2019-09-06 |
2023-08-13 |
mouse |
| A R Murtazina, Yu O Nikishina, L K Dil'mukhametova, A Ya Sapronova, M V Ugrumo. The Role of the Brain in the Regulation of Peripheral Noradrenaline-producing Organs in Rats During Morphogenesis. Doklady. Biochemistry and biophysics. vol 486. issue 1. 2019-08-29. PMID:31367831. |
in this study, we used a rat model that allowed blocking the synthesis of noradrenalin in the brain and evaluated gene expression and protein levels of noradrenaline key synthesis enzymes such as tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) in peripheral noradrenaline-producing organs. |
2019-08-29 |
2023-08-13 |
rat |
| Chunxiao Qi, Xiaoming Ji, Guoliang Zhang, Yunxiao Kang, Yuanxiang Huang, Rui Cui, Shuangcheng Li, Huixian Cui, Geming Sh. Haloperidol ameliorates androgen-induced behavioral deficits in developing male rats. The Journal of endocrinology. vol 237. issue 2. 2019-08-27. PMID:29563235. |
the tp treatment produced the hyperactive motor behavior and grooming behavior as well as the increased levels of dopamine, tyrosine hydroxylase and dopamine transporter in the mesodopaminergic system and the elevated levels of serotonin in the nucleus accumbens, without affecting the levels of glutamate, γ-aminobutyric acid, norepinephrine and histamine in the caudate putamen and nucleus accumbens of pnd21 and pnd49 rats. |
2019-08-27 |
2023-08-13 |
rat |
| Yoshitaka Hamanaka, Makoto Mizunam. Tyrosine hydroxylase-immunoreactive neurons in the mushroom body of the field cricket, Gryllus bimaculatus. Cell and tissue research. vol 376. issue 1. 2019-08-19. PMID:30578444. |
immunocytochemistry to tyrosine hydroxylase (th), a rate-limiting enzyme in dopamine biosynthesis, revealed the following four distinct classes of neurons: (1) th-slp projecting to the distal vertical lobe; (2) th-ip1 extending to the medial and γ lobes; (3) th-ip2 projecting to the basal vertical lobe; and (4) a multiglomerular projection neuron invading the anterior calyx and the lateral horn (th-mpn). |
2019-08-19 |
2023-08-13 |
cricket |
| Dennis Paliga, Fabian Raudzus, Stephen H Leppla, Rolf Heumann, Sebastian Neuman. Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells. Molecular neurobiology. vol 56. issue 5. 2019-08-13. PMID:30121937. |
addition of the nurr1 fusion protein to dopaminergic sh-sy5y cells generated a cleaved, cytosolic nurr1-containing fragment which was associated with increased levels of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2019-08-13 |
2023-08-13 |
mouse |
| Devin P Merullo, Jeremy A Spool, Changjiu Zhao, Lauren V Riter. Co-localization patterns of neurotensin receptor 1 and tyrosine hydroxylase in brain regions involved in motivation and social behavior in male European starlings. Journal of chemical neuroanatomy. vol 89. 2019-08-02. PMID:29407461. |
double fluorescent immunolabeling was performed to detect co-localization patterns between tyrosine hydroxylase (th; the rate-limiting enzyme in dopamine synthesis) and ntr1 in brain regions implicated in motivation and song production (the ventral tegmental area, medial preoptic nucleus, periaqueductal gray, and lateral septum). |
2019-08-02 |
2023-08-13 |
Not clear |
| Siew Hoong Yip, Jade York, Brian Hyland, Stephen J Bunn, David R Gratta. Incomplete concordance of dopamine transporter Cre (DAT Journal of chemical neuroanatomy. vol 90. 2019-07-29. PMID:29217488. |
incomplete concordance of dopamine transporter cre (dat co-localization of the expression of the dopamine transporter (dat) with the catecholamine synthesising enzyme tyrosine hydroxylase (th) has been investigated using transgenic mice expressing cre recombinase (cre) dependent green fluorescent protein (gfp) under the control of the dat promoter (dat |
2019-07-29 |
2023-08-13 |
mouse |
| Lalit P Chandravanshi, Richa Gupta, Rajendra K Shukl. Arsenic-Induced Neurotoxicity by Dysfunctioning Cholinergic and Dopaminergic System in Brain of Developing Rats. Biological trace element research. vol 189. issue 1. 2019-07-22. PMID:30051311. |
further, a protein expression of tyrosine hydroxylase (th), levels of dopamine, and its metabolites were also significantly impaired in corpus striatum. |
2019-07-22 |
2023-08-13 |
rat |
| Susana Paredes-Zúñiga, Nils Trost, Javiera F De la Paz, Julio Alcayaga, Miguel L Allend. Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways. Progress in neuro-psychopharmacology & biological psychiatry. vol 92. 2019-06-27. PMID:30593828. |
the lowest concentration does not alter neither locomotor activity nor dopamine levels but produced changes in the expression of two genes, tyrosine hydroxylase 1 (th1) and dopamine transporter (dat). |
2019-06-27 |
2023-08-13 |
zebrafish |
| Patrícia C R Rabelo, Nayara A C Horta, Letícia M S Cordeiro, Maristela O Poletini, Cândido C Coimbra, Raphael E Szawka, Danusa D Soare. Intrinsic exercise capacity in rats influences dopamine neuroplasticity induced by physical training. Journal of applied physiology (Bethesda, Md. : 1985). vol 123. issue 6. 2019-06-20. PMID:28883047. |
after that, concentrations of dopamine (da), serotonin (5-ht), and their metabolites and mrna levels of d1 receptor ( drd1), d2 receptor ( drd2), dopamine transporter ( dat), tyrosine hydroxylase ( th), glia cell line neurotrophic factor ( gdnf), and brain-derived neurotrophic factor ( bdnf) were determined in the caudate-putamen (cpu). |
2019-06-20 |
2023-08-13 |
rat |
| Patrícia C R Rabelo, Nayara A C Horta, Letícia M S Cordeiro, Maristela O Poletini, Cândido C Coimbra, Raphael E Szawka, Danusa D Soare. Intrinsic exercise capacity in rats influences dopamine neuroplasticity induced by physical training. Journal of applied physiology (Bethesda, Md. : 1985). vol 123. issue 6. 2019-06-20. PMID:28883047. |
to evaluate the dopaminergic neuroplasticity, we analyzed mrna levels of d1 receptor, d2 receptor, dopamine transporter, tyrosine hydroxylase, glia cell line neurotrophic factor, and brain-derived neurotrophic factor as well as concentrations of dopamine, serotonin, and their metabolites. |
2019-06-20 |
2023-08-13 |
rat |
| Hyenjong Hong, Marcel M Daad. Generating Neural Stem Cells from iPSCs with Dopaminergic Neurons Reporter Gene. Methods in molecular biology (Clifton, N.J.). vol 1919. 2019-06-14. PMID:30656625. |
tyrosine hydroxylase (th) is the rate-limiting enzyme for the biosynthesis of the dopamine neurotransmitter, and thus it has been used as a reliable marker for dopaminergic neurons in vitro and in vivo. |
2019-06-14 |
2023-08-13 |
Not clear |
| b' Albert Torra, Annabelle Parent, Thais Cuadros, Beatriz Rodr\\xc3\\xadguez-Galv\\xc3\\xa1n, Esther Ruiz-Bronchal, Andrea Ballabio, Anal\\xc3\\xada Bortolozzi, Miquel Vila, Jordi Bov\\xc3\\xa. Overexpression of TFEB Drives a Pleiotropic Neurotrophic Effect and Prevents Parkinson\'s Disease-Related Neurodegeneration. Molecular therapy : the journal of the American Society of Gene Therapy. vol 26. issue 6. 2019-06-11. PMID:29628303.' |
we demonstrate that tfeb overexpression drives a previously unknown bona fide neurotrophic effect, giving rise to cell growth, higher tyrosine hydroxylase levels, and increased dopamine release in the striatum. |
2019-06-11 |
2023-08-13 |
mouse |
| Lingling Lu, Huanzhen Jia, Ge Gao, Chunli Duan, Jing Ren, Yi Li, Hui Yan. Pink1 Regulates Tyrosine Hydroxylase Expression and Dopamine Synthesis. Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29843233. |
pink1 regulates tyrosine hydroxylase expression and dopamine synthesis. |
2019-06-10 |
2023-08-13 |
Not clear |
| Lingling Lu, Huanzhen Jia, Ge Gao, Chunli Duan, Jing Ren, Yi Li, Hui Yan. Pink1 Regulates Tyrosine Hydroxylase Expression and Dopamine Synthesis. Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29843233. |
we found that pink1 knockdown resulted in dopamine content to decrease with suppressed tyrosine hydroxylase expression in cells. |
2019-06-10 |
2023-08-13 |
Not clear |
| Lingling Lu, Huanzhen Jia, Ge Gao, Chunli Duan, Jing Ren, Yi Li, Hui Yan. Pink1 Regulates Tyrosine Hydroxylase Expression and Dopamine Synthesis. Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29843233. |
these data suggest that pink1 regulates tyrosine hydroxylase gene expression and dopamine content by modulating the transcriptional activity of nuclear receptor-related 1. |
2019-06-10 |
2023-08-13 |
Not clear |
| Shraddha Pai, Peipei Li, Bryan Killinger, Lee Marshall, Peixin Jia, Ji Liao, Arturas Petronis, Piroska E Szabó, Viviane Labri. Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis. Nature communications. vol 10. issue 1. 2019-06-06. PMID:31053723. |
chromatin conformation analysis revealed that this enhancer targets the nearby tyrosine hydroxylase (th) gene responsible for dopamine synthesis. |
2019-06-06 |
2023-08-13 |
mouse |