| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying-Li Zhu, Meng-Fei Sun, Xue-Bing Jia, Pei-Hao Zhang, Yi-Da Xu, Zhi-Lan Zhou, Zhou-Heng Xu, Chun Cui, Xue Chen, Xu-Sheng Yang, Yan-Qin She. Aucubin alleviates glial cell activation and preserves dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian mice. Neuroreport. vol 29. issue 13. 2019-02-18. PMID:29985188. |
auc treatment rescued the decreased dopamine and tyrosine hydroxylase levels in the striatum of parkinsonian mice. |
2019-02-18 |
2023-08-13 |
mouse |
| M E Johnson, M F Salvatore, S A Maiolo, L Bobrovskay. Tyrosine hydroxylase as a sentinel for central and peripheral tissue responses in Parkinson's progression: Evidence from clinical studies and neurotoxin models. Progress in neurobiology. vol 165-167. 2019-02-12. PMID:29331395. |
given that the loss of dopamine, and its rate-limiting enzyme tyrosine hydroxylase (th) occurs in pd, the expression and accompanying post-translational changes in th during pd progression could yield insight into the disruption of cellular signalling occurring in the cns, and also in peripheral tissues wherein catecholamine function plays a role. |
2019-02-12 |
2023-08-13 |
human |
| Douglas R Miller, Fatemeh Shaerzadeh, Leah Phan, Nesrin Sharif, Joyonna Gamble-George, Jay P McLaughlin, Wolfgang J Streit, Habibeh Khoshboue. HIV-1 Tat regulation of dopamine transmission and microglial reactivity is brain region specific. Glia. vol 66. issue 9. 2019-02-12. PMID:29733459. |
immunohistochemistry for microglia and tyrosine hydroxylase (th) showed that the ratio of microglia to dopamine neurons is smaller in the snc than in the ventral tegmental area (vta) and that this difference is maintained following 7-day dox exposure in wild type animals. |
2019-02-12 |
2023-08-13 |
mouse |
| Emmanuel Quansah, Victor Ruiz-Rodado, Martin Grootveld, Tyra S C Zetterströ. Methylphenidate alters monoaminergic and metabolic pathways in the cerebellum of adolescent rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 4. 2019-02-11. PMID:29478746. |
in contrast, protein levels of tyrosine hydroxylase (th) and the dopamine d1 receptor were not significantly altered by neither acute nor chronic mph treatment. |
2019-02-11 |
2023-08-13 |
rat |
| Jialin Liu, Fang Zheng, Yan Long, Liu Tong, Yuan Zheng, Xiaoqing Liu, Chuan Qi. Preliminary Analysis of Parkinson-like Motor Coordination Abnormityin Brain-specific hS100B Transgenic Mice. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 39. issue 2. 2019-02-07. PMID:28483024. |
the expressions of s100b,dopamine d1 receptor,dopamine d2 receptor,g protein-coupled receptor kinase (grk)2,grk5,and tyrosine hydroxylase in brain tissue were detected by reverse transcription-polymerase chain reaction and western blot. |
2019-02-07 |
2023-08-13 |
mouse |
| Jialin Liu, Fang Zheng, Yan Long, Liu Tong, Yuan Zheng, Xiaoqing Liu, Chuan Qi. Preliminary Analysis of Parkinson-like Motor Coordination Abnormityin Brain-specific hS100B Transgenic Mice. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 39. issue 2. 2019-02-07. PMID:28483024. |
results compared with cg,the s100b protein expression in brain tissue significantly increased in tg (p<0.05);the motor coordination ability of mice showed progressive decline (p<0.05);the mrna and protein expressions of dopamine d2 receptor and grk2 significantly decreased (p<0.05);the levels of levodopa,dopamine,and homovanillic acid were significantly elevated (p<0.05);the expression of tyrosine hydroxylase was also down-regulated,although there was no significant difference (p>0.05). |
2019-02-07 |
2023-08-13 |
mouse |
| Marika Cordaro, Rosalba Siracusa, Rosalia Crupi, Daniela Impellizzeri, Alessio Filippo Peritore, Ramona D'Amico, Enrico Gugliandolo, Rosanna Di Paola, Salvatore Cuzzocre. 2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29656363. |
moreover, pea-oxa treatment prevented dopamine depletion, increased tyrosine hydroxylase and dopamine transporter activities, and decreased α-synuclein aggregation in neurons. |
2019-01-18 |
2023-08-13 |
mouse |
| Alireza Mohammadi, Ehsan Rashidi, Vahid Ghasem Amooeia. Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia. Psychiatry research. vol 265. 2019-01-16. PMID:29680514. |
the levels of dopamine, tyrosine hydroxylase (th), serotonin or 5-hydroxytryptamine (5-ht) receptor 1a and b (5-htr1a and 5-htr1b), and 5-ht1b were significantly increased in scz patients, while the levels of gamma-aminobutyric acid (gaba), 5-ht transporter (5-htt), and 5-ht receptor 2a (5-htr2a) were decreased. |
2019-01-16 |
2023-08-13 |
human |
| Mostafa A Rabie, Mai A Abd El Fattah, Noha N Nassar, Hanan S El-Abhar, Dalaal M Abdalla. Angiotensin 1-7 ameliorates 6-hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor/PI3K/Akt/BDNF pathway and inhibition of angiotensin II type-1 receptor/NF-κB axis. Biochemical pharmacology. vol 151. 2019-01-09. PMID:29428223. |
moreover, ang1-7 increased substantia nigral tyrosine hydroxylase (th) expression and striatal dopamine (da) content to indicate the preservation of the dopaminergic neuronal signal. |
2019-01-09 |
2023-08-13 |
rat |
| Amit Kumar Chauhan, Namrata Mittra, Devendra Kumar Patel, Chetna Sing. Cyclooxygenase-2 Directs Microglial Activation-Mediated Inflammation and Oxidative Stress Leading to Intrinsic Apoptosis in Zn-Induced Parkinsonism. Molecular neurobiology. vol 55. issue 3. 2018-12-31. PMID:28290146. |
zn reduced the neurobehavioral activities, striatal dopamine content, tyrosine hydroxylase (th) expression and number of dopaminergic neurons. |
2018-12-31 |
2023-08-13 |
rat |
| Sasuk Kim, Juhee Lim, Yeojin Bang, Jisook Moon, Min-Soo Kwon, Jin Tae Hong, Jeha Jeon, Hyemyung Seo, Hyun Jin Cho. Alpha-Synuclein Suppresses Retinoic Acid-Induced Neuronal Differentiation by Targeting the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28190238. |
our results indicate that overexpression of wild-type or mutant a53t α-syn attenuated the ra-induced upregulation of tyrosine hydroxylase and dopamine transporter as well as neurite outgrowth in sh-sy5y cells. |
2018-12-21 |
2023-08-13 |
mouse |
| Stefanie Dichtl, David Haschka, Manfred Nairz, Markus Seifert, Chiara Volani, Oliver Lutz, Günter Weis. Dopamine promotes cellular iron accumulation and oxidative stress responses in macrophages. Biochemical pharmacology. vol 148. 2018-12-17. PMID:29208364. |
iron is essential for many biological functions including neurotransmitter synthesis, where the metal is a co-factor of tyrosine hydroxylase, which converts tyrosine to dopamine and further to norepinephrine. |
2018-12-17 |
2023-08-13 |
Not clear |
| Rosalia Crupi, Daniela Impellizzeri, Marika Cordaro, Rosalba Siracusa, Giovanna Casili, Maurizio Evangelista, Salvatore Cuzzocre. N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice. Molecular neurobiology. vol 55. issue 11. 2018-12-17. PMID:29552727. |
pretreatment with peam ameliorated behavioral deficits and the reductions in expression of tyrosine hydroxylase and dopamine transporter, while blunting the upregulation of α-synuclein and β3-tubulin in the substantia nigra after mptp induction. |
2018-12-17 |
2023-08-13 |
mouse |
| Li Li, Yun-Xiao Kang, Xiao-Ming Ji, Ying-Kun Li, Shuang-Cheng Li, Xiang-Jian Zhang, Hui-Xian Cui, Ge-Ming Sh. Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats. CNS neuroscience & therapeutics. vol 24. issue 2. 2018-12-11. PMID:29214729. |
the present study therefore investigates the effects of finasteride in adolescent and early developmental rats on dopaminergic system, including contents of dopamine and its metabolites (dihydroxy phenyl acetic acid and homovanillic acid) and tyrosine hydroxylase expressions both at gene and protein levels. |
2018-12-11 |
2023-08-13 |
rat |
| Sugumar Mani, Sathiya Sekar, Rajamani Barathidasan, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Murugan Sevanan, Saravana Babu Chidambaram, Musthafa Mohamed Essa, Gilles J Guillemin, Meena Kishore Sakharka. Naringenin Decreases α-Synuclein Expression and Neuroinflammation in MPTP-Induced Parkinson's Disease Model in Mice. Neurotoxicity research. vol 33. issue 3. 2018-12-11. PMID:29427283. |
the ngn significantly downregulated syn and upregulated dopamine transporter (dat) and tyrosine hydroxylase (th) protein expressions. |
2018-12-11 |
2023-08-13 |
mouse |
| Daniela Molina-Mateo, Nicolás Fuenzalida-Uribe, Sergio Hidalgo, Claudia Molina-Fernández, Jorge Abarca, Rafaella V Zárate, Marcela Escandón, Reinaldo Figueroa, María Florencia Tevy, Jorge M Campusan. Characterization of a presymptomatic stage in a Drosophila Parkinson's disease model: Unveiling dopaminergic compensatory mechanisms. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 11. 2018-11-26. PMID:28716706. |
these compensatory changes are associated to specific components of the dopaminergic system: the biosynthetic enzymes, tyrosine hydroxylase and dopa decarboxylase, and the dopamine transporter, a plasma membrane protein involved in maintaining dopamine extracellular levels at physiologically relevant levels. |
2018-11-26 |
2023-08-13 |
drosophila_melanogaster |
| Pingting Ji, Liwen Chen, Jieling Gong, Yuxiang Yuan, Mu Li, Yin Zhao, Hong Zhan. Co-expression of vasoactive intestinal peptide and protein gene product 9.5 surrounding the lumen of human Schlemm's canal. Experimental eye research. vol 170. 2018-11-26. PMID:29432726. |
we then characterized the nerves by double staining for pgp9.5 and sympathetic nerve markers, such as tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dβh), or the parasympathetic marker vasoactive intestinal peptide (vip), as well as sensory nerve marker calcitonin gene-related peptide (cgrp) and vesicular glutamate transporter 2 (vglut2). |
2018-11-26 |
2023-08-13 |
human |
| Yi-Ting Wang, Hui-Ching Lin, Wei-Zhong Zhao, Hui-Ju Huang, Yu-Li Lo, Hsiang-Tsui Wang, Anya Maan-Yuh Li. Acrolein acts as a neurotoxin in the nigrostriatal dopaminergic system of rat: involvement of α-synuclein aggregation and programmed cell death. Scientific reports. vol 7. 2018-11-16. PMID:28401906. |
acrolein-induced neurodegeneration of nigrostriatal dopaminergic system was delineated by reductions in tyrosine hydroxylase (th) levels, dopamine transporter levels and th-positive neurons in the infused sn as well as in striatal dopamine content. |
2018-11-16 |
2023-08-13 |
rat |
| Yuxiang Yuan, Ying Zhu, Yinwei Song, Yin Zhao, Xiaoqin Yan, Wei Chen, Mu Li, Jieling Gong, Ketao Mu, Junming Wang, Hong Zhang, Zhiqi Che. Morphological and Functional Changes of Locus Coeruleus in Patients with Primary Open-Angle Glaucoma and Animal Models. Neuroscience. vol 372. 2018-11-13. PMID:29294337. |
immunohistochemistry and immunofluorescence staining were used to investigate lc tyrosine hydroxylase (th) and dopamine β-hydroxylase (dβh) expression, as well as cell apoptosis by terminal deoxynucleotidyl transferase dutp nick-end labeling staining. |
2018-11-13 |
2023-08-13 |
mouse |
| Ila Mishra, Devraj Singh, Vinod Kuma. Temporal Expression of c-fos and Genes Coding for Neuropeptides and Enzymes of Amino Acid and Amine Neurotransmitter Biosynthesis in Retina, Pineal and Hypothalamus of a Migratory Songbird: Evidence for Circadian Rhythm-Dependent Seasonal Responses. Neuroscience. vol 371. 2018-11-09. PMID:29273324. |
during all four seasonal states, we measured in the retina, pineal and hypothalamus, which together form avian cps, 4-hourly mrna expression of c-fos (a neuronal-activity marker) and of genes coding for neuropeptides (vasoactive intestinal peptide, vip; somatostatin, sst; neuropeptide y, npy) and for intermediary enzymes of amino acid (glutamate: glutaminase, gls and glutamic-oxaloacetic transaminase 2, got2; gaba: glutamic acid decarboxylase, gad65) and amine (dopamine: tyrosine hydroxylase, th) neurotransmitters biosynthetic pathway. |
2018-11-09 |
2023-08-13 |
Not clear |