| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Troels Rahbek-Clemmensen, Matthew D Lycas, Simon Erlendsson, Jacob Eriksen, Mia Apuschkin, Frederik Vilhardt, Trine N Jørgensen, Freja H Hansen, Ulrik Gethe. Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains. Nature communications. vol 8. issue 1. 2018-01-26. PMID:28963530. |
in neurons, dual-color dstorm shows that tyrosine hydroxylase and vesicular monoamine transporter-2 are distinctively localized adjacent to, but not overlapping with, the dopamine transporter nanodomains. |
2018-01-26 |
2023-08-13 |
Not clear |
| Amit Kumar Chauhan, Namrata Mittra, Vinod Kumar, Devendra Kumar Patel, Chetna Sing. Inflammation and B-cell Lymphoma-2 Associated X Protein Regulate Zinc-Induced Apoptotic Degeneration of Rat Nigrostriatal Dopaminergic Neurons. Molecular neurobiology. vol 53. issue 8. 2018-01-22. PMID:26497033. |
zn caused neurobehavioral impairments and reduction in dopamine and its metabolites, tyrosine hydroxylase (th)-positive neurons, catalase activity, and expression of th, bcl-2, and noxa. |
2018-01-22 |
2023-08-13 |
rat |
| Toshiharu Nagatsu, Ikuko Nagats. Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson's disease (PD): historical overview and future prospects. Journal of neural transmission (Vienna, Austria : 1996). vol 123. issue 11. 2018-01-18. PMID:27491309. |
tyrosine hydroxylase (th), which was discovered at the national institutes of health (nih) in 1964, is a tetrahydrobiopterin (bh4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (cas), such as dopamine, noradrenaline, and adrenaline. |
2018-01-18 |
2023-08-13 |
mouse |
| Sohee Moon, Mak-Soon Lee, Sunyoon Jung, Bori Kang, Seog-Young Kim, Seonyoung Park, Hye-Yeon Son, Chong-Tai Kim, Young-Hee Jo, In-Hwan Kim, Young Soon Kim, Yangha Ki. High Hydrostatic Pressure Extract of Ginger Exerts Antistress Effects in Immobilization-Stressed Rats. Journal of medicinal food. vol 20. issue 9. 2018-01-17. PMID:28737969. |
moreover, immobilization stress elevated the mrna levels of tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), and cytochrome p450 side-chain cleavage (p450scc), which are related to catecholamine and corticosterone synthesis in the adrenal gland. |
2018-01-17 |
2023-08-13 |
rat |
| Sanna Barrand, Tamsyn M Crowley, Ryan J Wood-Bradley, Kirstie A De Jong, James A Armitag. Impact of maternal high fat diet on hypothalamic transcriptome in neonatal Sprague Dawley rats. PloS one. vol 12. issue 12. 2018-01-16. PMID:29240779. |
male high fat diet offspring showed significant changes in collagen genes (col1a1 and col3a1) and significant upregulation of two genes involved in regulation of dopamine availability in the brain, tyrosine hydroxylase (th) and dopamine reuptake transporter slc6a3 (also known as dat1). |
2018-01-16 |
2023-08-13 |
rat |
| Chia Li, Jonathan A Sugam, Emily G Lowery-Gionta, Zoe A McElligott, Nora M McCall, Alberto J Lopez, Jessica M McKlveen, Kristen E Pleil, Thomas L Kas. Mu Opioid Receptor Modulation of Dopamine Neurons in the Periaqueductal Gray/Dorsal Raphe: A Role in Regulation of Pain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 8. 2018-01-15. PMID:26792442. |
using a mouse line that expresses egfp under control of the tyrosine hydroxylase (th) promoter, we found that mu opioid receptor activation led to a decrease in inhibitory inputs onto the vpag/dr dopamine neurons. |
2018-01-15 |
2023-08-13 |
mouse |
| Alba Tristán-Noguero, Héctor Díez, Cristina Jou, Mercè Pineda, Aida Ormazábal, Aurora Sánchez, Rafael Artuch, Àngels Garcia-Cazorl. Study of a fetal brain affected by a severe form of tyrosine hydroxylase deficiency, a rare cause of early parkinsonism. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26686676. |
tyrosine hydroxylase (th) deficiency is an inborn error of dopamine synthesis. |
2018-01-12 |
2023-08-13 |
human |
| Ting Xu, Junjun Zhou, Jie Zhu, Shuai Zhang, Ning Zhang, Yan Zhao, Chunchun Ding, Xue Shi, Jihong Ya. Carnosic acid protects non-alcoholic fatty liver-induced dopaminergic neuron injury in rats. Metabolic brain disease. vol 32. issue 2. 2018-01-12. PMID:27957651. |
furthermore, ca treated-animals displayed an increase in the contents of dopamine (da) and its metabolites 3,4-dihydroxyphenylacelic acid (dopac) and elevated the expressions of tyrosine hydroxylase (th)-positive neurons in the substantia nigra (sn) as well as the th protein in the striatum. |
2018-01-12 |
2023-08-13 |
rat |
| Hui-Jun Yang, Yu Gao, Ji Young Yun, Young Eun Kim, Gwanhee Ehm, Ji Yeon Lee, Min-Yung Yoon, Young-Shin Lee, Han-Joon Kim, Beomseok Jeo. Acupuncture does not protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced damage of dopaminergic neurons in a preclinical mouse model of Parkinson's disease. Neuroreport. vol 28. issue 1. 2018-01-10. PMID:27893607. |
in this animal model of pd, acupuncture treatment did not attenuate tyrosine hydroxylase-immunoreactive neuronal death, depletion of striatal dopamine levels, or reduced striatal tyrosine hydroxylase expression. |
2018-01-10 |
2023-08-13 |
mouse |
| Hyun Jin Park, Kyung Sook Lee, Ting Ting Zhao, Kyung Eun Lee, Myung Koo Le. Effects of asarinin on dopamine biosynthesis and 6-hydroxydopamine-induced cytotoxicity in PC12 cells. Archives of pharmacal research. vol 40. issue 5. 2018-01-05. PMID:28397192. |
asarinin (25 μm) induced cyclic amp-dependent protein kinase a (pka) signaling, leading to increased cyclic amp-response element binding protein (creb) and tyrosine hydroxylase (th) phosphorylation, which in turn stimulated dopamine production. |
2018-01-05 |
2023-08-13 |
rat |
| Alpana Singh, Poonam Verma, Gillela Balaji, Supriti Samantaray, Kochupurackal P Mohanakuma. Nimodipine, an L-type calcium channel blocker attenuates mitochondrial dysfunctions to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neurochemistry international. vol 99. 2018-01-03. PMID:27395789. |
it attenuated mptp-induced loss of dopaminergic tyrosine hydroxylase positive neurons in substantia nigra, improved mitochondrial oxygen consumption and inhibited reactive oxygen species production in the striatal mitochondria measured using dichlorodihydrofluorescein fluorescence, but failed to block striatal dopamine depletion. |
2018-01-03 |
2023-08-13 |
mouse |
| Cody A Siciliano, Jason L Locke, Tiffany A Mathews, Marcelo F Lopez, Howard C Becker, Sara R Jone. Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains. Alcohol (Fayetteville, N.Y.). vol 58. 2018-01-03. PMID:27425261. |
by administering an l-aromatic acid decarboxylase inhibitor and measuring l-dopa accumulation via high-performance liquid chromatography as a measure of tyrosine hydroxylase activity, we found no difference in dopamine synthesis between mouse strains in the midbrain, dorsal striatum, or ventral striatum. |
2018-01-03 |
2023-08-13 |
mouse |
| André T R Goes, Cristiano R Jesse, Michelle S Antunes, Fernando V Lobo Ladd, Aliny A B Lobo Ladd, Cristiane Luchese, Natalia Paroul, Silvana P Boeir. Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins. Chemico-biological interactions. vol 279. 2018-01-03. PMID:29054324. |
the intrastriatal injection of 6-ohda also induced an decrease of dopamine, 3,4-dihydroxyphenylacetic acid, homovanylic acid levels and tyrosine hydroxylase content. |
2018-01-03 |
2023-08-13 |
mouse |
| Michael F Salvatore, Jennifer Terrebonne, Mark A Cantu, Tamara R McInnis, Katy Venable, Parker Kelley, Ella A Kasanga, Brian Latimer, Catherine L Owens, Brandon S Pruett, Yongmei Yu, Robert Luedtke, Michael J Forster, Nathalie Sumien, Donald K Ingra. Dissociation of Striatal Dopamine and Tyrosine Hydroxylase Expression from Aging-Related Motor Decline: Evidence from Calorie Restriction Intervention. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 73. issue 1. 2017-12-26. PMID:28637176. |
dissociation of striatal dopamine and tyrosine hydroxylase expression from aging-related motor decline: evidence from calorie restriction intervention. |
2017-12-26 |
2023-08-13 |
rat |
| Michael F Salvatore, Jennifer Terrebonne, Mark A Cantu, Tamara R McInnis, Katy Venable, Parker Kelley, Ella A Kasanga, Brian Latimer, Catherine L Owens, Brandon S Pruett, Yongmei Yu, Robert Luedtke, Michael J Forster, Nathalie Sumien, Donald K Ingra. Dissociation of Striatal Dopamine and Tyrosine Hydroxylase Expression from Aging-Related Motor Decline: Evidence from Calorie Restriction Intervention. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 73. issue 1. 2017-12-26. PMID:28637176. |
aging studies report little to moderate loss of striatal dopamine (da) or tyrosine hydroxylase (th) in nigrostriatal terminals, in contrast to ~70%-80% loss associated with bradykinesia onset in parkinson's disease. |
2017-12-26 |
2023-08-13 |
rat |
| Vinod Kumar, Brajesh Kumar Singh, Amit Kumar Chauhan, Deepali Singh, Devendra Kumar Patel, Chetna Sing. Minocycline Rescues from Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration: Biochemical and Molecular Interventions. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25764516. |
zn attenuated the expression of tyrosine hydroxylase (th) and vesicular monoamine transporter-2 (vmat-2) while augmented the expression of dopamine transporter (dat) and heme oxygenase-1 (ho-1). |
2017-12-22 |
2023-08-13 |
rat |
| Neha Sharma, Bimla Nehr. Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:26081143. |
subsequently, this resulted in dopaminergic loss as depicted by decreased tyrosine hydroxylase (th) expression with substantial loss in neurotransmitter dopamine and its metabolites, whereas treatment with apocyanin significantly reduced the number of glial fibrillary acidic protein (gfap) and iba-1-positive cells in lps-treated animals. |
2017-12-22 |
2023-08-13 |
rat |
| Yi-Da Xu, Chun Cui, Meng-Fei Sun, Ying-Li Zhu, Min Chu, Yun-Wei Shi, Stanley Li Lin, Xu-Sheng Yang, Yan-Qin She. Neuroprotective Effects of Loganin on MPTP-Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies. Journal of cellular biochemistry. vol 118. issue 10. 2017-12-21. PMID:28338241. |
loganin rescued decrease of dopamine levels and tyrosine hydroxylase (th) expression in the striatum, and shortened total locomotor activity (tla) time of mice. |
2017-12-21 |
2023-08-13 |
mouse |
| Asuka Morizane, Tetsuhiro Kikuchi, Takuya Hayashi, Hiroshi Mizuma, Sayuki Takara, Hisashi Doi, Aya Mawatari, Matthew F Glasser, Takashi Shiina, Hirohito Ishigaki, Yasushi Itoh, Keisuke Okita, Emi Yamasaki, Daisuke Doi, Hirotaka Onoe, Kazumasa Ogasawara, Shinya Yamanaka, Jun Takahash. MHC matching improves engraftment of iPSC-derived neurons in non-human primates. Nature communications. vol 8. issue 1. 2017-12-21. PMID:28855509. |
consequently, mhc-matching increases the survival of grafted dopamine neurons (tyrosine hydroxylase: th+). |
2017-12-21 |
2023-08-13 |
human |
| Andréia S Cunha, Filipe C Matheus, Morgana Moretti, Tuane B Sampaio, Anicleto Poli, Danúbia B Santos, Dirleise Colle, Mauricio P Cunha, Carlos H Blum-Silva, Louis P Sandjo, Flávio H Reginatto, Ana Lúcia S Rodrigues, Marcelo Farina, Rui D Predige. Agmatine attenuates reserpine-induced oral dyskinesia in mice: Role of oxidative stress, nitric oxide and glutamate NMDA receptors. Behavioural brain research. vol 312. 2017-12-19. PMID:27306571. |
however, no changes were observed in striatal immunocontent of proteins related to the dopaminergic system including tyrosine hydroxylase, dopamine transporter, vesicular monoamine transporter type 2, pdarpp-32[thr75], dopamine d1 and d2 receptors. |
2017-12-19 |
2023-08-13 |
mouse |