| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danielle E Mor, Elpida Tsika, Joseph R Mazzulli, Neal S Gould, Hanna Kim, Malcolm J Daniels, Shachee Doshi, Preetika Gupta, Jennifer L Grossman, Victor X Tan, Robert G Kalb, Kim A Caldwell, Guy A Caldwell, John H Wolfe, Harry Ischiropoulo. Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. Nature neuroscience. vol 20. issue 11. 2017-11-02. PMID:28920936. |
nigrally targeted expression of mutant tyrosine hydroxylase with enhanced catalytic activity increased dopamine levels without damaging neurons in non-transgenic mice. |
2017-11-02 |
2023-08-13 |
mouse |
| Zhi-Yong Wang, Hui Lian, Li Zhou, Yi-Min Zhang, Qing-Qing Cai, Li-Fei Zheng, Jin-Xia Zh. Altered Expression of D1 and D2 Dopamine Receptors in Vagal Neurons Innervating the Gastric Muscularis Externa in a Parkinson's Disease Rat Model. Journal of Parkinson's disease. vol 6. issue 2. 2017-10-30. PMID:27164043. |
we previously reported on the expression of enhanced tyrosine hydroxylase (th) and decreased choline acetyltransferase (chat) in the dmv of a pd animal model and colocalization of th and chat with the dopamine receptors d1 and d2. |
2017-10-30 |
2023-08-13 |
rat |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model. PloS one. vol 12. issue 10. 2017-10-27. PMID:29028815. |
the dopaminergic debris were found within spheroids (free-spheroids) which retained some proteins of dopaminergic neurons (e.g., tyrosine hydroxylase, the dopamine transporter protein, and app) but not others (e.g., α-synuclein). |
2017-10-27 |
2023-08-13 |
rat |
| Jung-Hoon Koo, Joon-Yong Cho, Ung-Bae Le. Treadmill exercise alleviates motor deficits and improves mitochondrial import machinery in an MPTP-induced mouse model of Parkinson's disease. Experimental gerontology. vol 89. 2017-10-26. PMID:28062370. |
treadmill exercise inhibited dopaminergic neuron loss by promoting the expression of tyrosine hydroxylase (th) and dopamine transporter (dat) and seemed to improve cell survival by reducing α-syn expression. |
2017-10-26 |
2023-08-13 |
mouse |
| Chi Wang Ip, Laura-Christin Klaus, Akua A Karikari, Naomi P Visanji, Jonathan M Brotchie, Anthony E Lang, Jens Volkmann, James B Kopric. AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28143577. |
aav1/2-driven overexpression of human mutated a53t-α-synuclein in rat and monkey substantia nigra (sn) induces degeneration of nigral dopaminergic neurons and decreases striatal dopamine and tyrosine hydroxylase (th). |
2017-10-25 |
2023-08-13 |
mouse |
| Francesco Longo, Daniela Mercatelli, Salvatore Novello, Ludovico Arcuri, Alberto Brugnoli, Fabrizio Vincenzi, Isabella Russo, Giulia Berti, Omar S Mabrouk, Robert T Kennedy, Derya R Shimshek, Katia Varani, Luigi Bubacco, Elisa Greggio, Michele Morar. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28292328. |
density of striatal dopaminergic terminals, nigral cell counts, tyrosine hydroxylase protein levels as well as exocytotic dopamine release measured in striatal synaptosomes, or striatal extracellular dopamine levels monitored by in vivo microdialysis were similar between ≥12-month-old g2019s knock-in mice and wild-type controls. |
2017-10-25 |
2023-08-13 |
mouse |
| Michael F Salvatore, Erin S Calipari, Sara R Jone. Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice. ACS chemical neuroscience. vol 7. issue 7. 2017-10-19. PMID:27124386. |
regulation of tyrosine hydroxylase expression and phosphorylation in dopamine transporter-deficient mice. |
2017-10-19 |
2023-08-13 |
mouse |
| Michael F Salvatore, Erin S Calipari, Sara R Jone. Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice. ACS chemical neuroscience. vol 7. issue 7. 2017-10-19. PMID:27124386. |
tyrosine hydroxylase (th) and dopamine transporters (dats) regulate dopamine (da) neurotransmission at the biosynthesis and reuptake steps, respectively. |
2017-10-19 |
2023-08-13 |
mouse |
| Nan Wang, Xiaofeng Shen, Senzhu Bao, Shan-Wu Feng, Wei Wang, Yusheng Liu, Yiquan Wang, Xian Wang, Xirong Guo, Rong Shen, Haibo Wu, Liming Lei, Shiqin Xu, Fuzhou Wan. Dopaminergic inhibition by G9a/Glp complex on tyrosine hydroxylase in nerve injury-induced hypersensitivity. Molecular pain. vol 12. 2017-10-18. PMID:27562335. |
correspondingly, the th cpg methylation is increased, but the tyrosine hydroxylase expression was downregulated and the dopamine level was decreased. |
2017-10-18 |
2023-08-13 |
mouse |
| Nan Wang, Xiaofeng Shen, Senzhu Bao, Shan-Wu Feng, Wei Wang, Yusheng Liu, Yiquan Wang, Xian Wang, Xirong Guo, Rong Shen, Haibo Wu, Liming Lei, Shiqin Xu, Fuzhou Wan. Dopaminergic inhibition by G9a/Glp complex on tyrosine hydroxylase in nerve injury-induced hypersensitivity. Molecular pain. vol 12. 2017-10-18. PMID:27562335. |
after the intracerebroventriclar injection of bix 01294 since the post-injury days 7 and 14 for consecutive three days, three weeks, and six weeks, the expression of tyrosine hydroxylase was upregulated with a significant decrease in th methylation and increase in dopamine level. |
2017-10-18 |
2023-08-13 |
mouse |
| Soo Jeong Kim, Min Jeong Ryu, Jeongsu Han, Yunseon Jang, Jungim Kim, Min Joung Lee, Ilhwan Ryu, Xianshu Ju, Eungseok Oh, Woosuk Chung, Gi Ryang Kweon, Jun Young He. Activation of the HMGB1-RAGE axis upregulates TH expression in dopaminergic neurons via JNK phosphorylation. Biochemical and biophysical research communications. vol 493. issue 1. 2017-10-16. PMID:28887039. |
the derangement of tyrosine hydroxylase (th) activity reduces dopamine synthesis and is implicated in the pathogenesis of parkinson's disease. |
2017-10-16 |
2023-08-13 |
Not clear |
| Lesley A McCollum, Robert E McCullumsmith, Rosalinda C Robert. Tyrosine hydroxylase localization in the nucleus accumbens in schizophrenia. Brain structure & function. vol 221. issue 9. 2017-10-13. PMID:26740229. |
we compared the immunohistochemical localization of tyrosine hydroxylase (th), the rate-limiting synthesizing enzyme of dopamine, in postmortem tissue from sz subjects and demographically matched controls. |
2017-10-13 |
2023-08-13 |
human |
| Gilda Guerrero-Flores, Aimée Bastidas-Ponce, Omar Collazo-Navarrete, Magdalena Guerra-Crespo, Luis Covarrubia. Functional determination of the differentiation potential of ventral mesencephalic neural precursor cells during dopaminergic neurogenesis. Developmental biology. vol 429. issue 1. 2017-10-12. PMID:28733161. |
here we show that e9.5 vmnpcs implanted in an ectopic area of e10.5 mesencephalic explants, retained their specification marker lmx1a and efficiently differentiated into neurons but did not express the gene encoding tyrosine hydroxylase (th), the limiting enzyme for dopamine synthesis. |
2017-10-12 |
2023-08-13 |
Not clear |
| Kate Karelina, Kristopher R Gaier, Zachary M Wei. Traumatic brain injuries during development disrupt dopaminergic signaling. Experimental neurology. vol 297. 2017-10-05. PMID:28802560. |
together with a histological analysis of tyrosine hydroxylase, dopamine transporter, and dopamine d2 receptor expression, our data are indicative of a persistent state of hypodopaminergia well into adulthood after a juvenile tbi. |
2017-10-05 |
2023-08-13 |
mouse |
| Angel Escamilla-Ramírez, Esperanza García, Guadalupe Palencia-Hernández, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Julio Sotelo, Abel Santamarí. URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA Receptors. Neurotoxicity research. vol 31. issue 4. 2017-10-02. PMID:28092019. |
mptp (40 mg/kg, s.c., single injection) decreased locomotor activity, depleted the striatal and nigral levels of dopamine (da), augmented the levels of lipid peroxidation and protein carbonylation in both regions, decreased the striatal protein levels of tyrosine hydroxylase, and increased the striatal protein content of the subunit 1 (nr1) of the n-methyl-d-aspartate receptor (nmdar). |
2017-10-02 |
2023-08-13 |
mouse |
| D Gagnon, L Gregoire, T Di Paolo, Martin Paren. Serotonin hyperinnervation of the striatum with high synaptic incidence in parkinsonian monkeys. Brain structure & function. vol 221. issue 7. 2017-09-29. PMID:26462663. |
the state of striatal serotonin and dopamine innervation was evaluated by means of immunohistochemistry with antibodies against serotonin transporter (sert) and tyrosine hydroxylase. |
2017-09-29 |
2023-08-13 |
monkey |
| Katarzyna Palus, Jarosław Całk. Neurochemical Plasticity of the Coeliac-Superior Mesenteric Ganglion Complex Neurons Projecting to the Prepyloric Area of the Porcine Stomach following Hyperacidity. Neural plasticity. vol 2016. 2017-09-20. PMID:27293908. |
in the control animals, fb-positive perikarya displayed immunoreactivity to tyrosine hydroxylase (th), dopamine β-hydroxylase (dβh), neuropeptide y (npy), and galanin (gal). |
2017-09-20 |
2023-08-13 |
Not clear |
| Randy J Leitermann, Amanda B Rostkowski, Janice H Urba. Neuropeptide Y input to the rat basolateral amygdala complex and modulation by conditioned fear. The Journal of comparative neurology. vol 524. issue 12. 2017-09-13. PMID:26779765. |
npy innervation of the bla was assessed in rats by examining the degree of npy coexpression within interneurons or catecholaminergic fibers with somatostatin and tyrosine hydroxylase (th) or dopamine β-hydroxylase (dβh), respectively. |
2017-09-13 |
2023-08-13 |
rat |
| Ana Jorge-Finnigan, Rune Kleppe, Kunwar Jung-Kc, Ming Ying, Michael Marie, Ivan Rios-Mondragon, Michael F Salvatore, Jaakko Saraste, Aurora Martine. Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules. The Journal of biological chemistry. vol 292. issue 34. 2017-09-12. PMID:28637871. |
tyrosine hydroxylase (th) catalyzes the conversion of l-tyrosine into l-dopa, which is the rate-limiting step in the synthesis of catecholamines, such as dopamine, in dopaminergergic neurons. |
2017-09-12 |
2023-08-13 |
mouse |
| Ichiro Kawahata, Gutierrez Rico Evelyn, Xu Huinan, Shiori Ohtaku, Yoshihisa Tomioka, Tohru Yamakun. Tyrosine hydroxylase gene expression is facilitated by alcohol followed by the degradation of the protein by ubiquitin proteasome system. Neuro endocrinology letters. vol 38. issue 1. 2017-08-29. PMID:28456147. |
dopamine biosynthesis is strictly regulated by tyrosine hydroxylase (th), a rate-limiting enzyme of dopamine. |
2017-08-29 |
2023-08-13 |
Not clear |