| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Giancola, F Gentilini, N Romagnoli, A Spadari, M E Turba, M Giunta, J Sadeghinezhad, C Sorteni, R Chiocchett. Extrinsic innervation of ileum and pelvic flexure of foals with ileocolonic aganglionosis. Cell and tissue research. vol 366. issue 1. 2017-05-16. PMID:27230228. |
the sympathetic fibers were immunohistochemically identified with the markers tyrosine hydroxylase and dopamine beta-hydroxylase. |
2017-05-16 |
2023-08-13 |
human |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
g protein-gated inwardly rectifying potassium channel girk2 and the calcium binding protein calbindin are the two best available histochemical markers currently used to label (with some overlap) a9- and a10-like dopamine neuron subtypes, respectively, in tyrosine hydroxylase expressing neurons both in the midbrain and grafts. |
2017-05-16 |
2023-08-13 |
rat |
| Leonardo A Parra, Tracy B Baust, Amanda D Smith, Juliann D Jaumotte, Michael J Zigmond, Soledad Torres, Rehana K Leak, Jose A Pino, Gonzalo E Torre. The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization. The Journal of biological chemistry. vol 291. issue 34. 2017-05-12. PMID:27365397. |
we previously reported that the vesicular monoamine transporter 2 (vmat2) is physically and functionally coupled with hsc70 as well as with the dopamine synthesis enzymes tyrosine hydroxylase (th) and aromatic amino acid decarboxylase, providing a novel mechanism for dopamine homeostasis regulation. |
2017-05-12 |
2023-08-13 |
mouse |
| Takashi Asano, Hirokazu Matsuzaki, Naohiro Iwata, Meiyan Xuan, Shinya Kamiuchi, Yasuhide Hibino, Takeshi Sakamoto, Mari Okazak. Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats. International journal of molecular sciences. vol 18. issue 3. 2017-04-20. PMID:28273833. |
2vo rats had an increased level of superoxide anion radical, and decreased dopamine and tyrosine hydroxylase enzyme levels in the striatum, suggesting that 2vo augmented cerebral oxidative stress and impaired the striatal dopaminergic system. |
2017-04-20 |
2023-08-13 |
rat |
| Nuramatjan Ablat, Deyong Lv, Rutong Ren, Yilixiati Xiaokaiti, Xiang Ma, Xin Zhao, Yi Sun, Hui Lei, Jiamin Xu, Yingcong Ma, Xianrong Qi, Min Ye, Feng Xu, Hongbin Han, Xiaoping P. Neuroprotective Effects of a Standardized Flavonoid Extract from Safflower against a Rotenone-Induced Rat Model of Parkinson's Disease. Molecules (Basel, Switzerland). vol 21. issue 9. 2017-04-17. PMID:27563865. |
safe (35 or 70 mg/kg/day) treatment reversed the decreased protein expression of tyrosine hydroxylase, dopamine transporter and dj-1 and increased the levels of dopamine and its metabolite. |
2017-04-17 |
2023-08-13 |
mouse |
| Michael De Santis, Jiamei Lian, Xu-Feng Huang, Chao Den. Early Antipsychotic Treatment in Juvenile Rats Elicits Long-Term Alterations to the Dopamine Neurotransmitter System. International journal of molecular sciences. vol 17. issue 11. 2017-04-04. PMID:27879654. |
levels of tyrosine hydroxylase (th), phosphorylated-th (p-th), dopamine active transporter (dat), and d₁ and d₂ receptors were measured via western blot and/or receptor autoradiography. |
2017-04-04 |
2023-08-13 |
rat |
| Liang Xiao-Feng, Zhu Wen-Ting, Xu Yuan-Yuan, Lai Chong-Fa, Zheng Lu, Rao Jin-Jun, Wang Wen-Y. Protective role of 6-Hydroxy-1-H-Indazole in an MPTP-induced mouse model of Parkinson's disease. European journal of pharmacology. vol 791. 2017-03-28. PMID:27614126. |
the results showed that mptp decreased the dopaminergic neurons in the substantia nigra and dopamine in the striatum, downregulated the expression of tyrosine hydroxylase (th), induced the impairment of behavior and hyperphosphorylation of tau, however, 6-hydroxy-1-h-indazole decreased the loss of dopaminergic neurons, increased dopamine concentration and th expression, alleviated the behavioral damage and level of phosphor-tau in the mptp-induced model of pd in c57bl/6 mice. |
2017-03-28 |
2023-08-13 |
mouse |
| A U Kurina, T S Pronina, L K Dilmukhametova, G V Maleev, M V Ugrumo. Cooperative Synthesis of Dopamine in Rat Mediobasal Hypothalamus as a Compensatory Mechanism in Hyperprolactinemia. Biochemistry. Biokhimiia. vol 82. issue 3. 2017-03-22. PMID:28320278. |
dopamine (da), synthesized in the mediobasal hypothalamus by dopaminergic neurons containing two enzymes of da synthesis - tyrosine hydroxylase and decarboxylase of aromatic l-amino acids, or by monoenzymatic non-dopaminergic neurons containing one da synthesis enzyme in cooperation, is known to have an inhibitory effect on prolactin secretion. |
2017-03-22 |
2023-08-13 |
rat |
| Catharina Olsso. Tyrosine hydroxylase immunoreactivity is common in the enteric nervous system in teleosts. Cell and tissue research. vol 364. issue 2. 2017-03-13. PMID:26572541. |
tyrosine hydroxylase (th) is the rate-limiting enzyme in the synthesis of catecholamines and th immunoreactivity is indicative of cells synthesising either adrenaline/noradrenaline or dopamine. |
2017-03-13 |
2023-08-13 |
zebrafish |
| Erika L Varner, Andrea Jaquins-Gerstl, Adrian C Michae. Enhanced Intracranial Microdialysis by Reduction of Traumatic Penetration Injury at the Probe Track. ACS chemical neuroscience. vol 7. issue 6. 2017-03-08. PMID:27003503. |
our approach to reducing the tpi reinstates normal evoked dopamine release activity in the tissue adjacent to the microdialysis probe, brings evoked dopamine release at the probe outlet into quantitative agreement with evoked dopamine release next to the probe, reinstates normal immunoreactivity for tyrosine hydroxylase and the dopamine transporter near the probe track, and greatly suppresses glial activation and scaring near the probe track. |
2017-03-08 |
2023-08-13 |
Not clear |
| Marcio Henrique Mello da Luz, Isaias Glezer, Andre Machado Xavier, Marcelo Alberti Paiva da Silva, Jessica Monteiro Volejnik Pino, Thiago Panaro Zamith, Taynara Fernanda Vieira, Bruno Brito Antonio, Hanna Karen Moreira Antunes, Vilma Regina Martins, Kil Sun Le. Expression of Tyrosine Hydroxylase is Negatively Regulated Via Prion Protein. Neurochemical research. vol 41. issue 7. 2017-03-03. PMID:26975317. |
recently, a number of studies have reported the involvement of prp(c) in dopamine metabolism and signaling, including its interactions with tyrosine hydroxylase (th) and dopamine receptors. |
2017-03-03 |
2023-08-13 |
Not clear |
| Yusuke Matsuda, Noriko Kimura, Takanobu Yoshimoto, Yoshihiro Sekiguchi, Junzo Tomoishi, Ichiro Kasahara, Yoshihito Hara, Yoshihiro Ogaw. Dopamine-Secreting Paraganglioma in the Retroperitoneum. Endocrine pathology. vol 28. issue 1. 2017-03-02. PMID:27743246. |
the histopathological diagnosis of the tumor was paraganglioma; this was confirmed by positive immunostaining of chromogranin a (cga), tyrosine hydroxylase (th), dopamine β-hydroxylase (dbh), and succinate dehydrogenase gene subunit b (sdhb). |
2017-03-02 |
2023-08-13 |
Not clear |
| N Spasojevic, B Stefanovic, P Jovanovic, S Dronja. Anxiety and Hyperlocomotion Induced by Chronic Unpredictable Mild Stress Can Be Moderated with Melatonin Treatment. Folia biologica. vol 62. issue 6. 2017-02-27. PMID:28189148. |
the content of dopamine (da) in the hippocampal tissues was determined using radioenzymatic assay, while changes in tyrosine hydroxylase (th) mrna and protein levels in the hippocampus were determined using real-time rt-pcr and western immunoblotting. |
2017-02-27 |
2023-08-13 |
rat |
| Yi Ren, Min Ye, Shengdi Chen, Jianqing Din. CD200 Inhibits Inflammatory Response by Promoting KATP Channel Opening in Microglia Cells in Parkinson's Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-02-24. PMID:27213506. |
immunohistochemistry (ihc) was utilized to assess cd11b (microglia marker) and tyrosine hydroxylase (th, a marker reveals dopamine level in neurons) expression levels. |
2017-02-24 |
2023-08-13 |
mouse |
| Li-Mao, Yin-Juan Liao, Guang-Han Hou, Zhong-Bao Yang, Mei-Ling Zu. Monosialotetrahexosylganglioside protect cerebral ischemia/reperfusion injury through upregulating the expression of tyrosine hydroxylase by inhibiting lipid peroxidation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 84. 2017-02-01. PMID:27847214. |
toxic aldehyde accumulation leaded to disfunction of tyrosine hydroxylase and excessive tyrosine and decreased synthesis of catecholamine neurotransmitter such as dopamine and accelerated neuron cell injury. |
2017-02-01 |
2023-08-13 |
rat |
| Samuela Cataldi, Michela Codini, Stéphane Hunot, François-Pierre Légeron, Ivana Ferri, Paola Siccu, Angelo Sidoni, Francesco Saverio Ambesi-Impiombato, Tommaso Beccari, Francesco Curcio, Elisabetta Alb. e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease. Mediators of inflammation. vol 2016. 2017-01-17. PMID:27194825. |
the results showed a strong expression of e-cadherin, variation of length and thickness of the heavy neurofilaments, increase of interleukin-6, and reduction of tyrosine hydroxylase known to be expression of dopamine cell loss, reduction of phosphatase and tensin homolog described to impair responses to dopamine, and reduction of caveolin-1 known to be expression of epithelial-mesenchymal transition and fibrosis. |
2017-01-17 |
2023-08-13 |
Not clear |
| Astrid Rohwedder, Nana L Wenz, Bernhard Stehle, Annina Huser, Nobuhiro Yamagata, Marta Zlatic, James W Truman, Hiromu Tanimoto, Timo Saumweber, Bertram Gerber, Andreas S Thu. Four Individually Identified Paired Dopamine Neurons Signal Reward in Larval Drosophila. Current biology : CB. vol 26. issue 5. 2017-01-10. PMID:26877086. |
we study larval drosophila, in which only approximately 120 of a total of 10,000 neurons are dopaminergic, as judged by the expression of tyrosine hydroxylase (th), the rate-limiting enzyme of dopamine biosynthesis [5, 13]. |
2017-01-10 |
2023-08-13 |
drosophila_melanogaster |
| Li Wang, Yunxiao Kang, Guoliang Zhang, Yingbo Zhang, Rui Cui, Wensheng Yan, Huibing Tan, Shuangcheng Li, Baiyila Wu, Huixian Cui, Geming Sh. Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate. Experimental gerontology. vol 78. 2017-01-10. PMID:26956479. |
increased tyrosine hydroxylase and dopamine transporter, as well as dopamine and its metabolites were found in the nsda system of tp-treated 24 month-old male rats, indicative of the amelioratory effects of tp supplements on nsda system of aged male rats. |
2017-01-10 |
2023-08-13 |
rat |
| Eric A Engleman, Simon N Katner, Bethany S Neal-Belivea. Caenorhabditis elegans as a Model to Study the Molecular and Genetic Mechanisms of Drug Addiction. Progress in molecular biology and translational science. vol 137. 2016-12-30. PMID:26810004. |
the one target/gene identified as essential for drug-induced behavioral responses across all drugs of abuse was the cat-2 gene coding for tyrosine hydroxylase, which is consistent with the role of dopamine neurotransmission in human addiction. |
2016-12-30 |
2023-08-13 |
human |
| Danila Del Rio, Nuria Del Olmo, Mariano Ruiz-Gay. Desensitization of leptin receptors is coincident with the upregulation of dopamine-related genes in the prefrontal cortex of adolescent mice. Neuroreport. vol 27. issue 7. 2016-12-20. PMID:27031872. |
we have investigated in adolescent mice the effect of subchronic leptin on (i) leptin receptor expression and functionality, and (ii) dopamine-related gene expression (tyrosine hydroxylase, th; dopamine type-1 receptor, drd1; dopamine type-2 receptor, drd2) within the prefrontal cortex (pfc), which is involved in sensory perception of food and reward sensitivity, and the hippocampus, a brain area sensitive to food composition and pivotal in learning and memory processes related to feeding behaviour. |
2016-12-20 |
2023-08-13 |
mouse |