| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenchuan Zhou, Yutong Zhou, Jincan He, Yuqing Rao, Ping Fei, Jing L. TREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment. Cell death & disease. vol 14. issue 3. 2023-03-28. PMID:36977680. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor exclusively expressed on microglial cells in the retina, and has been reported to affect microglial cell homeostasis, phagocytosis and inflammatory responses in the brain. |
2023-03-28 |
2023-08-14 |
Not clear |
| Chloe G McKee, Madison Hoffos, Haley A Vecchiarelli, Marie-Ève Trembla. Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease. Frontiers in pharmacology. vol 14. 2023-03-27. PMID:36969855. |
preclinical and early phase clinical trials investigating the therapeutic effects of pharmacological agents acting on microglia, including reactive oxygen species, trem2, fractalkine signaling, the complement cascade, and the nlrp3 inflammasome, are currently underway; however, important questions remain unanswered. |
2023-03-27 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression associations with alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. |
2023-03-25 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
trem2 gene expression of the dorsolateral prefrontal cortex, posterior cingulate cortex, and caudate nucleus was assessed with respect to core pathology of alzheimer's disease (amyloid-β, and tau), cerebrovascular pathology (cerebral infarcts, arteriolosclerosis, atherosclerosis, and cerebral amyloid angiopathy), microglial activation (proportion of activated microglia), and cognitive performance. |
2023-03-25 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
we found that cortical trem2 levels were positively related to ad diagnosis, cognitive decline, and amyloid-β neuropathology but were not related to the proportion of activated microglia. |
2023-03-25 |
2023-08-14 |
Not clear |
| Rebecca L Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A Bennett, Angela L Jefferson, Timothy J Hohma. TREM2 gene expression associations with Alzheimer's disease neuropathology are region-specific: implications for cortical versus subcortical microglia. Acta neuropathologica. 2023-03-25. PMID:36966244. |
in contrast, caudate trem2 levels were not related to ad pathology, cognition, or diagnosis, but were positively related to the proportion of activated microglia in the same region. |
2023-03-25 |
2023-08-14 |
Not clear |
| Lijuan Luo, Jie Chen, Qionghui Wu, Binlin Yuan, Chaoqun Hu, Ting Yang, Hua Wei, Tingyu L. Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. Environmental toxicology and pharmacology. 2023-03-04. PMID:36870407. |
the triggering receptor expressed on myeloid cells 2 (trem2) is revealed to be implicated in a range of microglia functions. |
2023-03-04 |
2023-08-14 |
rat |
| Lijuan Luo, Jie Chen, Qionghui Wu, Binlin Yuan, Chaoqun Hu, Ting Yang, Hua Wei, Tingyu L. Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. Environmental toxicology and pharmacology. 2023-03-04. PMID:36870407. |
trem2 overexpression partly ameliorated microglia dysfunction and autistic-like behaviors in prenatal vpa-exposed rats. |
2023-03-04 |
2023-08-14 |
rat |
| Lijuan Luo, Jie Chen, Qionghui Wu, Binlin Yuan, Chaoqun Hu, Ting Yang, Hua Wei, Tingyu L. Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. Environmental toxicology and pharmacology. 2023-03-04. PMID:36870407. |
our findings demonstrated that prenatally vpa exposure is likely to cause autistic-like behavior in the rat offspring via trem2 down-regulation to affect the microglial activation, microglial polarization and synaptic pruning of microglia for the first time. |
2023-03-04 |
2023-08-14 |
rat |
| Miguel Moutinho, Israel Coronel, Andy P Tsai, Gonzalo Viana Di Prisco, Taylor Pennington, Brady K Atwood, Shweta S Puntambekar, Daniel C Smith, Pablo Martinez, Seonggyun Han, Younghee Lee, Cristian A Lasagna-Reeves, Bruce T Lamb, Stephanie J Bissel, Kwangsik Nho, Gary E Landret. TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation. Genome medicine. vol 15. issue 1. 2023-02-22. PMID:36805764. |
trem2 governs the response of microglia to amyloid and tau pathologies in the alzheimer's disease (ad) brain. |
2023-02-22 |
2023-08-14 |
mouse |
| Na Zhao, Guojun B. A TREM2 antibody energizes microglia. Nature neuroscience. 2023-02-10. PMID:36765163. |
a trem2 antibody energizes microglia. |
2023-02-10 |
2023-08-14 |
Not clear |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-09. PMID:36755323. |
genetic models of cleavage-reduced and soluble trem2 reveal distinct effects on myelination and microglia function in the cuprizone model. |
2023-02-09 |
2023-08-14 |
mouse |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-09. PMID:36755323. |
triggering receptor expressed on myeloid cells 2 (trem2) is a cell-surface immunoreceptor expressed on microglia, osteoclasts, dendritic cells and macrophages. |
2023-02-09 |
2023-08-14 |
mouse |
| Nicolau Beckmann, Anna Neuhaus, Stefan Zurbruegg, Pia Volkmer, Claudia Patino, Stefanie Joller, Dominik Feuerbach, Arno Doelemeyer, Tatjana Schweizer, Stefan Rudin, Ulf Neumann, Ramon Berth, Wilfried Frieauff, Fabrizio Gasparini, Derya R Shimshe. Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model. Journal of neuroinflammation. vol 20. issue 1. 2023-02-09. PMID:36755323. |
taken together, our data suggest that sustained microglia activation led to increased remyelination, whereas microglia without plasma membrane trem2 and only soluble trem2 had reduced phagocytic activity despite efficient lysosomal function, as observed in bone marrow-derived macrophages, leading to a dysfunctional phenotype with improper myelin debris removal, lack of remyelination and axonal pathology following cuprizone intoxication. |
2023-02-09 |
2023-08-14 |
mouse |
| Mingchen Yu, Yuanhao Chang, You Zhai, Bo Pang, Peng Wang, Guanzhang Li, Tao Jiang, Fan Zen. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713360. |
single-cell analysis and multiple immunohistochemical staining results showed that microglia and macrophage cells expressed trem2. |
2023-01-30 |
2023-08-14 |
Not clear |
| Mingchen Yu, Yuanhao Chang, You Zhai, Bo Pang, Peng Wang, Guanzhang Li, Tao Jiang, Fan Zen. Frontiers in immunology. vol 13. 2023-01-30. PMID:36713360. |
in conclusion, our findings revealed that trem2 was significantly expressed in microglia and macrophage cells and was intimately associated with the tumor immune microenvironment. |
2023-01-30 |
2023-08-14 |
Not clear |
| Sk Chand Basha, Mekala Janaki Ramaiah, Jagannatha Rao Kosagishara. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-01-23. PMID:36683512. |
untangling the role of trem2 in conjugation with microglia in neuronal dysfunction: a hypothesis on a novel pathway in the pathophysiology of alzheimer's disease. |
2023-01-23 |
2023-08-14 |
Not clear |
| Sk Chand Basha, Mekala Janaki Ramaiah, Jagannatha Rao Kosagishara. Untangling the Role of TREM2 in Conjugation with Microglia in Neuronal Dysfunction: A Hypothesis on a Novel Pathway in the Pathophysiology of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-01-23. PMID:36683512. |
disease associated microglia (dam), a novel state of microglia with unique transcriptional and functional signatures reported in neurodegenerative conditions, also depend on the trem2 pathway for its differentiation. |
2023-01-23 |
2023-08-14 |
Not clear |
| Zhiyun Qiu, Huilin Wang, Mengdi Qu, Shuainan Zhu, Hao Zhang, Qingwu Liao, Changhong Mia. Consecutive Injection of High-Dose Lipopolysaccharide Modulates Microglia Polarization via TREM2 to Alter Status of Septic Mice. Brain sciences. vol 13. issue 1. 2023-01-21. PMID:36672106. |
consecutive injection of high-dose lipopolysaccharide modulates microglia polarization via trem2 to alter status of septic mice. |
2023-01-21 |
2023-08-14 |
mouse |
| Ivonne Jericó, Janire Vicuña-Urriza, Idoia Blanco-Luquin, Mónica Macias, Leyre Martinez-Merino, Miren Roldán, Ricard Rojas-Garcia, Inmaculada Pagola-Lorz, Alvaro Carbayo, Noemi De Luna, Victoria Zelaya, Maite Mendioro. Profiling TREM2 expression in amyotrophic lateral sclerosis. Brain, behavior, and immunity. 2023-01-21. PMID:36681358. |
trem2 gene plays a crucial role in shaping microglia in neurodegenerative conditions. |
2023-01-21 |
2023-08-14 |
Not clear |