| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Marzia Moretti, Riccardo Caraffi, Luca Lorenzini, Ilaria Ottonelli, Michele Sannia, Giuseppe Alastra, Vito Antonio Baldassarro, Alessandro Giuliani, Jason Thomas Duskey, Maura Cescatti, Barbara Ruozi, Luigi Aloe, Maria Angela Vandelli, Luciana Giardino, Giovanni Tosi, Laura Calz\\xc3\\xa. "Combo" Multi-Target Pharmacological Therapy and New Formulations to Reduce Inflammation and Improve Endogenous Remyelination in Traumatic Spinal Cord Injury. Cells. vol 12. issue 9. 2023-05-14. PMID:37174731.' |
a strong anti-inflammatory effect was observed in the short term with a reduction of type m1 microglia and glutamate levels, but with a subsequent increase of trem2. |
2023-05-14 |
2023-08-14 |
mouse |
| Rui Sun, Rowland Han, Colin McCornack, Saad Khan, G Travis Tabor, Yun Chen, Jinchao Hou, Haowu Jiang, Kathleen M Schoch, Diane D Mao, Ryan Cleary, Alicia Yang, Qin Liu, Jingqin Luo, Allegra Petti, Timothy M Miller, Jason D Ulrich, David M Holtzman, Albert H Ki. TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Science advances. vol 9. issue 19. 2023-05-12. PMID:37172094. |
here, we found that trem2 is highly expressed in myeloid subsets, including macrophages and microglia in human and mouse gbm tumors and that high trem2 expression correlates with poor prognosis in patients with gbm. |
2023-05-12 |
2023-08-14 |
mouse |
| Tingting Zhang, Weilun Pang, Tuancheng Feng, Jennifer Guo, Kenton Wu, Mariela Nunez Santos, Akshayakeerthi Arthanarisami, Alissa L Nana, Quynh Nguyen, Peter J Kim, Joanna L Jankowsky, William W Seeley, Fenghua H. TMEM106B regulates microglial proliferation and survival in response to demyelination. Science advances. vol 9. issue 18. 2023-05-05. PMID:37146150. |
furthermore, tmem106b loss results in a significant decrease in the protein levels of trem2, an innate immune receptor essential for microglia survival and activation. |
2023-05-05 |
2023-08-14 |
mouse |
| Chuan Qin, Sheng Yang, Man Chen, Ming-Hao Dong, Luo-Qi Zhou, Yun-Hui Chu, Zhu-Xia Shen, Dale B Bosco, Long-Jun Wu, Dai-Shi Tian, Wei Wan. Modulation of microglial metabolism facilitates regeneration in demyelination. iScience. vol 26. issue 5. 2023-05-04. PMID:37138776. |
in addition, microglial triggering receptor expressed on myeloid cells 2 (trem2) was greatly involved in the phenotype transition in demyelination, but not indispensable for microglia transition toward pems. |
2023-05-04 |
2023-08-14 |
human |
| Li Li, Qingyou Chen, Yinghui Qin, Guangna Yu, Tingting Qi, Hesong Sui, Xin Qi, Lijuan Huan. Regulation of TREM2 on BV2 inflammation through PI3K/AKT/mTOR pathway. Biotechnology & genetic engineering reviews. 2023-05-01. PMID:37125903. |
this work sought to determine how lipopolysaccharide (lps)-induced pro-inflammatory factor production in bv2 microglia was influenced by myeloid cell 2 (trem2) expressions. |
2023-05-01 |
2023-08-14 |
Not clear |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
defects in lysosomal function and lipid metabolism in human microglia harboring a trem2 loss of function mutation. |
2023-04-28 |
2023-08-14 |
human |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
trem2 is an innate immune receptor expressed by microglia in the adult brain. |
2023-04-28 |
2023-08-14 |
human |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
induced pluripotent stem cell (ipsc)-derived microglia (imgls) were generated from two nhd families: three homozygous trem2 p.q33x mutation carriers (termed nhd), two heterozygous mutation carriers, one related non-carrier, and two unrelated non-carriers. |
2023-04-28 |
2023-08-14 |
human |
| Fabia Filipello, Shih-Feng You, Farzaneh S Mirfakhar, Sidhartha Mahali, Bryan Bollman, Mariana Acquarone, Olena Korvatska, Jacob A Marsh, Anirudh Sivaraman, Rita Martinez, Claudia Cantoni, Luca De Feo, Laura Ghezzi, Miguel A Minaya, Arun Renganathan, Anil G Cashikar, Jun-Ichi Satoh, Wandy Beatty, Abhirami K Iyer, Marina Cella, Wendy H Raskind, Laura Piccio, Celeste M Karc. Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation. Acta neuropathologica. 2023-04-28. PMID:37115208. |
our study provides the first cellular and molecular evidence that the trem2 p.q33x mutation in microglia leads to defects in lysosomal function and that compounds targeting lysosomal biogenesis restore a number of nhd microglial defects. |
2023-04-28 |
2023-08-14 |
human |
| Raz Dvir-Szternfeld, Giulia Castellani, Michal Arad, Liora Cahalon, Sarah Phoebeluc Colaiuta, Hadas Keren-Shaul, Tommaso Croese, Chiara Burgaletto, Kuti Baruch, Tyler Ulland, Marco Colonna, Assaf Weiner, Ido Amit, Michal Schwart. Alzheimer's disease modification mediated by bone marrow-derived macrophages via a TREM2-independent pathway in mouse model of amyloidosis. Nature aging. vol 2. issue 1. 2023-04-28. PMID:37118355. |
in amyloidosis mouse models, activation of microglia was found to be trem2 dependent. |
2023-04-28 |
2023-08-14 |
mouse |
| Logan Brase, Shih-Feng You, Ricardo D'Oliveira Albanus, Jorge L Del-Aguila, Yaoyi Dai, Brenna C Novotny, Carolina Soriano-Tarraga, Taitea Dykstra, Maria Victoria Fernandez, John P Budde, Kristy Bergmann, John C Morris, Randall J Bateman, Richard J Perrin, Eric McDade, Chengjie Xiong, Alison M Goate, Martin Farlow, Greg T Sutherland, Jonathan Kipnis, Celeste M Karch, Bruno A Benitez, Oscar Harar. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Nature communications. vol 14. issue 1. 2023-04-21. PMID:37085492. |
trem2 oligodendrocytes show a dysregulated autophagy-lysosomal pathway, ms4a microglia have dysregulated complement cascade genes, and apoeε4 inhibitory neurons display signs of ferroptosis. |
2023-04-21 |
2023-08-14 |
Not clear |
| Charlotte Duwat, Pauline Léal, Audrey Vautheny, Gwennaëlle Aurégan, Charlène Joséphine, Marie-Claude Gaillard, Anne-Sophie Hérard, Caroline Jan, Pauline Gipchtein, Julien Mitja, Stéphane Fouquet, Marie-Laure Niepon, Philippe Hantraye, Emmanuel Brouillet, Gilles Bonvento, Karine Cambon, Alexis-Pierre Bemelman. Development of an AAV-based model of tauopathy targeting retinal ganglion cells and the mouse visual pathway to study the role of microglia in Tau pathology. Neurobiology of disease. 2023-04-13. PMID:37054900. |
the application of this model to mice deficient in trem2 (triggering receptor expressed on myeloid cells-2, an important genetic risk factor for ad) as well as to 15-month-old mice showed that microglia actively participate in the degeneration of rgcs. |
2023-04-13 |
2023-08-14 |
mouse |
| Yanhui Lu, Xiaofeng Huang, Wenping Liang, Yu Li, Mengen Xing, Wenhao Pan, Yun Zhang, Zhe Wang, Weihong Son. Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease. The Journal of biological chemistry. 2023-04-12. PMID:37044212. |
trem2 encoding the transmembrane receptor protein trem2 is a risk gene of alzheimer's disease (ad), and the impairment of trem2 functions in microglia due to mutations in trem2 may significantly increase the risk of ad by promoting ad pathologies. |
2023-04-12 |
2023-08-14 |
mouse |
| Yanhui Lu, Xiaofeng Huang, Wenping Liang, Yu Li, Mengen Xing, Wenhao Pan, Yun Zhang, Zhe Wang, Weihong Son. Regulation of TREM2 expression by transcription factor YY1 and its protective effect against Alzheimer's Disease. The Journal of biological chemistry. 2023-04-12. PMID:37044212. |
shrna-mediated yy1 silencing significantly reduced the activity of the trem2 minimal promoter and trem2 protein levels in the microglial cell line bv2 and the neuroblastoma neuro2a. |
2023-04-12 |
2023-08-14 |
mouse |
| Akihiro Iguchi, Sho Takatori, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Genta Ito, Haruaki Sato, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomit. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. iScience. vol 26. issue 4. 2023-04-10. PMID:37035000. |
the genetic associations of trem2 loss-of-function variants with alzheimer disease (ad) indicate the protective roles of microglia in ad pathogenesis. |
2023-04-10 |
2023-08-14 |
mouse |
| Yun-Fan You, Man Chen, Yue Tang, Wen-Xiang Yu, Xiao-Wei Pang, Yun-Hui Chu, Hang Zhang, Ke Shang, Gang Deng, Luo-Qi Zhou, Sheng Yang, Wei Wang, Jun Xiao, Dai-Shi Tian, Chuan Qi. TREM2 deficiency inhibits microglial activation and aggravates demyelinating injury in neuromyelitis optica spectrum disorder. Journal of neuroinflammation. vol 20. issue 1. 2023-04-04. PMID:37013543. |
triggering receptor expressed on myeloid cells 2 (trem2) is expressed by microglia and promotes microglial activation, survival and phagocytosis. |
2023-04-04 |
2023-08-14 |
mouse |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
trem2 and apoe are two major risk factors for alzheimer’s disease (ad) that have been proposed to play crucial roles in microglia pathophysiology by affecting their ability to phagocytose cellular debris or aggregated proteins. |
2023-03-30 |
2023-08-14 |
Not clear |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
our findings showed that the deletion of either trem2 or apoe did not affect the dynamics of microglia engagement with dying neurons or their efficiency in phagocytosing corpses. |
2023-03-30 |
2023-08-14 |
Not clear |
| Eyiyemisi C Damisah, Anupama Rai, Robert A Hill, Lei Tong, Jaime Grutzendle. TREM2 and APOE do not modulate phagocytic clearance of dying cells in the live mammalian brain. bioRxiv : the preprint server for biology. 2023-03-30. PMID:36993245. |
interestingly, while microglia that encapsulate amyloid deposits were capable of phagocytosing dying cells without disengaging from plaques or moving their cell bodies; in the absence of trem2, microglia cell bodies were observed to readily migrate towards dying cells, further disengaging from plaques. |
2023-03-30 |
2023-08-14 |
Not clear |
| Wenchuan Zhou, Yutong Zhou, Jincan He, Yuqing Rao, Ping Fei, Jing L. TREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment. Cell death & disease. vol 14. issue 3. 2023-03-28. PMID:36977680. |
trem2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment. |
2023-03-28 |
2023-08-14 |
Not clear |