| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
the purpose of this review is to provide a comprehensive analysis of the research of trem2, including its regulation of the inflammatory response, lipid metabolism and phagocytosis in microglia of cns in ad, and to explore the potential application prospects as well as limitations of targeting trem2 for the treatment of ad. |
2023-07-30 |
2023-08-14 |
Not clear |
| Manuela Leri, Marzia Vasarri, Federica Carnemolla, Francesco Oriente, Serena Cabaro, Maria Stio, Donatella Degl'Innocenti, Massimo Stefani, Monica Bucciantin. EVOO Polyphenols Exert Anti-Inflammatory Effects on the Microglia Cell through TREM2 Signaling Pathway. Pharmaceuticals (Basel, Switzerland). vol 16. issue 7. 2023-07-29. PMID:37513845. |
evoo polyphenols exert anti-inflammatory effects on the microglia cell through trem2 signaling pathway. |
2023-07-29 |
2023-08-14 |
human |
| Yan He, Kun Yang, Lu Zhang, Meng Zhan, Xiu-Wen Xia, Huai-Fu Wang, Ya Xie, Ling Huang, Ni Yang, Ya-Li Zheng, Hong Yang, Ying-Ning, Jia-Yi Sun, You-Jun Yang, Wei-Jun Din. Electroacupuncture for weight loss by regulating microglial polarization in the arcuate nucleus of the hypothalamus. Life sciences. 2023-07-29. PMID:37516430. |
at the same time, ea induced microglia to exhibit an m2 phenotype, representing reduced inos/tnf-α and increased arg-1/il-10/bdnf, which may be due to the promotion of trem2 expression. |
2023-07-29 |
2023-08-14 |
mouse |
| Chen Yu, Eleonora M Lad, Rose Mathew, Sejiro Littleton, Yun Chen, Kai Schlepckow, Simone Degan, Lindsey Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saba. Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 Interactions. bioRxiv : the preprint server for biology. 2023-07-28. PMID:37502831. |
microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and trem2 interactions. |
2023-07-28 |
2023-08-14 |
mouse |
| Xiuxiu Sun, Xinxin Jin, Xi Liu, Lumeng Wang, Li Li, Junjie Yang, Helong Feng, Zhengdan Lin, Cunlin Zhan, Wanpo Zhang, Changqin Gu, Xueying Hu, Xiaoli Liu, Guofu Chen. Microglia play an important role in PRV infection-induced immune responses of the central nervous system. Virology journal. vol 20. issue 1. 2023-07-14. PMID:37452371. |
this may be associated with the phagocytic ability of microglia because we observed a significant increase in the expression of the membrane receptor trem2 in microglia, which is closely related to phagocytosis, we observed that depletion of microglia exacerbated neurological symptoms, blood-brain barrier breakdown, and peripheral lymphocyte infiltration. |
2023-07-14 |
2023-08-14 |
mouse |
| Tao Yin, Luciano D'Adami. BRI2-mediated regulation of TREM2 processing in microglia and its potential implications for Alzheimer's disease and related dementias. bioRxiv : the preprint server for biology. 2023-07-03. PMID:37398330. |
bri2-mediated regulation of trem2 processing in microglia and its potential implications for alzheimer's disease and related dementias. |
2023-07-03 |
2023-08-14 |
Not clear |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
trem2 is a membrane receptor expressed on microglia that plays a pivotal role in the organization and function of these innate immune cell components within the neurodegenerated brain. |
2023-06-11 |
2023-08-14 |
mouse |
| Michael Fassler, Clara Benaim, Jacob Georg. TREM2 Agonism with a Monoclonal Antibody Attenuates Tau Pathology and Neurodegeneration. Cells. vol 12. issue 11. 2023-06-11. PMID:37296669. |
collectively, these observations show that trem2 engagement with an agonistic antibody result in reduced tau burden concomitant with attenuated neurodegeneration ascribed to the education of resident microglia. |
2023-06-11 |
2023-08-14 |
mouse |
| Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wan. TREM2, microglial and ischemic stroke. Journal of neuroimmunology. vol 381. 2023-06-11. PMID:37302170. |
the triggering receptor expressed on myeloid cell 2 (trem2) is an immune-related receptor on the surface of microglia. |
2023-06-11 |
2023-08-14 |
Not clear |
| Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wan. TREM2, microglial and ischemic stroke. Journal of neuroimmunology. vol 381. 2023-06-11. PMID:37302170. |
this paper reviews the following: 1) the phenotypic changes of microglia in various pathological stages after is and its relationship with inflammatory factors; 2) the relationship between the expression of the trem2 receptor and inflammatory factors; 3) the relationship between phenotypic changes of microglia and its surface receptor trem2; 4) the trem2-related signalling pathway of microglia after is and treatment for trem2 receptor; and finally 5) to clarify the relationship among trem2, inflammation, and microglia phenotype after is, as well as the mechanism among them and the some possible treatment of is targeting trem2. |
2023-06-11 |
2023-08-14 |
Not clear |
| Hongxia Wang, Xiaoling Li, Qi Wang, Jialiang Ma, Xiaohong Gao, Manxia Wan. TREM2, microglial and ischemic stroke. Journal of neuroimmunology. vol 381. 2023-06-11. PMID:37302170. |
moreover, the relationship between the new phenotype of microglia such as sam and trem2 has also been systematically summarized, but there are no relevant research reports on the relationship between trem2 and sam after is. |
2023-06-11 |
2023-08-14 |
Not clear |
| Han Gao, Jiawei Di, Bettina Hjelm Clausen, Nanxiang Wang, Xizhong Zhu, Tianlun Zhao, Yanyu Chang, Mao Pang, Yang Yang, Ronghan He, Yuge Wang, Liangming Zhang, Bin Liu, Wei Qiu, Kate Lykke Lambertsen, Roberta Brambilla, Limin Ron. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. Cell reports. vol 42. issue 6. 2023-06-08. PMID:37289590. |
here, we identify two distinct phenotypes of microglia and infiltrating myeloid populations dependent on trem2 expression levels at the acute stage and elucidate how they mediate the opposing effects of trem2 in spinal cord injury (sci) versus multiple sclerosis animal models (experimental autoimmune encephalomyelitis [eae]). |
2023-06-08 |
2023-08-14 |
Not clear |
| Han Gao, Jiawei Di, Bettina Hjelm Clausen, Nanxiang Wang, Xizhong Zhu, Tianlun Zhao, Yanyu Chang, Mao Pang, Yang Yang, Ronghan He, Yuge Wang, Liangming Zhang, Bin Liu, Wei Qiu, Kate Lykke Lambertsen, Roberta Brambilla, Limin Ron. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. Cell reports. vol 42. issue 6. 2023-06-08. PMID:37289590. |
high trem2 levels sustain phagocytic microglia and infiltrating macrophages after sci. |
2023-06-08 |
2023-08-14 |
Not clear |
| Han Gao, Jiawei Di, Bettina Hjelm Clausen, Nanxiang Wang, Xizhong Zhu, Tianlun Zhao, Yanyu Chang, Mao Pang, Yang Yang, Ronghan He, Yuge Wang, Liangming Zhang, Bin Liu, Wei Qiu, Kate Lykke Lambertsen, Roberta Brambilla, Limin Ron. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. Cell reports. vol 42. issue 6. 2023-06-08. PMID:37289590. |
in contrast, moderate trem2 levels sustain immunomodulatory microglia and infiltrating monocytes in eae. |
2023-06-08 |
2023-08-14 |
Not clear |
| Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kin. Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2. Communications biology. vol 6. issue 1. 2023-06-08. PMID:37291187. |
trem2 is a transmembrane receptor expressed in microglia and macrophages. |
2023-06-08 |
2023-08-14 |
human |
| Gongcan Chen, Mengmeng Han, Yi Chen, Yaling Lei, Min Li, Li Wang, Chen Wang, Yangxue Hu, Jinghu Niu, Cong Yang, Yousheng Mo, Qi Wang, Lin Yang, Xiang Chan. Danggui-Shaoyao-San Promotes Amyloid-β Clearance through Regulating Microglia Polarization via Trem2 in BV2 Cells. Journal of integrative neuroscience. vol 22. issue 3. 2023-05-31. PMID:37258433. |
danggui-shaoyao-san promotes amyloid-β clearance through regulating microglia polarization via trem2 in bv2 cells. |
2023-05-31 |
2023-08-14 |
Not clear |
| Peng Su, Jianbin Zhang, Jinxia Wu, Honggang Chen, Wenjing Luo, Min H. TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. Ecotoxicology and environmental safety. vol 260. 2023-05-28. PMID:37245276. |
trem2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. |
2023-05-28 |
2023-08-14 |
Not clear |
| Peng Su, Jianbin Zhang, Jinxia Wu, Honggang Chen, Wenjing Luo, Min H. TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. Ecotoxicology and environmental safety. vol 260. 2023-05-28. PMID:37245276. |
our results showed that pb treatment significantly downregulated trem2 expression and altered the localization of trem2 expression in microglia. |
2023-05-28 |
2023-08-14 |
Not clear |
| Peng Su, Jianbin Zhang, Jinxia Wu, Honggang Chen, Wenjing Luo, Min H. TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. Ecotoxicology and environmental safety. vol 260. 2023-05-28. PMID:37245276. |
furthermore, the phagocytosis and migratory capabilities of microglia, which were impaired due to pb exposure, were alleviated by trem2 overexpression. |
2023-05-28 |
2023-08-14 |
Not clear |
| Peng Su, Jianbin Zhang, Jinxia Wu, Honggang Chen, Wenjing Luo, Min H. TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities. Ecotoxicology and environmental safety. vol 260. 2023-05-28. PMID:37245276. |
our in vitro findings were corroborated in vivo, demonstrating that trem2 regulates the anti-inflammatory functions of microglia, thereby mitigating pb-induced neuroinflammation. |
2023-05-28 |
2023-08-14 |
Not clear |