| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chunhao Zhang, Chen Xu, Yao Jing, Heli Cao, Xuyang Wang, Jianwei Zhao, Qiuyuan Gong, Shiwen Che. Deferoxamine Induces Autophagy Following Traumatic Brain Injury via TREM2 on Microglia. Molecular neurobiology. 2023-12-19. PMID:38110648. |
deferoxamine induces autophagy following traumatic brain injury via trem2 on microglia. |
2023-12-19 |
2023-12-21 |
mouse |
| Chunhao Zhang, Chen Xu, Yao Jing, Heli Cao, Xuyang Wang, Jianwei Zhao, Qiuyuan Gong, Shiwen Che. Deferoxamine Induces Autophagy Following Traumatic Brain Injury via TREM2 on Microglia. Molecular neurobiology. 2023-12-19. PMID:38110648. |
however, the role of trem2 in modulating the microglia response in tbi has been rarely investigated. |
2023-12-19 |
2023-12-21 |
mouse |
| Chunhao Zhang, Chen Xu, Yao Jing, Heli Cao, Xuyang Wang, Jianwei Zhao, Qiuyuan Gong, Shiwen Che. Deferoxamine Induces Autophagy Following Traumatic Brain Injury via TREM2 on Microglia. Molecular neurobiology. 2023-12-19. PMID:38110648. |
trem2 expression was up-regulated in cortex of tbi mice model and in microglia stretching model, which was attenuated by dfo. |
2023-12-19 |
2023-12-21 |
mouse |
| Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane receptor protein predominantly expressed in microglia within the central nervous system (cns). |
2023-12-02 |
2023-12-10 |
mouse |
| Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
recent studies have found that trem2 is highly expressed in activated microglia after ischemic stroke. |
2023-12-02 |
2023-12-10 |
mouse |
| Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
meanwhile, in a neuron-microglia co-culture system under hypoxic conditions, we found that microglia lost their protective effect against neuronal injury and apoptosis when trem2 was knocked down. |
2023-12-02 |
2023-12-10 |
mouse |
| Wei Wei, Lin Zhang, Wenqiang Xin, Yongli Pan, Lars Tatenhorst, Zhongnan Hao, Stefan T Gerner, Sabine Huber, Martin Juenemann, Marius Butz, Hagen B Huttner, Mathias Bähr, Dirk Fitzner, Feng Jia, Thorsten R Doeppne. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 170. 2023-12-02. PMID:38042110. |
under in vivo conditions, trem2 knockdown mice express lower tgf-β1 expression levels and a lower number of anti-inflammatory m2 phenotype microglia, resulting in increased cerebral infarct size, exacerbated neuronal apoptosis, and aggravated neuronal impairment. |
2023-12-02 |
2023-12-10 |
mouse |
| Wendi Huang, Juan Huang, Nanqu Huang, Yong Lu. The role of TREM2 in Alzheimer's disease: from the perspective of Tau. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020891. |
triggering receptor expressed on myeloid cells 2 (trem2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for alzheimer's disease (ad). |
2023-12-01 |
2023-12-07 |
Not clear |
| Wendi Huang, Juan Huang, Nanqu Huang, Yong Lu. The role of TREM2 in Alzheimer's disease: from the perspective of Tau. Frontiers in cell and developmental biology. vol 11. 2023-12-01. PMID:38020891. |
triggering receptor expressed on myeloid cells 2 (trem2), a pattern recognition receptor abundantly expressed on microglia, has been identified as one of the risk factors for alzheimer's disease (ad). |
2023-11-29 |
2023-12-07 |
Not clear |
| Chulhwan Kwak, Gina M Finan, Yu Rim Park, Anjali Garg, Oscar Harari, Ji Young Mun, Hyun-Woo Rhee, Tae-Wan Ki. Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014048. |
proximity proteome analysis reveals novel trem2 interactors in the er-mitochondria interface of human microglia. |
2023-11-28 |
2023-11-29 |
human |
| Chulhwan Kwak, Gina M Finan, Yu Rim Park, Anjali Garg, Oscar Harari, Ji Young Mun, Hyun-Woo Rhee, Tae-Wan Ki. Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia. bioRxiv : the preprint server for biology. 2023-11-28. PMID:38014048. |
trem2 deficiency alters the thickness (inter-organelle distance) of mercs, a structural parameter of metabolic state, in microglia derived from human induced pluripotent stem cells. |
2023-11-28 |
2023-11-29 |
human |
| Yanxia Peng, Genmeng Yang, Shangwen Wang, Wanrong Lin, Lihua Zhu, Wenjuan Dong, Baoyu Shen, Qianyun Nie, Shijun Hong, Lihua L. Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Exacerbates Methamphetamine-Induced Activation of Microglia and Neuroinflammation. International journal of toxicology. 2023-11-25. PMID:38006258. |
triggering receptor expressed on myeloid cells 2 (trem2) is reported to play a key role in activation of microglia and neuroinflammation. |
2023-11-25 |
2023-11-28 |
mouse |
| Oliver Cousins, Julia J Schubert, Avinash Chandra, Mattia Veronese, Polena Valkimadi, Byron Creese, Zunera Khan, Ryan Arathimos, Adam Hampshire, Ivana Rosenzweig, Clive Ballard, Anne Corbett, Dag Aasland, Latha Velayudhan, Michael O'Neill, David Collier, Ramla Awais, Kerstin Sander, Erik Årstad, Oliver Howes, Federico Turkheimer, Angela Hodge. Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge. Journal of neuroinflammation. vol 20. issue 1. 2023-11-22. PMID:37990275. |
trem2 is a microglial cell surface receptor. |
2023-11-22 |
2023-11-29 |
Not clear |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
ipsc-derived microglia carrying the trem2 r47h/+ mutation are proinflammatory and promote synapse loss. |
2023-11-16 |
2023-11-20 |
mouse |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
we employed gene editing and stem cell models to gain insight into the effects of the trem2 r47h/+ mutation on human-induced pluripotent stem cell-derived microglia. |
2023-11-16 |
2023-11-20 |
mouse |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
trem2 r47h/+ also caused impairments in microglial movement and the uptake of multiple substrates, as well as rendering microglia hyperresponsive to inflammatory stimuli. |
2023-11-16 |
2023-11-20 |
mouse |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
we developed an in vitro laser-induced injury model in neuron-microglia cocultures, finding an impaired injury response by trem2 r47h/+ microglia. |
2023-11-16 |
2023-11-20 |
mouse |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
furthermore, mouse brains transplanted with trem2 r47h/+ microglia exhibited reduced synaptic density, with upregulation of multiple complement cascade components in trem2 r47h/+ microglia suggesting inappropriate synaptic pruning as one potential mechanism. |
2023-11-16 |
2023-11-20 |
mouse |
| Rui Zhong, Yingzheng Xu, Jesse W Williams, Ling L. Loss of TREM2 exacerbates parenchymal amyloid pathology but diminishes CAA in Tg-SwDI mice. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961542. |
trem2 is a surface receptor expressed on microglia and largely mediates microglial functions and immune homeostasis in the brain. |
2023-11-14 |
2023-11-20 |
mouse |
| Fardin Nabizade. sTREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology. Brain communications. vol 5. issue 6. 2023-11-09. PMID:37942087. |
triggering receptor expressed on myeloid cell 2 (trem2) plays a crucial role in the transition of microglia from a state of homeostasis to a state associated with the disease. |
2023-11-09 |
2023-11-20 |
human |