| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilayda Ozsan McMillan, Li Liang, Guowei Su, Xuehong Song, Kelly Drago, Hua Yang, Claudia Alvarez, Amika Sood, James Gibson, Robert J Woods, Chunyu Wang, Jian Liu, Fuming Zhang, Tom J Brett, Lianchun Wan. TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid. The Journal of biological chemistry. 2024-08-19. PMID:39159814. |
trem2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-o-sulfation and iduronic acid. |
2024-08-19 |
2024-08-22 |
Not clear |
| Ilayda Ozsan McMillan, Li Liang, Guowei Su, Xuehong Song, Kelly Drago, Hua Yang, Claudia Alvarez, Amika Sood, James Gibson, Robert J Woods, Chunyu Wang, Jian Liu, Fuming Zhang, Tom J Brett, Lianchun Wan. TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid. The Journal of biological chemistry. 2024-08-19. PMID:39159814. |
we confirm trem2's binding to cell surface hs and demonstrate that trem2 interacts with hs, forming hs-trem2 binary complexes on microglia cell surfaces. |
2024-08-19 |
2024-08-22 |
Not clear |
| Ilayda Ozsan McMillan, Li Liang, Guowei Su, Xuehong Song, Kelly Drago, Hua Yang, Claudia Alvarez, Amika Sood, James Gibson, Robert J Woods, Chunyu Wang, Jian Liu, Fuming Zhang, Tom J Brett, Lianchun Wan. TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid. The Journal of biological chemistry. 2024-08-19. PMID:39159814. |
by delineating the interaction between hs and trem2 on the microglial cell surface and demonstrating its role in facilitating trem2-mediated apoe uptake by microglia, our findings provide valuable insights that can inform targeted interventions for modulating microglial functions in alzheimer's disease. |
2024-08-19 |
2024-08-22 |
Not clear |
| Jie Zou, Yaxuan Wang, Xinyue Zhang, Xue Pan, Te Fang, Dasheng Cai, Lili Guo, Yu Li, Yi He, Xuezhao Ca. CD33 Ameliorates Surgery-Induced Spatial Learning and Memory Impairments Through TREM2. Molecular neurobiology. 2024-08-01. PMID:39088031. |
the regulation of cd33 and trem2 expression was achieved through sirna in the bv2 microglia cell line. |
2024-08-01 |
2024-08-03 |
mouse |
| Jie Zou, Yaxuan Wang, Xinyue Zhang, Xue Pan, Te Fang, Dasheng Cai, Lili Guo, Yu Li, Yi He, Xuezhao Ca. CD33 Ameliorates Surgery-Induced Spatial Learning and Memory Impairments Through TREM2. Molecular neurobiology. 2024-08-01. PMID:39088031. |
this is evidenced by the suppression of pro-inflammatory cytokines following cd33 knockdown in microglia and the reversal of these effects when both cd33 and trem2 are concurrently knocked down. |
2024-08-01 |
2024-08-03 |
mouse |
| Hannah Scheiblich, Frederik Eikens, Lena Wischhof, Sabine Opitz, Kay Jüngling, Csaba Cserép, Susanne V Schmidt, Jessica Lambertz, Tracy Bellande, Balázs Pósfai, Charlotte Geck, Jasper Spitzer, Alexandru Odainic, Sergio Castro-Gomez, Stephanie Schwartz, Ibrahim Boussaad, Rejko Krüger, Enrico Glaab, Donato A Di Monte, Daniele Bano, Ádám Dénes, Eike Latz, Ronald Melki, Hans-Christian Pape, Michael T Henek. Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes. Neuron. 2024-07-26. PMID:39059388. |
notably, tnt-mediated aggregate transfer is compromised in microglia carrying lrrk22(gly2019ser) or trem2(t66m) and (r47h) mutations, suggesting a role in the pathology of these gene variants in neurodegenerative diseases. |
2024-07-26 |
2024-07-29 |
Not clear |
| Cong Wang, Jing Dong, Heng Huang, Kegui Zhou, Zhenguo Liu, Richard Milner, Longxuan L. Astrocyte-TREM2 alleviates brain injury by regulating reactive astrocyte states following ischemic stroke. Glia. 2024-07-26. PMID:39056459. |
however, as the vast majority of research findings to date are based on its functions in microglia, the precise role of trem2 in astrocytes after ais is unknown. |
2024-07-26 |
2024-07-28 |
mouse |
| Jong-Chan Park, Jong Won Han, Woochan Lee, Jieun Kim, Sang-Eun Lee, Dongjoon Lee, Hayoung Choi, Jihui Han, You Jung Kang, Yen N Diep, Hansang Cho, Rian Kang, Won Jong Yu, Jean Lee, Murim Choi, Sun-Wha Im, Jong-Il Kim, Inhee Mook-Jun. Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-07-09. PMID:38981007. |
microglia gravitate toward amyloid plaques surrounded by externalized phosphatidylserine via trem2. |
2024-07-09 |
2024-07-12 |
Not clear |
| Jong-Chan Park, Jong Won Han, Woochan Lee, Jieun Kim, Sang-Eun Lee, Dongjoon Lee, Hayoung Choi, Jihui Han, You Jung Kang, Yen N Diep, Hansang Cho, Rian Kang, Won Jong Yu, Jean Lee, Murim Choi, Sun-Wha Im, Jong-Il Kim, Inhee Mook-Jun. Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-07-09. PMID:38981007. |
microglia play a crucial role in synaptic elimination by engulfing dystrophic neurons via triggering receptors expressed on myeloid cells 2 (trem2). |
2024-07-09 |
2024-07-12 |
Not clear |
| Fardin Nabizadeh, Homa Seyedmirzaei, Shaghayegh Karam. Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study. Scientific reports. vol 14. issue 1. 2024-07-03. PMID:38961148. |
understanding the exact pathophysiological mechanisms underlying the involvement of triggering receptor expressed on myeloid cells 2 (trem2) related microglia activation is crucial for the development of clinical trials targeting microglia activation at different stages of alzheimer's disease (ad). |
2024-07-03 |
2024-07-08 |
human |
| Fardin Nabizadeh, Homa Seyedmirzaei, Shaghayegh Karam. Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study. Scientific reports. vol 14. issue 1. 2024-07-03. PMID:38961148. |
given the contradictory findings in the literature, it is imperative to investigate the longitudinal alterations in cerebrospinal fluid (csf) soluble trem2 (strem2) levels as a marker for microglia activation, and its potential association with ad biomarkers, in order to address the current knowledge gap. |
2024-07-03 |
2024-07-08 |
human |
| Wenyu Ni, Yun Niu, Sitong Cao, Chunsun Fan, Jian Fan, Li Zhu, Xueting Wan. Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling. Journal of neuroinflammation. vol 21. issue 1. 2024-07-03. PMID:38956653. |
moreover, trem2 upregulation has been suggested to play a protective role in attenuating microglia activation and improving synaptic function in t2dm mice. |
2024-07-03 |
2024-07-06 |
mouse |
| Naser Gilani, Fatemeh Bitarafan, Mehmet Ozaslan, Sarah Åsheim, Morteza Heidari, Masoud Garshasb. Homozygous TREM2 c.549del; p.(Leu184Serfs*5) variant causing Nasu-Hakola disease in three siblings in a consanguineous Iraqi family: Case report and review of literature. Molecular genetics & genomic medicine. vol 12. issue 6. 2024-06-18. PMID:38888203. |
the triggering receptor expressed on myeloid cells 2 protein (trem2) plays a crucial role in various biological processes, including osteoclast differentiation, and disease-associated microglia (dam) activation to regulate neuroinflammation, and phagocytosis in the brain. |
2024-06-18 |
2024-06-21 |
Not clear |
| Mihyun Hwang, Cornelia C Bergman. Neurotropic murine coronavirus mediated demyelination: Factors dampening pathogenesis. Journal of neuroimmunology. vol 393. 2024-06-08. PMID:38850674. |
we specifically discuss the role of immune dampening factors programmed cell death ligand 1 (pd-l1) and interleukin (il)-10, as well as microglia and triggering receptor expressed on myeloid cells 2 (trem2), in limiting demyelination independent of viral persistence. |
2024-06-08 |
2024-06-11 |
mouse |
| Yi Tian, Rong Ai, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Xiaoping Zh. Mechanism of the effect of TREM2 on cognitive function in autistic mice. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 6. 2024-06-05. PMID:38836680. |
trem2 overexpression and knockdown viruses were given to autism spectrum disorder (asd) mice and bv2 microglia cell line. |
2024-06-05 |
2024-06-07 |
mouse |
| Michela Matteol. The role of microglial TREM2 in development: A path toward neurodegeneration? Glia. 2024-06-05. PMID:38837837. |
among the microglial genes, trem2 is a key player, controlling the functional state of microglia and being at the forefront of many processes that require interaction between microglia and other brain components, such as neurons and oligodendrocytes. |
2024-06-05 |
2024-06-08 |
Not clear |
| Ainhoa Etxeberria, Yun-An A Shen, Steve Vito, Sean Silverman, Jose Imperio, Guita Lalehzadeh, Allison Soung, Changchun Du, Luke Xie, Man Kin Choy, Yi-Chun Hsiao, Hai Ngu, Chang Hoon Cho, Soumitra Ghosh, Gloriia Novikova, Mitchell G Rezzonico, Rebecca Leahey, Martin Weber, Alvin Gogineni, Justin Elstrott, Monica Xiong, Jacob J Greene, Kimberly L Stark, Pamela Chan, Gillie A Roth, Max Adrian, Qingling Li, Meena Choi, Weng Ruh Wong, Wendy Sandoval, Oded Foreman, Alicia A Nugent, Brad A Friedman, Shraddha Sadekar, Isidro Hötzel, David V Hansen, Ben Chih, Tracy J Yuen, Robby M Weimer, Amy Easton, William J Meilandt, Christopher J Bohle. Neutral or detrimental effects of TREM2 agonist antibodies in preclinical models of Alzheimer's Disease and Multiple Sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-03. PMID:38830764. |
for mice bearing amyloid-β (aβ) pathology (ps2app) or combined aβ and tau pathology (taups2app), chronic trem2 agonist antibody treatment had limited impact on microglia engagement with pathology, overall pathology burden, or downstream neuronal damage. |
2024-06-03 |
2024-06-06 |
mouse |
| Xueting Wang, Yuqi Xie, Xiaoyang Fan, Xiaomei Wu, Dan Wang, Li Zh. Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease. Alzheimer's research & therapy. vol 16. issue 1. 2024-06-03. PMID:38831312. |
intermittent hypoxia training enhances aβ endocytosis by plaque associated microglia via vps35-dependent trem2 recycling in murine alzheimer's disease. |
2024-06-03 |
2024-06-06 |
Not clear |
| Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Elida Gomero, Alessandra d'Azz. Neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of Trem2. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826426. |
neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of trem2. |
2024-06-03 |
2024-06-05 |
Not clear |
| Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Elida Gomero, Alessandra d'Azz. Neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of Trem2. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826426. |
here we examined how neu1 influences microglia by modulating the sialylation of full-length trem2 (trem2-fl), a multifunctional receptor that regulates microglial survival, phagocytosis, and cytokine production. |
2024-06-03 |
2024-06-05 |
Not clear |