| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Qian Peng, Hong-Song Guo, Xiao Zhang, Xiang-Yuan Wu, John Bosco Ruganzu, Song-Di Wu, Ming-Tao Zhao, Lei Li, Yang Yang, Sheng-Feng Ji, Wei-Na Yang, Peng-Yu Re. TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice. Experimental neurology. 2025-03-06. PMID:40049315. |
triggering receptor expressed on myeloid cells-2 (trem2) mainly expressed on microglia in the brain, and its mutations can increase the risk of alzheimer's disease (ad). |
2025-03-06 |
2025-03-09 |
mouse |
| Xiao-Qian Peng, Hong-Song Guo, Xiao Zhang, Xiang-Yuan Wu, John Bosco Ruganzu, Song-Di Wu, Ming-Tao Zhao, Lei Li, Yang Yang, Sheng-Feng Ji, Wei-Na Yang, Peng-Yu Re. TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice. Experimental neurology. 2025-03-06. PMID:40049315. |
in vitro, treatment with ly294002, a pi3k inhibitor, abolished the beneficial effects of trem2 on shifting microglia from m1 to m2 and the proliferation and differentiation of nscs. |
2025-03-06 |
2025-03-09 |
mouse |
| Xiao-Qian Peng, Hong-Song Guo, Xiao Zhang, Xiang-Yuan Wu, John Bosco Ruganzu, Song-Di Wu, Ming-Tao Zhao, Lei Li, Yang Yang, Sheng-Feng Ji, Wei-Na Yang, Peng-Yu Re. TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice. Experimental neurology. 2025-03-06. PMID:40049315. |
lentivirus vectors were used to interfere with the expression of trem2 on microglia in the hippocampus of app/ps1 mice and bv2 cells. |
2025-03-06 |
2025-03-09 |
mouse |
| Xiao-Qian Peng, Hong-Song Guo, Xiao Zhang, Xiang-Yuan Wu, John Bosco Ruganzu, Song-Di Wu, Ming-Tao Zhao, Lei Li, Yang Yang, Sheng-Feng Ji, Wei-Na Yang, Peng-Yu Re. TREM2 promotes hippocampal neurogenesis through regulating microglial M2 polarization in APP/PS1 mice. Experimental neurology. 2025-03-06. PMID:40049315. |
furthermore, upregulation of trem2 increased the m2 microglia marker cd206, brain-derived neurotrophic factor (bdnf), and anti-inflammatory factors, while decreased the m1 microglia markers cd16/32 and cd86 and pro-inflammatory factors in vivo and in vitro. |
2025-03-06 |
2025-03-09 |
mouse |
| Lynn van Olst, Brooke Simonton, Alex J Edwards, Anne V Forsyth, Jake Boles, Pouya Jamshidi, Thomas Watson, Nate Shepard, Talia Krainc, Benney Mr Argue, Ziyang Zhang, Joshua Kuruvilla, Lily Camp, Mengwei Li, Hang Xu, Jeanette L Norman, Joshua Cahan, Robert Vassar, Jinmiao Chen, Rudolph J Castellani, James Ar Nicoll, Delphine Boche, David Gat. Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease. Nature medicine. 2025-03-06. PMID:40050704. |
our analysis reveals upregulation of the triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) in microglia across immunization approaches, which correlate positively with antibody responses and aβ removal. |
2025-03-06 |
2025-03-09 |
Not clear |
| Momoka Hikosaka, Md Sorwer Alam Parvez, Yuki Yamawaki, Souichi Oe, Yuan Liang, Yayoi Wada, Yukie Hirahara, Taro Koike, Hirohiko Imai, Naoya Oishi, Sina M Schalbetter, Asuka Kumagai, Mari Yoshida, Takeshi Sakurai, Masaaki Kitada, Urs Meyer, Shuh Narumiya, Gen Ohtsuk. Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition. Communications biology. vol 8. issue 1. 2025-03-03. PMID:40033126. |
highly multiplexed imaging-mass-cytometry identifies a cell transition to trem2(+) stress-associated microglia in the cerebellum. |
2025-03-03 |
2025-03-06 |
mouse |
| Milan Med. TREM2 in Regulating Macrophage Inflammatory Responses and Disease Pathogenesis. Critical reviews in immunology. vol 45. issue 2. 2025-02-20. PMID:39976515. |
triggering receptor expressed on myeloid cells 2 (trem2) is a cell surface receptor belonging to the trem family that is predominantly expressed on myeloid cells such as granulocytes, monocytes, osteocytes, macrophages, and microglia. |
2025-02-20 |
2025-02-23 |
Not clear |
| Milan Med. TREM2 in Regulating Macrophage Inflammatory Responses and Disease Pathogenesis. Critical reviews in immunology. vol 45. issue 2. 2025-02-20. PMID:39976515. |
the function of trem2 is highly conserved across the broad definition of macrophages, including microglia, osteoclasts, and vascular macrophages. |
2025-02-20 |
2025-02-23 |
Not clear |
| Jan Traub, Niklas Beyersdorf, Roxanne Sell, Stefan Frantz, Stefan Störk, Guido Stoll, Anna Fre. Plasma levels of soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) in chronic heart failure - predictors and prognostic relevance. American journal of physiology. Heart and circulatory physiology. 2025-02-07. PMID:39918245. |
trem2 (triggering receptor expressed on myeloid cells 2) is a transmembrane protein expressed on myeloid cells, including macrophages and microglia, and is involved in modulating inflammation and lipid metabolism. |
2025-02-07 |
2025-02-09 |
Not clear |
| Kelley C Larson, Frederick W Gergits, Abigail J Renoux, Elizabeth J Weisman, Borislav Dejanovic, Liyue Huang, Bhaumik Pandya, Donald G McLaren, Berkley A Lynch, Richard Fisher, Evan Thackaberry, David Gray, Francois Gaudreault, Christian Miresc. Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism. Journal of neuroinflammation. vol 22. issue 1. 2025-02-01. PMID:39891235. |
similar functions have also been ascribed to triggering receptor expressed on myeloid cells 2 (trem2), which shares an analogous microglia enrichment profile and converging intracellular signaling pathway mediated by spleen associated tyrosine kinase (syk) and phosphoinositide-3-kinase (pi3k). |
2025-02-01 |
2025-02-04 |
mouse |
| Xiaoye Ma, Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Can Zhang, Dan Lei, Yingxue Ren, Keiji Kawatani, Skylar C Starling, Ralph B Perkerson, Bhaskar Roy, Astrid C Quintero, Tammee M Parsons, Yining Pan, Zonghua Li, Minghui Wang, Hanmei Bao, Xianlin Han, Guojun Bu, Rudolph E Tanzi, Takahisa Kanekiy. Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice. Neurobiology of disease. 2025-01-29. PMID:39880319. |
in addition, we observed that abca7-a696s substitution disturbs the induction of proinflammatory cytokines interleukin 1β and interferon γ in the brains of 5xfad mice, although some disease-associated microglia gene expression, including trem2 and tyrobp, are upregulated. |
2025-01-29 |
2025-02-01 |
mouse |
| Sarbani Mishra, Preety Sthutika Swain, Sanghamitra Pati, Budheswar Dehur. Extracellular domain of TREM2 possess two distinct ligand recognition sites: Insights from machine-learning guided docking and all-atoms molecular dynamics simulations. Heliyon. vol 11. issue 1. 2025-01-27. PMID:39866401. |
the myeloid-specific triggering receptors expressed on myeloid cells 2 (trem2) is a group of class i receptors expressed in brain microglia plays a decisive role in neurodegenerative diseases such as alzheimer's disease (ad) and nasu hakola disease (nhd). |
2025-01-27 |
2025-01-29 |
Not clear |
| Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d'Azz. Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation. Cell reports. vol 44. issue 1. 2025-01-16. PMID:39817909. |
neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of trem2 sialylation. |
2025-01-16 |
2025-01-19 |
Not clear |
| Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d'Azz. Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation. Cell reports. vol 44. issue 1. 2025-01-16. PMID:39817909. |
here, we examine how neu1 influences microglia by modulating the sialylation of full-length trem2 (trem2-fl), a multifunctional receptor that regulates microglial survival, phagocytosis, and cytokine production. |
2025-01-16 |
2025-01-19 |
Not clear |
| Jessica A Greven, Joshua R Wydra, Rory A Greer, Cynthia Zhi, David A Price, Jordyn D Svoboda, Christopher L M Camitta, Mya Washington, Daisy W Leung, Yuhua Song, Jen Alexander-Brett, Tom J Bret. Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands. Molecular neurodegeneration. vol 20. issue 1. 2025-01-10. PMID:39789647. |
trem2 is a signaling receptor expressed on microglia that has emerged as an important drug target for alzheimer's disease and other neurodegenerative diseases. |
2025-01-10 |
2025-01-13 |
Not clear |
| Yuchen Yao, Liru Hu, Danni Li, Yuhao Wang, Jian Pan, Dan Fa. Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke. Frontiers in neuroscience. vol 18. 2025-01-06. PMID:39758888. |
perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia trem2 via pi3k/akt pathway in mouse model of ischemic stroke. |
2025-01-06 |
2025-01-08 |
mouse |
| Yuchen Yao, Liru Hu, Danni Li, Yuhao Wang, Jian Pan, Dan Fa. Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke. Frontiers in neuroscience. vol 18. 2025-01-06. PMID:39758888. |
however, we observed that an enriched environment (ee) could ameliorate this cognitive impairment by upregulating microglia trem2 expression in the hippocampus and suppressing neuroinflammation. |
2025-01-06 |
2025-01-08 |
mouse |
| Jessica A Greven, Jennifer M Alexander-Brett, Thomas J Bret. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750848. |
understanding the molecular mechanisms underlying trem2 signaling in microglia will facilitate the development of specific, safe and efficacious therapies for ad that target trem2. |
2025-01-03 |
2025-01-05 |
Not clear |
| Harry Crook, Malak Wahdan, Marie Emilie Tuil, Nicholas R Livingston, Sanara Raza, Joseph Nowell, Paul Ediso. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750876. |
triggering receptor expressed on myeloid cells 2 (trem2) is crucial to microglial involvement in ad, mediating trem2-dependent activation and disease-associated microglia (dam) polarization. |
2025-01-03 |
2025-01-05 |
Not clear |
| Shahnawaz A Bha. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751305. |
following the genome-wide association studies (gwas) discovery of microglia-specific genes, particularly trem-2, ship-1, and cd33, significantly associated with higher alzheimer's disease (ad) risk, the microglia trem2 pathway has become central for regulating amyloid load, tissue damage, and limiting its spread. |
2025-01-03 |
2025-01-05 |
mouse |