| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hanjie Liu, Hui Yang, Shuqing Liu, Siyu Li, Wen Yang, Anwar Ayesha, Xin Tan, Cen Jiang, Yi Liu, Lushuang Xi. Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles. Journal of visualized experiments : JoVE. issue 207. 2024-06-03. PMID:38829108. |
protein-protein interaction network (ppi) identified mt3, calm2, dlg2, kcnd2, pakacb, camk2d, and nlgn4y in astrocytes, trem2, fos, apoe, app, and nlgn4y in microglia, and grin2a, itpr2, gnas, and nlgn4y in oligodendrocytes as key genes. |
2024-06-03 |
2024-06-05 |
Not clear |
| Jennifer Pocock, Foteini Vasilopoulou, Elina Svensson, Katharina Coske. Microglia and TREM2. Neuropharmacology. 2024-05-31. PMID:38821351. |
microglia and trem2. |
2024-05-31 |
2024-06-02 |
human |
| Jennifer Pocock, Foteini Vasilopoulou, Elina Svensson, Katharina Coske. Microglia and TREM2. Neuropharmacology. 2024-05-31. PMID:38821351. |
trem2 is a membrane receptor solely expressed on microglia in normal brain. |
2024-05-31 |
2024-06-02 |
human |
| Jennifer Pocock, Foteini Vasilopoulou, Elina Svensson, Katharina Coske. Microglia and TREM2. Neuropharmacology. 2024-05-31. PMID:38821351. |
in this review we outline recent advances in trem2 biology and its implications for microglial function, with particular emphasis on findings from ipsc-derived microglia (img) expressing trem2 loss-of-function mutations. |
2024-05-31 |
2024-06-02 |
human |
| Erpan Ahat, Zanyu Shi, Shaoyou Chu, Hai Hoang Bui, Emily R Mason, Disha M Soni, Kenneth D Roth, Michael James Chalmers, Adrian L Oblak, Jie Zhang, Jesus A Gutierrez, Timothy Richardso. SHIP1 modulation and proteome characterization of microglia. Journal of proteomics. 2024-05-22. PMID:38777089. |
understanding microglial states in the aging brain has become crucial, especially with the discovery of numerous alzheimer's disease (ad) risk and protective variants in genes such as inpp5d and trem2, which are essential to microglia function in ad. |
2024-05-22 |
2024-05-27 |
mouse |
| Qian Shi, Raul A Gutierrez, Manzoor A Bha. Microglia, Trem2, and Neurodegeneration. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-05-21. PMID:38769824. |
microglia, trem2, and neurodegeneration. |
2024-05-21 |
2024-05-27 |
human |
| Qian Shi, Raul A Gutierrez, Manzoor A Bha. Microglia, Trem2, and Neurodegeneration. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-05-21. PMID:38769824. |
microglia express trem2, which serves as a receptor for a multitude of ligands enhancing their phagocytic activity. |
2024-05-21 |
2024-05-27 |
human |
| Yunji Yan, Shengwei Bai, Hongxi Han, Junqiang Dai, Liang Niu, Hongyu Wang, Qiang Dong, Hang Yin, Guoqiang Yuan, Yawen Pa. Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways. Cell communication and signaling : CCS. vol 22. issue 1. 2024-05-15. PMID:38750472. |
knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the jak2/stat3 and nf-κb pathways. |
2024-05-15 |
2024-05-27 |
Not clear |
| Andrew R Gomez, Hyae Ran Byun, Shaogen Wu, Akm Ghulam Mohammad, Jasmine Ikbariyeh, Jaelin Chen, Alek Muro, Lin Li, Ken E Bernstein, Richard Ainsworth, Warren G Tourtellott. Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking. bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712251. |
ace-expressing microglia show enhanced aβ phagocytosis and endolysosomal trafficking, increased clustering around amyloid plaques, and increased syk tyrosine kinase activation downstream of the major aβ receptors, trem2 and clec7a. |
2024-05-07 |
2024-05-27 |
mouse |
| Yue Wang, Wen Niu, Shan Zhu, Jianyu Sun, Jianrui Lv, Ning Wang, Huijuan Zhang, Zhenni Zhang, Meijuan Wang, Lingli Cao, Shuwei Li, Qian Zhai, Lei M. STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation. Inflammation. 2024-04-26. PMID:38668837. |
trem2 upregulation induced by cgamp regulated the microglia from pro-inflammatory state to anti-inflammatory state, thereby relieving neuroinflammation in csr mice. |
2024-04-26 |
2024-04-28 |
mouse |
| Zhao Li, Shenghui Yu, Lin Li, Chao Zhou, Lin Wang, Shuang Tang, Nina Gu, Zhaosi Zhang, Zhijian Huang, Hong Chen, Wei Tang, Yingwen Wang, Xiaomin Yang, Xiaochuan Sun, Jin Ya. TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia. Clinical and translational medicine. vol 14. issue 4. 2024-04-22. PMID:38649789. |
trem2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of dhcr24/lxr pathway in microglia. |
2024-04-22 |
2024-04-26 |
mouse |
| Sujun Jiang, Guoen Cai, Zhimin Yang, Haoyuan Shi, Huajie Zeng, Qinyong Ye, Zhiyuan Hu, Zihua Wan. Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer's Disease. ACS nano. 2024-04-22. PMID:38649866. |
specifically, an upregulation of trem2 expression can reprogram microglia from a pro-inflammatory m1 phenotype to an anti-inflammatory m2 phenotype while also restoring its capacity to phagocytose aβ and its nerve repair function. |
2024-04-22 |
2024-04-26 |
mouse |
| Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwart. Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain. Nature neuroscience. 2024-04-18. PMID:38637622. |
microglia, and specifically those expressing the ad risk gene trem2, are considered important players in ad, but their exact contribution to pathology remains unclear. |
2024-04-18 |
2024-04-21 |
mouse |
| Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwart. Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain. Nature neuroscience. 2024-04-18. PMID:38637622. |
in this study, using high-throughput mass cytometry in the 5×fad mouse model of amyloidosis, we identified senescent microglia that express high levels of trem2 but also exhibit a distinct signature from trem2-dependent disease-associated microglia (dam). |
2024-04-18 |
2024-04-21 |
mouse |
| Gautham S Ramakrishnan, William L Berry, Angela Pacherille, William G Kerr, John D Chisholm, Chiara Pedicone, Mary Beth Humphre. SHIP inhibition mediates select TREM2-induced microglial functions. Molecular immunology. vol 170. 2024-04-13. PMID:38613944. |
microglia play a pivotal role in the pathology of alzheimer's disease (ad), with the triggering receptor expressed on myeloid cells 2 (trem2) central to their neuroprotective functions. |
2024-04-13 |
2024-04-16 |
mouse |
| Gautham S Ramakrishnan, William L Berry, Angela Pacherille, William G Kerr, John D Chisholm, Chiara Pedicone, Mary Beth Humphre. SHIP inhibition mediates select TREM2-induced microglial functions. Molecular immunology. vol 170. 2024-04-13. PMID:38613944. |
in summary, our findings offer a deeper understanding of the relationship between trem2 variants and ship1 in microglial functions, and emphasize the therapeutic potential of targeting the trem2 and ship1 pathways in microglia for neurodegenerative diseases. |
2024-04-13 |
2024-04-16 |
mouse |
| Yi-Kuan Chiang, Yung-Shuan Lin, Chun-Yu Chen, Jiing-Feng Lirng, Yu-Hsiu Yang, Wei-Ju Lee, Jong-Ling Fu. Different Splice Isoforms of Peripheral Triggering Receptor Expressed on Myeloid Cells 2 mRNA Expressions are Associated With Cognitive Decline in Mild Dementia Due to Alzheimer's Disease and Reflect Central Neuroinflammation. American journal of Alzheimer's disease and other dementias. vol 39. 2024-04-09. PMID:38592304. |
triggering receptor expressed on myeloid cells 2 (trem2) is upregulated in activated microglia and may be related to cognitive decline in patients with alzheimer's disease (ad). |
2024-04-09 |
2024-04-11 |
Not clear |
| Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murat. Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2. Scientific reports. vol 14. issue 1. 2024-03-29. PMID:38548872. |
taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of trem2. |
2024-03-29 |
2024-03-31 |
mouse |
| Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murat. Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2. Scientific reports. vol 14. issue 1. 2024-03-29. PMID:38548872. |
in conclusion, the present study suggests that taurine treatment may upregulate trem2 to protect against microglia over-activation by decreasing the accumulation of phospho-tau and aβ; providing an insight into a novel preventive strategy in ad. |
2024-03-29 |
2024-03-31 |
mouse |
| Hongxia Wang, Jialiang Ma, Xiaoling Li, Yanhui Peng, Manxia Wan. FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury. European journal of pharmacology. 2024-03-01. PMID:38428662. |
the triggering receptor expressed on myeloid cells 2 (trem2), primarily expressed on microglial cell membranes, plays a critical role in reducing inflammation and oxidative stress in ais. |
2024-03-01 |
2024-03-04 |
mouse |