| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jessica A Greven, Jennifer M Alexander-Brett, Thomas J Bret. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750848. |
understanding the molecular mechanisms underlying trem2 signaling in microglia will facilitate the development of specific, safe and efficacious therapies for ad that target trem2. |
2025-01-03 |
2025-01-05 |
Not clear |
| Harry Crook, Malak Wahdan, Marie Emilie Tuil, Nicholas R Livingston, Sanara Raza, Joseph Nowell, Paul Ediso. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750876. |
triggering receptor expressed on myeloid cells 2 (trem2) is crucial to microglial involvement in ad, mediating trem2-dependent activation and disease-associated microglia (dam) polarization. |
2025-01-03 |
2025-01-05 |
Not clear |
| Shahnawaz A Bha. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751305. |
following the genome-wide association studies (gwas) discovery of microglia-specific genes, particularly trem-2, ship-1, and cd33, significantly associated with higher alzheimer's disease (ad) risk, the microglia trem2 pathway has become central for regulating amyloid load, tissue damage, and limiting its spread. |
2025-01-03 |
2025-01-05 |
mouse |
| Shahnawaz A Bha. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751305. |
these discoveries have opened up the exciting possibility of therapeutic microglia trem2 manipulation in ad. |
2025-01-03 |
2025-01-05 |
mouse |
| Junyi Liang, Aditya Aditya Menon, Taylor Tomco, Lynn M Bekri. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751383. |
triggering receptor expressed on myeloid cells 2 (trem2) is increasingly recognized to play a central role in amyloid beta clearance and microglia activation in ad. |
2025-01-03 |
2025-01-05 |
Not clear |
| Berta Sanz Morello, Elin Byman Shatri, Sofie Frandsen, Benjamin Schmid, Kenneth Thirstrup, Bjørn Hols. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751449. |
these activities are tightly regulated by microglia receptors cd33 and trem2. |
2025-01-03 |
2025-01-05 |
Not clear |
| Masataka Kikuchi, Akinori Miyashita, Yu Hirota, Norikazu Hara, Mai Hasegawa, Yasufumi Sakakibara, Michiko Sekiya, Yuko Saito, Shigeo Murayama, Koichi M Iijima, Takeshi Ikeuch. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751567. |
however, reactive microglia are less likely to be induced in trem2 mutation carriers. |
2025-01-03 |
2025-01-05 |
Not clear |
| Li Gan, Sarah Nagui. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751696. |
trem2 is required for the induction of a disease-associated microglia (dam) signature and microglial neurodegenerative phenotype (mgnd) in response to disease pathology, signatures which both include apoe upregulation. |
2025-01-03 |
2025-01-05 |
Not clear |
| Foteini Vasilopoulou, Thomas M Piers, Jingzhang Wei, John Hardy, Jennifer M Pococ. Amelioration of signaling deficits underlying metabolic shortfall in TREM2 The FEBS journal. 2024-12-27. PMID:39726135. |
amelioration of signaling deficits underlying metabolic shortfall in trem2 the microglial triggering receptor expressed on myeloid cells 2 (trem2) is required for diverse microglia responses in neurodegeneration, including immunometabolic plasticity, phagocytosis, and survival. |
2024-12-27 |
2024-12-29 |
Not clear |
| Foteini Vasilopoulou, Thomas M Piers, Jingzhang Wei, John Hardy, Jennifer M Pococ. Amelioration of signaling deficits underlying metabolic shortfall in TREM2 The FEBS journal. 2024-12-27. PMID:39726135. |
we previously identified that patient ipsc-derived microglia (ips-mg) harboring the alzheimer's disease (ad) trem2 |
2024-12-27 |
2024-12-29 |
Not clear |
| Yong-Chang Wang, Liang-Yu Huang, Hai-Hua Guo, Min Liu, Yu-Ying Zhang, Zi-Qi Zhang, Quan Hao, Chen-Chen Tan, Lan Ta. Higher CSF sTREM2 attenuates APOE ε4-related risk for amyloid pathology in cognitively intact adults: The CABLE study. Journal of neurochemistry. vol 169. issue 1. 2024-12-26. PMID:39725857. |
the triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane protein found in microglia within the brain, and its soluble form (strem2) has been shown to reduce amyloid deposition. |
2024-12-26 |
2024-12-29 |
human |
| Min Xiong, Danhao Xia, Honglu Yu, Lanxia Meng, Xingyu Zhang, Jiehui Chen, Ye Tian, Xin Yuan, Xuan Niu, Shuke Nie, Zhaohui Zhang, Chaoyang Liu, Qiang Chen, Keqiang Ye, Zhentao Zhan. Microglia Process α-Synuclein Fibrils and Enhance their Pathogenicity in a TREM2-Dependent Manner. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-12-12. PMID:39665233. |
the phagocytosis of α-syn fibrils by microglia is partially mediated by triggering a receptor expressed on myeloid cells 2 (trem2), a transmembrane protein expressed on the surface of microglia. |
2024-12-12 |
2024-12-14 |
mouse |
| Nóra Baligács, Giulia Albertini, Sarah C Borrie, Lutgarde Serneels, Clare Pridans, Sriram Balusu, Bart De Stroope. Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer's Disease. Nature communications. vol 15. issue 1. 2024-12-05. PMID:39639016. |
human microglia with the trem2 |
2024-12-05 |
2024-12-08 |
human |
| Zhenzhen Fan, Dandan Su, Zi Chao Li, Songtang Sun, Zhaoming G. Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine. Journal of neuroinflammation. vol 21. issue 1. 2024-12-04. PMID:39627853. |
triggering receptor expressed on myeloid cells 2 (trem2) is presented solely in microglia residing within the central nervous system and plays a key role in neuroinflammation. |
2024-12-04 |
2024-12-06 |
mouse |
| Huaizhi Sun, Xinran Gao, Jiachun Niu, Pengquan Chen, Shuai He, Songlin Xu, Jinfang G. AD-like neuropsychiatric dysfunction in a mice model induced by a combination of high-fat diet and intraperitoneal injection of streptozotocin. eNeuro. 2024-12-03. PMID:39626951. |
moreover, the model mice presented the increased level of app, p-tau, p-irs1, trem2, il-1β, il-6, tnf-α, ocln, zo-1 and clnds, the decreased level of p-akt, p-erk and trem1, as well as the neuron damage and the hyperactivation of astrocytes and microglia in the hippocampus as compared with control mice. |
2024-12-03 |
2024-12-06 |
mouse |
| Yiheng Zhao, Qian Guo, Jia Tian, Wei Liu, Xiaochuan Wan. TREM2 Bridges Microglia and Extracellular Microenvironment: Mechanistic Landscape and Therapeutical Prospects on Alzheimer's Disease. Ageing research reviews. 2024-11-28. PMID:39608728. |
trem2 bridges microglia and extracellular microenvironment: mechanistic landscape and therapeutical prospects on alzheimer's disease. |
2024-11-28 |
2024-12-01 |
Not clear |
| Yiheng Zhao, Qian Guo, Jia Tian, Wei Liu, Xiaochuan Wan. TREM2 Bridges Microglia and Extracellular Microenvironment: Mechanistic Landscape and Therapeutical Prospects on Alzheimer's Disease. Ageing research reviews. 2024-11-28. PMID:39608728. |
this review illustrates how trem2 modulates microglia to affect ad pathogenesis. |
2024-11-28 |
2024-12-01 |
Not clear |
| Lin Li, Nan Xu, Yulin He, Mingsui Tang, Binrui Yang, Jun Du, Liang Chen, Xiaowen Mao, Bing Song, Zhou Hua, Benqin Tang, Simon Ming-Yuen Le. Dehydroervatamine as a promising novel TREM2 agonist, attenuates neuroinflammation. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-11-28. PMID:39609160. |
trem2, a cell surface receptor expressed by microglia, is implicated in the modulation of neuroinflammatory responses. |
2024-11-28 |
2024-12-01 |
zebrafish |
| M Lin, J-X Yu, W-X Zhang, F-X Lao, H-C Huan. Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 11. issue 6. 2024-11-19. PMID:39559879. |
the triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane receptor that is mainly expressed by microglia in the central nervous system (cns). |
2024-11-19 |
2024-11-22 |
Not clear |
| M Lin, J-X Yu, W-X Zhang, F-X Lao, H-C Huan. Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 11. issue 6. 2024-11-19. PMID:39559879. |
trem2 plays an important role in the physiological function of microglia, and the dyshomeostasis of trem2 is related to the development of late-onset ad. |
2024-11-19 |
2024-11-22 |
Not clear |