| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
we employed gene editing and stem cell models to gain insight into the effects of the trem2 r47h/+ mutation on human-induced pluripotent stem cell-derived microglia. |
2023-11-16 |
2023-11-20 |
mouse |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
trem2 r47h/+ also caused impairments in microglial movement and the uptake of multiple substrates, as well as rendering microglia hyperresponsive to inflammatory stimuli. |
2023-11-16 |
2023-11-20 |
mouse |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
we developed an in vitro laser-induced injury model in neuron-microglia cocultures, finding an impaired injury response by trem2 r47h/+ microglia. |
2023-11-16 |
2023-11-20 |
mouse |
| Jay Penney, William T Ralvenius, Anjanet Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Ping-Chieh Pao, Hannah Woolf, Li-Huei Tsa. iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 2023-11-16. PMID:37969043. |
furthermore, mouse brains transplanted with trem2 r47h/+ microglia exhibited reduced synaptic density, with upregulation of multiple complement cascade components in trem2 r47h/+ microglia suggesting inappropriate synaptic pruning as one potential mechanism. |
2023-11-16 |
2023-11-20 |
mouse |
| Rui Zhong, Yingzheng Xu, Jesse W Williams, Ling L. Loss of TREM2 exacerbates parenchymal amyloid pathology but diminishes CAA in Tg-SwDI mice. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961542. |
trem2 is a surface receptor expressed on microglia and largely mediates microglial functions and immune homeostasis in the brain. |
2023-11-14 |
2023-11-20 |
mouse |
| Fardin Nabizade. sTREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology. Brain communications. vol 5. issue 6. 2023-11-09. PMID:37942087. |
triggering receptor expressed on myeloid cell 2 (trem2) plays a crucial role in the transition of microglia from a state of homeostasis to a state associated with the disease. |
2023-11-09 |
2023-11-20 |
human |
| Jingjing Shi, Xiaohong Wang, Chuanyi Kang, Jiacheng Liu, Caina Ma, Liying Yang, Jian Hu, Na Zha. TREM2 regulates BV2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders. Brain research. vol 1822. 2023-11-05. PMID:37923002. |
trem2 regulates bv2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders. |
2023-11-05 |
2023-11-08 |
Not clear |
| Jingjing Shi, Xiaohong Wang, Chuanyi Kang, Jiacheng Liu, Caina Ma, Liying Yang, Jian Hu, Na Zha. TREM2 regulates BV2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders. Brain research. vol 1822. 2023-11-05. PMID:37923002. |
trem2, an immune protein mainly expressed in microglia, is an important part of nerve cells involved in inflammatory response. |
2023-11-05 |
2023-11-08 |
Not clear |
| Jingjing Shi, Xiaohong Wang, Chuanyi Kang, Jiacheng Liu, Caina Ma, Liying Yang, Jian Hu, Na Zha. TREM2 regulates BV2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders. Brain research. vol 1822. 2023-11-05. PMID:37923002. |
therefore, this study investigated the role of trem2 in cort-induced bv2 cell damage and preliminarily analyzed the effects of trem2 on jak2/stat3 signaling pathway and microglia polarization. |
2023-11-05 |
2023-11-08 |
Not clear |
| Jingjing Shi, Xiaohong Wang, Chuanyi Kang, Jiacheng Liu, Caina Ma, Liying Yang, Jian Hu, Na Zha. TREM2 regulates BV2 microglia activation and influences corticosterone-induced neuroinflammation in depressive disorders. Brain research. vol 1822. 2023-11-05. PMID:37923002. |
trem2 can affect the release of inflammatory factors through the jak2/stat3 signaling pathway and regulate the m1/m2 phenotypic transformation of microglia. |
2023-11-05 |
2023-11-08 |
Not clear |
| Xin Zhang, Xue Chen, Ling Zhang, Yuqing Sun, Ying Liang, Huan Li, Yulin Zhan. Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia. Neurochemistry international. 2023-11-05. PMID:37926352. |
the triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane immune receptor that is primarily expressed by microglia in the central nervous system (cns). |
2023-11-05 |
2023-11-08 |
Not clear |
| Xin Zhang, Xue Chen, Ling Zhang, Yuqing Sun, Ying Liang, Huan Li, Yulin Zhan. Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia. Neurochemistry international. 2023-11-05. PMID:37926352. |
notably, trem2 directly regulates microglia inflammation through various signaling pathways. |
2023-11-05 |
2023-11-08 |
Not clear |
| Xin Zhang, Xue Chen, Ling Zhang, Yuqing Sun, Ying Liang, Huan Li, Yulin Zhan. Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia. Neurochemistry international. 2023-11-05. PMID:37926352. |
additionally, studies have suggested that trem2 mediates microglial phagocytosis, autophagy, metabolism, and microglia phenotypes, which may be involved in the modulation of neuroinflammation. |
2023-11-05 |
2023-11-08 |
Not clear |
| Xin Zhang, Xue Chen, Ling Zhang, Yuqing Sun, Ying Liang, Huan Li, Yulin Zhan. Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia. Neurochemistry international. 2023-11-05. PMID:37926352. |
in this review, we aim to discuss the critical role of trem2 in several microglia functions and the underlying molecular mechanism the modulatory which further mediate neuroinflammation, and elaborate. |
2023-11-05 |
2023-11-08 |
Not clear |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
triggering receptor expressed on myeloid cells 2 (trem2) confers strong neuroprotective effects in pd by regulating the phenotype of microglia. |
2023-11-02 |
2023-11-08 |
mouse |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
in an in vitro experiment, lentivirus was used to interfere with the expression of trem2 in bv2 microglia, and then lipopolysaccharide (lps) and adenopterin nucleoside triphosphate (atp) were used to stimulate inflammation to construct a cellular inflammation model. |
2023-11-02 |
2023-11-08 |
mouse |
| Peiting Huang, Zhanyu Zhang, Piao Zhang, Jiezhu Feng, Jianwei Xie, Yinjuan Zheng, Xiaomei Liang, Baoyu Zhu, Zhenzhen Chen, Shujun Feng, Lijuan Wang, Jiahong Lu, Yawei Liu, Yuhu Zhan. TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells. Molecular neurobiology. 2023-11-02. PMID:37917301. |
after trem2 knockdown, the number of activated microglia was significantly increased, and the expression of cleaved caspase-1, nlrp3 inflammasome, il-1β, gsdmd, and gsdmd-n was increased. |
2023-11-02 |
2023-11-08 |
mouse |
| Xingyu Zhang, Li Tang, Jiaolong Yang, Lanxia Meng, Jiehui Chen, Lingyan Zhou, Jiangyu Wang, Min Xiong, Zhentao Zhan. Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-10-21. PMID:37865646. |
triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane protein that is predominantly expressed by microglia in the brain. |
2023-10-21 |
2023-11-08 |
mouse |
| Neriman Eren, Susanna Gerike, Berk Üsekes, Oliver Peters, Nicoleta-Carmen Cosma, Julian Hellmann-Rege. Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer's patients. Immunity & ageing : I & A. vol 20. issue 1. 2023-10-14. PMID:37833781. |
monocyte-derived macrophages (mo-mФs) infiltrating the brain alongside microglia are postulated to play a modulatory role in load and both express triggering receptor expressed on myeloid cells 2 (trem2). |
2023-10-14 |
2023-10-15 |
Not clear |
| Xiao-Wei Pang, Yun-Hui Chu, Luo-Qi Zhou, Man Chen, Yun-Fan You, Yue Tang, Sheng Yang, Hang Zhang, Jun Xiao, Gang Deng, Wei Wang, Ke Shang, Chuan Qin, Dai-Shi Tia. Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion. Journal of neurochemistry. 2023-10-12. PMID:37823326. |
triggering receptor expressed on myeloid cells 2 (trem2), which is expressed exclusively on microglia in the central nervous system (cns), plays an essential role in microglial response in various cns disorders. |
2023-10-12 |
2023-10-15 |
mouse |