| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Wei Pang, Yun-Hui Chu, Luo-Qi Zhou, Man Chen, Yun-Fan You, Yue Tang, Sheng Yang, Hang Zhang, Jun Xiao, Gang Deng, Wei Wang, Ke Shang, Chuan Qin, Dai-Shi Tia. Trem2 deficiency attenuates microglial phagocytosis and autophagic-lysosomal activation in white matter hypoperfusion. Journal of neurochemistry. 2023-10-12. PMID:37823326. |
furthermore, trem2 knockout inhibited lipid droplet accumulation in microglia in vitro. |
2023-10-12 |
2023-10-15 |
mouse |
| Ernest K J Pauwels, Gerard J Boe. Friends and Foes in Alzheimer's Disease. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2023-10-03. PMID:37788649. |
apart from the function of astrocytes and microglia, molecular entities such as trem2, syk, c22 and c33 play a role in the physiopathology of ad. |
2023-10-03 |
2023-10-07 |
Not clear |
| Qin Fan, Yue-Zhang Wu, Xiao-Xi Jia, Ruhan A, Chu-Mou Liu, Wei-Wei Zhang, Zhi-Yue Chao, Dong-Hua Zhou, Yuan Wang, Jia Chen, Kang Xiao, Cao Chen, Qi Shi, Xiao-Ping Don. Increased Gal-3 Mediates Microglia Activation and Neuroinflammation via the TREM2 Signaling Pathway in Prion Infection. ACS chemical neuroscience. 2023-09-28. PMID:37769016. |
increased gal-3 mediates microglia activation and neuroinflammation via the trem2 signaling pathway in prion infection. |
2023-09-28 |
2023-10-07 |
Not clear |
| Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Ha. Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-09-02. PMID:37658943. |
finally, a series of molecular biological experiments including knock-down of triggering receptor expressed on myeloid cells 2 (trem2) and analysis of the level of apolipoprotein e (apoe) expression were performed to investigate the underlying mechanism of involvement of ccm-activated oecs in modulating microglia polarization, leading to neural regeneration and function recovery. |
2023-09-02 |
2023-09-07 |
rat |
| Chao Jiang, Zhe Chen, Xiaohui Wang, Yongyuan Zhang, Xinyu Guo, Hong Fan, Dageng Huang, Yuqing He, Xiangwen Tang, Yixiang Ai, Youjun Liu, Hao Yang, Dingjun Ha. Curcumin-activated Olfactory Ensheathing Cells Improve Functional Recovery After Spinal Cord Injury by Modulating Microglia Polarization Through APOE/TREM2/NF-κB Signaling Pathway. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2023-09-02. PMID:37658943. |
in addition, microglial polarization to m2 elicited by aoecs-cm in lps-induced microglia was effectively reversed when trem2 expression was downregulated. |
2023-09-02 |
2023-09-07 |
rat |
| Xuezhen Chen, Yue Zhao, Yimin Huang, Kaichuan Zhu, Fan Zeng, Junyi Zhao, Huaqiu Zhang, Xinzhou Zhu, Helmut Kettenmann, Xianyuan Xian. TREM2 promotes glioma progression and angiogenesis mediated by microglia/brain macrophages. Glia. 2023-08-29. PMID:37641212. |
triggering receptor expressed on myeloid cell 2 (trem2), a myeloid cell-specific signaling molecule, controls essential functions of microglia and impacts on the pathogenesis of alzheimer's disease and other neurodegenerative disorders. |
2023-08-29 |
2023-09-07 |
Not clear |
| Fabrizio Biundo, Violeta Chitu, Şölen Gökhan, Edward Chen, Jude Oppong-Asare, E Richard Stanle. Trem2 Enhances Demyelination in the Biomedicines. vol 11. issue 8. 2023-08-26. PMID:37626591. |
triggering receptor expressed on myeloid cells-2 (trem2) is a microglial receptor that promotes the activation of microglia and phagocytic clearance of apoptotic neurons and myelin debris. |
2023-08-26 |
2023-09-07 |
Not clear |
| Stefanie Fruhwürth, Line S Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R Paluda. TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain. Science advances. vol 9. issue 33. 2023-08-21. PMID:37595041. |
trem2 is down-regulated by hsv1 in microglia and involved in antiviral defense in the brain. |
2023-08-21 |
2023-09-07 |
human |
| Stefanie Fruhwürth, Line S Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R Paluda. TREM2 is down-regulated by HSV1 in microglia and involved in antiviral defense in the brain. Science advances. vol 9. issue 33. 2023-08-21. PMID:37595041. |
here, we report that herpes simplex virus type 1 (hsv1) infection of human induced pluripotent stem cell (hipsc)-derived microglia down-regulates expression of genes in the trem2 pathway. |
2023-08-21 |
2023-09-07 |
human |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. Correction: APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. 2023-08-17. PMID:37589745. |
correction: apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2023-08-17 |
2023-09-07 |
Not clear |
| Javier Rueda-Carrasco, Dimitra Sokolova, Sang-Eun Lee, Thomas Childs, Natália Jurčáková, Gerard Crowley, Sebastiaan De Schepper, Judy Z Ge, Joanne I Lachica, Christina E Toomey, Oliver J Freeman, John Hardy, Samuel J Barnes, Tammaryn Lashley, Beth Stevens, Sunghoe Chang, Soyon Hon. Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models. The EMBO journal. 2023-08-14. PMID:37575021. |
these apoptotic-like spines are targeted by microglia for engulfment via trem2 leading to amelioration of aβ oligomer-induced synaptic hyperactivity. |
2023-08-14 |
2023-08-16 |
mouse |
| Bartolo Tamburini, Giusto Davide Badami, Marco Pio La Manna, Mojtaba Shekarkar Azgomi, Nadia Caccamo, Francesco Diel. Emerging Roles of Cells and Molecules of Innate Immunity in Alzheimer's Disease. International journal of molecular sciences. vol 24. issue 15. 2023-08-12. PMID:37569296. |
in this review, we focus on the role of cells (microglia, astrocytes, and oligodendrocytes) and molecules (trem2, tau, and β-amyloid) of the innate immune system in the pathogenesis of alzheimer's disease and their possible exploitation as disease biomarkers and targets of therapeutical approaches. |
2023-08-12 |
2023-08-16 |
Not clear |
| Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Werni. A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell stem cell. vol 30. issue 8. 2023-08-04. PMID:37541210. |
for example, loss of function of the microglial gene trem2 renders microglia dysfunctional and causes an early-onset neurodegenerative syndrome, and trem2 variants are among the strongest genetic risk factors for ad. |
2023-08-04 |
2023-08-14 |
mouse |
| Yongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Werni. A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease. Cell stem cell. vol 30. issue 8. 2023-08-04. PMID:37541210. |
here, we show that systemic hematopoietic cell transplantation followed by enhancement of microglia replacement restores microglial function in a trem2 mutant mouse model of ad. |
2023-08-04 |
2023-08-14 |
mouse |
| Yung Ning Chu, Aika Akahori, Sho Takatori, Taisuke Tomit. Pathological Roles of INPP5D in Alzheimer's Disease. Advances in experimental medicine and biology. vol 1423. 2023-07-31. PMID:37525057. |
the discovery of the genetic association between triggering receptor expressed on myeloid cells 2 (trem2) with increased ad risk points to a causal link between microglia and ad pathogenesis, and revealed a crucial role of trem2-dependent clustering of microglia around amyloid plaques that prevents aβ toxicity to facilitate tau deposition near the plaques. |
2023-07-31 |
2023-08-14 |
mouse |
| Yung Ning Chu, Aika Akahori, Sho Takatori, Taisuke Tomit. Pathological Roles of INPP5D in Alzheimer's Disease. Advances in experimental medicine and biology. vol 1423. 2023-07-31. PMID:37525057. |
inpp5d seems to exert its function by acting antagonistically at downstream of the trem2 signaling pathway, suggesting that it is a novel regulator of the protective barrier by microglia. |
2023-07-31 |
2023-08-14 |
mouse |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
trem2: potential therapeutic targeting of microglia for alzheimer's disease. |
2023-07-30 |
2023-08-14 |
Not clear |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
current studies show that triggering receptor expressed on myeloid cells 2 (trem2) is predominantly expressed in microglia of the central nervous system (cns) and is involved in microglia proliferation, survival, migration and phagocytosis. |
2023-07-30 |
2023-08-14 |
Not clear |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
specifically, trem2 acts by regulating the function of microglia and promoting the clearance of neuronal toxic substances and abnormal proteins by microglia. |
2023-07-30 |
2023-08-14 |
Not clear |
| Yueran Li, Huifang Xu, Huifang Wang, Kui Yang, Jiajie Luan, Sheng Wan. TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 165. 2023-07-30. PMID:37517293. |
in addition, trem2 is also involved in regulating inflammatory response and cell signaling pathways, affecting the immune response and regulatory role of microglia. |
2023-07-30 |
2023-08-14 |
Not clear |