| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guoyu Lan, Xuhui Chen, Jie Yang, Pan Sun, Yue Cai, Anqi Li, Yalin Zhu, Zhen Liu, Shaohua Ma, Tengfei Gu. Microglial Reactivity Correlates with Presynaptic Loss Independent of β-Amyloid and Tau. Annals of neurology. 2024-02-15. PMID:38356322. |
triggering receptor expressed on myeloid cells-2 (trem2) and progranulin (pgrn) are critical regulators of microglia activation and can be detected in cerebrospinal fluid (csf). |
2024-02-15 |
2024-02-17 |
Not clear |
| Tao Yin, Metin Yesiltepe, Luciano D'Adami. Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias. EMBO reports. 2024-02-12. PMID:38347225. |
we observe heightened itm2b/bri2 expression in microglia, a pivotal cell type in ad due to risk-increasing variants in the microglial gene trem2. |
2024-02-12 |
2024-02-15 |
mouse |
| Tao Yin, Metin Yesiltepe, Luciano D'Adami. Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias. EMBO reports. 2024-02-12. PMID:38347225. |
constitutive and microglial-specific itm2b-knock-out mice, and itm2b-knock-out primary microglia provide evidence that bri2 reduces trem2 processing, boosts trem2 mrna expression, and influences trem2 protein levels through α-secretase-independent pathways, revealing a multifaceted bri2-trem2 functional interaction. |
2024-02-12 |
2024-02-15 |
mouse |
| Lin Li, Yu-Lin He, Nan Xu, Xiu-Fen Wang, Bing Song, Ben-Qin Tang, Simon Ming-Yuen Le. A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Redox biology. vol 70. 2024-02-07. PMID:38325196. |
the triggering receptor expressed on myeloid cells 2 (trem2), highly expressed by microglia in the central nervous system (cns), can modulate neuroinflammatory responses. |
2024-02-07 |
2024-02-10 |
zebrafish |
| Lin Li, Yu-Lin He, Nan Xu, Xiu-Fen Wang, Bing Song, Ben-Qin Tang, Simon Ming-Yuen Le. A natural small molecule aspidosperma-type alkaloid, hecubine, as a new TREM2 activator for alleviating lipopolysaccharide-induced neuroinflammation in vitro and in vivo. Redox biology. vol 70. 2024-02-07. PMID:38325196. |
knockdown of trem2 mrna expression significantly abolished the anti-inflammatory and antioxidant effects of hecubine on lps-stimulated proinflammatory mediators (no, tnf-α, il-6, and il-1β) and oxidative stress in microglia cells. |
2024-02-07 |
2024-02-10 |
zebrafish |
| Chen Yu, Eleonora M Lad, Rose Mathew, Nobuhiko Shiraki, Sejiro Littleton, Yun Chen, Jinchao Hou, Kai Schlepckow, Simone Degan, Lindsey Chew, Joshua Amason, Joan Kalnitsky, Catherine Bowes Rickman, Alan D Proia, Marco Colonna, Christian Haass, Daniel R Saba. Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. The Journal of experimental medicine. vol 221. issue 3. 2024-01-30. PMID:38289348. |
microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and trem2. |
2024-01-30 |
2024-02-01 |
mouse |
| André F Batista, Khyrul A Khan, Maria-Tzousi Papavergi, Cynthia A Lemer. The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255891. |
in this review, we provide an overview of previously known and newly established roles for the complement cascade in the cns and we explore how complement interactions with microglia, astrocytes, and other risk factors such as trem2 and apoe4 modulate the processes of neurodegeneration in both amyloid and tau models of ad. |
2024-01-23 |
2024-01-25 |
Not clear |
| Dale B Bosco, Vaclav Kremen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A Ebner, Jiaying Zheng, Aastha Dheer, Jadyn F Perry, Manling Xie, Aivi T Nguyen, Gregory A Worrell, Long-Jun W. Impaired microglial phagocytosis promotes seizure development. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260601. |
in the central nervous system, triggering receptor expressed on myeloid cells 2 (trem2) is exclusively expressed by microglia and is critical for microglial proliferation, migration, and phagocytosis. |
2024-01-23 |
2024-01-25 |
mouse |
| Nicholas R W Cleland, Garrett J Potter, Courtney Buck, Daphne Quang, Dean Oldham, Mikaela Neal, Anthony Saviola, Christy S Niemeyer, Evgenia Dobrinskikh, Kimberley D Bruc. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain research. 2024-01-20. PMID:38244754. |
transcriptomic analysis revealed increased expression of disease-associated microglia (dam) genes (e.g., apoe, trem2, lpl), and genes involved in glycolysis and oxidative metabolism in microglia from aged females compared to males. |
2024-01-20 |
2024-01-23 |
mouse |
| Jian Shi, Shiwei Huan. Comparative Insight into Microglia/Macrophages-Associated Pathways in Glioblastoma and Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203185. |
the review culminates with a discussion on how insights into nf-κb, mirnas, and trem2 signaling may inform novel therapeutic approaches targeting microglia and macrophages in these neurodegenerative and neoplastic conditions. |
2024-01-11 |
2024-01-13 |
Not clear |
| Xiao-Fen Chen, Guojun B. TREMendous microglial effects on neurons. Immunity. vol 57. issue 1. 2024-01-10. PMID:38198847. |
trem2 is exclusively expressed by microglia in the brain and is strongly associated with alzheimer's disease risk. |
2024-01-10 |
2024-01-13 |
Not clear |
| Guangtong Liu, Linlin Zhang, Yongzhao Fan, Wenliang J. The Pathogenesis in Alzheimer's Disease: TREM2 as a Potential Target. Journal of integrative neuroscience. vol 22. issue 6. 2024-01-04. PMID:38176932. |
trem2 interacts with adaptor protein dap12 to initiate signal pathways that mainly dominant microglia phenotype and phagocytosis mobility. |
2024-01-04 |
2024-01-07 |
Not clear |
| Erica Tagliatti, Genni Desiato, Sara Mancinelli, Matteo Bizzotto, Maria C Gagliani, Elisa Faggiani, Rebeca Hernández-Soto, Andrea Cugurra, Paola Poliseno, Matteo Miotto, Rafael J Argüello, Fabia Filipello, Katia Cortese, Raffaella Morini, Simona Lodato, Michela Matteol. Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development. Immunity. 2023-12-30. PMID:38159572. |
trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development. |
2023-12-30 |
2024-01-05 |
Not clear |
| Erica Tagliatti, Genni Desiato, Sara Mancinelli, Matteo Bizzotto, Maria C Gagliani, Elisa Faggiani, Rebeca Hernández-Soto, Andrea Cugurra, Paola Poliseno, Matteo Miotto, Rafael J Argüello, Fabia Filipello, Katia Cortese, Raffaella Morini, Simona Lodato, Michela Matteol. Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development. Immunity. 2023-12-30. PMID:38159572. |
triggering receptor expressed on myeloid cells 2 (trem2) is a myeloid cell-specific gene expressed in brain microglia, with variants that are associated with neurodegenerative diseases, including alzheimer's disease. |
2023-12-30 |
2024-01-05 |
Not clear |
| Sheng Yang, Chuan Qin, Man Chen, Yun-Hui Chu, Yue Tang, Luo-Qi Zhou, Hang Zhang, Ming-Hao Dong, Xiao-Wei Pang, Lian Chen, Long-Jun Wu, Dai-Shi Tian, Wei Wan. TREM2-IGF1 Mediated Glucometabolic Enhancement Underlies Microglial Neuroprotective Properties During Ischemic Stroke. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023-12-27. PMID:38151703. |
microglial depletion by plx3397 exacerbates ischemic brain damage, which is reversed by repopulating the microglia with high igf1 and trem2 phenotype. |
2023-12-27 |
2023-12-30 |
Not clear |
| Jian Meng, Linkun Han, Hui Xu, Lingliang Zhang, Zhaoji Liu, Yunqiang Zhou, Xian Zhang, Hong Luo, Yun-Wu Zhan. TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. International immunopharmacology. vol 127. 2023-12-26. PMID:38147777. |
microglia are brain-resident innate immune cells and execute inflammatory and phagocytic functions upon environmental stimulation, during which processes triggering receptor expressed on myeloid cells 2 (trem2) plays an important regulatory role. |
2023-12-26 |
2023-12-29 |
mouse |
| Jian Meng, Linkun Han, Hui Xu, Lingliang Zhang, Zhaoji Liu, Yunqiang Zhou, Xian Zhang, Hong Luo, Yun-Wu Zhan. TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. International immunopharmacology. vol 127. 2023-12-26. PMID:38147777. |
however, although microglia are known to exhibit innate immune memory related to inflammation when subjected to continuous inflammatory stimuli, whether microglia exhibit innate immune memory related to phagocytosis and whether trem2 participates in innate immune memory of microglia remain unknown. |
2023-12-26 |
2023-12-29 |
mouse |
| Jian Meng, Linkun Han, Hui Xu, Lingliang Zhang, Zhaoji Liu, Yunqiang Zhou, Xian Zhang, Hong Luo, Yun-Wu Zhan. TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. International immunopharmacology. vol 127. 2023-12-26. PMID:38147777. |
while 4xlps had no effect on reducing synapse phagocytosis in trem2 ko microglia. |
2023-12-26 |
2023-12-29 |
mouse |
| Jian Meng, Linkun Han, Hui Xu, Lingliang Zhang, Zhaoji Liu, Yunqiang Zhou, Xian Zhang, Hong Luo, Yun-Wu Zhan. TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance. International immunopharmacology. vol 127. 2023-12-26. PMID:38147777. |
our results demonstrate that microglia also exhibit immune tolerance related to phagocytosis of synapses and that trem2 plays a crucial role in this process possibly through regulating complement system and phagosome-related gene expressions. |
2023-12-26 |
2023-12-29 |
mouse |
| Sanjay, Jae-Ho Shin, Miey Park, Hae-Jeung Le. Correction to: Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model. Molecular neurobiology. 2023-12-22. PMID:38129702. |
correction to: cyanidin-3-o-glucoside regulates the m1/m2 polarization of microglia via pparγ and aβ42 phagocytosis through trem2 in an alzheimer's disease model. |
2023-12-22 |
2023-12-24 |
Not clear |