| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sijia Yin, Xiaosa Chi, Fang Wan, Yunna Li, Qiulu Zhou, Liang Kou, Yadi Sun, Jiawei Wu, Wenkai Zou, Yiming Wang, Zongjie Jin, Jinsha Huang, Nian Xiong, Yun Xia, Tao Wan. TREM2 signaling in Parkinson's disease: Regulation of microglial function and α-synuclein pathology. International immunopharmacology. vol 143. issue Pt 2. 2024-11-03. PMID:39490141. |
triggering receptor expressed on myeloid cells 2 (trem2) regulates multiple functions of microglia in the brain, and several studies have shown that trem2 variant r47h is a risk factor for pd. |
2024-11-03 |
2024-11-06 |
Not clear |
| Sijia Yin, Xiaosa Chi, Fang Wan, Yunna Li, Qiulu Zhou, Liang Kou, Yadi Sun, Jiawei Wu, Wenkai Zou, Yiming Wang, Zongjie Jin, Jinsha Huang, Nian Xiong, Yun Xia, Tao Wan. TREM2 signaling in Parkinson's disease: Regulation of microglial function and α-synuclein pathology. International immunopharmacology. vol 143. issue Pt 2. 2024-11-03. PMID:39490141. |
however, the regulation of microglia by trem2 in pd remains poorly understood. |
2024-11-03 |
2024-11-06 |
Not clear |
| Haley A Vecchiarelli, Kanchan Bisht, Kaushik Sharma, Sammy Weiser Novak, Marianela E Traetta, Monica Emili Garcia-Segura, Marie-Kim St-Pierre, Julie C Savage, Cory Willis, Katherine Picard, Maude Bordeleau, Nathalie Vernoux, Mohammadparsa Khakpour, Rishika Garg, Sophia M Loewen, Colin J Murray, Yelena Y Grinberg, Joel Faustino, Torin Halvorson, Victor Lau, Stefano Pluchino, Zinaida S Vexler, Monica J Carson, Uri Manor, Luca Peruzzotti-Jametti, Marie-Ève Trembla. Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2. bioRxiv : the preprint server for biology. 2024-10-28. PMID:39463930. |
dark microglia are abundant in normal postnatal development, where they remodel synapses via phagocytosis and trogocytosis, and are dependent on trem2. |
2024-10-28 |
2024-10-30 |
mouse |
| Haley A Vecchiarelli, Kanchan Bisht, Kaushik Sharma, Sammy Weiser Novak, Marianela E Traetta, Monica Emili Garcia-Segura, Marie-Kim St-Pierre, Julie C Savage, Cory Willis, Katherine Picard, Maude Bordeleau, Nathalie Vernoux, Mohammadparsa Khakpour, Rishika Garg, Sophia M Loewen, Colin J Murray, Yelena Y Grinberg, Joel Faustino, Torin Halvorson, Victor Lau, Stefano Pluchino, Zinaida S Vexler, Monica J Carson, Uri Manor, Luca Peruzzotti-Jametti, Marie-Ève Trembla. Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2. bioRxiv : the preprint server for biology. 2024-10-28. PMID:39463930. |
furthermore, we found that dark microglia in development notably expressed c-type lectin domain family 7 member a (clec7a), lipoprotein lipase (lpl) and triggering receptor expressed on myeloid cells 2 (trem2) and required trem2, differently from other microglia, suggesting a link between their role in remodeling during development and central nervous system pathology. |
2024-10-28 |
2024-10-30 |
mouse |
| Sucheta Sridhar, Yingyue Zhou, Adiljan Ibrahim, Sergio Bertazzo, Tania Wyss, Amanda Swain, Upasana Maheshwari, Sheng-Fu Huang, Marco Colonna, Annika Kelle. Targeting TREM2 signaling shows limited impact on cerebrovascular calcification. Life science alliance. vol 8. issue 1. 2024-10-28. PMID:39467636. |
we previously showed that microglia curtail the growth of small vessel calcification via the triggering receptor expressed in myeloid 2 (trem2) in the |
2024-10-28 |
2024-10-31 |
Not clear |
| Hua Long, Adam Simmons, Arthur Mayorga, Brady Burgess, Tuan Nguyen, Balasubrahmanyam Budda, Anna Rychkova, Herve Rhinn, Ilaria Tassi, Michael Ward, Felix Yeh, Tina Schwabe, Robert Paul, Sara Kenkare-Mitra, Arnon Rosentha. Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer's disease. Alzheimer's research & therapy. vol 16. issue 1. 2024-10-24. PMID:39444037. |
signaling by trem2, an innate immune receptor expressed by microglia, is thought to enhance phagocytosis of amyloid beta (aβ) and other damaged proteins, promote microglial proliferation, migration, and survival, and regulate inflammatory signaling. |
2024-10-24 |
2024-10-26 |
mouse |
| Monireh Shojaei, Rebecca Schaefer, Kai Schlepckow, Lea H Kunze, Felix L Struebing, Bettina Brunner, Michael Willem, Laura M Bartos, Astrid Feiten, Giovanna Palumbo, Thomas Arzberger, Peter Bartenstein, Gian Carlo Parico, Dan Xia, Kathryn M Monroe, Christian Haass, Matthias Brendel, Simon Lindne. PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies. Theranostics. vol 14. issue 16. 2024-10-21. PMID:39431020. |
pet imaging of microglia in alzheimer's disease using copper-64 labeled trem2 antibodies. |
2024-10-21 |
2024-10-23 |
Not clear |
| Monireh Shojaei, Rebecca Schaefer, Kai Schlepckow, Lea H Kunze, Felix L Struebing, Bettina Brunner, Michael Willem, Laura M Bartos, Astrid Feiten, Giovanna Palumbo, Thomas Arzberger, Peter Bartenstein, Gian Carlo Parico, Dan Xia, Kathryn M Monroe, Christian Haass, Matthias Brendel, Simon Lindne. PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies. Theranostics. vol 14. issue 16. 2024-10-21. PMID:39431020. |
triggering receptor expressed on myeloid cells 2 (trem2) plays an essential role in microglia activation and is being investigated as a potential therapeutic target for modulation of microglia in several neurological diseases. |
2024-10-21 |
2024-10-23 |
Not clear |
| Verena Haage, John F Tuddenham, Alex Bautista, Charles C White, Frankie Garcia, Ronak Patel, Natacha Comandante-Lou, Victoria Marshe, Rajesh Kumar Soni, Peter A Sims, Vilas Menon, Andrew A Sproul, Philip L De Jage. HDAC Inhibitors recapitulate Human Disease-Associated Microglia Signatures bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416157. |
hdac inhibitors recapitulate human disease-associated microglia signatures disease-associated microglia (dam), initially described in mouse models of neurodegenerative diseases, have been classified into two related states; starting from a trem2-independent dam1 state to a trem2 dependent state termed dam2, with each state being characterized by the expression of specific marker genes |
2024-10-17 |
2024-10-19 |
mouse |
| Dale B Bosco, Vaclav Kremen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A Ebner, Jiaying Zheng, Manling Xie, Aastha Dheer, Jadyn F Perry, Abhijeet Barath, Aivi T Nguyen, Gregory A Worrell, Long-Jun W. Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus. Brain, behavior, and immunity. 2024-10-01. PMID:39353548. |
in the central nervous system, triggering receptor expressed on myeloid cells 2 (trem2) is exclusively expressed by microglia and is critical for microglial proliferation, migration, and phagocytosis. |
2024-10-01 |
2024-10-05 |
mouse |
| Dale B Bosco, Vaclav Kremen, Koichiro Haruwaka, Shunyi Zhao, Lingxiao Wang, Blake A Ebner, Jiaying Zheng, Manling Xie, Aastha Dheer, Jadyn F Perry, Abhijeet Barath, Aivi T Nguyen, Gregory A Worrell, Long-Jun W. Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus. Brain, behavior, and immunity. 2024-10-01. PMID:39353548. |
phagocytic clearance of damaged neurons by microglia was also impaired by trem2 ko and reduced phagocytic activity correlated with increased spontaneous seizures. |
2024-10-01 |
2024-10-05 |
mouse |
| Jessica Greven, Joshua Wydra, Rory Greer, Cynthia Zhi, Christopher Camitta, Yuhua Song, Jennifer Alexander-Brett, Thomas John Bret. Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands. Research square. 2024-09-24. PMID:39315272. |
trem2 is a signaling receptor expressed on microglia that has emerged as an important drug target for alzheimer's disease and other neurodegenerative diseases. |
2024-09-24 |
2024-09-26 |
Not clear |
| Wireko Andrew Awuah, Adam Ben-Jaafar, Jonathan Sing Huk Kong, Vivek Sankar, Muhammad Hamza Shah, Jeisun Poornaselvan, Mabel Frimpong, Shahzeb Imran, Tony Alocious, Toufik Abdul-Rahman, Oday Atalla. Novel insights into the role of TREM2 in cerebrovascular diseases. Brain research. 2024-09-21. PMID:39305972. |
recently, research has focused on triggering receptor expressed on myeloid cells 2 (trem2), an immune receptor predominantly found on microglia. |
2024-09-21 |
2024-09-24 |
Not clear |
| Tyler J McCray, Logan M Bedford, Stephanie J Bissel, Bruce T Lam. Trem2-deficiency aggravates and accelerates age-related myelin degeneration. Acta neuropathologica communications. vol 12. issue 1. 2024-09-20. PMID:39300502. |
microglia participate in modulating white matter events from demyelination to remyelination, including regulation of (de)myelination by the microglial innate immune receptor triggering receptor expressed on myeloid cells 2 (trem2). |
2024-09-20 |
2024-09-22 |
Not clear |
| Maria L Serradas, Yingying Ding, Paula V Martorell, Ida Kulińska, Sergio Castro-Gome. Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease. Cells. vol 13. issue 17. 2024-09-14. PMID:39272998. |
here, we summarize the role of neuroinflammation in the pathogenesis and progression of ad and discuss potential targets such as microglia, trem2, the complement system, inflammasomes, and cytosolic dna sensors. |
2024-09-14 |
2024-09-16 |
Not clear |
| Junyi Liang, Aditya Menon, Taylor Tomco, Nisha Bhattarai, Iris Nira Smith, Maria Khrestian, Shane V Formica, Charis Eng, Matthias Buck, Lynn M Bekri. A Computational Approach in the Systematic Search of the Interaction Partners of Alternatively Spliced TREM2 Isoforms. International journal of molecular sciences. vol 25. issue 17. 2024-09-14. PMID:39273614. |
triggering receptor expressed on myeloid cells 2 (trem2) is increasingly recognized as playing a central role in aβ clearance and microglia activation in ad. |
2024-09-14 |
2024-09-16 |
Not clear |
| Ilayda Ozsan McMillan, Li Liang, Guowei Su, Xuehong Song, Kelly Drago, Hua Yang, Claudia Alvarez, Amika Sood, James Gibson, Robert J Woods, Chunyu Wang, Jian Liu, Fuming Zhang, Tom J Brett, Lianchun Wan. TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid. The Journal of biological chemistry. 2024-08-19. PMID:39159814. |
trem2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-o-sulfation and iduronic acid. |
2024-08-19 |
2024-08-22 |
Not clear |
| Ilayda Ozsan McMillan, Li Liang, Guowei Su, Xuehong Song, Kelly Drago, Hua Yang, Claudia Alvarez, Amika Sood, James Gibson, Robert J Woods, Chunyu Wang, Jian Liu, Fuming Zhang, Tom J Brett, Lianchun Wan. TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid. The Journal of biological chemistry. 2024-08-19. PMID:39159814. |
we confirm trem2's binding to cell surface hs and demonstrate that trem2 interacts with hs, forming hs-trem2 binary complexes on microglia cell surfaces. |
2024-08-19 |
2024-08-22 |
Not clear |
| Ilayda Ozsan McMillan, Li Liang, Guowei Su, Xuehong Song, Kelly Drago, Hua Yang, Claudia Alvarez, Amika Sood, James Gibson, Robert J Woods, Chunyu Wang, Jian Liu, Fuming Zhang, Tom J Brett, Lianchun Wan. TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid. The Journal of biological chemistry. 2024-08-19. PMID:39159814. |
by delineating the interaction between hs and trem2 on the microglial cell surface and demonstrating its role in facilitating trem2-mediated apoe uptake by microglia, our findings provide valuable insights that can inform targeted interventions for modulating microglial functions in alzheimer's disease. |
2024-08-19 |
2024-08-22 |
Not clear |
| Jie Zou, Yaxuan Wang, Xinyue Zhang, Xue Pan, Te Fang, Dasheng Cai, Lili Guo, Yu Li, Yi He, Xuezhao Ca. CD33 Ameliorates Surgery-Induced Spatial Learning and Memory Impairments Through TREM2. Molecular neurobiology. 2024-08-01. PMID:39088031. |
the regulation of cd33 and trem2 expression was achieved through sirna in the bv2 microglia cell line. |
2024-08-01 |
2024-08-03 |
mouse |