| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoqian Peng, Hongsong Guo, Xiao Zhang, Zikang Yang, John Bosco Ruganzu, Zhuoyuan Yang, Xiangyuan Wu, Wei Bi, Shengfeng Ji, Weina Yan. TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro. Molecular neurobiology. 2023-01-20. PMID:36662361. |
triggering receptor expressed on myeloid cells-2 (trem2), a cell surface receptor mainly expressed on microglia, has been shown to play a critical role in alzheimer's disease (ad) pathogenesis and progression. |
2023-01-20 |
2023-08-14 |
mouse |
| Yingyue Zhou, Mari Tada, Zhangying Cai, Prabhakar S Andhey, Amanda Swain, Kelly R Miller, Susan Gilfillan, Maxim N Artyomov, Masaki Takao, Akiyoshi Kakita, Marco Colonn. Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia. Nature immunology. 2023-01-19. PMID:36658241. |
heterozygous hypofunctional trem2 variants impair microglia, accelerating late-onset alzheimer's disease. |
2023-01-19 |
2023-08-14 |
mouse |
| Gunel Ayyubov. TREM2-signaling as a multifaceted player in brain homeostasis and a potential target for Alzheimer's Disease treatment. The European journal of neuroscience. 2023-01-13. PMID:36637116. |
trem2 also ameliorates the pathological effects of activated microglia on neuronal tau pathology, demonstrating its protective anti-inflammatory effects. |
2023-01-13 |
2023-08-14 |
mouse |
| Gunel Ayyubov. TREM2-signaling as a multifaceted player in brain homeostasis and a potential target for Alzheimer's Disease treatment. The European journal of neuroscience. 2023-01-13. PMID:36637116. |
however, since the excessive activation of trem2 signaling can inhibit pro-inflammatory reactions and suppress the role of microglia in immune surveillance, at the late stages of the disease it might promote immune tolerance, which is detrimental. |
2023-01-13 |
2023-08-14 |
mouse |
| Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea H Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monro. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience. 2023-01-12. PMID:36635496. |
in human induced pluripotent stem cell (ipsc)-derived microglia, atv:trem2 induced proliferation and improved mitochondrial metabolism. |
2023-01-12 |
2023-08-14 |
mouse |
| Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Joshua I Park, David Tatarakis, Meredith Calvert, Selina Hummel, Steve Lianoglou, Michelle E Pizzo, Rachel Prorok, Elliot Thomsen, Laura M Bartos, Philipp Beumers, Anja Capell, Sonnet S Davis, Lis de Weerd, Jason C Dugas, Joseph Duque, Timothy Earr, Kapil Gadkar, Tina Giese, Audrey Gill, Johannes Gnörich, Connie Ha, Malavika Kannuswamy, Do Jin Kim, Sebastian T Kunte, Lea H Kunze, Diana Lac, Kendra Lechtenberg, Amy Wing-Sze Leung, Chun-Chi Liang, Isabel Lopez, Paul McQuade, Anuja Modi, Vanessa O Torres, Hoang N Nguyen, Ida Pesämaa, Nicholas Propson, Marvin Reich, Yaneth Robles-Colmenares, Kai Schlepckow, Luna Slemann, Hilda Solanoy, Jung H Suh, Robert G Thorne, Chandler Vieira, Karin Wind-Mark, Ken Xiong, Y Joy Yu Zuchero, Dolo Diaz, Mark S Dennis, Fen Huang, Kimberly Scearce-Levie, Ryan J Watts, Christian Haass, Joseph W Lewcock, Gilbert Di Paolo, Matthias Brendel, Pascal E Sanchez, Kathryn M Monro. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature neuroscience. 2023-01-12. PMID:36635496. |
single-cell rna sequencing and morphometry revealed that atv:trem2 shifted microglia to metabolically responsive states, which were distinct from those induced by amyloid pathology. |
2023-01-12 |
2023-08-14 |
mouse |
| Yuanyuan Wang, Roxanne V Kyauk, Yun-An A Shen, Luke Xie, Mike Reichelt, Han Lin, Zhiyu Jiang, Hai Ngu, Kimberle Shen, Jacob J Greene, Morgan Sheng, Tracy J Yue. TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection. Glia. 2023-01-10. PMID:36625077. |
microglia, and specifically triggering receptor expressed on myeloid cells 2 (trem2), a factor highly expressed in microglia, have been shown to play an important role in remyelination. |
2023-01-10 |
2023-08-14 |
mouse |
| Yuanyuan Wang, Roxanne V Kyauk, Yun-An A Shen, Luke Xie, Mike Reichelt, Han Lin, Zhiyu Jiang, Hai Ngu, Kimberle Shen, Jacob J Greene, Morgan Sheng, Tracy J Yue. TREM2-dependent microglial function is essential for remyelination and subsequent neuroprotection. Glia. 2023-01-10. PMID:36625077. |
trem2 knockout microglia demonstrate defects in migration and phagocytosis of myelin debris. |
2023-01-10 |
2023-08-14 |
mouse |
| Suzanne A E van Wouw, Marlene van den Berg, Maroua El Ouraoui, Amber Meurs, Jenina Kingma, Roelof Ottenhoff, Melanie Loix, Marten A Hoeksema, Koen Prange, Gerard Pasterkamp, Jerome J A Hendriks, Jeroen F J Bogie, Jan B van Klinken, Frederic M Vaz, Aldo Jongejan, Menno P J de Winther, Noam Zelce. Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages. Journal of lipid research. 2023-01-02. PMID:36592658. |
we demonstrate that tmem86a is a direct transcriptional target of lxr in macrophages and microglia and that it is highly expressed in trem2 |
2023-01-02 |
2023-08-14 |
Not clear |
| Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonn. TREM2 dependent and independent functions of microglia in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-12-23. PMID:36564824. |
trem2 dependent and independent functions of microglia in alzheimer's disease. |
2022-12-23 |
2023-08-14 |
mouse |
| Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonn. TREM2 dependent and independent functions of microglia in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-12-23. PMID:36564824. |
given the heightened ad risk posed by rare variants of the microglial triggering receptor expressed on myeloid cells 2 (trem2), we will focus on the studies addressing the impact of this receptor on microglia responses to amyloid plaques, tauopathy and demyelination pathologies in mouse and human. |
2022-12-23 |
2023-08-14 |
mouse |
| Jinchao Hou, Yun Chen, Gary Grajales-Reyes, Marco Colonn. TREM2 dependent and independent functions of microglia in Alzheimer's disease. Molecular neurodegeneration. vol 17. issue 1. 2022-12-23. PMID:36564824. |
finally, we will discuss the implications of recent discoveries on microglia and trem2 biology on potential therapeutic strategies for ad. |
2022-12-23 |
2023-08-14 |
mouse |
| Peter Bor-Chian Lin, Andy Po-Yi Tsai, Disha Soni, Audrey Lee-Gosselin, Miguel Moutinho, Shweta S Puntambekar, Gary E Landreth, Bruce T Lamb, Adrian L Obla. INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2022-12-16. PMID:36524682. |
inpp5d negatively regulates signaling via several microglial cell surface receptors, including triggering receptor expressed on myeloid cells 2 (trem2); however, the impact of inpp5d inhibition on ad pathology remains unclear. |
2022-12-16 |
2023-08-14 |
mouse |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
triggering receptor on myeloid cells 2 (trem2) is an innate immune receptor, upregulated on the surface of microglia associated with amyloid plaques in alzheimer's disease (ad). |
2022-12-08 |
2023-08-14 |
mouse |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
we examined the effects of wild-type (wt), r47h and knock-out (ko) of human trem2 expression in three microglial cell systems. |
2022-12-08 |
2023-08-14 |
mouse |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
addition of mouse bv-2 microglia expressing r47h trem2 to primary mouse neuronal cultures caused neuronal loss, not observed with wt trem2. |
2022-12-08 |
2023-08-14 |
mouse |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
addition of human chme-3 microglia expressing r47h trem2 to luhmes neuronal-like cells also caused loss compared to wt trem2. |
2022-12-08 |
2023-08-14 |
mouse |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
expression of r47h trem2 in bv-2 and chme-3 microglia increased their uptake of phosphatidylserine-beads and synaptosomes versus wt trem2. |
2022-12-08 |
2023-08-14 |
mouse |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
human ipsc-derived microglia with heterozygous r47h trem2 had increased phagocytosis of synaptosomes vs common-variant trem2. |
2022-12-08 |
2023-08-14 |
mouse |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
additionally, phosphatidylserine liposomes increased activation of human ipsc-derived microglia expressing homozygous r47h trem2 versus common-variant trem2. |
2022-12-08 |
2023-08-14 |
mouse |