| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y Huan. Trem2 deletion enhances tau dispersion and pathology through microglia exosomes. Molecular neurodegeneration. vol 17. issue 1. 2022-09-02. PMID:36056435. |
trem2 deletion enhances tau dispersion and pathology through microglia exosomes. |
2022-09-02 |
2023-08-14 |
Not clear |
| Xue Han, Xiaolei Cheng, Jiyan Xu, Yujia Liu, Jiawen Zhou, Linhao Jiang, Xiaoping Gu, Tianjiao Xi. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology. 2022-08-30. PMID:36041498. |
we found that hippocampus-dependent learning and memory were impaired in pocd mice, which was accompanied by activation of microglia and downregulation of trem2. |
2022-08-30 |
2023-08-14 |
mouse |
| Xue Han, Xiaolei Cheng, Jiyan Xu, Yujia Liu, Jiawen Zhou, Linhao Jiang, Xiaoping Gu, Tianjiao Xi. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology. 2022-08-30. PMID:36041498. |
pretreatment with the trem2 agonist heat shock protein (hsp)60 inhibited surgery-induced microglia activation and alleviated postoperative cognitive impairment. |
2022-08-30 |
2023-08-14 |
mouse |
| Xue Han, Xiaolei Cheng, Jiyan Xu, Yujia Liu, Jiawen Zhou, Linhao Jiang, Xiaoping Gu, Tianjiao Xi. Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice. Neuropharmacology. 2022-08-30. PMID:36041498. |
these results demonstrate that trem2 is involved in the regulation of the inflammatory response mediated by microglia and cognitive impairment following surgery. |
2022-08-30 |
2023-08-14 |
mouse |
| Aymeric Silvin, Stefan Uderhardt, Cecile Piot, Sandro Da Mesquita, Katharine Yang, Laufey Geirsdottir, Kevin Mulder, David Eyal, Zhaoyuan Liu, Cecile Bridlance, Morgane Sonia Thion, Xiao Meng Zhang, Wan Ting Kong, Marc Deloger, Vasco Fontes, Assaf Weiner, Rachel Ee, Regine Dress, Jing Wen Hang, Akhila Balachander, Svetoslav Chakarov, Benoit Malleret, Garett Dunsmore, Olivier Cexus, Jinmiao Chen, Sonia Garel, Charles Antoine Dutertre, Ido Amit, Jonathan Kipnis, Florent Ginhou. Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration. Immunity. 2022-08-05. PMID:35931085. |
we show that the previously identified disease-associated microglia (dam) population detected in murine alzheimer's disease models actually comprises two ontogenetically and functionally distinct cell lineages: embryonically derived triggering receptor expressed on myeloid cells 2 (trem2)-dependent dam expressing a neuroprotective signature and monocyte-derived trem2-expressing disease inflammatory macrophages (dims) accumulating in the brain during aging. |
2022-08-05 |
2023-08-14 |
human |
| Vladimira Durmanova, Juraj Javor, Zuzana Parnicka, Gabriel Minarik, Agata Ocenasova, Barbora Vaseckova, Iliana Kiralyova, Stanislav Sutovsky, Robert Petrovic, Ivana Shawkatov. Journal of integrative neuroscience. vol 21. issue 4. 2022-07-22. PMID:35864757. |
in the human brain, trem2 is primarily expressed on microglia and is involved in cell survival, phagocytosis, and regulation of inflammation. |
2022-07-22 |
2023-08-14 |
human |
| Juan García-Revilla, Antonio Boza-Serrano, Ana M Espinosa-Oliva, Manuel Sarmiento Soto, Tomas Deierborg, Rocío Ruiz, Rocío M de Pablos, Miguel Angel Burguillos, Jose L Vener. Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration. Cell death & disease. vol 13. issue 7. 2022-07-20. PMID:35859075. |
in this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, tlr4 and trem2 and the importance of galectin-3 in the regulation of microglia activation. |
2022-07-20 |
2023-08-14 |
Not clear |
| Anna Fracassi, Michela Marcatti, Batbayar Tumurbaatar, Randall Woltjer, Sandra Moreno, Giulio Taglialatel. TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology. Brain pathology (Zurich, Switzerland). 2022-07-11. PMID:35816404. |
based on trem2 role in the scavenging function of microglia, we hypothesize that an efficient microglial phagocytosis of damaged synapses underlies synaptic resilience in ndan, thus protecting from memory deficits. |
2022-07-11 |
2023-08-14 |
human |
| Marino Muxfeldt Bianchin, Zhezu Sno. Primary microglia dysfunction or microgliopathy: A cause of dementias and other neurological or psychiatric disorders. Neuroscience. 2022-06-27. PMID:35760218. |
observations that the impairment of normal microglia function per se could lead to neurological or psychiatric diseases have been mainly obtained from genetic and molecular studies of nasu-hakola disease, caused by tyrobp or trem2 mutations, and from studies of adult-onset leukoencephalopathy with axonal spheroids (alsp), caused by csf1r mutations. |
2022-06-27 |
2023-08-14 |
human |
| Hannah Schwarz, Sarah Bässler, Denise Balta, Eileen Socher, Friederike Zunke, Philipp Arnol. The role of Triggering Receptor Expressed on Myeloid Cells 2 in Parkinson's disease and other neurodegenerative disorders. Behavioural brain research. 2022-06-25. PMID:35752274. |
expressed on phagocytic cells, such as macrophages and microglia, trem2 puts the focus on inflammation associated conditions in pd and provides a molecular target that could at least partly explain the role of immune cells in pd. |
2022-06-25 |
2023-08-14 |
Not clear |
| Darya Khantakova, Simone Brioschi, Martina Molgor. Exploring the Impact of TREM2 in Tumor-Associated Macrophages. Vaccines. vol 10. issue 6. 2022-06-24. PMID:35746551. |
trem2 has been extensively studied in microglia and neurodegenerative diseases and recently emerged as a marker of pro-tumorigenic macrophages. |
2022-06-24 |
2023-08-14 |
Not clear |
| Yoshiki Hase, Kamar E Ameen-Ali, Rachel Waller, Julie E Simpson, Charlotte Stafford, Ayushi Mahesh, Lucy Ryan, Lucy Pickering, Caroline Bodman, Mai Hase, Delphine Boche, Karen Horsburgh, Stephen B Wharton, Raj N Kalari. Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke. Brain pathology (Zurich, Switzerland). 2022-06-24. PMID:35748290. |
we primarily used cd68 as a marker of phagocytic microglia, as well as other markers of microglia including iba-1 and tmem119, and the myeloid cell marker trem2 to assess dementia-specific changes. |
2022-06-24 |
2023-08-14 |
human |
| Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Molecular neurodegeneration. vol 17. issue 1. 2022-06-18. PMID:35717259. |
lilrb2-mediated trem2 signaling inhibition suppresses microglia functions. |
2022-06-18 |
2023-08-14 |
Not clear |
| Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions. Molecular neurodegeneration. vol 17. issue 1. 2022-06-18. PMID:35717259. |
triggering receptor expressed on myeloid cells 2 (trem2) in association with dap12 mediates signaling affecting microglia function. |
2022-06-18 |
2023-08-14 |
Not clear |
| Sepideh Kiani Shabestari, Samuel Morabito, Emma Pascal Danhash, Amanda McQuade, Jessica Ramirez Sanchez, Emily Miyoshi, Jean Paul Chadarevian, Christel Claes, Morgan Alexandra Coburn, Jonathan Hasselmann, Jorge Hidalgo, Kayla Nhi Tran, Alessandra C Martini, Winston Chang Rothermich, Jesse Pascual, Elizabeth Head, David A Hume, Clare Pridans, Hayk Davtyan, Vivek Swarup, Mathew Blurton-Jone. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell reports. vol 39. issue 11. 2022-06-15. PMID:35705056. |
to further understand the clinical implications of these findings, human ad tissue and ipsc-microglia were examined, providing evidence that microglia phagocytose calcium crystals, and this process is impaired by loss of the ad risk gene, trem2. |
2022-06-15 |
2023-08-14 |
mouse |
| Yi-Jun Xu, Ngan Pan Bennett Au, Chi Him Eddie M. Functional and Phenotypic Diversity of Microglia: Implication for Microglia-Based Therapies for Alzheimer's Disease. Frontiers in aging neuroscience. vol 14. 2022-06-13. PMID:35693341. |
recent in-depth transcriptomic analysis identifies apoe and trem2 from microglia as the major risk factors for ad pathogenesis. |
2022-06-13 |
2023-08-14 |
Not clear |
| Sanjay, Jae-Ho Shin, Miey Park, Hae-Jeung Le. Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model. Molecular neurobiology. 2022-06-07. PMID:35670898. |
cyanidin-3-o-glucoside regulates the m1/m2 polarization of microglia via pparγ and aβ42 phagocytosis through trem2 in an alzheimer's disease model. |
2022-06-07 |
2023-08-14 |
mouse |
| Qian Shi, Cheng Chang, Afaf Saliba, Manzoor A Bha. Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-06-07. PMID:35672148. |
microglial mtor activation upregulates trem2 and enhances β-amyloid plaque clearance in the the mechanistic target of rapamycin (mtor) signaling pathway plays a major role in key cellular processes including metabolism and differentiation; however, the role of mtor in microglia and its importance in alzheimer's disease (ad) has remained largely uncharacterized. |
2022-06-07 |
2023-08-14 |
Not clear |
| Rui-Yang Li, Qi Qin, Han-Chen Yang, Ying-Ying Wang, Ying-Xin Mi, Yun-Si Yin, Meng Wang, Chao-Ji Yu, Yi Tan. TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target. Molecular neurodegeneration. vol 17. issue 1. 2022-06-06. PMID:35658903. |
triggering receptor expressed on myeloid cells 2 (trem2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and macrophages in the periphery. |
2022-06-06 |
2023-08-14 |
Not clear |
| Rui-Yang Li, Qi Qin, Han-Chen Yang, Ying-Ying Wang, Ying-Xin Mi, Yun-Si Yin, Meng Wang, Chao-Ji Yu, Yi Tan. TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target. Molecular neurodegeneration. vol 17. issue 1. 2022-06-06. PMID:35658903. |
in the cns, trem2 affects the metabolism of cholesterol, myelin, and phospholipids and promotes the transition of microglia into a disease-associated phenotype. |
2022-06-06 |
2023-08-14 |
Not clear |