| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Qin, Meng Wang, Yunsi Yin, Yi Tan. The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-06-06. PMID:35663962. |
trem2 is involved in the synaptic clearance of microglia, acting alone or with other molecules, such as apolipoprotein e (apoe). |
2022-06-06 |
2023-08-14 |
Not clear |
| Qi Qin, Meng Wang, Yunsi Yin, Yi Tan. The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-06-06. PMID:35663962. |
in this review, we systematically summarized the potential mechanisms of microglia involved in synaptic clearance, comprehensively reviewed the role of trem2 in microglia regulating synaptic clearance and proposed our hypothesis that trem2 interacts with apoe and c1q to promote synaptic clearance. |
2022-06-06 |
2023-08-14 |
Not clear |
| Qi Qin, Meng Wang, Yunsi Yin, Yi Tan. The Specific Mechanism of TREM2 Regulation of Synaptic Clearance in Alzheimer's Disease. Frontiers in immunology. vol 13. 2022-06-06. PMID:35663962. |
this review provides new insights into the role of trem2 regulation in microglia synaptic clearance and provides potential prospects for the treatment of ad. |
2022-06-06 |
2023-08-14 |
Not clear |
| Rahul Dhandapani, Marilisa Neri, Mario Bernhard, Irena Brzak, Tatjana Schweizer, Stefan Rudin, Stefanie Joller, Ramon Berth, Jasmin Kernen, Anna Neuhaus, Annick Waldt, Rachel Cuttat, Ulrike Naumann, Caroline Gubser Keller, Guglielmo Roma, Dominik Feuerbach, Derya R Shimshek, Ulf Neumann, Fabrizio Gasparini, Ivan Galimbert. Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease. Cell reports. vol 39. issue 9. 2022-06-01. PMID:35649351. |
sustained trem2 stabilization accelerates microglia heterogeneity and aβ pathology in a mouse model of alzheimer's disease. |
2022-06-01 |
2023-08-13 |
mouse |
| Rahul Dhandapani, Marilisa Neri, Mario Bernhard, Irena Brzak, Tatjana Schweizer, Stefan Rudin, Stefanie Joller, Ramon Berth, Jasmin Kernen, Anna Neuhaus, Annick Waldt, Rachel Cuttat, Ulrike Naumann, Caroline Gubser Keller, Guglielmo Roma, Dominik Feuerbach, Derya R Shimshek, Ulf Neumann, Fabrizio Gasparini, Ivan Galimbert. Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer's disease. Cell reports. vol 39. issue 9. 2022-06-01. PMID:35649351. |
trem2 is a transmembrane protein expressed exclusively in microglia in the brain that regulates inflammatory responses to pathological conditions. |
2022-06-01 |
2023-08-13 |
mouse |
| Li Zhang, Wei Dong, Yuanwu Ma, Lin Bai, Xu Zhang, Caixian Sun, Jingwen Li, Lianfeng Zhan. Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo. Molecular neurobiology. 2022-05-19. PMID:35589918. |
pon1 deficiency in rat primary microglia increased trem2 (triggering receptor expressed in myeloid cells 2) expression, phagocytosis, and il-10 (m2-phenotype marker) release, but decreased production of pro-inflammatory cytokines such as il-1β, il-6, and il-18 especially tnf-α (m1-phenotype markers) induced by lps. |
2022-05-19 |
2023-08-13 |
rat |
| Li Zhang, Wei Dong, Yuanwu Ma, Lin Bai, Xu Zhang, Caixian Sun, Jingwen Li, Lianfeng Zhan. Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo. Molecular neurobiology. 2022-05-19. PMID:35589918. |
pon1 deficiency in rat primary microglia activated trem2 pathway but decreased lps-induced erk activation. |
2022-05-19 |
2023-08-13 |
rat |
| Alyson L Essex, Joshua R Huot, Padmini Deosthale, Alison Wagner, Jorge Figueras, Azaria Davis, John Damrath, Fabrizio Pin, Joseph Wallace, Andrea Bonetto, Lilian I Plotki. TREM2 R47H variant causes distinct age- and sex-dependent musculoskeletal alterations in mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2022-05-16. PMID:35575023. |
previous studies proposed the triggering receptor expressed on myeloid cells 2 (trem2), a receptor expressed in myeloid cells including microglia in brain and osteoclasts in bone, as a link between brain and bone disease. |
2022-05-16 |
2023-08-13 |
mouse |
| Wen-Yu Ma, Sha-Sha Wang, Qing-Lin Wu, Xin Zhou, Shi-Feng Chu, Nai-Hong Che. The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke. International immunopharmacology. vol 109. 2022-05-07. PMID:35525233. |
the versatile role of trem2 in regulating of microglia fate in the ischemic stroke. |
2022-05-07 |
2023-08-13 |
Not clear |
| Wen-Yu Ma, Sha-Sha Wang, Qing-Lin Wu, Xin Zhou, Shi-Feng Chu, Nai-Hong Che. The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke. International immunopharmacology. vol 109. 2022-05-07. PMID:35525233. |
triggering receptor expressed on myeloid cells-2 (trem2) is a cell surface receptor that is mainly expressed in microglia of the central nervous system. |
2022-05-07 |
2023-08-13 |
Not clear |
| Wen-Yu Ma, Sha-Sha Wang, Qing-Lin Wu, Xin Zhou, Shi-Feng Chu, Nai-Hong Che. The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke. International immunopharmacology. vol 109. 2022-05-07. PMID:35525233. |
however, trem2 does not provide a systematic summary of the functional transformation and intrinsic molecular mechanisms of microglia after stroke. |
2022-05-07 |
2023-08-13 |
Not clear |
| Wen-Yu Ma, Sha-Sha Wang, Qing-Lin Wu, Xin Zhou, Shi-Feng Chu, Nai-Hong Che. The versatile role of TREM2 in regulating of microglia fate in the ischemic stroke. International immunopharmacology. vol 109. 2022-05-07. PMID:35525233. |
in this paper, we have summarized the functional changes of trem2 in microglia after stroke in recent years, and found that trem2 has important effects on energy metabolism, phagocytosis and anti-inflammatory function of microglia after stroke, suggesting that trem2 is a potential therapeutic target for the treatment of stroke. |
2022-05-07 |
2023-08-13 |
Not clear |
| Kaori Endo-Umeda, Eunyoung Kim, David G Thomas, Wenli Liu, Huijuan Dou, Mustafa Yalcinkaya, Sandra Abramowicz, Tong Xiao, Per Antonson, Jan-Åke Gustafsson, Makoto Makishima, Muredach P Reilly, Nan Wang, Alan R Tal. Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology. 2022-04-28. PMID:35477277. |
single-cell rna sequencing has identified foam cells as trem2 (triggering receptor expressed on myeloid cells 2) positive populations with low expression of inflammatory genes, resembling the trem2 positive microglia of neurodegenerative diseases. |
2022-04-28 |
2023-08-13 |
Not clear |
| Linlin Zhang, Yanzhong Liu, Xin Wang, Dan Wang, Hao Wu, Haichun Chen, Jiaxi Chen, Yiping Li. Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer's disease model. Physiology & behavior. 2022-04-22. PMID:35452628. |
this study aims to explore the relationship of trem2, microglia activation and neuroinflammation in the development of alzheimer's disease, followed by investigating why physical exercises improve cognition in the alzheimer's disease model by means of the adeno-associated virus (aav) injection. |
2022-04-22 |
2023-08-13 |
Not clear |
| Linlin Zhang, Yanzhong Liu, Xin Wang, Dan Wang, Hao Wu, Haichun Chen, Jiaxi Chen, Yiping Li. Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer's disease model. Physiology & behavior. 2022-04-22. PMID:35452628. |
together, the improvement of ad-associated recognition memory by exercises is associated with up-regulation of the trem2 pathway which promotes the phenotypic conversion of microglia and decreases the level of neuroinflammation. |
2022-04-22 |
2023-08-13 |
Not clear |
| Haining Liu, Mingming Jin, Minxiu Ji, Wei Zhang, An Liu, Tao Wan. Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer's disease mice model. Aging. vol 14. issue undefined. 2022-04-02. PMID:35366241. |
bv2 cells were used to show the regulatory relationships between circ-epc1, mir-770-3p, and trem2 and to show how these interactions modulated phenotypic transformations and inflammatory cytokine expressions in microglia. |
2022-04-02 |
2023-08-13 |
mouse |
| Haining Liu, Mingming Jin, Minxiu Ji, Wei Zhang, An Liu, Tao Wan. Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer's disease mice model. Aging. vol 14. issue undefined. 2022-04-02. PMID:35366241. |
overexpressing mir-770-3p or downregulating trem2 reversed the effects of circ-epc1 on m2 microglia during lipopolysaccharide treatment. |
2022-04-02 |
2023-08-13 |
mouse |
| Evgenii Gerasimov, Ekaterina Pchitskaya, Ilya Bezprozvann. TREM2 and calcium signaling in microglia - is it relevant for Alzheimer's disease? Cell calcium. vol 104. 2022-04-02. PMID:35366517. |
trem2 and calcium signaling in microglia - is it relevant for alzheimer's disease? |
2022-04-02 |
2023-08-13 |
Not clear |
| Chun-Xiang He, Wen-Jing Yu, Miao Yang, Ze Li, Xiao-Fang Xia, Ping Li, Shao-Wu Cheng, Zhen-Yan Son. [Baicalin inhibits LPS/IFN-γ-induced inflammation via TREM2/TLR4/NF-κB pathway in BV2 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347959. |
this study investigated the mechanism of baicalin on lipopolysaccharide(lps)/interferon γ(ifn-γ)-induced inflammatory microglia based on the triggering receptor expressed on myeloid cells 2(trem2)/toll-like receptor 4(tlr4)/nuclear factor kappab(nf-κb) pathway. |
2022-03-29 |
2023-08-13 |
mouse |
| Chun-Xiang He, Wen-Jing Yu, Miao Yang, Ze Li, Xiao-Fang Xia, Ping Li, Shao-Wu Cheng, Zhen-Yan Son. [Baicalin inhibits LPS/IFN-γ-induced inflammation via TREM2/TLR4/NF-κB pathway in BV2 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 6. 2022-03-29. PMID:35347959. |
in summary, these results suggest that baicalin can regulate the imbalance between trem2 and tlr4 of microglia and inhibit the activation of downstream nf-κb, thus promoting the polarization of microglia from pro-inflammatory phenotype to anti-inflammatory phenotype. |
2022-03-29 |
2023-08-13 |
mouse |