| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brow. Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss. Glia. 2022-12-08. PMID:36480007. |
finally, overexpression of trem2 in chme-3 microglia caused increased expression of cystatin f, a cysteine protease inhibitor, and knock-down of cystatin f increased chme-3 uptake of phosphatidylserine-beads. |
2022-12-08 |
2023-08-14 |
mouse |
| Nimansha Jain, Jason D Ulric. TREM2 and microglia exosomes: a potential highway for pathological tau. Molecular neurodegeneration. vol 17. issue 1. 2022-11-18. PMID:36397070. |
trem2 and microglia exosomes: a potential highway for pathological tau. |
2022-11-18 |
2023-08-14 |
Not clear |
| Atsuko Katsumoto, Olga N Kokiko-Cochran, Shane M Bemiller, Guixiang Xu, Richard M Ransohoff, Bruce T Lam. Triggering receptor expressed on myeloid cells 2 deficiency exacerbates injury-induced inflammation in a mouse model of tauopathy. Frontiers in immunology. vol 13. 2022-11-17. PMID:36389767. |
triggering receptor expressed on myeloid cells 2 (trem2) is a critical regulator of microglia and macrophage phenotype, but its mechanisms on tbi remain unclear. |
2022-11-17 |
2023-08-14 |
mouse |
| Alyssa L Thomas, Maria A Lehn, Edith M Janssen, David A Hildeman, Claire A Chougne. Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease. Scientific reports. vol 12. issue 1. 2022-11-14. PMID:36376530. |
we also found downregulation of many phagocytic receptors on old microglia, including trem2, an aβ phagocytic receptor. |
2022-11-14 |
2023-08-14 |
Not clear |
| Alyssa L Thomas, Maria A Lehn, Edith M Janssen, David A Hildeman, Claire A Chougne. Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease. Scientific reports. vol 12. issue 1. 2022-11-14. PMID:36376530. |
trem2 protein expression was diminished in old microglia and loss of trem2 |
2022-11-14 |
2023-08-14 |
Not clear |
| Maud Gratuze, Johannes C M Schlachetzki, Ricardo D'Oliveira Albanus, Nimansha Jain, Brenna Novotny, Logan Brase, Lea Rodriguez, Clayton Mansel, Michal Kipnis, Sydney O'Brien, Martina P Pasillas, Choonghee Lee, Melissa Manis, Marco Colonna, Oscar Harari, Christopher K Glass, Jason D Ulrich, David M Holtzma. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron. 2022-11-11. PMID:36368315. |
microglia adopt a heterogeneous population of transcriptomic states in response to pathology, at least some of which are dependent on trem2. |
2022-11-11 |
2023-08-14 |
mouse |
| Lujuan He, Yi Zheng, Lixuan Huang, Jingyi Ye, Yinyi Ye, Hanyue Luo, Xi Chen, Wei Yao, Jiaxu Chen, Ji-Chun Zhan. Nrf2 regulates the arginase 1 Translational psychiatry. vol 12. issue 1. 2022-11-01. PMID:36316319. |
nrf2 regulates the arginase 1 the expression of the triggering receptor on myeloid cell-2 (trem2) knockdown in microglia from the lateral habenula (lhb) reportedly induces depression-like behaviors in mice. |
2022-11-01 |
2023-08-14 |
mouse |
| Chao-Ji Yu, Meng Wang, Rui-Yang Li, Tao Wei, Han-Chen Yang, Yun-Si Yin, Ying-Xin Mi, Qi Qin, Yi Tan. TREM2 and Microglia Contribute to the Synaptic Plasticity: from Physiology to Pathology. Molecular neurobiology. 2022-11-01. PMID:36318443. |
trem2 and microglia contribute to the synaptic plasticity: from physiology to pathology. |
2022-11-01 |
2023-08-14 |
Not clear |
| Shoutang Wang, Raki Sudan, Vincent Peng, Yingyue Zhou, Siling Du, Carla M Yuede, Tingting Lei, Jinchao Hou, Zhangying Cai, Marina Cella, Khai Nguyen, Pietro L Poliani, Wandy L Beatty, Yun Chen, Siyan Cao, Kent Lin, Cecilia Rodrigues, Ali H Ellebedy, Susan Gilfillan, Gordon D Brown, David M Holtzman, Simone Brioschi, Marco Colonn. TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell. vol 185. issue 22. 2022-10-28. PMID:36306735. |
trem2 drives microglia response to amyloid-β via syk-dependent and -independent pathways. |
2022-10-28 |
2023-08-14 |
human |
| Kenjiro Bandow, Avi Smith, Jonathan Garlic. Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) positively regulates lipopolysaccharide-induced expression of CXC chemokine ligand 10 and 11 in mouse macrophages. Biochemical and biophysical research communications. vol 635. 2022-10-25. PMID:36283335. |
trem2 is an immunoreceptor expressed on dendritic cells, microglia, osteoclasts, and macrophages. |
2022-10-25 |
2023-08-14 |
mouse |
| Chunhao Zhang, Shiwen Che. Role of TREM2 in the Development of Neurodegenerative Diseases After Traumatic Brain Injury. Molecular neurobiology. 2022-10-20. PMID:36264434. |
microglia in the brain can express the triggering receptor expressed on myeloid cells 2 (trem2), which is a single transmembrane receptor pertaining to the immunoglobulin superfamily. |
2022-10-20 |
2023-08-14 |
Not clear |
| Nimansha Jain, Caroline A Lewis, Jason D Ulrich, David M Holtzma. Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading. The Journal of experimental medicine. vol 220. issue 1. 2022-10-11. PMID:36219197. |
thus, microglia and trem2 are at a critical intersection of aβ and tau pathologies in ad. |
2022-10-11 |
2023-08-14 |
mouse |
| Inge C M Hoogland, Jutka Yik, Dunja Westhoff, Joo-Yeon Engelen-Lee, Merche Valls Seron, Wing-Kit Man, Judith H P M Houben-Weerts, Michael W Tanck, David J van Westerloo, Tom van der Poll, Willem A van Gool, Diederik van de Bee. Microglial Response in Triggering Receptor Expressed on Myeloid Cells 2 (Trem2) Knock-Out Mice After Systemic Stimulation with Escherichia Coli. Neuroscience letters. 2022-10-02. PMID:36183964. |
microglial cell response is a known key player in this process and we hypothesize that the triggering receptor expressed on myeloid cells 2 (trem2) plays an important role in the regulation of this response. |
2022-10-02 |
2023-08-14 |
mouse |
| Kiran K Dayananda, Sahabuddin Ahmed, Daniel Wang, Baruh Polis, Rafiad Islam, Arie Kaffma. Early life stress impairs synaptic pruning in the developing hippocampus. Brain, behavior, and immunity. 2022-09-29. PMID:36174883. |
exposure to both lb and ups reduced the ramification of microglia, impaired their ability to phagocytose synaptic material in vivo and ex vivo, and decreased expression of trem2. |
2022-09-29 |
2023-08-14 |
mouse |
| Na Zhao, Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng, Yuka A Martens, Xusheng Wang, Ling Li, Chia-Chen Liu, Kai Chen, Yiyang Zhu, Tadafumi C Ikezu, Zonghua Li, Axel D Meneses, Yunjung Jin, Joshua A Knight, Yixing Chen, Ligia Bastea, Cynthia Linares, Berkiye Sonustun, Lucy Job, Madeleine L Smith, Manling Xie, Yong U Liu, Anthony D Umpierre, Koichiro Haruwaka, Zachary S Quicksall, Peter Storz, Yan W Asmann, Long-Jun Wu, Guojun B. Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia. The Journal of experimental medicine. vol 219. issue 12. 2022-09-15. PMID:36107206. |
elevating microglia trem2 reduces amyloid seeding and suppresses disease-associated microglia. |
2022-09-15 |
2023-08-14 |
mouse |
| Na Zhao, Wenhui Qiao, Fuyao Li, Yingxue Ren, Jiaying Zheng, Yuka A Martens, Xusheng Wang, Ling Li, Chia-Chen Liu, Kai Chen, Yiyang Zhu, Tadafumi C Ikezu, Zonghua Li, Axel D Meneses, Yunjung Jin, Joshua A Knight, Yixing Chen, Ligia Bastea, Cynthia Linares, Berkiye Sonustun, Lucy Job, Madeleine L Smith, Manling Xie, Yong U Liu, Anthony D Umpierre, Koichiro Haruwaka, Zachary S Quicksall, Peter Storz, Yan W Asmann, Long-Jun Wu, Guojun B. Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia. The Journal of experimental medicine. vol 219. issue 12. 2022-09-15. PMID:36107206. |
trem2 is exclusively expressed by microglia in the brain and is strongly linked to the risk for alzheimer's disease (ad). |
2022-09-15 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine. vol 14. issue 661. 2022-09-07. PMID:36070367. |
triggering receptor expressed on myeloid cells 2 (trem2) plays crucial roles in alzheimer's disease (ad) by regulating microglia migration toward, and phagocytosis of oligomeric amyloid-β (oaβ) and amyloid plaques. |
2022-09-07 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine. vol 14. issue 661. 2022-09-07. PMID:36070367. |
stronger trem2 activation led to enhanced microglia phagocytosis of the oaβ-lipid complex, migration toward oaβ, and improved microglia survival in vitro. |
2022-09-07 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine. vol 14. issue 661. 2022-09-07. PMID:36070367. |
mechanistic studies showed increased trem2 clustering on microglia by the tetravalent ab18 tvd-ig without altering microglial trem2 amount. |
2022-09-07 |
2023-08-14 |
mouse |
| Peng Zhao, Yuanzhong Xu, LuLin Jiang, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Yingjun Zhao, Wei Cao, Hui Zheng, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang A. A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. Science translational medicine. vol 14. issue 661. 2022-09-07. PMID:36070367. |
this study demonstrated the feasibility of engineering multivalent trem2 agonistic ab coupled with tfr-mediated brain delivery to enhance microglia functions and reduce amyloid pathology in vitro and in vivo. |
2022-09-07 |
2023-08-14 |
mouse |