| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Si Huang, Xiaoli Liao, Junyong Wu, Xiaojie Zhang, Yamin Li, Daxiong Xiang, Shilin Lu. The microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid-β by microglia. FEBS letters. 2022-03-16. PMID:35292963. |
the microglial membrane receptor trem2 mediates exosome secretion to promote phagocytosis of amyloid-β by microglia. |
2022-03-16 |
2023-08-13 |
Not clear |
| Si Huang, Xiaoli Liao, Junyong Wu, Xiaojie Zhang, Yamin Li, Daxiong Xiang, Shilin Lu. The microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid-β by microglia. FEBS letters. 2022-03-16. PMID:35292963. |
considerable evidence links the microglial transmembrane receptor trem2 to the progression of alzheimer's disease through its involvement in aβ phagocytosis by microglia. |
2022-03-16 |
2023-08-13 |
Not clear |
| Mengying Shi, Yating Gong, Muyao Wu, Haiping Gu, Jiejie Yu, Fan Gao, Zhe Ren, Min Qian, Baoqi Dang, Gang Che. Downregulation of TREM2/NF-кB signaling may damage the blood-brain barrier and aggravate neuronal apoptosis in experimental rats with surgically injured brain. Brain research bulletin. 2022-03-05. PMID:35247489. |
trem2, an immune protein mainly expressed in microglia, is an important link for nerve cells to participate in the inflammatory response. |
2022-03-05 |
2023-08-13 |
rat |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
hippocampal overexpression of trem2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. |
2022-02-28 |
2023-08-13 |
mouse |
| Min Wu, Maolin Liao, Rongfeng Huang, Chunxiu Chen, Tian Tian, Hongying Wang, Jiayu Li, Jibin Li, Yuxiang Sun, Chaodong Wu, Qifu Li, Xiaoqiu Xia. Hippocampal overexpression of TREM2 ameliorates high fat diet induced cognitive impairment and modulates phenotypic polarization of the microglia. Genes & diseases. vol 9. issue 2. 2022-02-28. PMID:35224156. |
furthermore, trem2 markedly increased the number of iba-1/arg-1-positive microglia in the hippocampus, suppressed neuroinflammation and microglial activation. |
2022-02-28 |
2023-08-13 |
mouse |
| Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael D Cahala. TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. eLife. vol 11. 2022-02-22. PMID:35191835. |
trem2 regulates purinergic receptor-mediated calcium signaling and motility in human ipsc-derived microglia. |
2022-02-22 |
2023-08-13 |
human |
| Guy C Brown, Peter St George-Hyslo. Does Soluble TREM2 Protect Against Alzheimer's Disease? Frontiers in aging neuroscience. vol 13. 2022-02-14. PMID:35153729. |
triggering receptor expressed in myeloid cells 2 (trem2) is a pattern recognition receptor on myeloid cells, and is upregulated on microglia surrounding amyloid plaques in alzheimer's disease (ad). |
2022-02-14 |
2023-08-13 |
Not clear |
| Bhargavi Kulkarni, Natália Cruz-Martins, Dileep Kuma. Microglia in Alzheimer's Disease: An Unprecedented Opportunity as Prospective Drug Target. Molecular neurobiology. 2022-02-12. PMID:35149973. |
immune receptors revealed on microglia as potential drug targets can be paired immunoglobulin-like type 2 receptor (pilr), cd3358, and triggering receptor expressed on myeloid cells 2 (trem2), as they can have impact on late-onset ad occurrence and progression. |
2022-02-12 |
2023-08-13 |
Not clear |
| Shan-Shan Zhang, Lin Zhu, Yan Peng, Lei Zhang, Feng-Lei Chao, Lin Jiang, Qian Xiao, Xin Liang, Jing Tang, Hao Yang, Qi He, Yi-Jing Guo, Chun-Ni Zhou, Yong Tan. Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice. Journal of neuroinflammation. vol 19. issue 1. 2022-02-06. PMID:35123512. |
triggering receptor expressed in myeloid cells 2 (trem2) is expressed on microglia and is known to mediate microglial metabolic activity and brain glucose metabolism. |
2022-02-06 |
2023-08-13 |
mouse |
| Raz Dvir-Szternfeld, Giulia Castellani, Michal Arad, Liora Cahalon, Sara P Colaiuta, Hadas Keren-Shaul, Tommaso Croese, Tyler K Ulland, Marco Colonna, Assaf Weiner, Ido Amit, Michal Schwart. TREM2-independent neuroprotection is mediated by monocyte-derived macrophages in a mouse model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108946. |
in the 5xfad animal model of amyloidosis, disease-associated microglia (dam) expressing the triggering receptor expressed on myeloid cells 2 (trem2), are found in close proximity to amyloid beta (aβ) plaques. |
2022-02-03 |
2023-08-13 |
mouse |
| Shih-Feng You, Logan Brase, Fabia Filipello, Jorge L Del-Aguila, Kathie A Mihindukulasuriya, Bruno A Benitez, Carlos Cruchaga, Oscar Harari, Celeste M Karc. Multi-omics approaches reveal a link between the MS4A gene loci, TREM2, and microglia function. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109103. |
multi-omics approaches reveal a link between the ms4a gene loci, trem2, and microglia function. |
2022-02-03 |
2023-08-13 |
human |
| Shih-Feng You, Logan Brase, Fabia Filipello, Jorge L Del-Aguila, Kathie A Mihindukulasuriya, Bruno A Benitez, Carlos Cruchaga, Oscar Harari, Celeste M Karc. Multi-omics approaches reveal a link between the MS4A gene loci, TREM2, and microglia function. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109103. |
using human induced pluripotent stem cell-derived microglia, we found that ms4a4a and trem2 colocalize on lipid rafts at the plasma membrane. |
2022-02-03 |
2023-08-13 |
human |
| Peter Bor-Chian Lin, Andy Po-Yi Tsai, Kwangsik Nho, Bruce T Lamb, Adrian L Obla. INPP5D as a potential therapeutic target against Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109109. |
inpp5d is linked to the triggering receptor expressed on myeloid cells 2 (trem2) signaling, but little is known about the function of inpp5d in microglia and how inpp5d regulates trem2-related ad pathogenesis. |
2022-02-03 |
2023-08-13 |
Not clear |
| Milan Stoiljkovic, Karel Otero Gutierrez, Craig Kelley, Tamas Horvath, Mihaly Hajo. Impact of TREM2 on hippocampal network oscillations in Tg2576 mice modeling amyloid-β pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109230. |
in the brain, trem2 is specifically expressed on microglia suggesting their active involvement in driving disease pathology. |
2022-02-03 |
2023-08-13 |
mouse |
| Anna Fracassi, Michela Marcatti, Randy L Woltjer, Giulio Taglialatel. TREM2-induced activation of microglia contributes to synaptic resilience in non-demented individuals with Alzheimer's neuropathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109255. |
based on trem2 role in the scavenging function of microglia, we hypothesize that an efficient microglial phagocytosis of damaged synapses underlies synaptic resilience in ndan, thus protecting from memory deficits. |
2022-02-03 |
2023-08-13 |
Not clear |
| Jolanta Dorszewska, Michal Prendecki, Mikolaj Hurla, Natalia Banaszek, Paulina Szejn, Jolanta Florczak-Wyspianska, Jan Ilkowski, Wojciech Kozubsk. Analysis of genetic variants associated with the removal of the pathological Abeta form in patients with Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109288. |
trem2, acts as a receptor for the aβ oligomers and mediates its degradation by microglia. |
2022-02-03 |
2023-08-13 |
human |
| Fabia Filipello, Claire Goldsbury, You Shih Feng, Alberto Locca, Celeste M Karch, Laura Picci. Soluble TREM2: Innocent bystander or active player in neurological diseases? Neurobiology of disease. 2022-01-18. PMID:35041990. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor expressed by macrophages and microglia in the central nervous system (cns). |
2022-01-18 |
2023-08-13 |
Not clear |
| Fabia Filipello, Claire Goldsbury, You Shih Feng, Alberto Locca, Celeste M Karch, Laura Picci. Soluble TREM2: Innocent bystander or active player in neurological diseases? Neurobiology of disease. 2022-01-18. PMID:35041990. |
trem2 has attracted a lot of interest in the past decade for its critical role in modulating microglia functions under homeostatic conditions and in neurodegenerative diseases. |
2022-01-18 |
2023-08-13 |
Not clear |
| Fabia Filipello, Claire Goldsbury, You Shih Feng, Alberto Locca, Celeste M Karch, Laura Picci. Soluble TREM2: Innocent bystander or active player in neurological diseases? Neurobiology of disease. 2022-01-18. PMID:35041990. |
beyond the role played by trem2 genetic variants in these diseases, trem2 engagement is a key step in microglia activation in response to different types of tissue injury (e.g. |
2022-01-18 |
2023-08-13 |
Not clear |
| Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl-Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haas. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. The EMBO journal. 2022-01-12. PMID:35019161. |
loss of trem2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. |
2022-01-12 |
2023-08-13 |
mouse |