| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fulton T Crews, Jian Zou, Leon G Colema. Extracellular microvesicles promote microglia-mediated pro-inflammatory responses to ethanol. Journal of neuroscience research. vol 99. issue 8. 2021-11-18. PMID:33611821. |
ethanol caused a unique immune gene signature that featured: temporal induction of pro-inflammatory tnf-α and il-1β, reduction of homeostatic microglia state gene tmem119, progressive increases in purinergic receptor p2ry12 and the microglial inhibitory fractalkine receptor cx3cr1, an increase in the microglial presynaptic gene c1q, and a reduction in the phagocytic gene trem2. |
2021-11-18 |
2023-08-13 |
Not clear |
| Mei-Dan Wei, Yan-Xian Lan, Kun Lu, Yan Wang, Wen-Ying Che. Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. Behavioural brain research. vol 397. 2021-11-15. PMID:32991925. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor that is expressed mainly on the surfaces of microglia. |
2021-11-15 |
2023-08-13 |
mouse |
| Mei-Dan Wei, Yan-Xian Lan, Kun Lu, Yan Wang, Wen-Ying Che. Knockdown of astrocytic TREM2 in the hippocampus relieves cognitive decline in elderly male mice. Behavioural brain research. vol 397. 2021-11-15. PMID:32991925. |
although trem2 is more highly expressed in microglia than in astrocytes, little attention has been focused on astrocytic trem2, and the precise role of astrocytic trem2 in the aging process remains unknown. |
2021-11-15 |
2023-08-13 |
mouse |
| Aleksandra Szykowska, Yu Chen, Thomas B Smith, Charlotta Preger, Jingjing Yang, Dongming Qian, Shubhashish M Mukhopadhyay, Edvard Wigren, Stephen J Neame, Susanne Gräslund, Helena Persson, Peter J Atkinson, Elena Di Daniel, Emma Mead, John Wang, John B Davis, Nicola A Burgess-Brown, Alex N Bulloc. Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain. Structure (London, England : 1993). vol 29. issue 11. 2021-11-12. PMID:34233201. |
mutations in trem2, a receptor expressed by microglia in the brain, are associated with an increased risk of neurodegeneration, including alzheimer's disease. |
2021-11-12 |
2023-08-13 |
human |
| Antero Salminen, Kai Kaarniranta, Anu Kauppine. Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis. Neurochemistry international. vol 150. 2021-11-11. PMID:34530055. |
in particular, the cd33 receptor, also called siglec-3, inhibits the trem2 receptor-induced phagocytic activity of microglia. |
2021-11-11 |
2023-08-13 |
human |
| Andrew Folick, Suneil K Koliwad, Martin Valdearco. Microglial Lipid Biology in the Hypothalamic Regulation of Metabolic Homeostasis. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34122343. |
such techniques have highlighted specific subsets of microglia notable for their capacity to regulate the expression of lipid metabolic genes, including lipoprotein lipase (lpl), apolipoprotein e (apoe) and triggering receptor expressed on myeloid cells 2 (trem2). |
2021-11-10 |
2023-08-13 |
Not clear |
| Yuumi Okuzono, Hiroyuki Sakuma, Shuuichi Miyakawa, Masataka Ifuku, Jonghun Lee, Debashree Das, Antara Banerjee, Yang Zhao, Koji Yamamoto, Tatsuya Ando, Shuji Sat. Reduced TREM2 activation in microglia of patients with Alzheimer's disease. FEBS open bio. vol 11. issue 11. 2021-11-10. PMID:34523252. |
reduced trem2 activation in microglia of patients with alzheimer's disease. |
2021-11-10 |
2023-08-13 |
human |
| Yuumi Okuzono, Hiroyuki Sakuma, Shuuichi Miyakawa, Masataka Ifuku, Jonghun Lee, Debashree Das, Antara Banerjee, Yang Zhao, Koji Yamamoto, Tatsuya Ando, Shuji Sat. Reduced TREM2 activation in microglia of patients with Alzheimer's disease. FEBS open bio. vol 11. issue 11. 2021-11-10. PMID:34523252. |
we generated an anti-human trem2 agonistic antibody and defined trem2 activation in terms of the downstream expression changes induced by this antibody in microglia developed from human induced pluripotent stem cells (ipsc). |
2021-11-10 |
2023-08-13 |
human |
| Yuumi Okuzono, Hiroyuki Sakuma, Shuuichi Miyakawa, Masataka Ifuku, Jonghun Lee, Debashree Das, Antara Banerjee, Yang Zhao, Koji Yamamoto, Tatsuya Ando, Shuji Sat. Reduced TREM2 activation in microglia of patients with Alzheimer's disease. FEBS open bio. vol 11. issue 11. 2021-11-10. PMID:34523252. |
trem2 activation was lower in ad microglia than in microglia from healthy subjects or patients with mild cognitive impairment. |
2021-11-10 |
2023-08-13 |
human |
| Yuumi Okuzono, Hiroyuki Sakuma, Shuuichi Miyakawa, Masataka Ifuku, Jonghun Lee, Debashree Das, Antara Banerjee, Yang Zhao, Koji Yamamoto, Tatsuya Ando, Shuji Sat. Reduced TREM2 activation in microglia of patients with Alzheimer's disease. FEBS open bio. vol 11. issue 11. 2021-11-10. PMID:34523252. |
pathway enrichment analysis of degs controlled by trem2 activity indicated that trem2 activation in ad may lead to anti-apoptotic signaling, immune response, and cytoskeletal changes in the microglia. |
2021-11-10 |
2023-08-13 |
human |
| Yuumi Okuzono, Hiroyuki Sakuma, Shuuichi Miyakawa, Masataka Ifuku, Jonghun Lee, Debashree Das, Antara Banerjee, Yang Zhao, Koji Yamamoto, Tatsuya Ando, Shuji Sat. Reduced TREM2 activation in microglia of patients with Alzheimer's disease. FEBS open bio. vol 11. issue 11. 2021-11-10. PMID:34523252. |
in addition, the agonistic anti-trem2 antibody can be used to identify trem2 activation state in ad microglia. |
2021-11-10 |
2023-08-13 |
human |
| Kostantin Kiianitsa, Irina Kurtz, Neal Beeman, Mark Matsushita, Wei-Ming Chien, Wendy H Raskind, Olena Korvatsk. Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain. Journal of leukocyte biology. vol 110. issue 5. 2021-11-05. PMID:34061398. |
triggering receptor expressed on myeloid cells 2 (trem2) is an immunoglobulin-like receptor expressed by certain myeloid cells, such as macrophages, dendritic cells, osteoclasts, and microglia. |
2021-11-05 |
2023-08-13 |
human |
| Kostantin Kiianitsa, Irina Kurtz, Neal Beeman, Mark Matsushita, Wei-Ming Chien, Wendy H Raskind, Olena Korvatsk. Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain. Journal of leukocyte biology. vol 110. issue 5. 2021-11-05. PMID:34061398. |
in the brain, trem2 plays an important role in the immune function of microglia, and its dysfunction is linked to various neurodegenerative conditions in humans. |
2021-11-05 |
2023-08-13 |
human |
| Pranav Joshi, Florian Riffel, Sathish Kumar, Nàdia Villacampa, Sandra Theil, Samira Parhizkar, Christian Haass, Marco Colonna, Michael T Heneka, Thomas Arzberger, Jochen Herms, Jochen Walte. TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits. Acta neuropathologica communications. vol 9. issue 1. 2021-11-05. PMID:34663480. |
post-translational modifications of aβ could modulate the interaction with trem2, and the uptake by microglia. |
2021-11-05 |
2023-08-13 |
mouse |
| Ping Li, Tingting Shen, Xue Luo, Ju Yang, Zhen Luo, Yulong Tan, Genlin He, Zeze Wang, Xueting Yu, Ying Wang, Xuesen Yan. Modulation of microglial phenotypes by dexmedetomidine through TREM2 reduces neuroinflammation in heatstroke. Scientific reports. vol 11. issue 1. 2021-11-03. PMID:34172807. |
trem2, whose neuro-protective function has been validated by genetic studies in alzheimer's disease and nasu-hakola disease, was significantly promoted by dex in the microglia. |
2021-11-03 |
2023-08-13 |
mouse |
| Silvio R Meier, Dag Sehlin, Greta Hultqvist, Stina Syväne. Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease. Molecular imaging and biology. vol 23. issue 5. 2021-10-29. PMID:33620643. |
the triggering receptor expressed on myeloid cells 2 (trem2) is expressed by brain microglia. |
2021-10-29 |
2023-08-13 |
mouse |
| Ludmila Belayev, Sung-Ha Hong, Raul S Freitas, Hemant Menghani, Shawn J Marcell, Larissa Khoutorova, Pranab K Mukherjee, Madigan M Reid, Reinaldo B Oria, Nicolas G Baza. DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke. CNS neuroscience & therapeutics. vol 26. issue 11. 2021-10-25. PMID:32757264. |
the microglia cell surface receptor (triggering receptor expressed on myeloid cells-2; trem2) regulates the production of pro- and antiinflammatory mediators after stroke. |
2021-10-25 |
2023-08-13 |
Not clear |
| Antonella De Palma, Anna Maria Agresta, Simona Viglio, Rossana Rossi, Maura D'Amato, Dario Di Silvestre, Pierluigi Mauri, Paolo Iadarol. A Shotgun Proteomic Platform for a Global Mapping of Lymphoblastoid Cells to Gain Insight into Nasu-Hakola Disease. International journal of molecular sciences. vol 22. issue 18. 2021-10-19. PMID:34576123. |
nhd is known to be genetically related to a structural defect of trem2 and dap12, two genes that encode for different subunits of the membrane receptor signaling complex expressed by microglia and osteoclast cells. |
2021-10-19 |
2023-08-13 |
human |
| Hiroyuki Konishi, Hiroshi Kiyam. Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the physiological functions of microglia from development to aging. Neurochemistry international. vol 141. 2021-10-18. PMID:33049336. |
a wide variety of protein and non-protein ligands, including lipids and dna, can bind to trem2, inducing the activation of microglia via dap12. |
2021-10-18 |
2023-08-13 |
Not clear |
| Si-Yi Wang, Yan Liu, Xiao-Mao Li, Adnan Mohammed Algradi, Hai Jiang, Yan-Ping Sun, Wei Guan, Juan Pan, Hai-Xue Kuang, Bing-You Yan. Discovery of Active Ingredients Targeted TREM2 by SPR Biosensor-UPLC/MS Recognition System, and Investigating the Mechanism of Anti-Neuroinflammatory Activity on the Lignin-Amides from Molecules (Basel, Switzerland). vol 26. issue 19. 2021-10-16. PMID:34641490. |
discovery of active ingredients targeted trem2 by spr biosensor-uplc/ms recognition system, and investigating the mechanism of anti-neuroinflammatory activity on the lignin-amides from as a new target protein for alzheimer's disease (ad), the triggering receptor expressed on myeloid cells 2 (trem2) was expressed on the surface of microglia, which was shown to regulate neuroinflammation, be associated with a variety of neuropathologic, and regarded as a potential indicator for monitoring ad. |
2021-10-16 |
2023-08-13 |
Not clear |